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Protein

Phosphatidylinositol 3-kinase catalytic subunit type 3

Gene

pik3c3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).By similarity

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAutophagy, Cell cycle, Cell division
LigandATP-binding, Manganese, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC:2.7.1.137)
Short name:
PI3-kinase type 3
Short name:
PI3K type 3
Short name:
PtdIns-3-kinase type 3
Alternative name(s):
Phosphoinositide-3-kinase class 3
Gene namesi
Name:pik3c3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6085232. pik3c3.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000888061 – 886Phosphatidylinositol 3-kinase catalytic subunit type 3Add BLAST886

Proteomic databases

PRIDEiQ6AZN6.

Interactioni

Subunit structurei

Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex the core of which is composed of the catalytic subunit pik3c3, the regulatory subunit pik3r4 and becn1 associating with additional regulatory/auxilliary subunits to form alternative complex forms.By similarity

Protein-protein interaction databases

IntActiQ6AZN6. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ6AZN6.
SMRiQ6AZN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 184C2 PI3K-typePROSITE-ProRule annotationAdd BLAST150
Domaini283 – 519PIK helicalPROSITE-ProRule annotationAdd BLAST237
Domaini630 – 884PI3K/PI4KPROSITE-ProRule annotationAdd BLAST255

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG082145.
KOiK00914.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
2.60.40.150. 1 hit.
InterProiView protein in InterPro
IPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR008290. PI3K_Vps34.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiView protein in Pfam
PF00454. PI3_PI4_kinase. 2 hits.
PF00792. PI3K_C2. 1 hit.
PF00613. PI3Ka. 1 hit.
PIRSFiPIRSF000587. PI3K_Vps34. 1 hit.
SMARTiView protein in SMART
SM00142. PI3K_C2. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51545. PIK_HELICAL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AZN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGESDRFCYV YSCDLDISVR LKIGSLEGKR EQKSYKAVLE DPMLKFSGLY
60 70 80 90 100
QETCSDLYVT CQVFAEGKPL ALPVRTSYKA FSTRWNWNEW LKLPVKYADL
110 120 130 140 150
PRSAQVALTI WDVYGPGKAI PVGGATVSLF GKYGMFRQGM HDLKVWPNIE
160 170 180 190 200
ADGSELTKTP GRTNSSASED QMSRLAKLTK AHRQGHMVKV DWLDRLTFRE
210 220 230 240 250
IEMINESEKR SSNFMYLMVE FPCVKCDEKE YGIVYYEKDG DESTPISTSS
260 270 280 290 300
EIVRVPDPQM SMENLVEIKH HKLARSLRSG PSDHDLKPNA ATRDQLNIIV
310 320 330 340 350
SYPPTKQLTS EEQDLVWKFR SYLTSQEKAL TKFLKCVNWD LPQEAKQALE
360 370 380 390 400
LLGKWKPMDV EDSLELLSSH FTNPTVRRYA VARLQQADDE DLLMYLLQLV
410 420 430 440 450
QALKYENFED IKSGLEPTKK DSQGPMLESM TTSGINPETD SSQILSNPLP
460 470 480 490 500
AVSSPAPPSK TKDGLDAETL EQDLCTFLIS RACKNSTLAN YLYWYVIVEC
510 520 530 540 550
EDQDTQLRDP KTHEMYLNVM RRFSQALLKG DKSVRVMRSL LATQQTFVDR
560 570 580 590 600
LVHLMKAVQR ESGNRKKKNE RLQALLGDNE KMNLSEFEPI PLPLEPQVKI
610 620 630 640 650
RGIIPEKATL FKSALMPAKL YFKTEDGGKY PVIFKNGDDL RQDQLILQII
660 670 680 690 700
SLMDKLLRKE NLDLKLTPYK VLATSTKHGF MQFIQSVPVA EVLATEGSIQ
710 720 730 740 750
NFFRKYSPSE KGPYGISAEV MDTYVKSCAG YCVITYILGV GDRHLDNLLL
760 770 780 790 800
TKTGKLFHID FGYILGRDPK PLPPPMKLNK EMVEGMGGTQ SEQYQAFRKQ
810 820 830 840 850
CYTAFLHLRR YSNLILNLFS LMVDANIPDI ALEPDKTVKK VQDKFRLDLS
860 870 880
DEEAVHYMQT LIDDSVNALF AAVVEQIHKF AQYWRR
Length:886
Mass (Da):101,157
Last modified:September 13, 2004 - v1
Checksum:iFBAFB8847FBB60A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC077528 mRNA. Translation: AAH77528.1.
RefSeqiNP_001086836.1. NM_001093367.1.
UniGeneiXl.11237.

Genome annotation databases

GeneIDi446671.
KEGGixla:446671.

Similar proteinsi

Entry informationi

Entry nameiPK3C3_XENLA
AccessioniPrimary (citable) accession number: Q6AZN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: September 13, 2004
Last modified: September 27, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families