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Q6AZN6 (PK3C3_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylinositol 3-kinase catalytic subunit type 3

Short name=PI3-kinase type 3
Short name=PI3K type 3
Short name=PtdIns-3-kinase type 3
EC=2.7.1.137
Alternative name(s):
Phosphoinositide-3-kinase class 3
Gene names
Name:pik3c3
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length886 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis By similarity.

Catalytic activity

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

Subcellular location

Midbody By similarity.

Sequence similarities

Belongs to the PI3/PI4-kinase family.

Contains 1 C2 PI3K-type domain.

Contains 1 PI3K/PI4K domain.

Contains 1 PIK helical domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 886886Phosphatidylinositol 3-kinase catalytic subunit type 3
PRO_0000088806

Regions

Domain35 – 184150C2 PI3K-type
Domain283 – 519237PIK helical
Domain630 – 884255PI3K/PI4K

Sequences

Sequence LengthMass (Da)Tools
Q6AZN6 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: FBAFB8847FBB60A9

FASTA886101,157
        10         20         30         40         50         60 
MGESDRFCYV YSCDLDISVR LKIGSLEGKR EQKSYKAVLE DPMLKFSGLY QETCSDLYVT 

        70         80         90        100        110        120 
CQVFAEGKPL ALPVRTSYKA FSTRWNWNEW LKLPVKYADL PRSAQVALTI WDVYGPGKAI 

       130        140        150        160        170        180 
PVGGATVSLF GKYGMFRQGM HDLKVWPNIE ADGSELTKTP GRTNSSASED QMSRLAKLTK 

       190        200        210        220        230        240 
AHRQGHMVKV DWLDRLTFRE IEMINESEKR SSNFMYLMVE FPCVKCDEKE YGIVYYEKDG 

       250        260        270        280        290        300 
DESTPISTSS EIVRVPDPQM SMENLVEIKH HKLARSLRSG PSDHDLKPNA ATRDQLNIIV 

       310        320        330        340        350        360 
SYPPTKQLTS EEQDLVWKFR SYLTSQEKAL TKFLKCVNWD LPQEAKQALE LLGKWKPMDV 

       370        380        390        400        410        420 
EDSLELLSSH FTNPTVRRYA VARLQQADDE DLLMYLLQLV QALKYENFED IKSGLEPTKK 

       430        440        450        460        470        480 
DSQGPMLESM TTSGINPETD SSQILSNPLP AVSSPAPPSK TKDGLDAETL EQDLCTFLIS 

       490        500        510        520        530        540 
RACKNSTLAN YLYWYVIVEC EDQDTQLRDP KTHEMYLNVM RRFSQALLKG DKSVRVMRSL 

       550        560        570        580        590        600 
LATQQTFVDR LVHLMKAVQR ESGNRKKKNE RLQALLGDNE KMNLSEFEPI PLPLEPQVKI 

       610        620        630        640        650        660 
RGIIPEKATL FKSALMPAKL YFKTEDGGKY PVIFKNGDDL RQDQLILQII SLMDKLLRKE 

       670        680        690        700        710        720 
NLDLKLTPYK VLATSTKHGF MQFIQSVPVA EVLATEGSIQ NFFRKYSPSE KGPYGISAEV 

       730        740        750        760        770        780 
MDTYVKSCAG YCVITYILGV GDRHLDNLLL TKTGKLFHID FGYILGRDPK PLPPPMKLNK 

       790        800        810        820        830        840 
EMVEGMGGTQ SEQYQAFRKQ CYTAFLHLRR YSNLILNLFS LMVDANIPDI ALEPDKTVKK 

       850        860        870        880 
VQDKFRLDLS DEEAVHYMQT LIDDSVNALF AAVVEQIHKF AQYWRR 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC077528 mRNA. Translation: AAH77528.1.
RefSeqNP_001086836.1. NM_001093367.1.
UniGeneXl.11237.

3D structure databases

ProteinModelPortalQ6AZN6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID446671.
KEGGxla:446671.

Organism-specific databases

CTD5289.
XenbaseXB-GENE-6085232. pik3c3.

Phylogenomic databases

HOVERGENHBG082145.
KOK00914.

Family and domain databases

Gene3D1.10.1070.11. 1 hit.
1.25.40.70. 2 hits.
2.60.40.150. 1 hit.
InterProIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR008290. PI3K_Vps34.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view]
PANTHERPTHR10048. PTHR10048. 1 hit.
PfamPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
PIRSFPIRSF000587. PI3K_Vps34. 1 hit.
SMARTSM00239. C2. 1 hit.
SM00142. PI3K_C2. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 2 hits.
SSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePK3C3_XENLA
AccessionPrimary (citable) accession number: Q6AZN6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families