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Q6AZN6

- PK3C3_XENLA

UniProt

Q6AZN6 - PK3C3_XENLA

Protein

Phosphatidylinositol 3-kinase catalytic subunit type 3

Gene

pik3c3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis By similarity.By similarity

    Catalytic activityi

    ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

    GO - Molecular functioni

    1. 1-phosphatidylinositol-3-kinase activity Source: UniProtKB
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. autophagy Source: UniProtKB-KW
    2. cytokinesis Source: UniProtKB
    3. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
    4. phosphatidylinositol-mediated signaling Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Autophagy, Cell cycle, Cell division

    Keywords - Ligandi

    ATP-binding, Manganese, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC:2.7.1.137)
    Short name:
    PI3-kinase type 3
    Short name:
    PI3K type 3
    Short name:
    PtdIns-3-kinase type 3
    Alternative name(s):
    Phosphoinositide-3-kinase class 3
    Gene namesi
    Name:pik3c3
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6085232. pik3c3.

    Subcellular locationi

    Midbody By similarity

    GO - Cellular componenti

    1. midbody Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 886886Phosphatidylinositol 3-kinase catalytic subunit type 3PRO_0000088806Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AZN6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 184150C2 PI3K-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini283 – 519237PIK helicalPROSITE-ProRule annotationAdd
    BLAST
    Domaini630 – 884255PI3K/PI4KPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation
    Contains 1 C2 PI3K-type domain.PROSITE-ProRule annotation
    Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation
    Contains 1 PIK helical domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG082145.
    KOiK00914.

    Family and domain databases

    Gene3Di1.10.1070.11. 1 hit.
    1.25.40.70. 2 hits.
    2.60.40.150. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR002420. PI3K_C2_dom.
    IPR008290. PI3K_Vps34.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    [Graphical view]
    PANTHERiPTHR10048. PTHR10048. 1 hit.
    PfamiPF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF00613. PI3Ka. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000587. PI3K_Vps34. 1 hit.
    SMARTiSM00239. C2. 1 hit.
    SM00142. PI3K_C2. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.
    SSF49562. SSF49562. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6AZN6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGESDRFCYV YSCDLDISVR LKIGSLEGKR EQKSYKAVLE DPMLKFSGLY    50
    QETCSDLYVT CQVFAEGKPL ALPVRTSYKA FSTRWNWNEW LKLPVKYADL 100
    PRSAQVALTI WDVYGPGKAI PVGGATVSLF GKYGMFRQGM HDLKVWPNIE 150
    ADGSELTKTP GRTNSSASED QMSRLAKLTK AHRQGHMVKV DWLDRLTFRE 200
    IEMINESEKR SSNFMYLMVE FPCVKCDEKE YGIVYYEKDG DESTPISTSS 250
    EIVRVPDPQM SMENLVEIKH HKLARSLRSG PSDHDLKPNA ATRDQLNIIV 300
    SYPPTKQLTS EEQDLVWKFR SYLTSQEKAL TKFLKCVNWD LPQEAKQALE 350
    LLGKWKPMDV EDSLELLSSH FTNPTVRRYA VARLQQADDE DLLMYLLQLV 400
    QALKYENFED IKSGLEPTKK DSQGPMLESM TTSGINPETD SSQILSNPLP 450
    AVSSPAPPSK TKDGLDAETL EQDLCTFLIS RACKNSTLAN YLYWYVIVEC 500
    EDQDTQLRDP KTHEMYLNVM RRFSQALLKG DKSVRVMRSL LATQQTFVDR 550
    LVHLMKAVQR ESGNRKKKNE RLQALLGDNE KMNLSEFEPI PLPLEPQVKI 600
    RGIIPEKATL FKSALMPAKL YFKTEDGGKY PVIFKNGDDL RQDQLILQII 650
    SLMDKLLRKE NLDLKLTPYK VLATSTKHGF MQFIQSVPVA EVLATEGSIQ 700
    NFFRKYSPSE KGPYGISAEV MDTYVKSCAG YCVITYILGV GDRHLDNLLL 750
    TKTGKLFHID FGYILGRDPK PLPPPMKLNK EMVEGMGGTQ SEQYQAFRKQ 800
    CYTAFLHLRR YSNLILNLFS LMVDANIPDI ALEPDKTVKK VQDKFRLDLS 850
    DEEAVHYMQT LIDDSVNALF AAVVEQIHKF AQYWRR 886
    Length:886
    Mass (Da):101,157
    Last modified:September 13, 2004 - v1
    Checksum:iFBAFB8847FBB60A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC077528 mRNA. Translation: AAH77528.1.
    RefSeqiNP_001086836.1. NM_001093367.1.
    UniGeneiXl.11237.

    Genome annotation databases

    GeneIDi446671.
    KEGGixla:446671.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC077528 mRNA. Translation: AAH77528.1 .
    RefSeqi NP_001086836.1. NM_001093367.1.
    UniGenei Xl.11237.

    3D structure databases

    ProteinModelPortali Q6AZN6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 446671.
    KEGGi xla:446671.

    Organism-specific databases

    CTDi 5289.
    Xenbasei XB-GENE-6085232. pik3c3.

    Phylogenomic databases

    HOVERGENi HBG082145.
    KOi K00914.

    Family and domain databases

    Gene3Di 1.10.1070.11. 1 hit.
    1.25.40.70. 2 hits.
    2.60.40.150. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR002420. PI3K_C2_dom.
    IPR008290. PI3K_Vps34.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    [Graphical view ]
    PANTHERi PTHR10048. PTHR10048. 1 hit.
    Pfami PF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF00613. PI3Ka. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000587. PI3K_Vps34. 1 hit.
    SMARTi SM00239. C2. 1 hit.
    SM00142. PI3K_C2. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    SSF49562. SSF49562. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiPK3C3_XENLA
    AccessioniPrimary (citable) accession number: Q6AZN6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3