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Protein

Histone H2A

Gene

hist1h2aj

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2AUniRule annotation
Gene namesi
Name:hist1h2ajImported
Synonyms:LOC494591Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-994962. hist1h2aj.

Subcellular locationi

  • Chromosome SAAS annotation
  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiQ6AZJ8.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotationSAAS annotation

Protein-protein interaction databases

DIPiDIP-38576N.
IntActiQ6AZJ8. 1 interaction.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KXBX-ray3.20C/G2-130[»]
3LELX-ray2.95C/G/M/Q2-130[»]
3LZ0X-ray2.50C/G2-120[»]
3LZ1X-ray2.50C/G2-120[»]
3MGPX-ray2.44C/G2-120[»]
3MGQX-ray2.65C/G2-120[»]
3MGRX-ray2.30C/G2-120[»]
3MGSX-ray3.15C/G2-120[»]
3MVDX-ray2.90C/G2-130[»]
4KGCX-ray2.69C/G1-130[»]
4KHAX-ray2.35B15-103[»]
4R8PX-ray3.28C/G2-130[»]
4XUJX-ray3.18C/G2-130[»]
5E5AX-ray2.81C/G1-130[»]
ProteinModelPortaliQ6AZJ8.
SMRiQ6AZJ8. Positions 2-118.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6AZJ8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 8985HistoneInterPro annotationAdd
BLAST
Domaini92 – 12534Histone_H2A_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the histone H2A family.UniRule annotationSAAS annotation

Phylogenomic databases

HOVERGENiHBG009342.
KOiK11251.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00046. HISTONE_H2A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AZJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKQGGK TRAKAKTRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV
60 70 80 90 100
YLAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAVRN DEELNKLLGR
110 120 130
VTIAQGGVLP NIQSVLLPKK TESSKSAKSK
Length:130
Mass (Da):14,081
Last modified:September 13, 2004 - v1
Checksum:i62E46ABF27FA5E98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC077816 mRNA. Translation: AAH77816.1.
RefSeqiNP_001087948.1. NM_001094479.1.
UniGeneiXl.79701.

Genome annotation databases

GeneIDi494591.
KEGGixla:494591.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC077816 mRNA. Translation: AAH77816.1.
RefSeqiNP_001087948.1. NM_001094479.1.
UniGeneiXl.79701.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KXBX-ray3.20C/G2-130[»]
3LELX-ray2.95C/G/M/Q2-130[»]
3LZ0X-ray2.50C/G2-120[»]
3LZ1X-ray2.50C/G2-120[»]
3MGPX-ray2.44C/G2-120[»]
3MGQX-ray2.65C/G2-120[»]
3MGRX-ray2.30C/G2-120[»]
3MGSX-ray3.15C/G2-120[»]
3MVDX-ray2.90C/G2-130[»]
4KGCX-ray2.69C/G1-130[»]
4KHAX-ray2.35B15-103[»]
4R8PX-ray3.28C/G2-130[»]
4XUJX-ray3.18C/G2-130[»]
5E5AX-ray2.81C/G1-130[»]
ProteinModelPortaliQ6AZJ8.
SMRiQ6AZJ8. Positions 2-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-38576N.
IntActiQ6AZJ8. 1 interaction.

Proteomic databases

PRIDEiQ6AZJ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi494591.
KEGGixla:494591.

Organism-specific databases

CTDi8331.
XenbaseiXB-GENE-994962. hist1h2aj.

Phylogenomic databases

HOVERGENiHBG009342.
KOiK11251.

Miscellaneous databases

EvolutionaryTraceiQ6AZJ8.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00046. HISTONE_H2A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EmbryoImported.
  2. "Structural characterization of H3K56Q nucleosomes and nucleosomal arrays."
    Watanabe S., Resch M., Lilyestrom W., Clark N., Hansen J.C., Peterson C., Luger K.
    Biochim. Biophys. Acta 1799:480-486(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 2-130.
  3. "Crystal structures of nucleosome core particles containing the '601' strong positioning sequence."
    Vasudevan D., Chua E.Y., Davey C.A.
    J. Mol. Biol. 403:1-10(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 2-120.
  4. "Structure of RCC1 chromatin factor bound to the nucleosome core particle."
    Makde R.D., England J.R., Yennawar H.P., Tan S.
    Nature 467:562-566(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 2-130.
  5. "Perturbations in nucleosome structure from heavy metal association."
    Mohideen K., Muhammad R., Davey C.A.
    Nucleic Acids Res. 38:6301-6311(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 2-120.
  6. "Structural insight into the sequence dependence of nucleosome positioning."
    Wu B., Mohideen K., Vasudevan D., Davey C.A.
    Structure 18:528-536(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS) OF 2-130.
  7. "Structural basis of histone H2A-H2B recognition by the essential chaperone FACT."
    Hondele M., Stuwe T., Hassler M., Halbach F., Bowman A., Zhang E.T., Nijmeijer B., Kotthoff C., Rybin V., Amlacher S., Hurt E., Ladurner A.G.
    Nature 499:111-114(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 15-103.
  8. "Ligand substitutions between ruthenium-cymene compounds can control protein versus DNA targeting and anticancer activity."
    Adhireksan Z., Davey G.E., Campomanes P., Groessl M., Clavel C.M., Yu H., Nazarov A.A., Yeo C.H., Ang W.H., Droge P., Rothlisberger U., Dyson P.J., Davey C.A.
    Nat. Commun. 5:3462-3462(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS).
  9. "Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome."
    McGinty R.K., Henrici R.C., Tan S.
    Nature 514:591-596(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.28 ANGSTROMS) OF 2-130.
  10. "Contrasting Cytotoxicity and Reactivity of RuII-Arene Complexes of Morpholine vs Thiomorpholine Substituted 3-Hydroxy-2-pyridone Ligands."
    Hanif M., Meier S.M., Adhireksan Z., Henke H., Martic S., Labib M., Kandioller W., Jakupec M.A., Kraatz H.B., Davey C.A., Keppler B.K., Hartinger C.G.
    Submitted (JAN-2015) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (3.18 ANGSTROMS) OF 2-130.
  11. "Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome."
    Fang Q., Chen P., Wang M., Fang J., Yang N., Li G., Xu R.M.
    Elife 5:0-0(2016) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS).

Entry informationi

Entry nameiQ6AZJ8_XENLA
AccessioniPrimary (citable) accession number: Q6AZJ8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: May 11, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.