Reviewed, UniProtKB/Swiss-Prot Q6AZG6 (SYFAA_XENLA)

Names and origin

Protein names

Recommended name:
    Phenylalanyl-tRNA synthetase alpha chain A
    EC=6.1.1.20
Alternative name(s):
    Phenylalanine--tRNA ligase alpha chain A
      Short name=PheRS

Gene names

Name:	farsa-A
Synonyms:	farsla-A

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).
Subunit structure	Tetramer of two alpha and two beta chains By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 2 subfamily.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Gene Ontology (GO)
Biological process	phenylalanyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phenylalanine-tRNA ligase activity Inferred from electronic annotation. Source: EC tRNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 498	497	Phenylalanyl-tRNA synthetase alpha chain A		PRO_0000280452

Sequences

	Sequence		Length	Mass (Da)
	Q6AZG6-1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 88609B0FFC25C2DF	FASTA	498	56,753
	10 20 30 40 50 60 MADNSVSEQL LQRLQDGGSK GVDSLELAAL LGVEHQQVVG AVKSLQCLGE IIQAEQRSSK 70 80 90 100 110 120 KWELSSEGEE IGREGSHEAR VFQTLPKEGL LQAQLMKQPF SKVGFSKAMS NKWIRLDKAA 130 140 150 160 170 180 EGGPRIYRVV DSIEDTVKEK LQLILKGRAD DVNEKDRNEL KKRKLVNEVT VKSYWVTKGS 190 200 210 220 230 240 GFSTSITKQE TDLTPEMIAS GSWREKQFKG YNFDALGVMP ECGHLHPLLK VRTQFRQIFL 250 260 270 280 290 300 EMGFTEMPTN NFIESSFWNF DALFQPQQHP ARDQHDTFFL QDPALATEFP MEYLERVKKV 310 320 330 340 350 360 HSEGGYGSQG YKYDWSIHEA QKNILRTHTT AVSARMLYKL ALQKDFTPVK YFSIDRVFRN 370 380 390 400 410 420 ETLDATHLAE FHQIEGVVAD RGLTLGNLMG VLKEFFHKLG ITKLRFKPAY NPYTEPSMEV 430 440 450 460 470 480 FSYHEGLKKW VEVGNSGLFR PELLLPMGLP EDVNVLGWGL SLERPTMIRY GIKNIRELVG 490 HKVNLQMVYD SPICRLDA

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC078035 mRNA. Translation: AAH78035.1.
RefSeq	NP_001087130.1.
UniGene	Xl.16760
3D structure databases
HSSP	HSSP built from PDB template 2ALY based on UniProtKB P27001.
SMR	Q6AZG6. Positions 191-493.
ModBase	Search...
Genome annotation databases
GeneID	447019.
KEGG	xla:447019.
Organism-specific databases
Xenbase	XB-FEAT-946392. farsa.
Phylogenomic databases
HOVERGEN	Q6AZG6.
Enzyme and pathway databases
BRENDA	6.1.1.20. 648.
Family and domain databases
InterPro	IPR006195. aa-tRNA-synth_II_cons-dom. IPR004529. Phe-tRNA-synth_IIc_asu. IPR002319. Phenylalanyl-tRNA_Synthase_acu. [Graphical view]
PANTHER	PTHR11538. tRNA-synt_2d. 1 hit.
Pfam	PF01409. tRNA-synt_2d. 1 hit. [Graphical view]
TIGRFAMs	TIGR00468. pheS. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYFAA_XENLA

Accession

Primary (citable) accession number: Q6AZG6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	September 13, 2004
Last modified:	February 9, 2010
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project