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Protein
Submitted name:

Proteasome (Prosome, macropain) 26S subunit, ATPase, 5

Gene

psmc5

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-1169091 Activation of NF-kappaB in B cells
R-DRE-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-DRE-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DRE-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DRE-174154 APC/C:Cdc20 mediated degradation of Securin
R-DRE-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DRE-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DRE-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DRE-195253 Degradation of beta-catenin by the destruction complex
R-DRE-202424 Downstream TCR signaling
R-DRE-2467813 Separation of Sister Chromatids
R-DRE-2871837 FCERI mediated NF-kB activation
R-DRE-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-DRE-350562 Regulation of ornithine decarboxylase (ODC)
R-DRE-382556 ABC-family proteins mediated transport
R-DRE-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DRE-4608870 Asymmetric localization of PCP proteins
R-DRE-4641257 Degradation of AXIN
R-DRE-4641258 Degradation of DVL
R-DRE-5358346 Hedgehog ligand biogenesis
R-DRE-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-DRE-5607764 CLEC7A (Dectin-1) signaling
R-DRE-5610780 Degradation of GLI1 by the proteasome
R-DRE-5610785 GLI3 is processed to GLI3R by the proteasome
R-DRE-5632684 Hedgehog 'on' state
R-DRE-5658442 Regulation of RAS by GAPs
R-DRE-5668541 TNFR2 non-canonical NF-kB pathway
R-DRE-5676590 NIK-->noncanonical NF-kB signaling
R-DRE-5687128 MAPK6/MAPK4 signaling
R-DRE-5689603 UCH proteinases
R-DRE-5689880 Ub-specific processing proteases
R-DRE-68827 CDT1 association with the CDC6:ORC:origin complex
R-DRE-68949 Orc1 removal from chromatin
R-DRE-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DRE-69229 Ubiquitin-dependent degradation of Cyclin D1
R-DRE-69481 G2/M Checkpoints
R-DRE-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DRE-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-DRE-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DRE-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-DRE-8939902 Regulation of RUNX2 expression and activity
R-DRE-8941858 Regulation of RUNX3 expression and activity
R-DRE-8948751 Regulation of PTEN stability and activity
R-DRE-9020702 Interleukin-1 signaling
R-DRE-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Submitted name:
Proteasome (Prosome, macropain) 26S subunit, ATPase, 5Imported
Submitted name:
Proteasome 26S subunit, ATPase 5Imported
Submitted name:
Psmc5 proteinImported
Gene namesi
Name:psmc5Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 12

Organism-specific databases

ZFINiZDB-GENE-030131-6547 psmc5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ProteasomeImported

Expressioni

Gene expression databases

BgeeiENSDARG00000015315

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000096969

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 321AAAInterPro annotationAdd BLAST140

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili28 – 69Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the AAA ATPase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0728 Eukaryota
COG1222 LUCA
GeneTreeiENSGT00550000074947
HOGENOMiHOG000225143
HOVERGENiHBG000109
KOiK03066
OMAiHGNNQEA
OrthoDBiEOG091G096W

Family and domain databases

InterProiView protein in InterPro
IPR005937 26S_Psome_P45-like
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027417 P-loop_NTPase
IPR035261 PSMC5
PANTHERiPTHR23073:SF12 PTHR23073:SF12, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01242 26Sp45, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AZC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALDGIEQMD IEDSKGGSGL RQYYLSKIEE LQLTVNEKSQ NLRRLQAQRN
60 70 80 90 100
ELNAKVRLLR EELQLLQEQG SYVGEVVRAM DKKKVLVKVH PEGKFVVDVD
110 120 130 140 150
KNIDINDVTP NCRVALRNDS YTLHKILPNK VDPLVSLMMV EKVPDSTYEM
160 170 180 190 200
IGGLDKQIKE IKEVIELPVK HPELFEALGI AQPKGVLLYG PPGTGKTLLA
210 220 230 240 250
RAVAHHTDCT FIRVSGSELV QKFIGEGARM VRELFVMARE HAPSIIFMDE
260 270 280 290 300
IDSIGSSRLE GGSGGDSEVQ RTMLELLNQL DGFEATKNIK VIMATNRIDI
310 320 330 340 350
LDSALLRPGR IDRKIEFPPP NEEARLDILK IHSRKMNLTR GINLRKIAEL
360 370 380 390 400
MPGASGAEVK GVCTEAGMYA LRERRVHVTQ EDFEMAVAKV MQKDSEKNMS

IKKLWK
Length:406
Mass (Da):45,632
Last modified:September 13, 2004 - v1
Checksum:i47C7F4C7C62CC398
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU459020 Genomic DNA No translation available.
BC078375 mRNA Translation: AAH78375.1
BC165834 mRNA Translation: AAI65834.1
RefSeqiNP_001003740.1, NM_001003740.1
UniGeneiDr.75934

Genome annotation databases

EnsembliENSDART00000106191; ENSDARP00000096969; ENSDARG00000015315
GeneIDi445285
KEGGidre:445285

Similar proteinsi

Entry informationi

Entry nameiQ6AZC1_DANRE
AccessioniPrimary (citable) accession number: Q6AZC1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health