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Protein
Submitted name:

Proteasome (Prosome, macropain) 26S subunit, ATPase, 5

Gene

psmc5

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-1169091. Activation of NF-kappaB in B cells.
R-DRE-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-DRE-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DRE-174154. APC/C:Cdc20 mediated degradation of Securin.
R-DRE-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DRE-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DRE-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-DRE-195253. Degradation of beta-catenin by the destruction complex.
R-DRE-202424. Downstream TCR signaling.
R-DRE-2467813. Separation of Sister Chromatids.
R-DRE-2871837. FCERI mediated NF-kB activation.
R-DRE-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-DRE-350562. Regulation of ornithine decarboxylase (ODC).
R-DRE-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-DRE-4608870. Asymmetric localization of PCP proteins.
R-DRE-4641257. Degradation of AXIN.
R-DRE-4641258. Degradation of DVL.
R-DRE-5358346. Hedgehog ligand biogenesis.
R-DRE-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-DRE-5607764. CLEC7A (Dectin-1) signaling.
R-DRE-5610780. Degradation of GLI1 by the proteasome.
R-DRE-5632684. Hedgehog 'on' state.
R-DRE-5658442. Regulation of RAS by GAPs.
R-DRE-5668541. TNFR2 non-canonical NF-kB pathway.
R-DRE-5676590. NIK-->noncanonical NF-kB signaling.
R-DRE-5687128. MAPK6/MAPK4 signaling.
R-DRE-68827. CDT1 association with the CDC6:ORC:origin complex.
R-DRE-68949. Orc1 removal from chromatin.
R-DRE-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-DRE-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-DRE-69481. G2/M Checkpoints.
R-DRE-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-DRE-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-DRE-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
Proteasome (Prosome, macropain) 26S subunit, ATPase, 5Imported
Submitted name:
Psmc5 proteinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:psmc5Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 12

Organism-specific databases

ZFINiZDB-GENE-030131-6547. psmc5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

ProteasomeImported

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000096969.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini182 – 321140AAAInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili28 – 6942Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the AAA ATPase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0728. Eukaryota.
COG1222. LUCA.
GeneTreeiENSGT00550000074947.
HOGENOMiHOG000225143.
HOVERGENiHBG000109.
KOiK03066.
OMAiVMGTKKV.
OrthoDBiEOG7TF78Z.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR005937. 26S_Psome_P45.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AZC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALDGIEQMD IEDSKGGSGL RQYYLSKIEE LQLTVNEKSQ NLRRLQAQRN
60 70 80 90 100
ELNAKVRLLR EELQLLQEQG SYVGEVVRAM DKKKVLVKVH PEGKFVVDVD
110 120 130 140 150
KNIDINDVTP NCRVALRNDS YTLHKILPNK VDPLVSLMMV EKVPDSTYEM
160 170 180 190 200
IGGLDKQIKE IKEVIELPVK HPELFEALGI AQPKGVLLYG PPGTGKTLLA
210 220 230 240 250
RAVAHHTDCT FIRVSGSELV QKFIGEGARM VRELFVMARE HAPSIIFMDE
260 270 280 290 300
IDSIGSSRLE GGSGGDSEVQ RTMLELLNQL DGFEATKNIK VIMATNRIDI
310 320 330 340 350
LDSALLRPGR IDRKIEFPPP NEEARLDILK IHSRKMNLTR GINLRKIAEL
360 370 380 390 400
MPGASGAEVK GVCTEAGMYA LRERRVHVTQ EDFEMAVAKV MQKDSEKNMS

IKKLWK
Length:406
Mass (Da):45,632
Last modified:September 13, 2004 - v1
Checksum:i47C7F4C7C62CC398
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU459020 Genomic DNA. No translation available.
BC078375 mRNA. Translation: AAH78375.1.
BC165834 mRNA. Translation: AAI65834.1.
RefSeqiNP_001003740.1. NM_001003740.1.
UniGeneiDr.75934.

Genome annotation databases

EnsembliENSDART00000106191; ENSDARP00000096969; ENSDARG00000015315.
GeneIDi445285.
KEGGidre:445285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU459020 Genomic DNA. No translation available.
BC078375 mRNA. Translation: AAH78375.1.
BC165834 mRNA. Translation: AAI65834.1.
RefSeqiNP_001003740.1. NM_001003740.1.
UniGeneiDr.75934.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000096969.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000106191; ENSDARP00000096969; ENSDARG00000015315.
GeneIDi445285.
KEGGidre:445285.

Organism-specific databases

CTDi5705.
ZFINiZDB-GENE-030131-6547. psmc5.

Phylogenomic databases

eggNOGiKOG0728. Eukaryota.
COG1222. LUCA.
GeneTreeiENSGT00550000074947.
HOGENOMiHOG000225143.
HOVERGENiHBG000109.
KOiK03066.
OMAiVMGTKKV.
OrthoDBiEOG7TF78Z.

Enzyme and pathway databases

ReactomeiR-DRE-1169091. Activation of NF-kappaB in B cells.
R-DRE-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-DRE-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DRE-174154. APC/C:Cdc20 mediated degradation of Securin.
R-DRE-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DRE-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DRE-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-DRE-195253. Degradation of beta-catenin by the destruction complex.
R-DRE-202424. Downstream TCR signaling.
R-DRE-2467813. Separation of Sister Chromatids.
R-DRE-2871837. FCERI mediated NF-kB activation.
R-DRE-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-DRE-350562. Regulation of ornithine decarboxylase (ODC).
R-DRE-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-DRE-4608870. Asymmetric localization of PCP proteins.
R-DRE-4641257. Degradation of AXIN.
R-DRE-4641258. Degradation of DVL.
R-DRE-5358346. Hedgehog ligand biogenesis.
R-DRE-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-DRE-5607764. CLEC7A (Dectin-1) signaling.
R-DRE-5610780. Degradation of GLI1 by the proteasome.
R-DRE-5632684. Hedgehog 'on' state.
R-DRE-5658442. Regulation of RAS by GAPs.
R-DRE-5668541. TNFR2 non-canonical NF-kB pathway.
R-DRE-5676590. NIK-->noncanonical NF-kB signaling.
R-DRE-5687128. MAPK6/MAPK4 signaling.
R-DRE-68827. CDT1 association with the CDC6:ORC:origin complex.
R-DRE-68949. Orc1 removal from chromatin.
R-DRE-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-DRE-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-DRE-69481. G2/M Checkpoints.
R-DRE-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-DRE-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-DRE-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR005937. 26S_Psome_P45.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: WholeImported.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescueImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  4. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ6AZC1_DANRE
AccessioniPrimary (citable) accession number: Q6AZC1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: July 6, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.