Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Brother of CDO

Gene

Boc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.

GO - Biological processi

  • axon guidance Source: MGI
  • cell-cell adhesion Source: HGNC
  • cell projection organization Source: MGI
  • positive regulation of myoblast differentiation Source: HGNC
  • regulation of striated muscle tissue development Source: MGI
  • smoothened signaling pathway Source: MGI

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Brother of CDO
Short name:
Protein BOC
Gene namesi
Name:Boc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2151153 Boc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 850ExtracellularSequence analysisAdd BLAST825
Transmembranei851 – 871HelicalSequence analysisAdd BLAST21
Topological domaini872 – 1110CytoplasmicSequence analysisAdd BLAST239

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000023405326 – 1110Brother of CDOAdd BLAST1085

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 101PROSITE-ProRule annotation
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi145 ↔ 195PROSITE-ProRule annotation
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi247 ↔ 294PROSITE-ProRule annotation
Glycosylationi270N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi339 ↔ 386PROSITE-ProRule annotation
Glycosylationi512N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi720N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi754N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6AZB0
PeptideAtlasiQ6AZB0
PRIDEiQ6AZB0

PTM databases

iPTMnetiQ6AZB0
PhosphoSitePlusiQ6AZB0

Expressioni

Tissue specificityi

Highly expressed in embryonic somites, limb buds, dermomyotomes and in the neural tube.1 Publication

Inductioni

Up-regulated during early stages of myoblast differentiation.1 Publication

Interactioni

Subunit structurei

Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with SHH, DHH and IHH. Interacts with NTN3 (By similarity). Interacts with CDH2 and CTNNB1. Interacts with CDH15 only during the early stages of myoblast differentiation.By similarity1 Publication

Protein-protein interaction databases

BioGridi228240, 1 interactor
DIPiDIP-60410N
IntActiQ6AZB0, 1 interactor
STRINGi10090.ENSMUSP00000023370

Structurei

Secondary structure

11110
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi595 – 597Combined sources3
Beta strandi608 – 611Combined sources4
Beta strandi614 – 620Combined sources7
Beta strandi633 – 643Combined sources11
Beta strandi648 – 654Combined sources7
Beta strandi660 – 665Combined sources6
Beta strandi671 – 680Combined sources10
Beta strandi712 – 717Combined sources6
Beta strandi719 – 722Combined sources4
Beta strandi724 – 729Combined sources6
Beta strandi742 – 747Combined sources6
Helixi755 – 757Combined sources3
Beta strandi761 – 764Combined sources4
Beta strandi769 – 772Combined sources4
Beta strandi780 – 788Combined sources9
Beta strandi800 – 803Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X4YNMR-A707-807[»]
1X4ZNMR-A591-698[»]
ProteinModelPortaliQ6AZB0
SMRiQ6AZB0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6AZB0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 118Ig-like C2-type 1Add BLAST88
Domaini124 – 208Ig-like C2-type 2Add BLAST85
Domaini229 – 310Ig-like C2-type 3Add BLAST82
Domaini318 – 402Ig-like C2-type 4Add BLAST85
Domaini469 – 566Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST98
Domaini603 – 698Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini707 – 807Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST101

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHIH Eukaryota
ENOG410XSVT LUCA
HOVERGENiHBG061102
InParanoidiQ6AZB0
KOiK20020
PhylomeDBiQ6AZB0
TreeFamiTF332268

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR032982 BOC
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
PANTHERiPTHR44170:SF3 PTHR44170:SF3, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF07679 I-set, 1 hit
PF00047 ig, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 4 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 4 hits

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6AZB0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTCRRERPI LTLLWILMAT AGCLADLNEV PQVTVQPMST VQKLGGTVIL
60 70 80 90 100
GCVVEPPWMN VTWRFNGKEL NGSDDALGVF ITRGTLVIAA LNNHTVGRYQ
110 120 130 140 150
CVARMPAGAV ASVPATVTLA NLQDFKLDVQ HVIEVDEGNT AVIACHLPES
160 170 180 190 200
HPKAQVRYSV KQEWLEASRD NYLIMPSGNL QIVNASQEDE GMYKCAAYNP
210 220 230 240 250
VTQEVKTSGS GDRLRVRRST AEAARIIYPL EAQTVIVTKG QSLILECVAS
260 270 280 290 300
GIPPPRVTWA KDGSSIAAYN KTRFLLSNLL IDTTSEEDSG TYRCMASNGV
310 320 330 340 350
GDPGAAVILY NVQVFEPPEV TVELSQLVIP WGQSAKLTCE VRGNPPPSVL
360 370 380 390 400
WLRNAVPLTS SQRLRLSRRA LRVVSVGPED EGVYQCMAEN AVGSAHAVVQ
410 420 430 440 450
LRTARPDTTL RPGRDTKPIA ATPPMPPSRP SRPDQMLREQ PGLVKPPTSS
460 470 480 490 500
VQPTSLKCPG EEQVAPAEAP IILSSPRTSK TDSYELVWRP RHEGSSRTPI
510 520 530 540 550
LYYVVKHRKV TNSSDDWTIS GIPANQHRLT LTRLDPGSLY EVEMAAYNCA
560 570 580 590 600
GEGQTAMVTF RTGRRPKPEI VASKEQQIQR DDPGASLQSS SQPDHGRLSP
610 620 630 640 650
PEAPDRPTIS TASETSVYVT WIPRGNGGFP IQSFRVEYKK LKKVGDWILA
660 670 680 690 700
TSAIPPSRLS VEITGLEKGI SYKFRVRALN MLGESEPSAP SRPYVVSGYS
710 720 730 740 750
GRVYERPVAG PYITFTDAVN ETTIMLKWMY IPASNNNTPI HGFYIYYRPT
760 770 780 790 800
DSDNDSDYKK DMVEGDRYWH SISHLQPETS YDIKMQCFNE GGESEFSNVM
810 820 830 840 850
ICETKARKFS GQPGRPPPLT LAPPQPPPLE TMERPVGTGA MVARASDLPY
860 870 880 890 900
LIVGVVLGSI VLIIVTFIPF CLWRAWSKQK HTTDLGFPRS ALLSSSCQYT
910 920 930 940 950
MVPLEGLPGH QANGQPYLGG VSGRACVSRV HGSRGCPAAT VGCPGRKPQQ
960 970 980 990 1000
HCPGELAQQR EDTNSQLRQP IVSNGYDLQN QQVARGPQCA SGVGAFLYTL
1010 1020 1030 1040 1050
PDDSTHQLLQ PQDCCHLQKQ PVTTCQTAVR RTSESPGLES SWDPPYHSGP
1060 1070 1080 1090 1100
RCCLGLVPVE EVDSSDSCQV GGGDWSSQHP SGTYTGQERG MRFSPSPSVH
1110
VSFETPPPTI
Length:1,110
Mass (Da):121,331
Last modified:May 2, 2006 - v2
Checksum:iADC1B859CC126F2B
GO
Isoform 2 (identifier: Q6AZB0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-680: Missing.
     985-1109: Missing.

Show »
Length:305
Mass (Da):33,601
Checksum:i8024F0E73064C6DC
GO
Isoform 3 (identifier: Q6AZB0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     449-449: Missing.

Show »
Length:1,109
Mass (Da):121,244
Checksum:i99B1FF573EBEEC0D
GO
Isoform 4 (identifier: Q6AZB0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     958-958: Missing.

Show »
Length:1,109
Mass (Da):121,203
Checksum:i5156CD78DCBA731E
GO

Sequence cautioni

The sequence AAK71999 differs from that shown. Reason: Frameshift at positions 19, 35 and 46.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9P → A (PubMed:11782431).Curated1
Sequence conflicti24L → P in AAH78631 (PubMed:15489334).Curated1
Sequence conflicti64R → G in AAK71999 (PubMed:11782431).Curated1
Sequence conflicti74D → E in AAK71999 (PubMed:11782431).Curated1
Sequence conflicti85T → N in AAK71999 (PubMed:11782431).Curated1
Sequence conflicti105M → L in AAK71999 (PubMed:11782431).Curated1
Sequence conflicti304G → V in AAH62892 (PubMed:15489334).Curated1
Sequence conflicti453P → S in BAD21432 (PubMed:15449545).Curated1
Sequence conflicti878K → E in BAC26110 (PubMed:16141072).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti1051R → Q in strain: C57BL/6. 2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0181971 – 680Missing in isoform 2. 1 PublicationAdd BLAST680
Alternative sequenceiVSP_018198449Missing in isoform 3. 3 Publications1
Alternative sequenceiVSP_018199958Missing in isoform 4. 4 Publications1
Alternative sequenceiVSP_018200985 – 1109Missing in isoform 2. 1 PublicationAdd BLAST125

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028770 mRNA Translation: BAC26110.1
AK028889 mRNA Translation: BAC26176.1
BC026443 mRNA Translation: AAH26443.1
BC056138 mRNA Translation: AAH56138.1
BC062892 mRNA Translation: AAH62892.1
BC078631 mRNA Translation: AAH78631.1
AF388037 mRNA Translation: AAK71999.1 Frameshift.
AK131182 Transcribed RNA Translation: BAD21432.1
CCDSiCCDS28186.1 [Q6AZB0-1]
RefSeqiNP_766094.1, NM_172506.2
UniGeneiMm.41561

Genome annotation databases

GeneIDi117606
KEGGimmu:117606
UCSCiuc007zhl.1 mouse [Q6AZB0-1]
uc007zhm.1 mouse [Q6AZB0-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBOC_MOUSE
AccessioniPrimary (citable) accession number: Q6AZB0
Secondary accession number(s): Q6KAM5
, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: February 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health