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Protein
Submitted name:

K-ras

Gene

kras

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • embryonic cranial skeleton morphogenesis Source: ZFIN
  • heart development Source: ZFIN
  • hemopoiesis Source: ZFIN
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-1169092. Activation of RAS in B cells.
R-DRE-1250347. SHC1 events in ERBB4 signaling.
R-DRE-1433557. Signaling by SCF-KIT.
R-DRE-171007. p38MAPK events.
R-DRE-179812. GRB2 events in EGFR signaling.
R-DRE-180336. SHC1 events in EGFR signaling.
R-DRE-186763. Downstream signal transduction.
R-DRE-1963640. GRB2 events in ERBB2 signaling.
R-DRE-210993. Tie2 Signaling.
R-DRE-2179392. EGFR Transactivation by Gastrin.
R-DRE-2424491. DAP12 signaling.
R-DRE-2871796. FCERI mediated MAPK activation.
R-DRE-375165. NCAM signaling for neurite out-growth.
R-DRE-5218921. VEGFR2 mediated cell proliferation.
R-DRE-5621575. CD209 (DC-SIGN) signaling.
R-DRE-5654688. SHC-mediated cascade:FGFR1.
R-DRE-5654693. FRS-mediated FGFR1 signaling.
R-DRE-5654699. SHC-mediated cascade:FGFR2.
R-DRE-5654700. FRS-mediated FGFR2 signaling.
R-DRE-5654704. SHC-mediated cascade:FGFR3.
R-DRE-5654706. FRS-mediated FGFR3 signaling.
R-DRE-5654712. FRS-mediated FGFR4 signaling.
R-DRE-5654719. SHC-mediated cascade:FGFR4.
R-DRE-5658442. Regulation of RAS by GAPs.
R-DRE-5673000. RAF activation.
R-DRE-5673001. RAF/MAP kinase cascade.
R-DRE-5674135. MAP2K and MAPK activation.
R-DRE-5675221. Negative regulation of MAPK pathway.
R-DRE-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.

Names & Taxonomyi

Protein namesi
Submitted name:
K-rasImported
Submitted name:
Uncharacterized proteinImported
Submitted name:
V-Ki-ras2 Kirsten rat sarcoma viral oncogene homologImported
Gene namesi
Name:krasImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 25

Organism-specific databases

ZFINiZDB-GENE-040808-67. kras.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSDARG00000010844.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000021124.

Structurei

3D structure databases

SMRiQ6AZA4. Positions 1-166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121849.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
KOiK07827.
OMAiKKSRTRC.
OrthoDBiEOG091G0UAU.
PhylomeDBiQ6AZA4.
TreeFamiTF312796.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AZA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET
60 70 80 90 100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI
110 120 130 140 150
KRVKDSEDVP MVLVGNKCDL QSHNVDSKQA QDLARSYGIP FIETSAKTRQ
160 170 180
GVDDAFYTLV REIRKHKEKM SKEGKKKKKK SKTKCALM
Length:188
Mass (Da):21,421
Last modified:September 13, 2004 - v1
Checksum:i3E35BB6DEA877ED1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ976913 Genomic DNA. No translation available.
BC078646 mRNA. Translation: AAH78646.1.
DQ486868 mRNA. Translation: ABF46832.1.
RefSeqiNP_001003744.1. NM_001003744.1.
UniGeneiDr.20193.

Genome annotation databases

EnsembliENSDART00000009126; ENSDARP00000021124; ENSDARG00000010844.
GeneIDi445289.
KEGGidre:445289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ976913 Genomic DNA. No translation available.
BC078646 mRNA. Translation: AAH78646.1.
DQ486868 mRNA. Translation: ABF46832.1.
RefSeqiNP_001003744.1. NM_001003744.1.
UniGeneiDr.20193.

3D structure databases

SMRiQ6AZA4. Positions 1-166.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000021124.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000009126; ENSDARP00000021124; ENSDARG00000010844.
GeneIDi445289.
KEGGidre:445289.

Organism-specific databases

CTDi3845.
ZFINiZDB-GENE-040808-67. kras.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121849.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
KOiK07827.
OMAiKKSRTRC.
OrthoDBiEOG091G0UAU.
PhylomeDBiQ6AZA4.
TreeFamiTF312796.

Enzyme and pathway databases

ReactomeiR-DRE-1169092. Activation of RAS in B cells.
R-DRE-1250347. SHC1 events in ERBB4 signaling.
R-DRE-1433557. Signaling by SCF-KIT.
R-DRE-171007. p38MAPK events.
R-DRE-179812. GRB2 events in EGFR signaling.
R-DRE-180336. SHC1 events in EGFR signaling.
R-DRE-186763. Downstream signal transduction.
R-DRE-1963640. GRB2 events in ERBB2 signaling.
R-DRE-210993. Tie2 Signaling.
R-DRE-2179392. EGFR Transactivation by Gastrin.
R-DRE-2424491. DAP12 signaling.
R-DRE-2871796. FCERI mediated MAPK activation.
R-DRE-375165. NCAM signaling for neurite out-growth.
R-DRE-5218921. VEGFR2 mediated cell proliferation.
R-DRE-5621575. CD209 (DC-SIGN) signaling.
R-DRE-5654688. SHC-mediated cascade:FGFR1.
R-DRE-5654693. FRS-mediated FGFR1 signaling.
R-DRE-5654699. SHC-mediated cascade:FGFR2.
R-DRE-5654700. FRS-mediated FGFR2 signaling.
R-DRE-5654704. SHC-mediated cascade:FGFR3.
R-DRE-5654706. FRS-mediated FGFR3 signaling.
R-DRE-5654712. FRS-mediated FGFR4 signaling.
R-DRE-5654719. SHC-mediated cascade:FGFR4.
R-DRE-5658442. Regulation of RAS by GAPs.
R-DRE-5673000. RAF activation.
R-DRE-5673001. RAF/MAP kinase cascade.
R-DRE-5674135. MAP2K and MAPK activation.
R-DRE-5675221. Negative regulation of MAPK pathway.
R-DRE-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.

Gene expression databases

BgeeiENSDARG00000010844.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6AZA4_DANRE
AccessioniPrimary (citable) accession number: Q6AZA4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.