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Protein

Acetyl-CoA acetyltransferase, mitochondrial

Gene

acat1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a major role in ketone body metabolism.By similarity

Catalytic activityi

2 acetyl-CoA = CoA + acetoacetyl-CoA.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei119Acyl-thioester intermediateBy similarity1
Metal bindingi212PotassiumBy similarity1
Binding sitei212Coenzyme ABy similarity1
Binding sitei256Coenzyme ABy similarity1
Metal bindingi273Potassium; via carbonyl oxygenBy similarity1
Metal bindingi274Potassium; via carbonyl oxygenBy similarity1
Metal bindingi276Potassium; via carbonyl oxygenBy similarity1
Binding sitei277Coenzyme ABy similarity1
Metal bindingi374Potassium; via carbonyl oxygenBy similarity1
Active sitei378Proton acceptorPROSITE-ProRule annotation1
Active sitei406Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
LigandMetal-binding, Potassium

Enzyme and pathway databases

ReactomeiR-DRE-70895 Branched-chain amino acid catabolism
R-DRE-77108 Utilization of Ketone Bodies
R-DRE-77111 Synthesis of Ketone Bodies

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA acetyltransferase, mitochondrial (EC:2.3.1.9)
Alternative name(s):
Acetoacetyl-CoA thiolase
Gene namesi
Name:acat1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 10

Organism-specific databases

ZFINiZDB-GENE-040808-68 acat1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26MitochondrionBy similarityAdd BLAST26
ChainiPRO_000035627527 – 420Acetyl-CoA acetyltransferase, mitochondrialAdd BLAST394

Proteomic databases

PaxDbiQ6AZA0
PeptideAtlasiQ6AZA0
PRIDEiQ6AZA0

Expressioni

Gene expression databases

BgeeiENSDARG00000045888
ExpressionAtlasiQ6AZA0 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000067447

Structurei

3D structure databases

ProteinModelPortaliQ6AZA0
SMRiQ6AZA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni251 – 253Coenzyme A bindingBy similarity3

Sequence similaritiesi

Belongs to the thiolase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1390 Eukaryota
COG0183 LUCA
GeneTreeiENSGT00390000009412
HOGENOMiHOG000012238
HOVERGENiHBG003112
InParanoidiQ6AZA0
KOiK00626
OMAiWDVYNKF
PhylomeDBiQ6AZA0
TreeFamiTF300650

Family and domain databases

CDDicd00751 thiolase, 1 hit
Gene3Di3.40.47.10, 4 hits
InterProiView protein in InterPro
IPR002155 Thiolase
IPR016039 Thiolase-like
IPR020615 Thiolase_acyl_enz_int_AS
IPR020610 Thiolase_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PfamiView protein in Pfam
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
PROSITEiView protein in PROSITE
PS00098 THIOLASE_1, 1 hit
PS00737 THIOLASE_2, 1 hit
PS00099 THIOLASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AZA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRALYSTR SQLCRHLAHK YLSRSYSTRP SLNEVVIVSA VRTPIGSFKG
60 70 80 90 100
SLSTLPATKL GSIAIKGAID KAGIPVEEVK EVYMGNVLQA GEGQAPTRQA
110 120 130 140 150
LLGAGLPLST PATTINKVCA SGMKSIMLAS QSLMCGHQDV MVAGGMESMS
160 170 180 190 200
QVPYIMAREA PPYGGVKMED LIVKDGLTDV YNKFHMGNCA ENTAKNSSIS
210 220 230 240 250
REEQDAFAIK SYTLSKAAWE SGILAKEVVP VSIPQRGKPD VVVKEDEEYR
260 270 280 290 300
KVDFSKVPKL KAVFLKENGT VTAANASTLN DGAAALVLMT ADAAQRLNVT
310 320 330 340 350
PLAKIVAFAD AAVAPIDFPI APAFAVPKVL KAAGIKKEDI AMWEINEAFS
360 370 380 390 400
VVVLANIKML DIDPDRVNIN GGAVSLGHPI GMSGARIVGH MVHNLKSGQY
410 420
GLAGICNGGG GASSIVIQKF
Length:420
Mass (Da):44,342
Last modified:September 13, 2004 - v1
Checksum:i9A9323F4C36674C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078651 mRNA Translation: AAH78651.1
RefSeqiNP_001003746.1, NM_001003746.1
UniGeneiDr.77084

Genome annotation databases

EnsembliENSDART00000067448; ENSDARP00000067447; ENSDARG00000045888
GeneIDi445290
KEGGidre:445290

Similar proteinsi

Entry informationi

Entry nameiTHIL_DANRE
AccessioniPrimary (citable) accession number: Q6AZA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: September 13, 2004
Last modified: February 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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