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Protein

Acetyl-CoA acetyltransferase, mitochondrial

Gene

acat1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in ketone body metabolism.By similarity

Catalytic activityi

2 acetyl-CoA = CoA + acetoacetyl-CoA.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei119 – 1191Acyl-thioester intermediateBy similarity
Metal bindingi212 – 2121PotassiumBy similarity
Binding sitei212 – 2121Coenzyme ABy similarity
Binding sitei256 – 2561Coenzyme ABy similarity
Metal bindingi273 – 2731Potassium; via carbonyl oxygenBy similarity
Metal bindingi274 – 2741Potassium; via carbonyl oxygenBy similarity
Metal bindingi276 – 2761Potassium; via carbonyl oxygenBy similarity
Binding sitei277 – 2771Coenzyme ABy similarity
Metal bindingi374 – 3741Potassium; via carbonyl oxygenBy similarity
Active sitei378 – 3781Proton acceptorPROSITE-ProRule annotation
Active sitei406 – 4061Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Potassium

Enzyme and pathway databases

ReactomeiR-DRE-70895. Branched-chain amino acid catabolism.
R-DRE-77108. Utilization of Ketone Bodies.
R-DRE-77111. Synthesis of Ketone Bodies.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA acetyltransferase, mitochondrial (EC:2.3.1.9)
Alternative name(s):
Acetoacetyl-CoA thiolase
Gene namesi
Name:acat1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 10

Organism-specific databases

ZFINiZDB-GENE-040808-68. acat1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2626MitochondrionBy similarityAdd
BLAST
Chaini27 – 420394Acetyl-CoA acetyltransferase, mitochondrialPRO_0000356275Add
BLAST

Proteomic databases

PaxDbiQ6AZA0.
PRIDEiQ6AZA0.

Expressioni

Gene expression databases

BgeeiQ6AZA0.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000067447.

Structurei

3D structure databases

ProteinModelPortaliQ6AZA0.
SMRiQ6AZA0. Positions 29-420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni251 – 2533Coenzyme A bindingBy similarity

Sequence similaritiesi

Belongs to the thiolase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1390. Eukaryota.
COG0183. LUCA.
GeneTreeiENSGT00390000009412.
HOGENOMiHOG000012238.
HOVERGENiHBG003112.
InParanoidiQ6AZA0.
KOiK00626.
OMAiKKGELGC.
OrthoDBiEOG7JQBNG.
PhylomeDBiQ6AZA0.
TreeFamiTF300650.

Family and domain databases

Gene3Di3.40.47.10. 4 hits.
InterProiIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamiPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEiPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AZA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRALYSTR SQLCRHLAHK YLSRSYSTRP SLNEVVIVSA VRTPIGSFKG
60 70 80 90 100
SLSTLPATKL GSIAIKGAID KAGIPVEEVK EVYMGNVLQA GEGQAPTRQA
110 120 130 140 150
LLGAGLPLST PATTINKVCA SGMKSIMLAS QSLMCGHQDV MVAGGMESMS
160 170 180 190 200
QVPYIMAREA PPYGGVKMED LIVKDGLTDV YNKFHMGNCA ENTAKNSSIS
210 220 230 240 250
REEQDAFAIK SYTLSKAAWE SGILAKEVVP VSIPQRGKPD VVVKEDEEYR
260 270 280 290 300
KVDFSKVPKL KAVFLKENGT VTAANASTLN DGAAALVLMT ADAAQRLNVT
310 320 330 340 350
PLAKIVAFAD AAVAPIDFPI APAFAVPKVL KAAGIKKEDI AMWEINEAFS
360 370 380 390 400
VVVLANIKML DIDPDRVNIN GGAVSLGHPI GMSGARIVGH MVHNLKSGQY
410 420
GLAGICNGGG GASSIVIQKF
Length:420
Mass (Da):44,342
Last modified:September 13, 2004 - v1
Checksum:i9A9323F4C36674C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078651 mRNA. Translation: AAH78651.1.
RefSeqiNP_001003746.1. NM_001003746.1.
UniGeneiDr.77084.

Genome annotation databases

EnsembliENSDART00000067448; ENSDARP00000067447; ENSDARG00000045888.
GeneIDi445290.
KEGGidre:445290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078651 mRNA. Translation: AAH78651.1.
RefSeqiNP_001003746.1. NM_001003746.1.
UniGeneiDr.77084.

3D structure databases

ProteinModelPortaliQ6AZA0.
SMRiQ6AZA0. Positions 29-420.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000067447.

Proteomic databases

PaxDbiQ6AZA0.
PRIDEiQ6AZA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000067448; ENSDARP00000067447; ENSDARG00000045888.
GeneIDi445290.
KEGGidre:445290.

Organism-specific databases

CTDi38.
ZFINiZDB-GENE-040808-68. acat1.

Phylogenomic databases

eggNOGiKOG1390. Eukaryota.
COG0183. LUCA.
GeneTreeiENSGT00390000009412.
HOGENOMiHOG000012238.
HOVERGENiHBG003112.
InParanoidiQ6AZA0.
KOiK00626.
OMAiKKGELGC.
OrthoDBiEOG7JQBNG.
PhylomeDBiQ6AZA0.
TreeFamiTF300650.

Enzyme and pathway databases

ReactomeiR-DRE-70895. Branched-chain amino acid catabolism.
R-DRE-77108. Utilization of Ketone Bodies.
R-DRE-77111. Synthesis of Ketone Bodies.

Miscellaneous databases

PROiQ6AZA0.

Gene expression databases

BgeeiQ6AZA0.

Family and domain databases

Gene3Di3.40.47.10. 4 hits.
InterProiIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamiPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEiPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiTHIL_DANRE
AccessioniPrimary (citable) accession number: Q6AZA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.