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Protein

Acetyl-CoA acetyltransferase, mitochondrial

Gene

acat1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in ketone body metabolism.By similarity

Catalytic activityi

2 acetyl-CoA = CoA + acetoacetyl-CoA.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei119Acyl-thioester intermediateBy similarity1
Metal bindingi212PotassiumBy similarity1
Binding sitei212Coenzyme ABy similarity1
Binding sitei256Coenzyme ABy similarity1
Metal bindingi273Potassium; via carbonyl oxygenBy similarity1
Metal bindingi274Potassium; via carbonyl oxygenBy similarity1
Metal bindingi276Potassium; via carbonyl oxygenBy similarity1
Binding sitei277Coenzyme ABy similarity1
Metal bindingi374Potassium; via carbonyl oxygenBy similarity1
Active sitei378Proton acceptorPROSITE-ProRule annotation1
Active sitei406Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Potassium

Enzyme and pathway databases

ReactomeiR-DRE-70895. Branched-chain amino acid catabolism.
R-DRE-77108. Utilization of Ketone Bodies.
R-DRE-77111. Synthesis of Ketone Bodies.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA acetyltransferase, mitochondrial (EC:2.3.1.9)
Alternative name(s):
Acetoacetyl-CoA thiolase
Gene namesi
Name:acat1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 10

Organism-specific databases

ZFINiZDB-GENE-040808-68. acat1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26MitochondrionBy similarityAdd BLAST26
ChainiPRO_000035627527 – 420Acetyl-CoA acetyltransferase, mitochondrialAdd BLAST394

Proteomic databases

PaxDbiQ6AZA0.
PeptideAtlasiQ6AZA0.
PRIDEiQ6AZA0.

Expressioni

Gene expression databases

BgeeiENSDARG00000045888.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000067447.

Structurei

3D structure databases

ProteinModelPortaliQ6AZA0.
SMRiQ6AZA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni251 – 253Coenzyme A bindingBy similarity3

Sequence similaritiesi

Belongs to the thiolase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1390. Eukaryota.
COG0183. LUCA.
GeneTreeiENSGT00390000009412.
HOGENOMiHOG000012238.
HOVERGENiHBG003112.
InParanoidiQ6AZA0.
KOiK00626.
OMAiYGGACAQ.
PhylomeDBiQ6AZA0.
TreeFamiTF300650.

Family and domain databases

Gene3Di3.40.47.10. 4 hits.
InterProiIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamiPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEiPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AZA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRALYSTR SQLCRHLAHK YLSRSYSTRP SLNEVVIVSA VRTPIGSFKG
60 70 80 90 100
SLSTLPATKL GSIAIKGAID KAGIPVEEVK EVYMGNVLQA GEGQAPTRQA
110 120 130 140 150
LLGAGLPLST PATTINKVCA SGMKSIMLAS QSLMCGHQDV MVAGGMESMS
160 170 180 190 200
QVPYIMAREA PPYGGVKMED LIVKDGLTDV YNKFHMGNCA ENTAKNSSIS
210 220 230 240 250
REEQDAFAIK SYTLSKAAWE SGILAKEVVP VSIPQRGKPD VVVKEDEEYR
260 270 280 290 300
KVDFSKVPKL KAVFLKENGT VTAANASTLN DGAAALVLMT ADAAQRLNVT
310 320 330 340 350
PLAKIVAFAD AAVAPIDFPI APAFAVPKVL KAAGIKKEDI AMWEINEAFS
360 370 380 390 400
VVVLANIKML DIDPDRVNIN GGAVSLGHPI GMSGARIVGH MVHNLKSGQY
410 420
GLAGICNGGG GASSIVIQKF
Length:420
Mass (Da):44,342
Last modified:September 13, 2004 - v1
Checksum:i9A9323F4C36674C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078651 mRNA. Translation: AAH78651.1.
RefSeqiNP_001003746.1. NM_001003746.1.
UniGeneiDr.77084.

Genome annotation databases

EnsembliENSDART00000067448; ENSDARP00000067447; ENSDARG00000045888.
GeneIDi445290.
KEGGidre:445290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078651 mRNA. Translation: AAH78651.1.
RefSeqiNP_001003746.1. NM_001003746.1.
UniGeneiDr.77084.

3D structure databases

ProteinModelPortaliQ6AZA0.
SMRiQ6AZA0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000067447.

Proteomic databases

PaxDbiQ6AZA0.
PeptideAtlasiQ6AZA0.
PRIDEiQ6AZA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000067448; ENSDARP00000067447; ENSDARG00000045888.
GeneIDi445290.
KEGGidre:445290.

Organism-specific databases

CTDi38.
ZFINiZDB-GENE-040808-68. acat1.

Phylogenomic databases

eggNOGiKOG1390. Eukaryota.
COG0183. LUCA.
GeneTreeiENSGT00390000009412.
HOGENOMiHOG000012238.
HOVERGENiHBG003112.
InParanoidiQ6AZA0.
KOiK00626.
OMAiYGGACAQ.
PhylomeDBiQ6AZA0.
TreeFamiTF300650.

Enzyme and pathway databases

ReactomeiR-DRE-70895. Branched-chain amino acid catabolism.
R-DRE-77108. Utilization of Ketone Bodies.
R-DRE-77111. Synthesis of Ketone Bodies.

Miscellaneous databases

PROiQ6AZA0.

Gene expression databases

BgeeiENSDARG00000045888.

Family and domain databases

Gene3Di3.40.47.10. 4 hits.
InterProiIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamiPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEiPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHIL_DANRE
AccessioniPrimary (citable) accession number: Q6AZA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: September 13, 2004
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.