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Protein

Glucose-6-phosphatase 3

Gene

G6pc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + H2O = D-glucose + phosphate.

Enzyme regulationi

Inhibited by vanadate.By similarity

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei79SubstrateSequence analysis1
Active sitei114Proton donorSequence analysis1
Binding sitei161SubstrateSequence analysis1
Active sitei167NucleophileBy similarity1

GO - Molecular functioni

  • glucose-6-phosphatase activity Source: RGD

GO - Biological processi

  • gluconeogenesis Source: RGD
  • glucose 6-phosphate metabolic process Source: RGD
  • glucose-6-phosphate transport Source: Ensembl
  • phosphate-containing compound metabolic process Source: RGD

Keywordsi

Molecular functionHydrolase
Biological processGluconeogenesis

Enzyme and pathway databases

ReactomeiR-RNO-70263. Gluconeogenesis.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphatase 3 (EC:3.1.3.9)
Short name:
G-6-Pase 3
Short name:
G6Pase 3
Gene namesi
Name:G6pc3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi727875. G6pc3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25LumenalSequence analysisAdd BLAST25
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Topological domaini47 – 56CytoplasmicSequence analysis10
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78 – 115LumenalSequence analysisAdd BLAST38
Transmembranei116 – 135HelicalSequence analysisAdd BLAST20
Topological domaini136 – 140CytoplasmicSequence analysis5
Transmembranei141 – 162HelicalSequence analysisAdd BLAST22
Topological domaini163 – 167LumenalSequence analysis5
Transmembranei168 – 186HelicalSequence analysisAdd BLAST19
Topological domaini187 – 197CytoplasmicSequence analysisAdd BLAST11
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 254LumenalSequence analysisAdd BLAST36
Transmembranei255 – 273HelicalSequence analysisAdd BLAST19
Topological domaini274 – 283CytoplasmicSequence analysis10
Transmembranei284 – 304HelicalSequence analysisAdd BLAST21
Topological domaini305 – 307LumenalSequence analysis3
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 346CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003345141 – 346Glucose-6-phosphatase 3Add BLAST346

Proteomic databases

PaxDbiQ6AZ83.
PRIDEiQ6AZ83.

Expressioni

Tissue specificityi

Expressed in liver and kidney. It is the major glucose-6-phosphatase expressed in the small intestine.1 Publication

Inductioni

Up-regulated upon fasting.1 Publication

Gene expression databases

BgeeiENSRNOG00000020902.
GenevisibleiQ6AZ83. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028375.

Structurei

3D structure databases

ProteinModelPortaliQ6AZ83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphatase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDXG. Eukaryota.
ENOG4110AJ7. LUCA.
GeneTreeiENSGT00510000046465.
HOGENOMiHOG000264239.
HOVERGENiHBG003560.
InParanoidiQ6AZ83.
KOiK01084.
OMAiTLWPCLV.
OrthoDBiEOG091G0AXF.
PhylomeDBiQ6AZ83.
TreeFamiTF324388.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiView protein in InterPro
IPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
PfamiView protein in Pfam
PF01569. PAP2. 1 hit.
PIRSFiPIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTiView protein in SMART
SM00014. acidPPc. 1 hit.
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AZ83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESTLSAGIM MAEALQNQLP GLENMWLWVT FLADPKNLFQ FYFPAVYYAS
60 70 80 90 100
RRLGISLFWI AFITEWLNLV FKWFLFGDRP FWWVHESGYS AQTPVQIHQF
110 120 130 140 150
PSSCETGPGS PSGHCMITGA ALWPVMIAIS SQVASQTRSP WVRVIPGLAY
160 170 180 190 200
CTFLLAVGLS RVFLLAHFPH QVLAGLLAGV ILGWLLSPRV PMERELSFYG
210 220 230 240 250
LTALTLMLGA SLMYWTLFTL GLDLSWSINL ASKWCDRPEW VLVDSRPFAS
260 270 280 290 300
LSRDSGSALG LGIALHTPCY AQIRRVHLGN GQKIACFVLA MGLLVFLEWL
310 320 330 340
GHPPQISLFY IFNFLKFTLW PCLVVALVPW MVHTLSAQEA PPIRSS
Length:346
Mass (Da):38,834
Last modified:September 13, 2004 - v1
Checksum:i59531F3030990F2F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106T → I in AAO39165 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY186240 mRNA. Translation: AAO39165.1.
BC078689 mRNA. Translation: AAH78689.1.
RefSeqiNP_788266.2. NM_176077.3.
UniGeneiRn.66254.

Genome annotation databases

EnsembliENSRNOT00000028375; ENSRNOP00000028375; ENSRNOG00000020902.
GeneIDi303565.
KEGGirno:303565.
UCSCiRGD:727875. rat.

Similar proteinsi

Entry informationi

Entry nameiG6PC3_RAT
AccessioniPrimary (citable) accession number: Q6AZ83
Secondary accession number(s): Q811R7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 13, 2004
Last modified: September 27, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families