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Q6AZ83

- G6PC3_RAT

UniProt

Q6AZ83 - G6PC3_RAT

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Protein

Glucose-6-phosphatase 3

Gene

G6pc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + H2O = D-glucose + phosphate.

Enzyme regulationi

Inhibited by vanadate.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791SubstrateSequence Analysis
Active sitei114 – 1141Proton donorSequence Analysis
Binding sitei161 – 1611SubstrateSequence Analysis
Active sitei167 – 1671NucleophileBy similarity

GO - Molecular functioni

  1. glucose-6-phosphatase activity Source: RGD

GO - Biological processi

  1. dephosphorylation Source: GOC
  2. gluconeogenesis Source: RGD
  3. glucose 6-phosphate metabolic process Source: RGD
  4. glucose-6-phosphate transport Source: Ensembl
  5. phosphate-containing compound metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Gluconeogenesis

Enzyme and pathway databases

ReactomeiREACT_205960. Glucose transport.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphatase 3 (EC:3.1.3.9)
Short name:
G-6-Pase 3
Short name:
G6Pase 3
Gene namesi
Name:G6pc3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi727875. G6pc3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525LumenalSequence AnalysisAdd
BLAST
Transmembranei26 – 4621HelicalSequence AnalysisAdd
BLAST
Topological domaini47 – 5610CytoplasmicSequence Analysis
Transmembranei57 – 7721HelicalSequence AnalysisAdd
BLAST
Topological domaini78 – 11538LumenalSequence AnalysisAdd
BLAST
Transmembranei116 – 13520HelicalSequence AnalysisAdd
BLAST
Topological domaini136 – 1405CytoplasmicSequence Analysis
Transmembranei141 – 16222HelicalSequence AnalysisAdd
BLAST
Topological domaini163 – 1675LumenalSequence Analysis
Transmembranei168 – 18619HelicalSequence AnalysisAdd
BLAST
Topological domaini187 – 19711CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei198 – 21821HelicalSequence AnalysisAdd
BLAST
Topological domaini219 – 25436LumenalSequence AnalysisAdd
BLAST
Transmembranei255 – 27319HelicalSequence AnalysisAdd
BLAST
Topological domaini274 – 28310CytoplasmicSequence Analysis
Transmembranei284 – 30421HelicalSequence AnalysisAdd
BLAST
Topological domaini305 – 3073LumenalSequence Analysis
Transmembranei308 – 32821HelicalSequence AnalysisAdd
BLAST
Topological domaini329 – 34618CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Glucose-6-phosphatase 3PRO_0000334514Add
BLAST

Proteomic databases

PRIDEiQ6AZ83.

Expressioni

Tissue specificityi

Expressed in liver and kidney. It is the major glucose-6-phosphatase expressed in the small intestine.1 Publication

Inductioni

Up-regulated upon fasting.1 Publication

Gene expression databases

GenevestigatoriQ6AZ83.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028375.

Structurei

3D structure databases

ProteinModelPortaliQ6AZ83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphatase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82628.
GeneTreeiENSGT00510000046465.
HOGENOMiHOG000264239.
HOVERGENiHBG003560.
InParanoidiQ6AZ83.
KOiK01084.
OMAiKWFLFGD.
OrthoDBiEOG73NG4N.
PhylomeDBiQ6AZ83.
TreeFamiTF324388.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
PIRSFiPIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AZ83-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESTLSAGIM MAEALQNQLP GLENMWLWVT FLADPKNLFQ FYFPAVYYAS
60 70 80 90 100
RRLGISLFWI AFITEWLNLV FKWFLFGDRP FWWVHESGYS AQTPVQIHQF
110 120 130 140 150
PSSCETGPGS PSGHCMITGA ALWPVMIAIS SQVASQTRSP WVRVIPGLAY
160 170 180 190 200
CTFLLAVGLS RVFLLAHFPH QVLAGLLAGV ILGWLLSPRV PMERELSFYG
210 220 230 240 250
LTALTLMLGA SLMYWTLFTL GLDLSWSINL ASKWCDRPEW VLVDSRPFAS
260 270 280 290 300
LSRDSGSALG LGIALHTPCY AQIRRVHLGN GQKIACFVLA MGLLVFLEWL
310 320 330 340
GHPPQISLFY IFNFLKFTLW PCLVVALVPW MVHTLSAQEA PPIRSS
Length:346
Mass (Da):38,834
Last modified:September 13, 2004 - v1
Checksum:i59531F3030990F2F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061T → I in AAO39165. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY186240 mRNA. Translation: AAO39165.1.
BC078689 mRNA. Translation: AAH78689.1.
RefSeqiNP_788266.2. NM_176077.3.
UniGeneiRn.66254.

Genome annotation databases

EnsembliENSRNOT00000028375; ENSRNOP00000028375; ENSRNOG00000020902.
GeneIDi303565.
KEGGirno:303565.
UCSCiRGD:727875. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY186240 mRNA. Translation: AAO39165.1 .
BC078689 mRNA. Translation: AAH78689.1 .
RefSeqi NP_788266.2. NM_176077.3.
UniGenei Rn.66254.

3D structure databases

ProteinModelPortali Q6AZ83.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000028375.

Proteomic databases

PRIDEi Q6AZ83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000028375 ; ENSRNOP00000028375 ; ENSRNOG00000020902 .
GeneIDi 303565.
KEGGi rno:303565.
UCSCi RGD:727875. rat.

Organism-specific databases

CTDi 92579.
RGDi 727875. G6pc3.

Phylogenomic databases

eggNOGi NOG82628.
GeneTreei ENSGT00510000046465.
HOGENOMi HOG000264239.
HOVERGENi HBG003560.
InParanoidi Q6AZ83.
KOi K01084.
OMAi KWFLFGD.
OrthoDBi EOG73NG4N.
PhylomeDBi Q6AZ83.
TreeFami TF324388.

Enzyme and pathway databases

UniPathwayi UPA00138 .
Reactomei REACT_205960. Glucose transport.

Miscellaneous databases

NextBioi 651620.
PROi Q6AZ83.

Gene expression databases

Genevestigatori Q6AZ83.

Family and domain databases

Gene3Di 1.20.144.10. 1 hit.
InterProi IPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view ]
Pfami PF01569. PAP2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTi SM00014. acidPPc. 1 hit.
[Graphical view ]
SUPFAMi SSF48317. SSF48317. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a glucose-6-phosphatase catalytic subunit-related sequence expressed in rodent tissues."
    Middleditch C., Darakhshan F., Guionie O., Bonnefont J., Burchell A., Clottes E.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Liver glyconeogenesis: a pathway to cope with postprandial amino acid excess in high-protein fed rats?"
    Azzout-Marniche D., Gaudichon C., Blouet C., Bos C., Mathe V., Huneau J.-F., Tome D.
    Am. J. Physiol. 292:R1400-R1407(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiG6PC3_RAT
AccessioniPrimary (citable) accession number: Q6AZ83
Secondary accession number(s): Q811R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 13, 2004
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3