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Q6AZ83

- G6PC3_RAT

UniProt

Q6AZ83 - G6PC3_RAT

Protein

Glucose-6-phosphatase 3

Gene

G6pc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function By similarity.By similarity

    Catalytic activityi

    D-glucose 6-phosphate + H2O = D-glucose + phosphate.

    Enzyme regulationi

    Inhibited by vanadate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei79 – 791SubstrateSequence Analysis
    Active sitei114 – 1141Proton donorSequence Analysis
    Binding sitei161 – 1611SubstrateSequence Analysis
    Active sitei167 – 1671NucleophileBy similarity

    GO - Molecular functioni

    1. glucose-6-phosphatase activity Source: RGD

    GO - Biological processi

    1. dephosphorylation Source: GOC
    2. gluconeogenesis Source: RGD
    3. glucose 6-phosphate metabolic process Source: RGD
    4. glucose-6-phosphate transport Source: Ensembl
    5. phosphate-containing compound metabolic process Source: RGD

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Gluconeogenesis

    Enzyme and pathway databases

    ReactomeiREACT_205960. Glucose transport.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphatase 3 (EC:3.1.3.9)
    Short name:
    G-6-Pase 3
    Short name:
    G6Pase 3
    Gene namesi
    Name:G6pc3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi727875. G6pc3.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Glucose-6-phosphatase 3PRO_0000334514Add
    BLAST

    Proteomic databases

    PRIDEiQ6AZ83.

    Expressioni

    Tissue specificityi

    Expressed in liver and kidney. It is the major glucose-6-phosphatase expressed in the small intestine.1 Publication

    Inductioni

    Up-regulated upon fasting.1 Publication

    Gene expression databases

    GenevestigatoriQ6AZ83.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000028375.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AZ83.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525LumenalSequence AnalysisAdd
    BLAST
    Topological domaini47 – 5610CytoplasmicSequence Analysis
    Topological domaini78 – 11538LumenalSequence AnalysisAdd
    BLAST
    Topological domaini136 – 1405CytoplasmicSequence Analysis
    Topological domaini163 – 1675LumenalSequence Analysis
    Topological domaini187 – 19711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini219 – 25436LumenalSequence AnalysisAdd
    BLAST
    Topological domaini274 – 28310CytoplasmicSequence Analysis
    Topological domaini305 – 3073LumenalSequence Analysis
    Topological domaini329 – 34618CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei57 – 7721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei116 – 13520HelicalSequence AnalysisAdd
    BLAST
    Transmembranei141 – 16222HelicalSequence AnalysisAdd
    BLAST
    Transmembranei168 – 18619HelicalSequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei255 – 27319HelicalSequence AnalysisAdd
    BLAST
    Transmembranei284 – 30421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei308 – 32821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphatase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG82628.
    GeneTreeiENSGT00510000046465.
    HOGENOMiHOG000264239.
    HOVERGENiHBG003560.
    InParanoidiQ811R7.
    KOiK01084.
    OMAiKWFLFGD.
    OrthoDBiEOG73NG4N.
    PhylomeDBiQ6AZ83.
    TreeFamiTF324388.

    Family and domain databases

    Gene3Di1.20.144.10. 1 hit.
    InterProiIPR016275. Glucose-6-phosphatase.
    IPR000326. P_Acid_Pase_2/haloperoxidase.
    [Graphical view]
    PfamiPF01569. PAP2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000905. Glucose-6-phosphatase. 1 hit.
    SMARTiSM00014. acidPPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48317. SSF48317. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6AZ83-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESTLSAGIM MAEALQNQLP GLENMWLWVT FLADPKNLFQ FYFPAVYYAS    50
    RRLGISLFWI AFITEWLNLV FKWFLFGDRP FWWVHESGYS AQTPVQIHQF 100
    PSSCETGPGS PSGHCMITGA ALWPVMIAIS SQVASQTRSP WVRVIPGLAY 150
    CTFLLAVGLS RVFLLAHFPH QVLAGLLAGV ILGWLLSPRV PMERELSFYG 200
    LTALTLMLGA SLMYWTLFTL GLDLSWSINL ASKWCDRPEW VLVDSRPFAS 250
    LSRDSGSALG LGIALHTPCY AQIRRVHLGN GQKIACFVLA MGLLVFLEWL 300
    GHPPQISLFY IFNFLKFTLW PCLVVALVPW MVHTLSAQEA PPIRSS 346
    Length:346
    Mass (Da):38,834
    Last modified:September 13, 2004 - v1
    Checksum:i59531F3030990F2F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti106 – 1061T → I in AAO39165. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY186240 mRNA. Translation: AAO39165.1.
    BC078689 mRNA. Translation: AAH78689.1.
    RefSeqiNP_788266.2. NM_176077.3.
    UniGeneiRn.66254.

    Genome annotation databases

    EnsembliENSRNOT00000028375; ENSRNOP00000028375; ENSRNOG00000020902.
    GeneIDi303565.
    KEGGirno:303565.
    UCSCiRGD:727875. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY186240 mRNA. Translation: AAO39165.1 .
    BC078689 mRNA. Translation: AAH78689.1 .
    RefSeqi NP_788266.2. NM_176077.3.
    UniGenei Rn.66254.

    3D structure databases

    ProteinModelPortali Q6AZ83.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000028375.

    Proteomic databases

    PRIDEi Q6AZ83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000028375 ; ENSRNOP00000028375 ; ENSRNOG00000020902 .
    GeneIDi 303565.
    KEGGi rno:303565.
    UCSCi RGD:727875. rat.

    Organism-specific databases

    CTDi 92579.
    RGDi 727875. G6pc3.

    Phylogenomic databases

    eggNOGi NOG82628.
    GeneTreei ENSGT00510000046465.
    HOGENOMi HOG000264239.
    HOVERGENi HBG003560.
    InParanoidi Q811R7.
    KOi K01084.
    OMAi KWFLFGD.
    OrthoDBi EOG73NG4N.
    PhylomeDBi Q6AZ83.
    TreeFami TF324388.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    Reactomei REACT_205960. Glucose transport.

    Miscellaneous databases

    NextBioi 651620.
    PROi Q6AZ83.

    Gene expression databases

    Genevestigatori Q6AZ83.

    Family and domain databases

    Gene3Di 1.20.144.10. 1 hit.
    InterProi IPR016275. Glucose-6-phosphatase.
    IPR000326. P_Acid_Pase_2/haloperoxidase.
    [Graphical view ]
    Pfami PF01569. PAP2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000905. Glucose-6-phosphatase. 1 hit.
    SMARTi SM00014. acidPPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48317. SSF48317. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a glucose-6-phosphatase catalytic subunit-related sequence expressed in rodent tissues."
      Middleditch C., Darakhshan F., Guionie O., Bonnefont J., Burchell A., Clottes E.
      Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "Liver glyconeogenesis: a pathway to cope with postprandial amino acid excess in high-protein fed rats?"
      Azzout-Marniche D., Gaudichon C., Blouet C., Bos C., Mathe V., Huneau J.-F., Tome D.
      Am. J. Physiol. 292:R1400-R1407(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.

    Entry informationi

    Entry nameiG6PC3_RAT
    AccessioniPrimary (citable) accession number: Q6AZ83
    Secondary accession number(s): Q811R7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3