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Protein

Epidermal growth factor-like protein 7

Gene

Egfl7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Cell adhesion, Differentiation

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Epidermal growth factor-like protein 7
Short name:
EGF-like protein 7
Alternative name(s):
Multiple epidermal growth factor-like domains protein 7
Short name:
Multiple EGF-like domains protein 7
Gene namesi
Name:Egfl7
Synonyms:Cbl20, Megf7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi708507. Egfl7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 279258Epidermal growth factor-like protein 7PRO_0000007530Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 94By similarity
Disulfide bondi57 ↔ 63By similarity
Disulfide bondi93 ↔ 107By similarity
Disulfide bondi112 ↔ 122By similarity
Disulfide bondi116 ↔ 128By similarity
Disulfide bondi130 ↔ 139By similarity
Disulfide bondi146 ↔ 157By similarity
Disulfide bondi153 ↔ 166By similarity
Disulfide bondi168 ↔ 181By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6AZ60.
PRIDEiQ6AZ60.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019388.
GenevisibleiQ6AZ60. RN.

Interactioni

Subunit structurei

Interacts with ITGAV/ITGB3 in an RGD-dependent manner, increasing endothelial cell's motility.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026318.

Structurei

3D structure databases

ProteinModelPortaliQ6AZ60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 10982EMIPROSITE-ProRule annotationAdd
BLAST
Domaini108 – 14033EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini142 – 18241EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili200 – 22425Sequence analysisAdd
BLAST
Coiled coili250 – 27425Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi131 – 1333Cell attachment siteBy similarity

Sequence similaritiesi

Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 1 EMI domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
GeneTreeiENSGT00840000129786.
HOGENOMiHOG000231494.
HOVERGENiHBG051453.
InParanoidiQ6AZ60.
OMAiPQHCVNT.
OrthoDBiEOG091G0H5E.
PhylomeDBiQ6AZ60.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR013111. EGF_extracell.
IPR011489. EMI_domain.
[Graphical view]
PfamiPF07974. EGF_2. 1 hit.
PF07645. EGF_CA. 1 hit.
PF07546. EMI. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
[Graphical view]
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS51041. EMI. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6AZ60-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWGSGELLVA WFLVLAAGGT TEHVYRPSRR VCTVGVSGGS ISETFVQRVY
60 70 80 90 100
QPYLTTCDGH RACSTYRTIY RTAYRIAYRH SPGLTPSRPR YACCPGWKRT
110 120 130 140 150
NGLPGACGAA ICQPPCGNEG SCIRPGRCRC PVGWQGDTCQ IDVDECSTGE
160 170 180 190 200
ARCPQRCVNT VGSYWCQCWE GQSPSADGVL CLPKEGPSPV APSPTPGVDS
210 220 230 240 250
VVREEVYKLQ ARVDVLEQKL QLVLAPLHSL ASRSPEHGLQ DPGSLLAHSF
260 270
QQLDRIDSLS EQVSFLEEQL GSCSCKKDL
Length:279
Mass (Da):30,371
Last modified:September 13, 2004 - v1
Checksum:i01F2B70BDE22AD36
GO
Isoform 2 (identifier: Q6AZ60-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-109: MWGSGELLVA...TNGLPGACGA → MPQGSGNSPEWVTDRPLLPT

Note: No experimental confirmation available.
Show »
Length:190
Mass (Da):20,546
Checksum:iC540F535AEEBDAB1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 109109MWGSG…GACGA → MPQGSGNSPEWVTDRPLLPT in isoform 2. 1 PublicationVSP_011766Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF223678 mRNA. Translation: AAF35352.1.
BC078725 mRNA. Translation: AAH78725.1.
RefSeqiNP_620804.1. NM_139104.1.
UniGeneiRn.144669.

Genome annotation databases

EnsembliENSRNOT00000026318; ENSRNOP00000026318; ENSRNOG00000019388. [Q6AZ60-1]
GeneIDi245963.
KEGGirno:245963.
UCSCiRGD:708507. rat. [Q6AZ60-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF223678 mRNA. Translation: AAF35352.1.
BC078725 mRNA. Translation: AAH78725.1.
RefSeqiNP_620804.1. NM_139104.1.
UniGeneiRn.144669.

3D structure databases

ProteinModelPortaliQ6AZ60.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026318.

Proteomic databases

PaxDbiQ6AZ60.
PRIDEiQ6AZ60.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026318; ENSRNOP00000026318; ENSRNOG00000019388. [Q6AZ60-1]
GeneIDi245963.
KEGGirno:245963.
UCSCiRGD:708507. rat. [Q6AZ60-1]

Organism-specific databases

CTDi51162.
RGDi708507. Egfl7.

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
GeneTreeiENSGT00840000129786.
HOGENOMiHOG000231494.
HOVERGENiHBG051453.
InParanoidiQ6AZ60.
OMAiPQHCVNT.
OrthoDBiEOG091G0H5E.
PhylomeDBiQ6AZ60.

Miscellaneous databases

PROiQ6AZ60.

Gene expression databases

BgeeiENSRNOG00000019388.
GenevisibleiQ6AZ60. RN.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR013111. EGF_extracell.
IPR011489. EMI_domain.
[Graphical view]
PfamiPF07974. EGF_2. 1 hit.
PF07645. EGF_CA. 1 hit.
PF07546. EMI. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
[Graphical view]
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS51041. EMI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEGFL7_RAT
AccessioniPrimary (citable) accession number: Q6AZ60
Secondary accession number(s): Q9JKW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.