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Protein

Epidermal growth factor-like protein 7

Gene

Egfl7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processAngiogenesis, Cell adhesion, Differentiation
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Epidermal growth factor-like protein 7
Short name:
EGF-like protein 7
Alternative name(s):
Multiple epidermal growth factor-like domains protein 7
Short name:
Multiple EGF-like domains protein 7
Gene namesi
Name:Egfl7
Synonyms:Cbl20, Megf7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi708507 Egfl7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000753022 – 279Epidermal growth factor-like protein 7Add BLAST258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 94By similarity
Disulfide bondi57 ↔ 63By similarity
Disulfide bondi93 ↔ 107By similarity
Disulfide bondi112 ↔ 122By similarity
Disulfide bondi116 ↔ 128By similarity
Disulfide bondi130 ↔ 139By similarity
Disulfide bondi146 ↔ 157By similarity
Disulfide bondi153 ↔ 166By similarity
Disulfide bondi168 ↔ 181By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6AZ60
PRIDEiQ6AZ60

Expressioni

Gene expression databases

BgeeiENSRNOG00000019388
GenevisibleiQ6AZ60 RN

Interactioni

Subunit structurei

Interacts with ITGAV/ITGB3 in an RGD-dependent manner, increasing endothelial cell's motility.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026318

Structurei

3D structure databases

ProteinModelPortaliQ6AZ60
SMRiQ6AZ60
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 109EMIPROSITE-ProRule annotationAdd BLAST82
Domaini108 – 140EGF-like 1PROSITE-ProRule annotationAdd BLAST33
Domaini142 – 182EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili200 – 224Sequence analysisAdd BLAST25
Coiled coili250 – 274Sequence analysisAdd BLAST25

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi131 – 133Cell attachment siteBy similarity3

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA
GeneTreeiENSGT00900000141064
HOGENOMiHOG000231494
HOVERGENiHBG051453
InParanoidiQ6AZ60
OMAiPQHCVNT
OrthoDBiEOG091G0H5E
PhylomeDBiQ6AZ60

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR013111 EGF_extracell
IPR011489 EMI_domain
PfamiView protein in Pfam
PF07974 EGF_2, 1 hit
PF07645 EGF_CA, 1 hit
PF07546 EMI, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00179 EGF_CA, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit
PS51041 EMI, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6AZ60-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWGSGELLVA WFLVLAAGGT TEHVYRPSRR VCTVGVSGGS ISETFVQRVY
60 70 80 90 100
QPYLTTCDGH RACSTYRTIY RTAYRIAYRH SPGLTPSRPR YACCPGWKRT
110 120 130 140 150
NGLPGACGAA ICQPPCGNEG SCIRPGRCRC PVGWQGDTCQ IDVDECSTGE
160 170 180 190 200
ARCPQRCVNT VGSYWCQCWE GQSPSADGVL CLPKEGPSPV APSPTPGVDS
210 220 230 240 250
VVREEVYKLQ ARVDVLEQKL QLVLAPLHSL ASRSPEHGLQ DPGSLLAHSF
260 270
QQLDRIDSLS EQVSFLEEQL GSCSCKKDL
Length:279
Mass (Da):30,371
Last modified:September 13, 2004 - v1
Checksum:i01F2B70BDE22AD36
GO
Isoform 2 (identifier: Q6AZ60-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-109: MWGSGELLVA...TNGLPGACGA → MPQGSGNSPEWVTDRPLLPT

Note: No experimental confirmation available.
Show »
Length:190
Mass (Da):20,546
Checksum:iC540F535AEEBDAB1
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0117661 – 109MWGSG…GACGA → MPQGSGNSPEWVTDRPLLPT in isoform 2. 1 PublicationAdd BLAST109

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF223678 mRNA Translation: AAF35352.1
BC078725 mRNA Translation: AAH78725.1
RefSeqiNP_620804.1, NM_139104.1
UniGeneiRn.144669

Genome annotation databases

EnsembliENSRNOT00000026318; ENSRNOP00000026318; ENSRNOG00000019388 [Q6AZ60-1]
GeneIDi245963
KEGGirno:245963
UCSCiRGD:708507 rat [Q6AZ60-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiEGFL7_RAT
AccessioniPrimary (citable) accession number: Q6AZ60
Secondary accession number(s): Q9JKW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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