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Protein

Interleukin-17 receptor E

Gene

Il17re

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Specific functional receptor for IL17C, signaling through the NF-kappa-B and MAPK pathways. Requires TRAF3IP2 /ACT1 for signaling. Crucial regulator in innate immunity to bacterial pathogens (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17 receptor E
Short name:
IL-17 receptor E
Short name:
IL-17RE
Gene namesi
Name:Il17re
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi735148. Il17re.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 415391ExtracellularSequence analysisAdd
BLAST
Transmembranei416 – 43621HelicalSequence analysisAdd
BLAST
Topological domaini437 – 637201CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 637613Interleukin-17 receptor EPRO_0000309469Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence analysis
Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6AZ51.
PRIDEiQ6AZ51.

Expressioni

Gene expression databases

GenevisibleiQ6AZ51. RN.

Interactioni

Subunit structurei

Forms heterodimers with IL17RE; the heterodimer binds IL17C.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini447 – 583137SEFIRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SEFIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFAR. Eukaryota.
ENOG410XTAY. LUCA.
GeneTreeiENSGT00730000111008.
HOGENOMiHOG000059623.
HOVERGENiHBG102913.
InParanoidiQ6AZ51.
KOiK05168.
OMAiQFAWKHL.
OrthoDBiEOG78D7KB.
PhylomeDBiQ6AZ51.
TreeFamiTF335690.

Family and domain databases

InterProiIPR027841. IL-17_rcpt_C/E_N.
IPR013568. SEFIR_dom.
[Graphical view]
PfamiPF15037. IL17_R_N. 1 hit.
PF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AZ51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSPRLAALL LSQPLLFICL AVSAQVACPC LPRWTSHCLL AFRVDKHFAG
60 70 80 90 100
LQCGWFPLLV RKSKSSHEFE VCWRHWTPSP FQRKLLGSPS LSQESHRIST
110 120 130 140 150
HFLAISHRGL RTKRTQPSAA EGIEHLPGAG SQKHGGPEFS FDLLPEVQAI
160 170 180 190 200
RVTIPPGPEA NVRLCYQWAL ECEDMSSPFD TQKIVSGGHT VDLPYEFLLP
210 220 230 240 250
CMCIEASYLQ EDTVRHKKCP FRSWPEAYGS DFWKSIRFTD YSQHSQMVMA
260 270 280 290 300
LTLRCPLKLE ASLCWRQDPV TPCKILPNAT AKESEGWYIL ENVDLHPQLC
310 320 330 340 350
FKFSFENSSH VECPHQSGSL PSWTVSMDTQ AQQLILHFST RTYATFSAAW
360 370 380 390 400
SNPGLGLDSS MTPVYSISQT QGSVPVTLNL IIPFLRQGSC ILVWRSDVQF
410 420 430 440 450
AWKHLLCPDV SHRHLGLLIL ALLGLTTLLG VVLVLFCRRL LPGPGRTRPV
460 470 480 490 500
LLLHAADSEA QRRLVGALAE LLRTALGGGR DVIVDLWEGT HVARIGPLPW
510 520 530 540 550
LWAARERVAR EQGTVLLLWS CAGPSTACSG DPQTASLRTL SCAAPRQLLL
560 570 580 590 600
AYFSRLCAKG DIPGPLRALP RYRLLRDLPR LLRALDARPA TLATSWSHLG
610 620 630
AKECLKSRLE LCHLLELEAA KDDYHGSTNS PCGFSCL
Length:637
Mass (Da):70,852
Last modified:September 13, 2004 - v1
Checksum:iBB6C71838AB1C9D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061739 mRNA. Translation: AAH61739.1.
BC078742 mRNA. Translation: AAH78742.1.
RefSeqiNP_001004091.1. NM_001004091.1.
UniGeneiRn.129068.

Genome annotation databases

EnsembliENSRNOT00000056508; ENSRNOP00000053347; ENSRNOG00000009204.
GeneIDi362417.
KEGGirno:362417.
UCSCiRGD:735148. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061739 mRNA. Translation: AAH61739.1.
BC078742 mRNA. Translation: AAH78742.1.
RefSeqiNP_001004091.1. NM_001004091.1.
UniGeneiRn.129068.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ6AZ51.
PRIDEiQ6AZ51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000056508; ENSRNOP00000053347; ENSRNOG00000009204.
GeneIDi362417.
KEGGirno:362417.
UCSCiRGD:735148. rat.

Organism-specific databases

CTDi132014.
RGDi735148. Il17re.

Phylogenomic databases

eggNOGiENOG410IFAR. Eukaryota.
ENOG410XTAY. LUCA.
GeneTreeiENSGT00730000111008.
HOGENOMiHOG000059623.
HOVERGENiHBG102913.
InParanoidiQ6AZ51.
KOiK05168.
OMAiQFAWKHL.
OrthoDBiEOG78D7KB.
PhylomeDBiQ6AZ51.
TreeFamiTF335690.

Miscellaneous databases

NextBioi679850.
PROiQ6AZ51.

Gene expression databases

GenevisibleiQ6AZ51. RN.

Family and domain databases

InterProiIPR027841. IL-17_rcpt_C/E_N.
IPR013568. SEFIR_dom.
[Graphical view]
PfamiPF15037. IL17_R_N. 1 hit.
PF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Prostate.

Entry informationi

Entry nameiI17RE_RAT
AccessioniPrimary (citable) accession number: Q6AZ51
Secondary accession number(s): Q6P7B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: September 13, 2004
Last modified: May 11, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.