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Reviewed, UniProtKB/Swiss-Prot Q6AZ50 (ATG3_RAT)

Last modified July 22, 2008. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Autophagy-related protein 3
Alternative name(s):
    APG3-like
    Preconditioning-inducible gene 1 protein
Gene names
Name: Atg3
Synonyms: Apg3l
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

GABARAPL1 (GABARAPL2 or GABARAP or MAP1LC3)-modifier protein conjugating enzyme involved in its E2-like covalent binding to PE. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3 (E2-like enzyme). Preferred substrate is MAP1LC3A. Formation of the GABARAPL1-PE conjugate is essential for autophagy By similarity.

Subunit structure

Interacts with ATG7 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5 By similarity.

Subcellular location

CytoplasmBy similarity.

Sequence similarities

Belongs to the ATG3 family.

Ontologies

Keywords

   Biological processAutophagy
Protein transport
Transport
Ubl conjugation pathway
   Cellular componentCytoplasm
   PTMPhosphoprotein

Gene Ontology (GO)

None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 314314Autophagy-related protein 3

Sites

Active site2641Glycyl thioester intermediate Potential

Amino acid modifications

Modified residue181Phosphotyrosine By similarity

Experimental info

Sequence conflict2571P → L in AAG09182. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q6AZ50-1 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 4C78AB0F628C9BDF

FASTA31435,822
        10         20         30         40         50         60 
MQNVINTVKG KALEVAEYLT PVLKESKFKE TGVITPEEFV AAGDHLVHHC PTWQWATGEE 

        70         80         90        100        110        120 
LKVKAYLPTG KQFLVTKNVP CYKRCKQMEY SDELEAIIEE DDGDGGWVDT YHNTGITGIT 

       130        140        150        160        170        180 
EAVKEITLES KDSIKLQDCS VLCDEEEEEE EGEAADMEEY EESGLLETDE ATLDTRRIVE 

       190        200        210        220        230        240 
ACKAKADAGG EDAILQTRTY DLYITYDKYY QTPRLWLFGY DEQRQPLTVE HMYEDISQDH 

       250        260        270        280        290        300 
VKKTVTIENH PHLPPPPMCS VHPCRHAEVM KKIIETVAEG GGELGVHMYL LIFLKFVQAV 

       310 
IPTIEYDYTR HFTM 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of a novel gene induced by ischemic preconditioning in the retina."
Laser M., Li Y., Xu L., Darden A., Wu B.X., Hazard E.S. III, Crosson C., Ma J.X.
Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

AF175224 mRNA. Translation: AAG09182.1.
BC078743 mRNA. Translation: AAH78743.1.
RefSeqNP_599221.1.
UniGeneRn.3084

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSRNOG00000002094. Rattus norvegicus. [Contig view]
GeneID171415.
KEGGrno:171415.

Organism-specific databases

RGD708464. Atg3.

Phylogenomic databases

HOVERGENQ6AZ50.

Gene expression databases

ArrayExpressQ6AZ50.
GermOnlineENSRNOG00000002094. Rattus norvegicus.

Family and domain databases

InterProIPR007135. Autophagy_C.
IPR007134. Autophagy_N.
[Graphical view]
PfamPF03987. Autophagy_C. 1 hit.
PF03986. Autophagy_N. 1 hit.
[Graphical view]
ProDomQ6AZ50.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

Entry information

Entry nameATG3_RAT
AccessionPrimary (citable) accession number: Q6AZ50
Secondary accession number(s): Q9ESH2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: September 13, 2004
Last modified: July 22, 2008
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents