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Protein

Acetyl-coenzyme A transporter 1

Gene

Slc33a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides. Negatively regulates BMP signaling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-425397. Transport of vitamins, nucleosides, and related molecules.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A transporter 1
Short name:
AT-1
Short name:
Acetyl-CoA transporter 1
Alternative name(s):
Solute carrier family 33 member 1
Gene namesi
Name:Slc33a1
Synonyms:Acatn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620653. Slc33a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 74CytoplasmicSequence analysisAdd BLAST74
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Topological domaini96 – 113ExtracellularSequence analysisAdd BLAST18
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 141CytoplasmicSequence analysis7
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 256ExtracellularSequence analysisAdd BLAST94
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Topological domaini278 – 300CytoplasmicSequence analysisAdd BLAST23
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 344ExtracellularSequence analysisAdd BLAST23
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Topological domaini366 – 375CytoplasmicSequence analysis10
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Topological domaini397 – 405ExtracellularSequence analysis9
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Topological domaini427 – 509CytoplasmicSequence analysisAdd BLAST83
Transmembranei510 – 530HelicalSequence analysisAdd BLAST21
Topological domaini531 – 550ExtracellularSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000761671 – 550Acetyl-coenzyme A transporter 1Add BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42PhosphoserineBy similarity1
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6AYY8.
PRIDEiQ6AYY8.

PTM databases

iPTMnetiQ6AYY8.
PhosphoSitePlusiQ6AYY8.

Expressioni

Tissue specificityi

Expressed in brain at all developmental stages. Detected in hippocampus, hypothalamus, cerebellum, cortex, olfactory bulb, and the ventral and dorsal anterior olfactory nucleus.1 Publication

Gene expression databases

BgeeiENSRNOG00000010023.
GenevisibleiQ6AYY8. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-4568490.
STRINGi10116.ENSRNOP00000013392.

Structurei

3D structure databases

ProteinModelPortaliQ6AYY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC33A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3574. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00730000111115.
HOGENOMiHOG000194770.
HOVERGENiHBG052723.
InParanoidiQ6AYY8.
KOiK03372.
OMAiLWFWGIT.
OrthoDBiEOG091G06Y7.
PhylomeDBiQ6AYY8.
TreeFamiTF300008.

Family and domain databases

InterProiIPR024371. Acetyl-CoA_trnpstr_1.
IPR004752. AmpG_permease/AT-1.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF13000. Acatn. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00901. 2A0125. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AYY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPTISHKDN SRQRRSGMFG HALDMKSGPL PPGGWDDNHQ DSVGGEGDRE
60 70 80 90 100
VLLGDVGPGD FPKAKRSYRA ELSSILLLLF LYVLQGIPLG LAGSIPLILQ
110 120 130 140 150
SKNVSYTDQA FFSFVFWPFS LKLLWAPLVD AVYFKNFGRR KSWLVPTQYI
160 170 180 190 200
LGIFMIYLST QVDRLLGNID GRTPDVVALT VTFFLFEFLA ATQDIAVDGW
210 220 230 240 250
ALTMLSRENV GYASTCNSVG QTAGYFLGNV LFLALESADF CNKYLRFQPQ
260 270 280 290 300
PRGIVTLSDF LFFWGTVFLI TTTLVALLKK ETREASVVKE ETQGITDTYK
310 320 330 340 350
LLFSIIKMPA VLAFCLLILT SKIGFSAADA VTGLKLVEEG VPKEHLALLA
360 370 380 390 400
VPMVPLQIIL PLLISKYTAG PQPLNIFYKA MPYRLLLGLE YALLVWWTPK
410 420 430 440 450
VEHQGGFPIY YYIIVLLSYA LHQVTLYSMY VSIMAFNAKV SDPLIGGTYM
460 470 480 490 500
TLLNTVSNLG GNWPSTVALW LVDPLTVKEC VGASNQNCRT PEAIELCKKL
510 520 530 540 550
GGSCVTALDG YYVESIVCVL IGFGWWFFLG PKFKKLQDEG PSSWKCKRTN
Length:550
Mass (Da):61,101
Last modified:September 13, 2004 - v1
Checksum:i1CAE30DDDD5D1254
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti245L → W in BAA95446 (PubMed:10965123).Curated1
Sequence conflicti549T → N in BAA95446 (PubMed:10965123).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039326 Genomic DNA. Translation: BAA95446.1.
BC078832 mRNA. Translation: AAH78832.1.
RefSeqiNP_071588.2. NM_022252.2.
XP_008759280.1. XM_008761058.1.
UniGeneiRn.209601.
Rn.95276.

Genome annotation databases

EnsembliENSRNOT00000013392; ENSRNOP00000013392; ENSRNOG00000010023.
ENSRNOT00000076880; ENSRNOP00000068212; ENSRNOG00000010023.
GeneIDi64018.
KEGGirno:64018.
UCSCiRGD:620653. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039326 Genomic DNA. Translation: BAA95446.1.
BC078832 mRNA. Translation: AAH78832.1.
RefSeqiNP_071588.2. NM_022252.2.
XP_008759280.1. XM_008761058.1.
UniGeneiRn.209601.
Rn.95276.

3D structure databases

ProteinModelPortaliQ6AYY8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4568490.
STRINGi10116.ENSRNOP00000013392.

PTM databases

iPTMnetiQ6AYY8.
PhosphoSitePlusiQ6AYY8.

Proteomic databases

PaxDbiQ6AYY8.
PRIDEiQ6AYY8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013392; ENSRNOP00000013392; ENSRNOG00000010023.
ENSRNOT00000076880; ENSRNOP00000068212; ENSRNOG00000010023.
GeneIDi64018.
KEGGirno:64018.
UCSCiRGD:620653. rat.

Organism-specific databases

CTDi9197.
RGDi620653. Slc33a1.

Phylogenomic databases

eggNOGiKOG3574. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00730000111115.
HOGENOMiHOG000194770.
HOVERGENiHBG052723.
InParanoidiQ6AYY8.
KOiK03372.
OMAiLWFWGIT.
OrthoDBiEOG091G06Y7.
PhylomeDBiQ6AYY8.
TreeFamiTF300008.

Enzyme and pathway databases

ReactomeiR-RNO-425397. Transport of vitamins, nucleosides, and related molecules.

Miscellaneous databases

PROiQ6AYY8.

Gene expression databases

BgeeiENSRNOG00000010023.
GenevisibleiQ6AYY8. RN.

Family and domain databases

InterProiIPR024371. Acetyl-CoA_trnpstr_1.
IPR004752. AmpG_permease/AT-1.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF13000. Acatn. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00901. 2A0125. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACATN_RAT
AccessioniPrimary (citable) accession number: Q6AYY8
Secondary accession number(s): Q9JM68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: September 13, 2004
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.