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Protein

Acetyl-coenzyme A transporter 1

Gene

Slc33a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides. Negatively regulates BMP signaling (By similarity).By similarity

GO - Molecular functioni

  • acetyl-CoA transporter activity Source: RGD

GO - Biological processi

  • acetyl-CoA transport Source: GOC
  • BMP signaling pathway Source: Ensembl
  • central nervous system development Source: RGD
  • SMAD protein signal transduction Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-425397. Transport of vitamins, nucleosides, and related molecules.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A transporter 1
Short name:
AT-1
Short name:
Acetyl-CoA transporter 1
Alternative name(s):
Solute carrier family 33 member 1
Gene namesi
Name:Slc33a1
Synonyms:Acatn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620653. Slc33a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7474CytoplasmicSequence analysisAdd
BLAST
Transmembranei75 – 9521HelicalSequence analysisAdd
BLAST
Topological domaini96 – 11318ExtracellularSequence analysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence analysisAdd
BLAST
Topological domaini135 – 1417CytoplasmicSequence analysis
Transmembranei142 – 16221HelicalSequence analysisAdd
BLAST
Topological domaini163 – 25694ExtracellularSequence analysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence analysisAdd
BLAST
Topological domaini278 – 30023CytoplasmicSequence analysisAdd
BLAST
Transmembranei301 – 32121HelicalSequence analysisAdd
BLAST
Topological domaini322 – 34423ExtracellularSequence analysisAdd
BLAST
Transmembranei345 – 36521HelicalSequence analysisAdd
BLAST
Topological domaini366 – 37510CytoplasmicSequence analysis
Transmembranei376 – 39621HelicalSequence analysisAdd
BLAST
Topological domaini397 – 4059ExtracellularSequence analysis
Transmembranei406 – 42621HelicalSequence analysisAdd
BLAST
Topological domaini427 – 50983CytoplasmicSequence analysisAdd
BLAST
Transmembranei510 – 53021HelicalSequence analysisAdd
BLAST
Topological domaini531 – 55020ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Acetyl-coenzyme A transporter 1PRO_0000076167Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421PhosphoserineBy similarity
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6AYY8.
PRIDEiQ6AYY8.

Expressioni

Tissue specificityi

Expressed in brain at all developmental stages. Detected in hippocampus, hypothalamus, cerebellum, cortex, olfactory bulb, and the ventral and dorsal anterior olfactory nucleus.1 Publication

Gene expression databases

GenevisibleiQ6AYY8. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-4568490.
STRINGi10116.ENSRNOP00000013392.

Structurei

3D structure databases

ProteinModelPortaliQ6AYY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC33A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3574. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00730000111115.
HOGENOMiHOG000194770.
HOVERGENiHBG052723.
InParanoidiQ6AYY8.
KOiK03372.
OMAiLWFWGIT.
OrthoDBiEOG747PHW.
PhylomeDBiQ6AYY8.
TreeFamiTF300008.

Family and domain databases

InterProiIPR024371. Acetyl-CoA_trnpstr_1.
IPR004752. AmpG_permease/AT-1.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF13000. Acatn. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00901. 2A0125. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AYY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPTISHKDN SRQRRSGMFG HALDMKSGPL PPGGWDDNHQ DSVGGEGDRE
60 70 80 90 100
VLLGDVGPGD FPKAKRSYRA ELSSILLLLF LYVLQGIPLG LAGSIPLILQ
110 120 130 140 150
SKNVSYTDQA FFSFVFWPFS LKLLWAPLVD AVYFKNFGRR KSWLVPTQYI
160 170 180 190 200
LGIFMIYLST QVDRLLGNID GRTPDVVALT VTFFLFEFLA ATQDIAVDGW
210 220 230 240 250
ALTMLSRENV GYASTCNSVG QTAGYFLGNV LFLALESADF CNKYLRFQPQ
260 270 280 290 300
PRGIVTLSDF LFFWGTVFLI TTTLVALLKK ETREASVVKE ETQGITDTYK
310 320 330 340 350
LLFSIIKMPA VLAFCLLILT SKIGFSAADA VTGLKLVEEG VPKEHLALLA
360 370 380 390 400
VPMVPLQIIL PLLISKYTAG PQPLNIFYKA MPYRLLLGLE YALLVWWTPK
410 420 430 440 450
VEHQGGFPIY YYIIVLLSYA LHQVTLYSMY VSIMAFNAKV SDPLIGGTYM
460 470 480 490 500
TLLNTVSNLG GNWPSTVALW LVDPLTVKEC VGASNQNCRT PEAIELCKKL
510 520 530 540 550
GGSCVTALDG YYVESIVCVL IGFGWWFFLG PKFKKLQDEG PSSWKCKRTN
Length:550
Mass (Da):61,101
Last modified:September 13, 2004 - v1
Checksum:i1CAE30DDDD5D1254
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti245 – 2451L → W in BAA95446 (PubMed:10965123).Curated
Sequence conflicti549 – 5491T → N in BAA95446 (PubMed:10965123).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039326 Genomic DNA. Translation: BAA95446.1.
BC078832 mRNA. Translation: AAH78832.1.
RefSeqiNP_071588.2. NM_022252.2.
XP_008759280.1. XM_008761058.1.
UniGeneiRn.209601.

Genome annotation databases

EnsembliENSRNOT00000013392; ENSRNOP00000013392; ENSRNOG00000010023.
ENSRNOT00000076880; ENSRNOP00000068212; ENSRNOG00000010023.
GeneIDi64018.
KEGGirno:64018.
UCSCiRGD:620653. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039326 Genomic DNA. Translation: BAA95446.1.
BC078832 mRNA. Translation: AAH78832.1.
RefSeqiNP_071588.2. NM_022252.2.
XP_008759280.1. XM_008761058.1.
UniGeneiRn.209601.

3D structure databases

ProteinModelPortaliQ6AYY8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4568490.
STRINGi10116.ENSRNOP00000013392.

Proteomic databases

PaxDbiQ6AYY8.
PRIDEiQ6AYY8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013392; ENSRNOP00000013392; ENSRNOG00000010023.
ENSRNOT00000076880; ENSRNOP00000068212; ENSRNOG00000010023.
GeneIDi64018.
KEGGirno:64018.
UCSCiRGD:620653. rat.

Organism-specific databases

CTDi9197.
RGDi620653. Slc33a1.

Phylogenomic databases

eggNOGiKOG3574. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00730000111115.
HOGENOMiHOG000194770.
HOVERGENiHBG052723.
InParanoidiQ6AYY8.
KOiK03372.
OMAiLWFWGIT.
OrthoDBiEOG747PHW.
PhylomeDBiQ6AYY8.
TreeFamiTF300008.

Enzyme and pathway databases

ReactomeiR-RNO-425397. Transport of vitamins, nucleosides, and related molecules.

Miscellaneous databases

NextBioi612608.
PROiQ6AYY8.

Gene expression databases

GenevisibleiQ6AYY8. RN.

Family and domain databases

InterProiIPR024371. Acetyl-CoA_trnpstr_1.
IPR004752. AmpG_permease/AT-1.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF13000. Acatn. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00901. 2A0125. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of putative rat acetyl-CoA transporter and its expression pattern in brain."
    Bora R.S., Ichikawa S., Kanamori A., Hirabayashi Y.
    Cytogenet. Cell Genet. 89:204-208(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: Wistar.
    Tissue: Embryonic brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiACATN_RAT
AccessioniPrimary (citable) accession number: Q6AYY8
Secondary accession number(s): Q9JM68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: September 13, 2004
Last modified: May 11, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.