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Protein

Outer dense fiber protein 2

Gene

Odf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Enzyme and pathway databases

ReactomeiR-RNO-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-RNO-380259. Loss of Nlp from mitotic centrosomes.
R-RNO-380270. Recruitment of mitotic centrosome proteins and complexes.
R-RNO-5620912. Anchoring of the basal body to the plasma membrane.
R-RNO-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer dense fiber protein 2
Alternative name(s):
84 kDa outer dense fiber protein
Cenexin
Outer dense fiber of sperm tails protein 2
Gene namesi
Name:Odf2
Synonyms:Odf84
ORF Names:KKT4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi3229. Odf2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 825825Outer dense fiber protein 2PRO_0000299460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei68 – 681PhosphoserineCombined sources
Modified residuei69 – 691PhosphoserineCombined sources
Modified residuei87 – 871PhosphothreonineCombined sources
Modified residuei101 – 1011PhosphoserineCombined sources
Modified residuei104 – 1041PhosphoserineCombined sources
Modified residuei105 – 1051PhosphothreonineCombined sources
Modified residuei110 – 1101PhosphoserineCombined sources
Modified residuei124 – 1241PhosphoserineCombined sources
Modified residuei134 – 1341PhosphoserineCombined sources
Modified residuei226 – 2261PhosphothreonineBy similarity
Modified residuei256 – 2561PhosphoserineCombined sources
Modified residuei627 – 6271PhosphoserineCombined sources
Isoform 3 (identifier: Q6AYX5-3)
Modified residuei22 – 221PhosphoserineCombined sourcesCurated
Modified residuei37 – 371PhosphoserineCombined sourcesCurated

Post-translational modificationi

Tyrosine phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AYX5.
PRIDEiQ6AYX5.

PTM databases

iPTMnetiQ6AYX5.

Expressioni

Tissue specificityi

Testis-specific (PubMed:9045620). Expressed in the proximal compartment of the elongated spermatid tail; later expression progresses to the distal spermatid tail compartment located in the lumen of the seminiferous epithelium (PubMed:9698445). In spermatids (stages II-III) expression of the tails peaks and remains strong during the remaining steps of spermiogenesis (at protein level) (PubMed:9698445). Expression correlates with the onset of spermatogenesis and is first detected at 30 days. Higher expression is seen in testis of 40-day-old and adults that are older than 50 days (PubMed:9092585). No expression is seen in 10- and 20-day-old testes (PubMed:9092585).4 Publications

Gene expression databases

ExpressionAtlasiQ6AYX5. baseline.
GenevisibleiQ6AYX5. RN.

Interactioni

Subunit structurei

Self-associates. Associates with microtubules and forms a fibrillar structure partially linked to the microtubule network. Interacts through its C-terminus with PLK1. Interacts with ODF1 (PubMed:9045620). Interacts with MARK4; the interaction is required for localization of ODF2 to centrioles (By similarity).By similarity1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041336.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili139 – 21274Sequence analysisAdd
BLAST
Coiled coili240 – 418179Sequence analysisAdd
BLAST
Coiled coili456 – 793338Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the ODF2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE8V. Eukaryota.
ENOG4111XWH. LUCA.
GeneTreeiENSGT00530000063497.
HOGENOMiHOG000246967.
HOVERGENiHBG052808.
InParanoidiQ6AYX5.
KOiK16479.
OMAiHAISKER.
PhylomeDBiQ6AYX5.

Family and domain databases

InterProiIPR026099. Odf2-rel.
[Graphical view]
PANTHERiPTHR23162. PTHR23162. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6AYX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKDRSSTPPL HVHVDENTPV HVHIKKLPKP SAASSQKSHK RGMKGDTVNV
60 70 80 90 100
RRSVRVKTKV PWMPPGKSSA RHVGCKWENP PHCLEITPPS SEKLVSVMRL
110 120 130 140 150
SDLSTEDDDS GHCKMNRYDK KIDSLMNAVG CLKSEVKMQK GERQMAKRFL
160 170 180 190 200
EERKEELEEV AHELAETEHE NTVLRHNIER IKEEKDFTML QKKHLQQEKE
210 220 230 240 250
CLMSKLVEAE MDGAAAAKQV MALKDTIGKL KTEKQMTCTD INTLTRQKEL
260 270 280 290 300
LLQKLSTFEE TNRTLRDLLR EQHCKEDSER LMEQQGALLK RLAEADSEKA
310 320 330 340 350
RLLLLLQDKD KEVEELLQEI QCEKAQAKTA SELSKSMESM RGHLQAQLRC
360 370 380 390 400
KEAENSRLCM QIKNLERSGN QHKAEVEAIM EQLKELKQKG DRDKETLKKA
410 420 430 440 450
IRAQKERAEK SEEYAEQLHV QLADKDLYVA EALSTLESWR SRYNQVVKDK
460 470 480 490 500
GDLELEIIVL NDRVTDLVNQ QQSLEEKMRE DRDSLVERLH RQTAEYSAFK
510 520 530 540 550
LENERLKASF APMEDKLNQA HLEVQQLKAS VKNYEGMIDN YKSQVMKTRL
560 570 580 590 600
EADEVAAQLE RCDKENKMLK DEMNKEIEAA RRQFQSQLAD LQQLPDILKI
610 620 630 640 650
TEAKLAECQD QLQGYERKNI DLTAIISDLR SRIEHQGDKL ELAREKHQAS
660 670 680 690 700
QKENKQLSQK VDELERKLEA TSTQNVEFLQ VIAKREEAIH QAQLRLEEKT
710 720 730 740 750
RECGSLARQL ESAIEDARRQ VEQTKEQALS KERAAQSKIL DLETQLSRTK
760 770 780 790 800
TELGQLRRTR DDVDRRYQSR LQDLKDRLEQ SESTNRSMQN YVQFLKSSYA
810 820
NVFGDGPYTS SYLTSSPIRS RSPPA
Length:825
Mass (Da):95,440
Last modified:September 11, 2007 - v2
Checksum:iFF1490FF9F96CEC7
GO
Isoform 2 (identifier: Q6AYX5-2) [UniParc]FASTAAdd to basket

Also known as: Cenexin 2

The sequence of this isoform differs from the canonical sequence as follows:
     763-769: VDRRYQS → ENQKCWK
     770-825: Missing.

Show »
Length:769
Mass (Da):89,095
Checksum:iEF6EFE3003F8365D
GO
Isoform 3 (identifier: Q6AYX5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MKDRSSTPPL...LPKPSAASSQ → MSASSSGGSP...PCGAPSVTVT
     60-78: Missing.
     633-652: IEHQGDKLELAREKHQASQK → VRDWQKGSHELARAGARLPR
     653-825: Missing.

Show »
Length:638
Mass (Da):73,359
Checksum:iC3DAA2F22ACA0A34
GO
Isoform 4 (identifier: Q6AYX5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     60-78: Missing.
     633-652: IEHQGDKLELAREKHQASQK → VRDWQKGSHELARAGARLPR
     653-825: Missing.

Show »
Length:591
Mass (Da):68,600
Checksum:i32B0FBFF3EC3DA40
GO
Isoform 5 (identifier: Q6AYX5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     60-78: Missing.
     276-276: E → ELCLKVPECARQHRPGRERQEDCQ
     630-652: RSRIEHQGDKLELAREKHQASQK → HSRVRDWQKGSHELARAGARLPR
     653-825: Missing.

Show »
Length:614
Mass (Da):71,315
Checksum:i291E30388CB3CEEE
GO

Sequence cautioni

The sequence CAA64567.1 differs from that shown. Reason: Frameshift at position 92. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461D → Y in AAC53134 (PubMed:9092585).Curated
Sequence conflicti107 – 1082DD → EE in CAA64567 (PubMed:9369191).Curated
Sequence conflicti120 – 1201K → E in AAC53134 (PubMed:9092585).Curated
Sequence conflicti483 – 4831D → H in AAC53134 (PubMed:9092585).Curated
Sequence conflicti511 – 5111A → P in AAC08408 (PubMed:9698445).Curated
Sequence conflicti543 – 5431S → T in CAA64567 (PubMed:9369191).Curated
Isoform 3 (identifier: Q6AYX5-3)
Sequence conflicti25 – 251Q → E in AAC08408 (PubMed:9698445).Combined sourcesCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4242Missing in isoform 4 and isoform 5. 2 PublicationsVSP_027677Add
BLAST
Alternative sequencei1 – 3636MKDRS…AASSQ → MSASSSGGSPRFPSCGKNGV TSLTQKKVLRTPCGAPSVTV T in isoform 3. 2 PublicationsVSP_027678Add
BLAST
Alternative sequencei60 – 7819Missing in isoform 3, isoform 4 and isoform 5. 4 PublicationsVSP_027679Add
BLAST
Alternative sequencei276 – 2761E → ELCLKVPECARQHRPGRERQ EDCQ in isoform 5. 1 PublicationVSP_027680
Alternative sequencei630 – 65223RSRIE…QASQK → HSRVRDWQKGSHELARAGAR LPR in isoform 5. 1 PublicationVSP_027681Add
BLAST
Alternative sequencei633 – 65220IEHQG…QASQK → VRDWQKGSHELARAGARLPR in isoform 3 and isoform 4. 3 PublicationsVSP_027682Add
BLAST
Alternative sequencei653 – 825173Missing in isoform 3, isoform 4 and isoform 5. 4 PublicationsVSP_027683Add
BLAST
Alternative sequencei763 – 7697VDRRYQS → ENQKCWK in isoform 2. 1 PublicationVSP_027684
Alternative sequencei770 – 82556Missing in isoform 2. 1 PublicationVSP_027685Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95272 mRNA. Translation: CAA64567.1. Frameshift.
U62821 mRNA. Translation: AAC53134.1.
AF053971 mRNA. Translation: AAC08408.1.
AF162756 mRNA. Translation: AAF80473.2.
AABR03024548 Genomic DNA. No translation available.
BC078857 mRNA. Translation: AAH78857.1.
RefSeqiNP_001138477.1. NM_001145005.1.
NP_058909.2. NM_017213.2. [Q6AYX5-3]
UniGeneiRn.144353.
Rn.91211.

Genome annotation databases

EnsembliENSRNOT00000040457; ENSRNOP00000049041; ENSRNOG00000014584. [Q6AYX5-3]
ENSRNOT00000041921; ENSRNOP00000041336; ENSRNOG00000014584. [Q6AYX5-1]
GeneIDi29479.
KEGGirno:29479.
UCSCiRGD:3229. rat. [Q6AYX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95272 mRNA. Translation: CAA64567.1. Frameshift.
U62821 mRNA. Translation: AAC53134.1.
AF053971 mRNA. Translation: AAC08408.1.
AF162756 mRNA. Translation: AAF80473.2.
AABR03024548 Genomic DNA. No translation available.
BC078857 mRNA. Translation: AAH78857.1.
RefSeqiNP_001138477.1. NM_001145005.1.
NP_058909.2. NM_017213.2. [Q6AYX5-3]
UniGeneiRn.144353.
Rn.91211.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041336.

PTM databases

iPTMnetiQ6AYX5.

Proteomic databases

PaxDbiQ6AYX5.
PRIDEiQ6AYX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000040457; ENSRNOP00000049041; ENSRNOG00000014584. [Q6AYX5-3]
ENSRNOT00000041921; ENSRNOP00000041336; ENSRNOG00000014584. [Q6AYX5-1]
GeneIDi29479.
KEGGirno:29479.
UCSCiRGD:3229. rat. [Q6AYX5-1]

Organism-specific databases

CTDi4957.
RGDi3229. Odf2.

Phylogenomic databases

eggNOGiENOG410IE8V. Eukaryota.
ENOG4111XWH. LUCA.
GeneTreeiENSGT00530000063497.
HOGENOMiHOG000246967.
HOVERGENiHBG052808.
InParanoidiQ6AYX5.
KOiK16479.
OMAiHAISKER.
PhylomeDBiQ6AYX5.

Enzyme and pathway databases

ReactomeiR-RNO-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-RNO-380259. Loss of Nlp from mitotic centrosomes.
R-RNO-380270. Recruitment of mitotic centrosome proteins and complexes.
R-RNO-5620912. Anchoring of the basal body to the plasma membrane.
R-RNO-8854518. AURKA Activation by TPX2.

Miscellaneous databases

PROiQ6AYX5.

Gene expression databases

ExpressionAtlasiQ6AYX5. baseline.
GenevisibleiQ6AYX5. RN.

Family and domain databases

InterProiIPR026099. Odf2-rel.
[Graphical view]
PANTHERiPTHR23162. PTHR23162. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression cloning of a rat testicular transcript abundant in germ cells, which contains two leucine zipper motifs."
    Turner K.J., Sharpe R.M., Gaughan J., Millar M.R., Foster P.M., Saunders P.T.
    Biol. Reprod. 57:1223-1232(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
    Tissue: Testis.
  2. "Identification and characterization of new cDNAs encoding outer dense fiber proteins of rat sperm."
    Brohmann H., Pinnecke S., Hoyer-Fender S.
    J. Biol. Chem. 272:10327-10332(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
    Strain: Sprague-Dawley.
    Tissue: Spermatid.
  3. "Developmental expression of the 84-kDa ODF sperm protein: localization to both the cortex and medulla of outer dense fibers and to the connecting piece."
    Schalles U., Shao X., van der Hoorn F.A., Oko R.
    Dev. Biol. 199:250-260(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
    Tissue: Testis.
  4. "Cenexin - a molecular scaffolding protein with dual functions in the mammalian centrosome and sperm tail."
    March P., Sibley K.D., Scott V., Lange B.M.H., Taylor S.S., Gull K.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  5. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  7. "Interactional cloning of the 84-kDa major outer dense fiber protein Odf84. Leucine zippers mediate associations of Odf84 and Odf27."
    Shao X., Tarnasky H.A., Schalles U., Oko R., van der Hoorn F.A.
    J. Biol. Chem. 272:6105-6113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ODF1, TISSUE SPECIFICITY.
  8. "Outer dense fibre protein 2 (ODF2) is a self-interacting centrosomal protein with affinity for microtubules."
    Donkor F.F., Monnich M., Czirr E., Hollemann T., Hoyer-Fender S.
    J. Cell Sci. 117:4643-4651(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SELF-ASSOCIATION, SUBCELLULAR LOCATION.
  9. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68; SER-69; THR-87; SER-101; SER-104; THR-105; SER-110; SER-124; SER-134; SER-256 AND SER-627, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND SER-37 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiODFP2_RAT
AccessioniPrimary (citable) accession number: Q6AYX5
Secondary accession number(s): O70408
, P97575, Q62693, Q9JIZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: July 6, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.