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Protein

Mortality factor 4-like protein 1

Gene

Morf4l1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processDNA damage, DNA recombination, DNA repair, Growth regulation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mortality factor 4-like protein 1
Alternative name(s):
MORF-related gene 15 protein
Transcription factor-like protein MRG15
Gene namesi
Name:Morf4l1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1307938 Morf4l1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000887671 – 323Mortality factor 4-like protein 1Add BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei104N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6AYU1
PRIDEiQ6AYU1

PTM databases

PhosphoSitePlusiQ6AYU1

Expressioni

Gene expression databases

BgeeiENSRNOG00000058412
GenevisibleiQ6AYU1 RN

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the mSin3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with RB1 and MYST1. May also interact with PHF12 and one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors. Interacts with the N-terminus of MRFAP1. Found in a complex composed of MORF4L1, MRFAP1 and RB1 Interacts with the entire BRCA complex, which contains BRCA1, PALB2, BRCA2 and RAD51. Interacts with PALB2 (By similarity). Forms a complex with MSL1 and NUPR1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019471

Structurei

3D structure databases

ProteinModelPortaliQ6AYU1
SMRiQ6AYU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini152 – 323MRGPROSITE-ProRule annotationAdd BLAST172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni94 – 227Sufficient for interaction with SIN3ABy similarityAdd BLAST134
Regioni125 – 191Interaction with RB1-1By similarityAdd BLAST67
Regioni149 – 303Sufficient for interaction with PHF12By similarityAdd BLAST155
Regioni284 – 305Interaction with RB1-2By similarityAdd BLAST22

Phylogenomic databases

eggNOGiKOG3001 Eukaryota
ENOG410XR9F LUCA
GeneTreeiENSGT00530000063018
HOGENOMiHOG000190863
HOVERGENiHBG052487
InParanoidiQ6AYU1
KOiK11339
OMAiPHYFVHY
OrthoDBiEOG091G0J32

Family and domain databases

CDDicd00024 CHROMO, 1 hit
Gene3Di1.10.274.30, 1 hit
InterProiView protein in InterPro
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR008676 MRG
IPR038011 MRG15
IPR038217 MRG_C_sf
IPR026541 MRG_dom
IPR025995 Tudor-knot
PANTHERiPTHR10880 PTHR10880, 2 hits
PTHR10880:SF29 PTHR10880:SF29, 2 hits
PfamiView protein in Pfam
PF05712 MRG, 1 hit
PF11717 Tudor-knot, 1 hit
PIRSFiPIRSF038133 HAT_Nua4_EAF3/MRG15, 1 hit
SMARTiView protein in SMART
SM00298 CHROMO, 1 hit
SUPFAMiSSF54160 SSF54160, 2 hits
PROSITEiView protein in PROSITE
PS51640 MRG, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AYU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKQDPKPK FQEGERVLCF HGPLLYEAKC VKVAIKDKQV KYFIHYSGWN
60 70 80 90 100
KNWDEWVPES RVLKYVDANL QKQRELQKAN QEQYAEGKMR GAAPGKKTSG
110 120 130 140 150
LQQKNVEVKT KKNKQKTPGN GDGGSTSETP QPPRKKRARV DPTVENEETF
160 170 180 190 200
MNRVEVKVKI PEELKPWLVD DWDLITRQKQ LFYLPAKKNV DSILEDYANY
210 220 230 240 250
KKSRGNTDNK EYAVNEVVAG IKEYFNVMLG TQLLYKFERP QYAEILADHP
260 270 280 290 300
DAPMSQVYGA PHLLRLFVRI GAMLAYTPLD EKSLALLLNY LHDFLKYLAK
310 320
NSATLFSASD YEVAPPEYHR KAV
Length:323
Mass (Da):37,201
Last modified:September 13, 2004 - v1
Checksum:i327DBECBA8CF513A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078910 mRNA Translation: AAH78910.1
RefSeqiNP_001011999.1, NM_001011999.1
UniGeneiRn.110179
Rn.156201

Genome annotation databases

EnsembliENSRNOT00000080421; ENSRNOP00000075745; ENSRNOG00000058412
GeneIDi300891
KEGGirno:300891
UCSCiRGD:1307938 rat

Similar proteinsi

Entry informationi

Entry nameiMO4L1_RAT
AccessioniPrimary (citable) accession number: Q6AYU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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