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Protein

Mortality factor 4-like protein 1

Gene

Morf4l1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, Growth regulation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mortality factor 4-like protein 1
Alternative name(s):
MORF-related gene 15 protein
Transcription factor-like protein MRG15
Gene namesi
Name:Morf4l1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1307938. Morf4l1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Mortality factor 4-like protein 1PRO_0000088767Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei104 – 1041N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6AYU1.
PRIDEiQ6AYU1.

PTM databases

PhosphoSiteiQ6AYU1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014410.
GenevisibleiQ6AYU1. RN.

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the mSin3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with RB1 and MYST1. May also interact with PHF12 and one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors. Interacts with the N-terminus of MRFAP1. Found in a complex composed of MORF4L1, MRFAP1 and RB1 Interacts with the entire BRCA complex, which contains BRCA1, PALB2, BRCA2 and RAD51. Interacts with PALB2 (By similarity). Forms a complex with MSL1 and NUPR1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019471.

Structurei

3D structure databases

ProteinModelPortaliQ6AYU1.
SMRiQ6AYU1. Positions 1-93, 156-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini152 – 323172MRGPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 227134Sufficient for interaction with SIN3ABy similarityAdd
BLAST
Regioni125 – 19167Interaction with RB1-1By similarityAdd
BLAST
Regioni149 – 303155Sufficient for interaction with PHF12By similarityAdd
BLAST
Regioni284 – 30522Interaction with RB1-2By similarityAdd
BLAST

Sequence similaritiesi

Contains 1 MRG domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3001. Eukaryota.
ENOG410XR9F. LUCA.
GeneTreeiENSGT00530000063018.
HOGENOMiHOG000190863.
HOVERGENiHBG052487.
InParanoidiQ6AYU1.
KOiK11339.
OMAiTGTDANT.
OrthoDBiEOG091G0J32.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR016197. Chromodomain-like.
IPR008676. MRG.
IPR026541. MRG_dom.
IPR025995. Tudor-knot.
[Graphical view]
PANTHERiPTHR10880. PTHR10880. 1 hit.
PfamiPF05712. MRG. 1 hit.
PF11717. Tudor-knot. 1 hit.
[Graphical view]
PIRSFiPIRSF038133. HAT_Nua4_EAF3/MRG15. 1 hit.
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 2 hits.
PROSITEiPS51640. MRG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AYU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKQDPKPK FQEGERVLCF HGPLLYEAKC VKVAIKDKQV KYFIHYSGWN
60 70 80 90 100
KNWDEWVPES RVLKYVDANL QKQRELQKAN QEQYAEGKMR GAAPGKKTSG
110 120 130 140 150
LQQKNVEVKT KKNKQKTPGN GDGGSTSETP QPPRKKRARV DPTVENEETF
160 170 180 190 200
MNRVEVKVKI PEELKPWLVD DWDLITRQKQ LFYLPAKKNV DSILEDYANY
210 220 230 240 250
KKSRGNTDNK EYAVNEVVAG IKEYFNVMLG TQLLYKFERP QYAEILADHP
260 270 280 290 300
DAPMSQVYGA PHLLRLFVRI GAMLAYTPLD EKSLALLLNY LHDFLKYLAK
310 320
NSATLFSASD YEVAPPEYHR KAV
Length:323
Mass (Da):37,201
Last modified:September 13, 2004 - v1
Checksum:i327DBECBA8CF513A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078910 mRNA. Translation: AAH78910.1.
RefSeqiNP_001011999.1. NM_001011999.1.
UniGeneiRn.156201.

Genome annotation databases

EnsembliENSRNOT00000080421; ENSRNOP00000075745; ENSRNOG00000058412.
GeneIDi300891.
KEGGirno:300891.
UCSCiRGD:1307938. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078910 mRNA. Translation: AAH78910.1.
RefSeqiNP_001011999.1. NM_001011999.1.
UniGeneiRn.156201.

3D structure databases

ProteinModelPortaliQ6AYU1.
SMRiQ6AYU1. Positions 1-93, 156-321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019471.

PTM databases

PhosphoSiteiQ6AYU1.

Proteomic databases

PaxDbiQ6AYU1.
PRIDEiQ6AYU1.

Protocols and materials databases

DNASUi300891.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000080421; ENSRNOP00000075745; ENSRNOG00000058412.
GeneIDi300891.
KEGGirno:300891.
UCSCiRGD:1307938. rat.

Organism-specific databases

CTDi10933.
RGDi1307938. Morf4l1.

Phylogenomic databases

eggNOGiKOG3001. Eukaryota.
ENOG410XR9F. LUCA.
GeneTreeiENSGT00530000063018.
HOGENOMiHOG000190863.
HOVERGENiHBG052487.
InParanoidiQ6AYU1.
KOiK11339.
OMAiTGTDANT.
OrthoDBiEOG091G0J32.

Miscellaneous databases

PROiQ6AYU1.

Gene expression databases

BgeeiENSRNOG00000014410.
GenevisibleiQ6AYU1. RN.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR016197. Chromodomain-like.
IPR008676. MRG.
IPR026541. MRG_dom.
IPR025995. Tudor-knot.
[Graphical view]
PANTHERiPTHR10880. PTHR10880. 1 hit.
PfamiPF05712. MRG. 1 hit.
PF11717. Tudor-knot. 1 hit.
[Graphical view]
PIRSFiPIRSF038133. HAT_Nua4_EAF3/MRG15. 1 hit.
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 2 hits.
PROSITEiPS51640. MRG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMO4L1_RAT
AccessioniPrimary (citable) accession number: Q6AYU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.