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Protein

Acyl-coenzyme A synthetase ACSM5, mitochondrial

Gene

Acsm5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C4 to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).By similarity

Catalytic activityi

ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei454 – 4541ATPBy similarity
Binding sitei469 – 4691ATPBy similarity
Binding sitei565 – 5651ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi229 – 2379ATPBy similarity
Nucleotide bindingi367 – 3726ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A synthetase ACSM5, mitochondrial (EC:6.2.1.2)
Gene namesi
Name:Acsm5
Synonyms:Macs3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1309578. Acsm5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222MitochondrionSequence analysisAdd
BLAST
Chaini23 – 578556Acyl-coenzyme A synthetase ACSM5, mitochondrialPRO_0000306103Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei96 – 961N6-acetyllysine; alternateBy similarity
Modified residuei96 – 961N6-succinyllysine; alternateBy similarity
Modified residuei151 – 1511N6-acetyllysineBy similarity
Modified residuei335 – 3351N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ6AYT9.

PTM databases

iPTMnetiQ6AYT9.
PhosphoSiteiQ6AYT9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000031211.
ExpressionAtlasiQ6AYT9. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ6AYT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi26 – 327Poly-Pro

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00760000119178.
HOGENOMiHOG000229982.
HOVERGENiHBG053031.
InParanoidiQ6AYT9.
KOiK01896.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AYT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLWLRGLVY QARRSSWGVF RIHTQPPPPP IPEVVATWEA ISLGKRPVPE
60 70 80 90 100
YFNFAHDVLD VWSQLEKTGH RPPNPAFWWV NGSGTEVKWT FEELGKQSRK
110 120 130 140 150
AANILEGACG LKPGDRLMLV LPRLPEWWLT IVACMRTGVV MIPGISQLTQ
160 170 180 190 200
KDLKYRLQAA RVKSIITSDA LAPHVDAISA DCPSLQSRLL VSDTSRPGWI
210 220 230 240 250
NFRELLRVAS PEHNCLRTRS GDSMAIYFTS GTTGTPKMVE HSQCSYGLGF
260 270 280 290 300
VASGRRLMAL TESDIFWNTT DTGWVKAAWT LFSAWANGAC VFVHELPQVD
310 320 330 340 350
AQTILNTLCR FPITTICCVP TLFRLLVQED LTRYKFQCLR HCLAGGEALN
360 370 380 390 400
SDVRDKWKNQ TGLEIHEGYG QSETVLICGN FRGSTIKSGS MGKASPPYDV
410 420 430 440 450
QIVDEEGNVL PPGKEGNIAI RIKPTRPFCL FNCYLDNPEK TAASEQGDFY
460 470 480 490 500
ITGDRAHMDE DGYFWFVGRN DDVINSSSYR IGPVEVESAL AEHPAVLESA
510 520 530 540 550
VVSSPDPIRG EVVKAFIVLS PAYVSHDPEA LTRELQEHVK TVTAPYKYPR
560 570
KVAFISELPK TVSGKILRSK LRNQEWGR
Length:578
Mass (Da):64,623
Last modified:September 13, 2004 - v1
Checksum:i0F2C8720E03E44CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078915 mRNA. Translation: AAH78915.1.
RefSeqiNP_001014184.3. NM_001014162.4.
XP_006230185.1. XM_006230123.1.
XP_006230188.1. XM_006230126.1.
UniGeneiRn.35367.

Genome annotation databases

EnsembliENSRNOT00000046025; ENSRNOP00000047613; ENSRNOG00000031211.
GeneIDi361637.
KEGGirno:361637.
UCSCiRGD:1309578. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078915 mRNA. Translation: AAH78915.1.
RefSeqiNP_001014184.3. NM_001014162.4.
XP_006230185.1. XM_006230123.1.
XP_006230188.1. XM_006230126.1.
UniGeneiRn.35367.

3D structure databases

ProteinModelPortaliQ6AYT9.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ6AYT9.
PhosphoSiteiQ6AYT9.

Proteomic databases

PRIDEiQ6AYT9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000046025; ENSRNOP00000047613; ENSRNOG00000031211.
GeneIDi361637.
KEGGirno:361637.
UCSCiRGD:1309578. rat.

Organism-specific databases

CTDi54988.
RGDi1309578. Acsm5.

Phylogenomic databases

GeneTreeiENSGT00760000119178.
HOGENOMiHOG000229982.
HOVERGENiHBG053031.
InParanoidiQ6AYT9.
KOiK01896.

Miscellaneous databases

PROiQ6AYT9.

Gene expression databases

BgeeiENSRNOG00000031211.
ExpressionAtlasiQ6AYT9. baseline and differential.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACSM5_RAT
AccessioniPrimary (citable) accession number: Q6AYT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.