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Q6AYT9 (ACSM5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acyl-coenzyme A synthetase ACSM5, mitochondrial

EC=6.2.1.2
Gene names
Name:Acsm5
Synonyms:Macs3
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length578 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C4 to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) By similarity.

Catalytic activity

ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA.

Cofactor

Magnesium or manganese By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2222Mitochondrion Potential
Chain23 – 578556Acyl-coenzyme A synthetase ACSM5, mitochondrial
PRO_0000306103

Regions

Nucleotide binding229 – 2379ATP By similarity
Nucleotide binding367 – 3726ATP By similarity
Compositional bias26 – 327Poly-Pro

Sites

Binding site4541ATP By similarity
Binding site4691ATP By similarity
Binding site5651ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AYT9 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 0F2C8720E03E44CA

FASTA57864,623
        10         20         30         40         50         60 
MRLWLRGLVY QARRSSWGVF RIHTQPPPPP IPEVVATWEA ISLGKRPVPE YFNFAHDVLD 

        70         80         90        100        110        120 
VWSQLEKTGH RPPNPAFWWV NGSGTEVKWT FEELGKQSRK AANILEGACG LKPGDRLMLV 

       130        140        150        160        170        180 
LPRLPEWWLT IVACMRTGVV MIPGISQLTQ KDLKYRLQAA RVKSIITSDA LAPHVDAISA 

       190        200        210        220        230        240 
DCPSLQSRLL VSDTSRPGWI NFRELLRVAS PEHNCLRTRS GDSMAIYFTS GTTGTPKMVE 

       250        260        270        280        290        300 
HSQCSYGLGF VASGRRLMAL TESDIFWNTT DTGWVKAAWT LFSAWANGAC VFVHELPQVD 

       310        320        330        340        350        360 
AQTILNTLCR FPITTICCVP TLFRLLVQED LTRYKFQCLR HCLAGGEALN SDVRDKWKNQ 

       370        380        390        400        410        420 
TGLEIHEGYG QSETVLICGN FRGSTIKSGS MGKASPPYDV QIVDEEGNVL PPGKEGNIAI 

       430        440        450        460        470        480 
RIKPTRPFCL FNCYLDNPEK TAASEQGDFY ITGDRAHMDE DGYFWFVGRN DDVINSSSYR 

       490        500        510        520        530        540 
IGPVEVESAL AEHPAVLESA VVSSPDPIRG EVVKAFIVLS PAYVSHDPEA LTRELQEHVK 

       550        560        570 
TVTAPYKYPR KVAFISELPK TVSGKILRSK LRNQEWGR 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC078915 mRNA. Translation: AAH78915.1.
IPIIPI00464802.
RefSeqNP_001014184.3. NM_001014162.3.
UniGeneRn.35367.

3D structure databases

HSSPHSSP built from PDB template 1LCI based on UniProtKB P08659.
ProteinModelPortalQ6AYT9.
ModBaseSearch...

Proteomic databases

PRIDEQ6AYT9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000046025; ENSRNOP00000047613; ENSRNOG00000031211.
GeneID361637.
KEGGrno:361637.
UCSCNM_001014162. rat.

Organism-specific databases

CTD54988.
RGD1309578. Acsm5.

Phylogenomic databases

GeneTreeENSGT00550000074278.
HOVERGENHBG053031.

Gene expression databases

GenevestigatorQ6AYT9.

Family and domain databases

InterProIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
KOK01896.
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio677039.

Entry information

Entry nameACSM5_RAT
AccessionPrimary (citable) accession number: Q6AYT9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 13, 2004
Last modified: November 16, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families