Q6AYT8 (MPZL1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myelin protein zero-like protein 1

Gene names

Name:

Mpzl1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. May be involved in regulation of integrin-mediated cell motility By similarity.
Subunit structure	Interacts with phosphorylated PTPN11/SHP-2 By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Domain	Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Post-translational modification	Phosphorylated on tyrosine residues upon stimulation with pervanadate and concanavalin-A (ConA). Phosphorylation at Tyr-242 and Tyr-264 is required for interaction with PTPN11/SHP-2. Dephosphorylated by PTPN11/SHP-2 (in vitro) By similarity. N-glycosylated By similarity.
Sequence similarities	Belongs to the myelin P0 protein family. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 35	35	Potential
	Chain	36 – 270	235	Myelin protein zero-like protein 1		PRO_0000240337
Regions
	Topological domain	36 – 162	127	Extracellular Potential
	Transmembrane	163 – 183	21	Helical; Potential
	Topological domain	184 – 270	87	Cytoplasmic Potential
	Domain	36 – 151	116	Ig-like V-type
	Motif	240 – 245	6	ITIM motif 1
	Motif	262 – 267	6	ITIM motif 2
Amino acid modifications
	Modified residue	210	1	Phosphoserine By similarity
	Modified residue	221	1	Phosphoserine By similarity
	Modified residue	242	1	Phosphotyrosine By similarity
	Modified residue	261	1	Phosphoserine By similarity
	Modified residue	264	1	Phosphotyrosine By similarity
	Glycosylation	50	1	N-linked (GlcNAc...) Potential
	Glycosylation	130	1	N-linked (GlcNAc...) Potential
	Disulfide bond	58 ↔ 135		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6AYT8 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: C1B6FBEBBBC45C3D	FASTA	270	29,502
	10 20 30 40 50 60 MAEAVGAVTL IAAPARRRWL WSALAAMLGL LTARISALEV HTPKEIFVVN GTQGKLTCTF 70 80 90 100 110 120 DSPNTTGWLT TVSWSFQPEG TDSAVSFFHY SQGQVYIGDY PPFKDRVTWA GDLDKKDASI 130 140 150 160 170 180 NIENIQAVHN GTYICDVKNP PDIVVRPGQI RLHVVEIDNL LVFLVWVVVG TVTAVVLGLT 190 200 210 220 230 240 LLISLVLVVL YRRKHSKRDY TGCSTSERLS PVKQAPRKCP SDTEGLVKSP PSAGSHQGPV 250 260 270 IYAQLDHSGG HHSGKINKSE SVVYADIRKD

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC078916 mRNA. Translation: AAH78916.1.
IPI	IPI00199885.
RefSeq	NP_001007729.1. NM_001007728.1.
UniGene	Rn.8087.
3D structure databases
ProteinModelPortal	Q6AYT8.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000004376.
PTM databases
PhosphoSite	Q6AYT8.
Proteomic databases
PaxDb	Q6AYT8.
PRIDE	Q6AYT8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000004376; ENSRNOP00000004376; ENSRNOG00000003248.
GeneID	360871.
KEGG	rno:360871.
UCSC	RGD:1359140. rat.
Organism-specific databases
CTD	9019.
RGD	1359140. Mpzl1.
Phylogenomic databases
eggNOG	NOG67913.
GeneTree	ENSGT00640000091161.
HOGENOM	HOG000232144.
HOVERGEN	HBG104511.
InParanoid	Q6AYT8.
KO	K06770.
OMA	RKNSKRD.
OrthoDB	EOG4HX51X.
Gene expression databases
ArrayExpress	Q6AYT8.
Genevestigator	Q6AYT8.
GermOnline	ENSRNOG00000003248. Rattus norvegicus.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013106. Ig_V-set. IPR003596. Ig_V-set_subgr. IPR000920. Myelin_P0. [Graphical view]
Pfam	PF07686. V-set. 1 hit. [Graphical view]
PRINTS	PR00213. MYELINP0.
SMART	SM00406. IGv. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	674440.

Entry information

Entry name

MPZL1_RAT

Accession

Primary (citable) accession number: Q6AYT8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	September 13, 2004
Last modified:	April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program