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Q6AYT8

- MPZL1_RAT

UniProt

Q6AYT8 - MPZL1_RAT

Protein

Myelin protein zero-like protein 1

Gene

Mpzl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. May be involved in regulation of integrin-mediated cell motility By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myelin protein zero-like protein 1
    Gene namesi
    Name:Mpzl1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi1359140. Mpzl1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 270235Myelin protein zero-like protein 1PRO_0000240337Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi58 ↔ 135PROSITE-ProRule annotation
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Modified residuei210 – 2101PhosphoserineBy similarity
    Modified residuei221 – 2211PhosphoserineBy similarity
    Modified residuei242 – 2421PhosphotyrosineBy similarity
    Modified residuei261 – 2611PhosphoserineBy similarity
    Modified residuei264 – 2641PhosphotyrosineBy similarity

    Post-translational modificationi

    Phosphorylated on tyrosine residues upon stimulation with pervanadate and concanavalin-A (ConA). Phosphorylation at Tyr-242 and Tyr-264 is required for interaction with PTPN11/SHP-2. Dephosphorylated by PTPN11/SHP-2 (in vitro) By similarity.By similarity
    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ6AYT8.
    PRIDEiQ6AYT8.

    PTM databases

    PhosphoSiteiQ6AYT8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6AYT8.

    Interactioni

    Subunit structurei

    Interacts with phosphorylated PTPN11/SHP-2.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000004376.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AYT8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini36 – 162127ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini184 – 27087CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei163 – 18321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 151116Ig-like V-typeAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi240 – 2456ITIM motif 1
    Motifi262 – 2676ITIM motif 2

    Domaini

    Sequence similaritiesi

    Belongs to the myelin P0 protein family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG67913.
    GeneTreeiENSGT00640000091161.
    HOGENOMiHOG000232144.
    HOVERGENiHBG104511.
    InParanoidiQ6AYT8.
    KOiK06770.
    OMAiHQGPVIY.
    OrthoDBiEOG7G1V80.
    PhylomeDBiQ6AYT8.
    TreeFamiTF331728.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    IPR000920. Myelin_P0.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    PRINTSiPR00213. MYELINP0.
    SMARTiSM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6AYT8-1 [UniParc]FASTAAdd to Basket

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    MAEAVGAVTL IAAPARRRWL WSALAAMLGL LTARISALEV HTPKEIFVVN    50
    GTQGKLTCTF DSPNTTGWLT TVSWSFQPEG TDSAVSFFHY SQGQVYIGDY 100
    PPFKDRVTWA GDLDKKDASI NIENIQAVHN GTYICDVKNP PDIVVRPGQI 150
    RLHVVEIDNL LVFLVWVVVG TVTAVVLGLT LLISLVLVVL YRRKHSKRDY 200
    TGCSTSERLS PVKQAPRKCP SDTEGLVKSP PSAGSHQGPV IYAQLDHSGG 250
    HHSGKINKSE SVVYADIRKD 270
    Length:270
    Mass (Da):29,502
    Last modified:September 13, 2004 - v1
    Checksum:iC1B6FBEBBBC45C3D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC078916 mRNA. Translation: AAH78916.1.
    RefSeqiNP_001007729.1. NM_001007728.1.
    UniGeneiRn.8087.

    Genome annotation databases

    EnsembliENSRNOT00000004376; ENSRNOP00000004376; ENSRNOG00000003248.
    GeneIDi360871.
    KEGGirno:360871.
    UCSCiRGD:1359140. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC078916 mRNA. Translation: AAH78916.1 .
    RefSeqi NP_001007729.1. NM_001007728.1.
    UniGenei Rn.8087.

    3D structure databases

    ProteinModelPortali Q6AYT8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000004376.

    PTM databases

    PhosphoSitei Q6AYT8.

    Proteomic databases

    PaxDbi Q6AYT8.
    PRIDEi Q6AYT8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000004376 ; ENSRNOP00000004376 ; ENSRNOG00000003248 .
    GeneIDi 360871.
    KEGGi rno:360871.
    UCSCi RGD:1359140. rat.

    Organism-specific databases

    CTDi 9019.
    RGDi 1359140. Mpzl1.

    Phylogenomic databases

    eggNOGi NOG67913.
    GeneTreei ENSGT00640000091161.
    HOGENOMi HOG000232144.
    HOVERGENi HBG104511.
    InParanoidi Q6AYT8.
    KOi K06770.
    OMAi HQGPVIY.
    OrthoDBi EOG7G1V80.
    PhylomeDBi Q6AYT8.
    TreeFami TF331728.

    Miscellaneous databases

    NextBioi 674440.
    PROi Q6AYT8.

    Gene expression databases

    Genevestigatori Q6AYT8.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    IPR000920. Myelin_P0.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    PRINTSi PR00213. MYELINP0.
    SMARTi SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiMPZL1_RAT
    AccessioniPrimary (citable) accession number: Q6AYT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3