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Q6AYT8 (MPZL1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Myelin protein zero-like protein 1
Gene names
Name:Mpzl1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. May be involved in regulation of integrin-mediated cell motility By similarity.

Subunit structure

Interacts with phosphorylated PTPN11/SHP-2 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Domain

Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

Post-translational modification

Phosphorylated on tyrosine residues upon stimulation with pervanadate and concanavalin-A (ConA). Phosphorylation at Tyr-242 and Tyr-264 is required for interaction with PTPN11/SHP-2. Dephosphorylated by PTPN11/SHP-2 (in vitro) By similarity.

N-glycosylated By similarity.

Sequence similarities

Belongs to the myelin P0 protein family.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3535 Potential
Chain36 – 270235Myelin protein zero-like protein 1
PRO_0000240337

Regions

Topological domain36 – 162127Extracellular Potential
Transmembrane163 – 18321Helical; Potential
Topological domain184 – 27087Cytoplasmic Potential
Domain36 – 151116Ig-like V-type
Motif240 – 2456ITIM motif 1
Motif262 – 2676ITIM motif 2

Amino acid modifications

Modified residue2101Phosphoserine By similarity
Modified residue2211Phosphoserine By similarity
Modified residue2421Phosphotyrosine By similarity
Modified residue2611Phosphoserine By similarity
Modified residue2641Phosphotyrosine By similarity
Glycosylation501N-linked (GlcNAc...) Potential
Glycosylation1301N-linked (GlcNAc...) Potential
Disulfide bond58 ↔ 135 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AYT8 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: C1B6FBEBBBC45C3D

FASTA27029,502
        10         20         30         40         50         60 
MAEAVGAVTL IAAPARRRWL WSALAAMLGL LTARISALEV HTPKEIFVVN GTQGKLTCTF 

        70         80         90        100        110        120 
DSPNTTGWLT TVSWSFQPEG TDSAVSFFHY SQGQVYIGDY PPFKDRVTWA GDLDKKDASI 

       130        140        150        160        170        180 
NIENIQAVHN GTYICDVKNP PDIVVRPGQI RLHVVEIDNL LVFLVWVVVG TVTAVVLGLT 

       190        200        210        220        230        240 
LLISLVLVVL YRRKHSKRDY TGCSTSERLS PVKQAPRKCP SDTEGLVKSP PSAGSHQGPV 

       250        260        270 
IYAQLDHSGG HHSGKINKSE SVVYADIRKD 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC078916 mRNA. Translation: AAH78916.1.
RefSeqNP_001007729.1. NM_001007728.1.
UniGeneRn.8087.

3D structure databases

ProteinModelPortalQ6AYT8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000004376.

PTM databases

PhosphoSiteQ6AYT8.

Proteomic databases

PaxDbQ6AYT8.
PRIDEQ6AYT8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000004376; ENSRNOP00000004376; ENSRNOG00000003248.
GeneID360871.
KEGGrno:360871.
UCSCRGD:1359140. rat.

Organism-specific databases

CTD9019.
RGD1359140. Mpzl1.

Phylogenomic databases

eggNOGNOG67913.
GeneTreeENSGT00640000091161.
HOGENOMHOG000232144.
HOVERGENHBG104511.
InParanoidQ6AYT8.
KOK06770.
OMAHQGPVIY.
OrthoDBEOG7G1V80.
PhylomeDBQ6AYT8.
TreeFamTF331728.

Gene expression databases

GenevestigatorQ6AYT8.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR000920. Myelin_P0.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
PRINTSPR00213. MYELINP0.
SMARTSM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio674440.
PROQ6AYT8.

Entry information

Entry nameMPZL1_RAT
AccessionPrimary (citable) accession number: Q6AYT8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families