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Q6AYT8

- MPZL1_RAT

UniProt

Q6AYT8 - MPZL1_RAT

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Protein

Myelin protein zero-like protein 1

Gene

Mpzl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. May be involved in regulation of integrin-mediated cell motility By similarity.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin protein zero-like protein 1
Gene namesi
Name:Mpzl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi1359140. Mpzl1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence AnalysisAdd
BLAST
Chaini36 – 270235Myelin protein zero-like protein 1PRO_0000240337Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi58 ↔ 135PROSITE-ProRule annotation
Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
Modified residuei210 – 2101PhosphoserineBy similarity
Modified residuei221 – 2211PhosphoserineBy similarity
Modified residuei242 – 2421PhosphotyrosineBy similarity
Modified residuei261 – 2611PhosphoserineBy similarity
Modified residuei264 – 2641PhosphotyrosineBy similarity

Post-translational modificationi

Phosphorylated on tyrosine residues upon stimulation with pervanadate and concanavalin-A (ConA). Phosphorylation at Tyr-242 and Tyr-264 is required for interaction with PTPN11/SHP-2. Dephosphorylated by PTPN11/SHP-2 (in vitro) By similarity.By similarity
N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6AYT8.
PRIDEiQ6AYT8.

PTM databases

PhosphoSiteiQ6AYT8.

Expressioni

Gene expression databases

GenevestigatoriQ6AYT8.

Interactioni

Subunit structurei

Interacts with phosphorylated PTPN11/SHP-2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004376.

Structurei

3D structure databases

ProteinModelPortaliQ6AYT8.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 162127ExtracellularSequence AnalysisAdd
BLAST
Topological domaini184 – 27087CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei163 – 18321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 151116Ig-like V-typeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi240 – 2456ITIM motif 1
Motifi262 – 2676ITIM motif 2

Domaini

Sequence similaritiesi

Belongs to the myelin P0 protein family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG67913.
GeneTreeiENSGT00640000091161.
HOGENOMiHOG000232144.
HOVERGENiHBG104511.
InParanoidiQ6AYT8.
KOiK06770.
OMAiHQGPVIY.
OrthoDBiEOG7G1V80.
PhylomeDBiQ6AYT8.
TreeFamiTF331728.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR000920. Myelin_P0_like.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AYT8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEAVGAVTL IAAPARRRWL WSALAAMLGL LTARISALEV HTPKEIFVVN
60 70 80 90 100
GTQGKLTCTF DSPNTTGWLT TVSWSFQPEG TDSAVSFFHY SQGQVYIGDY
110 120 130 140 150
PPFKDRVTWA GDLDKKDASI NIENIQAVHN GTYICDVKNP PDIVVRPGQI
160 170 180 190 200
RLHVVEIDNL LVFLVWVVVG TVTAVVLGLT LLISLVLVVL YRRKHSKRDY
210 220 230 240 250
TGCSTSERLS PVKQAPRKCP SDTEGLVKSP PSAGSHQGPV IYAQLDHSGG
260 270
HHSGKINKSE SVVYADIRKD
Length:270
Mass (Da):29,502
Last modified:September 13, 2004 - v1
Checksum:iC1B6FBEBBBC45C3D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC078916 mRNA. Translation: AAH78916.1.
RefSeqiNP_001007729.1. NM_001007728.1.
UniGeneiRn.8087.

Genome annotation databases

EnsembliENSRNOT00000004376; ENSRNOP00000004376; ENSRNOG00000003248.
GeneIDi360871.
KEGGirno:360871.
UCSCiRGD:1359140. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC078916 mRNA. Translation: AAH78916.1 .
RefSeqi NP_001007729.1. NM_001007728.1.
UniGenei Rn.8087.

3D structure databases

ProteinModelPortali Q6AYT8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000004376.

PTM databases

PhosphoSitei Q6AYT8.

Proteomic databases

PaxDbi Q6AYT8.
PRIDEi Q6AYT8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000004376 ; ENSRNOP00000004376 ; ENSRNOG00000003248 .
GeneIDi 360871.
KEGGi rno:360871.
UCSCi RGD:1359140. rat.

Organism-specific databases

CTDi 9019.
RGDi 1359140. Mpzl1.

Phylogenomic databases

eggNOGi NOG67913.
GeneTreei ENSGT00640000091161.
HOGENOMi HOG000232144.
HOVERGENi HBG104511.
InParanoidi Q6AYT8.
KOi K06770.
OMAi HQGPVIY.
OrthoDBi EOG7G1V80.
PhylomeDBi Q6AYT8.
TreeFami TF331728.

Miscellaneous databases

NextBioi 674440.
PROi Q6AYT8.

Gene expression databases

Genevestigatori Q6AYT8.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR000920. Myelin_P0_like.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
PRINTSi PR00213. MYELINP0.
SMARTi SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiMPZL1_RAT
AccessioniPrimary (citable) accession number: Q6AYT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: September 13, 2004
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3