Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myelin protein zero-like protein 1

Gene

Mpzl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. May be involved in regulation of integrin-mediated cell motility (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin protein zero-like protein 1
Gene namesi
Name:Mpzl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1359140 Mpzl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 162ExtracellularSequence analysisAdd BLAST127
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 270CytoplasmicSequence analysisAdd BLAST87

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000024033736 – 270Myelin protein zero-like protein 1Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi58 ↔ 135PROSITE-ProRule annotation
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei204PhosphoserineBy similarity1
Modified residuei206PhosphoserineBy similarity1
Modified residuei210PhosphoserineBy similarity1
Modified residuei221PhosphoserineBy similarity1
Modified residuei242PhosphotyrosineBy similarity1
Modified residuei261PhosphoserineBy similarity1
Modified residuei264PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine residues upon stimulation with pervanadate and concanavalin-A (ConA). Phosphorylation at Tyr-242 and Tyr-264 is required for interaction with PTPN11/SHP-2. Dephosphorylated by PTPN11/SHP-2 (in vitro) (By similarity).By similarity
N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6AYT8
PRIDEiQ6AYT8

PTM databases

iPTMnetiQ6AYT8
PhosphoSitePlusiQ6AYT8

Expressioni

Gene expression databases

BgeeiENSRNOG00000003248
GenevisibleiQ6AYT8 RN

Interactioni

Subunit structurei

Interacts with phosphorylated PTPN11/SHP-2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004376

Structurei

3D structure databases

ProteinModelPortaliQ6AYT8
SMRiQ6AYT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 151Ig-like V-typeAdd BLAST116

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi240 – 245ITIM motif 16
Motifi262 – 267ITIM motif 26

Domaini

Sequence similaritiesi

Belongs to the myelin P0 protein family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVXC Eukaryota
ENOG4111MDZ LUCA
GeneTreeiENSGT00900000140913
HOGENOMiHOG000232144
HOVERGENiHBG104511
InParanoidiQ6AYT8
KOiK06770
OMAiHQGPVIY
OrthoDBiEOG091G0H91
PhylomeDBiQ6AYT8
TreeFamiTF331728

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR029870 MPZL1
IPR000920 Myelin_P0-rel
PANTHERiPTHR13869 PTHR13869, 1 hit
PTHR13869:SF19 PTHR13869:SF19, 1 hit
PfamiView protein in Pfam
PF07686 V-set, 1 hit
PRINTSiPR00213 MYELINP0
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AYT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAVGAVTL IAAPARRRWL WSALAAMLGL LTARISALEV HTPKEIFVVN
60 70 80 90 100
GTQGKLTCTF DSPNTTGWLT TVSWSFQPEG TDSAVSFFHY SQGQVYIGDY
110 120 130 140 150
PPFKDRVTWA GDLDKKDASI NIENIQAVHN GTYICDVKNP PDIVVRPGQI
160 170 180 190 200
RLHVVEIDNL LVFLVWVVVG TVTAVVLGLT LLISLVLVVL YRRKHSKRDY
210 220 230 240 250
TGCSTSERLS PVKQAPRKCP SDTEGLVKSP PSAGSHQGPV IYAQLDHSGG
260 270
HHSGKINKSE SVVYADIRKD
Length:270
Mass (Da):29,502
Last modified:September 13, 2004 - v1
Checksum:iC1B6FBEBBBC45C3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078916 mRNA Translation: AAH78916.1
RefSeqiNP_001007729.1, NM_001007728.1
UniGeneiRn.8087

Genome annotation databases

EnsembliENSRNOT00000004376; ENSRNOP00000004376; ENSRNOG00000003248
GeneIDi360871
KEGGirno:360871
UCSCiRGD:1359140 rat

Similar proteinsi

Entry informationi

Entry nameiMPZL1_RAT
AccessioniPrimary (citable) accession number: Q6AYT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health