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Q6AYT8

- MPZL1_RAT

UniProt

Q6AYT8 - MPZL1_RAT

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Protein
Myelin protein zero-like protein 1
Gene
Mpzl1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. May be involved in regulation of integrin-mediated cell motility By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin protein zero-like protein 1
Gene namesi
Name:Mpzl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi1359140. Mpzl1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 162127Extracellular Reviewed prediction
Add
BLAST
Transmembranei163 – 18321Helical; Reviewed prediction
Add
BLAST
Topological domaini184 – 27087Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535 Reviewed prediction
Add
BLAST
Chaini36 – 270235Myelin protein zero-like protein 1
PRO_0000240337Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi58 ↔ 135 By similarity
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Modified residuei210 – 2101Phosphoserine By similarity
Modified residuei221 – 2211Phosphoserine By similarity
Modified residuei242 – 2421Phosphotyrosine By similarity
Modified residuei261 – 2611Phosphoserine By similarity
Modified residuei264 – 2641Phosphotyrosine By similarity

Post-translational modificationi

Phosphorylated on tyrosine residues upon stimulation with pervanadate and concanavalin-A (ConA). Phosphorylation at Tyr-242 and Tyr-264 is required for interaction with PTPN11/SHP-2. Dephosphorylated by PTPN11/SHP-2 (in vitro) By similarity.
N-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6AYT8.
PRIDEiQ6AYT8.

PTM databases

PhosphoSiteiQ6AYT8.

Expressioni

Gene expression databases

GenevestigatoriQ6AYT8.

Interactioni

Subunit structurei

Interacts with phosphorylated PTPN11/SHP-2 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004376.

Structurei

3D structure databases

ProteinModelPortaliQ6AYT8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 151116Ig-like V-type
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi240 – 2456ITIM motif 1
Motifi262 – 2676ITIM motif 2

Domaini

Sequence similaritiesi

Belongs to the myelin P0 protein family.

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG67913.
GeneTreeiENSGT00640000091161.
HOGENOMiHOG000232144.
HOVERGENiHBG104511.
InParanoidiQ6AYT8.
KOiK06770.
OMAiHQGPVIY.
OrthoDBiEOG7G1V80.
PhylomeDBiQ6AYT8.
TreeFamiTF331728.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR000920. Myelin_P0.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AYT8-1 [UniParc]FASTAAdd to Basket

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MAEAVGAVTL IAAPARRRWL WSALAAMLGL LTARISALEV HTPKEIFVVN    50
GTQGKLTCTF DSPNTTGWLT TVSWSFQPEG TDSAVSFFHY SQGQVYIGDY 100
PPFKDRVTWA GDLDKKDASI NIENIQAVHN GTYICDVKNP PDIVVRPGQI 150
RLHVVEIDNL LVFLVWVVVG TVTAVVLGLT LLISLVLVVL YRRKHSKRDY 200
TGCSTSERLS PVKQAPRKCP SDTEGLVKSP PSAGSHQGPV IYAQLDHSGG 250
HHSGKINKSE SVVYADIRKD 270
Length:270
Mass (Da):29,502
Last modified:September 13, 2004 - v1
Checksum:iC1B6FBEBBBC45C3D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC078916 mRNA. Translation: AAH78916.1.
RefSeqiNP_001007729.1. NM_001007728.1.
UniGeneiRn.8087.

Genome annotation databases

EnsembliENSRNOT00000004376; ENSRNOP00000004376; ENSRNOG00000003248.
GeneIDi360871.
KEGGirno:360871.
UCSCiRGD:1359140. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC078916 mRNA. Translation: AAH78916.1 .
RefSeqi NP_001007729.1. NM_001007728.1.
UniGenei Rn.8087.

3D structure databases

ProteinModelPortali Q6AYT8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000004376.

PTM databases

PhosphoSitei Q6AYT8.

Proteomic databases

PaxDbi Q6AYT8.
PRIDEi Q6AYT8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000004376 ; ENSRNOP00000004376 ; ENSRNOG00000003248 .
GeneIDi 360871.
KEGGi rno:360871.
UCSCi RGD:1359140. rat.

Organism-specific databases

CTDi 9019.
RGDi 1359140. Mpzl1.

Phylogenomic databases

eggNOGi NOG67913.
GeneTreei ENSGT00640000091161.
HOGENOMi HOG000232144.
HOVERGENi HBG104511.
InParanoidi Q6AYT8.
KOi K06770.
OMAi HQGPVIY.
OrthoDBi EOG7G1V80.
PhylomeDBi Q6AYT8.
TreeFami TF331728.

Miscellaneous databases

NextBioi 674440.
PROi Q6AYT8.

Gene expression databases

Genevestigatori Q6AYT8.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR000920. Myelin_P0.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
PRINTSi PR00213. MYELINP0.
SMARTi SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiMPZL1_RAT
AccessioniPrimary (citable) accession number: Q6AYT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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