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Protein

Monoacylglycerol lipase ABHD12

Gene

Abhd12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lysophosphatidylserine (LPS) lipase that plays a key role in the central nervous system. Represents a major LPS lipase in the brain. May also have a 2-arachidonoylglycerol (2-AG) hydrolase activity and act as a regulator of endocannabinoid signaling pathways.By similarity

Catalytic activityi

Hydrolyzes glycerol monoesters of long-chain fatty acids.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei246NucleophileBy similarity1
Active sitei333Charge relay systemBy similarity1
Active sitei372Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-RNO-426048. Arachidonate production from DAG.

Protein family/group databases

ESTHERiratno-q6ayt7. AlphaBeta_hydrolase.

Names & Taxonomyi

Protein namesi
Recommended name:
Monoacylglycerol lipase ABHD12Curated (EC:3.1.1.23By similarity)
Alternative name(s):
2-arachidonoylglycerol hydrolaseCurated
Abhydrolase domain-containing protein 12Curated
Gene namesi
Name:Abhd12Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1562570. Abhd12.

Subcellular locationi

  • Membrane By similarity; Single-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 74CytoplasmicBy similarityAdd BLAST74
Transmembranei75 – 95HelicalBy similarityAdd BLAST21
Topological domaini96 – 398ExtracellularBy similarityAdd BLAST303

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003758091 – 398Monoacylglycerol lipase ABHD12Add BLAST398

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6AYT7.
PRIDEiQ6AYT7.

PTM databases

iPTMnetiQ6AYT7.
PhosphoSitePlusiQ6AYT7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000036934.
GenevisibleiQ6AYT7. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010640.

Structurei

3D structure databases

ProteinModelPortaliQ6AYT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi18 – 25Poly-Ser8
Compositional biasi26 – 29Poly-Ala4

Sequence similaritiesi

Belongs to the serine esterase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1552. Eukaryota.
COG1073. LUCA.
GeneTreeiENSGT00390000006625.
HOGENOMiHOG000230822.
InParanoidiQ6AYT7.
KOiK13704.
OMAiKYPKGLD.
OrthoDBiEOG091G0QYO.
PhylomeDBiQ6AYT7.
TreeFamiTF315122.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR026605. ABHD12.
IPR022742. Hydrolase_4.
[Graphical view]
PANTHERiPTHR12277:SF61. PTHR12277:SF61. 1 hit.
PfamiPF12146. Hydrolase_4. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AYT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKRTEPVTL EHERCAASGS SSSGSAAAAL DADCSLKQNL RLAGKGTAEP
60 70 80 90 100
HSASDAGMKR ALGRRKSLWF RLRKILLCVL GFYIAIPFLV KLCPGIQAKL
110 120 130 140 150
IFLNFVRVPY FIDLKKPQDQ GLNHTCNYYL QPEDDVTIGV WHTIPSVWWK
160 170 180 190 200
NAQGKDQMWY EDALASNHPI ILYLHGNAGT RGGDHRVELY KVLSSLGYHV
210 220 230 240 250
VTFDYRGWGD SVGTPSERGM TYDALHVFDW IKARSGDNPV YIWGHSLGTG
260 270 280 290 300
VATNLVRRLC ERETPPDALI LESPFTNIRE EAKSHPFSVI YRYFPGFDWF
310 320 330 340 350
FLDPITSSGI KFANDENMKH ISCPLLILHA EDDPVVPFHL GRKLYNIAAP
360 370 380 390
SRSFRDFKVQ FIPFHSDLGY RHKYIYKSPE LPRILREFLG KSEPERQH
Length:398
Mass (Da):45,296
Last modified:September 13, 2004 - v1
Checksum:iB15C464EE3CBAFB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474050 Genomic DNA. Translation: EDL86136.1.
BC078918 mRNA. Translation: AAH78918.1.
RefSeqiNP_001019485.1. NM_001024314.1.
UniGeneiRn.128955.

Genome annotation databases

EnsembliENSRNOT00000010641; ENSRNOP00000010640; ENSRNOG00000036934.
GeneIDi499913.
KEGGirno:499913.
UCSCiRGD:1562570. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474050 Genomic DNA. Translation: EDL86136.1.
BC078918 mRNA. Translation: AAH78918.1.
RefSeqiNP_001019485.1. NM_001024314.1.
UniGeneiRn.128955.

3D structure databases

ProteinModelPortaliQ6AYT7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010640.

Protein family/group databases

ESTHERiratno-q6ayt7. AlphaBeta_hydrolase.

PTM databases

iPTMnetiQ6AYT7.
PhosphoSitePlusiQ6AYT7.

Proteomic databases

PaxDbiQ6AYT7.
PRIDEiQ6AYT7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010641; ENSRNOP00000010640; ENSRNOG00000036934.
GeneIDi499913.
KEGGirno:499913.
UCSCiRGD:1562570. rat.

Organism-specific databases

CTDi26090.
RGDi1562570. Abhd12.

Phylogenomic databases

eggNOGiKOG1552. Eukaryota.
COG1073. LUCA.
GeneTreeiENSGT00390000006625.
HOGENOMiHOG000230822.
InParanoidiQ6AYT7.
KOiK13704.
OMAiKYPKGLD.
OrthoDBiEOG091G0QYO.
PhylomeDBiQ6AYT7.
TreeFamiTF315122.

Enzyme and pathway databases

ReactomeiR-RNO-426048. Arachidonate production from DAG.

Miscellaneous databases

PROiQ6AYT7.

Gene expression databases

BgeeiENSRNOG00000036934.
GenevisibleiQ6AYT7. RN.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR026605. ABHD12.
IPR022742. Hydrolase_4.
[Graphical view]
PANTHERiPTHR12277:SF61. PTHR12277:SF61. 1 hit.
PfamiPF12146. Hydrolase_4. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiABD12_RAT
AccessioniPrimary (citable) accession number: Q6AYT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: September 13, 2004
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.