Abhd12

Functionⁱ

Lysophosphatidylserine (LPS) lipase that plays a key role in the central nervous system. Represents a major LPS lipase in the brain. May also have a 2-arachidonoylglycerol (2-AG) hydrolase activity and act as a regulator of endocannabinoid signaling pathways.By similarity

Catalytic activityⁱ

Hydrolyzes glycerol monoesters of long-chain fatty acids.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	246	NucleophileBy similarity	1
Active siteⁱ	333	Charge relay systemBy similarity	1
Active siteⁱ	372	Charge relay systemBy similarity	1

GO - Molecular functionⁱ

acylglycerol lipase activity Source: UniProtKB
lysophospholipase activity Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

acylglycerol catabolic process Source: UniProtKB
adult walking behavior Source: Ensembl
monoacylglycerol catabolic process Source: Ensembl
phosphatidylserine catabolic process Source: Ensembl
response to auditory stimulus Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	Hydrolase

Molecular function

Hydrolase

Enzyme and pathway databases

Reactomeⁱ	R-RNO-426048. Arachidonate production from DAG.

Reactomeⁱ

R-RNO-426048. Arachidonate production from DAG.

Protein family/group databases

ESTHERⁱ	ratno-q6ayt7. AlphaBeta_hydrolase.

ESTHERⁱ

ratno-q6ayt7. AlphaBeta_hydrolase.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Monoacylglycerol lipase ABHD12Curated (EC:3.1.1.23By similarity) Alternative name(s): 2-arachidonoylglycerol hydrolaseCurated Abhydrolase domain-containing protein 12Curated
Gene namesⁱ	Name:Abhd12Imported
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 3

Organism-specific databases

Rat genome database More...RGDⁱ	1562570. Abhd12.

RGDⁱ

1562570. Abhd12.

Subcellular locationⁱ

Membrane
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:Q99LR1 (ABD12_MOUSE)
; Single-pass membrane protein
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:Q99LR1 (ABD12_MOUSE)

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 74	CytoplasmicBy similarityAdd BLAST	74
Transmembraneⁱ	75 – 95	HelicalBy similarityAdd BLAST	21
Topological domainⁱ	96 – 398	ExtracellularBy similarityAdd BLAST	303

GO - Cellular componentⁱ

AMPA glutamate receptor complex Source: Ensembl
integral component of membrane Source: UniProtKB

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000375809	1 – 398	Monoacylglycerol lipase ABHD12Add BLAST		398

Post-translational modificationⁱ

Glycosylated.By similarity

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q6AYT7.
PRIDEⁱ	Q6AYT7.

PTM databases

iPTMnetⁱ	Q6AYT7.
PhosphoSitePlusⁱ	Q6AYT7.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000036934.
Genevisibleⁱ	Q6AYT7. RN.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000010640.

STRINGⁱ

10116.ENSRNOP00000010640.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6AYT7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	18 – 25	Poly-Ser		8
Compositional biasⁱ	26 – 29	Poly-Ala		4

Sequence similaritiesⁱ

Belongs to the serine esterase family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1552. Eukaryota. COG1073. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006625.
HOGENOMⁱ	HOG000230822.
InParanoidⁱ	Q6AYT7.
KEGG Orthology (KO) More...KOⁱ	K13704.
OMAⁱ	YLCRAPE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QYO.
PhylomeDBⁱ	Q6AYT7.
TreeFamⁱ	TF315122.

Family and domain databases

Gene3Dⁱ	3.40.50.1820. 1 hit.
InterProⁱ	View protein in InterPro IPR029058. AB_hydrolase. IPR026605. ABHD12. IPR022742. Hydrolase_4.
PANTHERⁱ	PTHR12277:SF104. PTHR12277:SF104. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12146. Hydrolase_4. 1 hit.
SUPFAMⁱ	SSF53474. SSF53474. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6AYT7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRKRTEPVTL EHERCAASGS SSSGSAAAAL DADCSLKQNL RLAGKGTAEP 
        60         70         80         90        100
HSASDAGMKR ALGRRKSLWF RLRKILLCVL GFYIAIPFLV KLCPGIQAKL 
       110        120        130        140        150
IFLNFVRVPY FIDLKKPQDQ GLNHTCNYYL QPEDDVTIGV WHTIPSVWWK 
       160        170        180        190        200
NAQGKDQMWY EDALASNHPI ILYLHGNAGT RGGDHRVELY KVLSSLGYHV 
       210        220        230        240        250
VTFDYRGWGD SVGTPSERGM TYDALHVFDW IKARSGDNPV YIWGHSLGTG 
       260        270        280        290        300
VATNLVRRLC ERETPPDALI LESPFTNIRE EAKSHPFSVI YRYFPGFDWF 
       310        320        330        340        350
FLDPITSSGI KFANDENMKH ISCPLLILHA EDDPVVPFHL GRKLYNIAAP 
       360        370        380        390 
SRSFRDFKVQ FIPFHSDLGY RHKYIYKSPE LPRILREFLG KSEPERQH

Length:398

Mass (Da):45,296

Last modified:September 13, 2004 - v1

Checksum:ⁱB15C464EE3CBAFB0

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH474050 Genomic DNA. Translation: EDL86136.1. BC078918 mRNA. Translation: AAH78918.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001019485.1. NM_001024314.1.
UniGeneⁱ	Rn.128955.

Genome annotation databases

Ensemblⁱ	ENSRNOT00000010641; ENSRNOP00000010640; ENSRNOG00000036934.
GeneIDⁱ	499913.
KEGGⁱ	rno:499913.
UCSC genome browser More...UCSCⁱ	RGD:1562570. rat.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH474050 Genomic DNA. Translation: EDL86136.1. BC078918 mRNA. Translation: AAH78918.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001019485.1. NM_001024314.1.
UniGeneⁱ	Rn.128955.

3D structure databases

ProteinModelPortalⁱ	Q6AYT7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000010640.

STRINGⁱ

10116.ENSRNOP00000010640.

Protein family/group databases

ESTHERⁱ	ratno-q6ayt7. AlphaBeta_hydrolase.

ESTHERⁱ

ratno-q6ayt7. AlphaBeta_hydrolase.

PTM databases

iPTMnetⁱ	Q6AYT7.
PhosphoSitePlusⁱ	Q6AYT7.

Proteomic databases

PaxDbⁱ	Q6AYT7.
PRIDEⁱ	Q6AYT7.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000010641; ENSRNOP00000010640; ENSRNOG00000036934.
GeneIDⁱ	499913.
KEGGⁱ	rno:499913.
UCSC genome browser More...UCSCⁱ	RGD:1562570. rat.

Organism-specific databases

CTDⁱ	26090.
Rat genome database More...RGDⁱ	1562570. Abhd12.

Phylogenomic databases

eggNOGⁱ	KOG1552. Eukaryota. COG1073. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006625.
HOGENOMⁱ	HOG000230822.
InParanoidⁱ	Q6AYT7.
KEGG Orthology (KO) More...KOⁱ	K13704.
OMAⁱ	YLCRAPE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QYO.
PhylomeDBⁱ	Q6AYT7.
TreeFamⁱ	TF315122.

Enzyme and pathway databases

Reactomeⁱ	R-RNO-426048. Arachidonate production from DAG.

Reactomeⁱ

R-RNO-426048. Arachidonate production from DAG.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q6AYT7.

PROⁱ

PR:Q6AYT7.

Gene expression databases

Bgeeⁱ	ENSRNOG00000036934.
Genevisibleⁱ	Q6AYT7. RN.

Family and domain databases

Gene3Dⁱ	3.40.50.1820. 1 hit.
InterProⁱ	View protein in InterPro IPR029058. AB_hydrolase. IPR026605. ABHD12. IPR022742. Hydrolase_4.
PANTHERⁱ	PTHR12277:SF104. PTHR12277:SF104. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12146. Hydrolase_4. 1 hit.
SUPFAMⁱ	SSF53474. SSF53474. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ABD12_RAT
Accessionⁱ	Q6AYT7Primary (citable) accession number: Q6AYT7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 26, 2009
	Last sequence update:	September 13, 2004
	Last modified:	June 7, 2017
	This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6AYT7 (ABD12_RAT)

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Monoacylglycerol lipase ABHD12

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ