UniProtKB - Q6AYT7 (ABD12_RAT)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Monoacylglycerol lipase ABHD12
Gene
Abhd12
Organism
Rattus norvegicus (Rat)
Status
Functioni
Lysophosphatidylserine (LPS) lipase that plays a key role in the central nervous system. Represents a major LPS lipase in the brain. May also have a 2-arachidonoylglycerol (2-AG) hydrolase activity and act as a regulator of endocannabinoid signaling pathways.By similarity
Catalytic activityi
Hydrolyzes glycerol monoesters of long-chain fatty acids.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 246 | NucleophileBy similarity | 1 | |
Active sitei | 333 | Charge relay systemBy similarity | 1 | |
Active sitei | 372 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- acylglycerol lipase activity Source: UniProtKB
- lysophospholipase activity Source: RGD
- palmitoyl-(protein) hydrolase activity Source: RGD
GO - Biological processi
- acylglycerol catabolic process Source: UniProtKB
- adult walking behavior Source: RGD
- glycerophospholipid catabolic process Source: RGD
- monoacylglycerol catabolic process Source: RGD
- phosphatidylserine catabolic process Source: RGD
- protein depalmitoylation Source: RGD
- response to auditory stimulus Source: RGD
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
Reactomei | R-RNO-426048. Arachidonate production from DAG. |
Protein family/group databases
ESTHERi | ratno-q6ayt7. ABHD12-PHARC. |
Names & Taxonomyi
Protein namesi | Recommended name: Monoacylglycerol lipase ABHD12Curated (EC:3.1.1.23By similarity)Alternative name(s): 2-arachidonoylglycerol hydrolaseCurated Abhydrolase domain-containing protein 12Curated |
Gene namesi | Name:Abhd12Imported |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1562570. Abhd12. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 74 | CytoplasmicBy similarityAdd BLAST | 74 | |
Transmembranei | 75 – 95 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 96 – 398 | ExtracellularBy similarityAdd BLAST | 303 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000375809 | 1 – 398 | Monoacylglycerol lipase ABHD12Add BLAST | 398 |
Post-translational modificationi
Glycosylated.By similarity
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q6AYT7. |
PRIDEi | Q6AYT7. |
PTM databases
iPTMneti | Q6AYT7. |
PhosphoSitePlusi | Q6AYT7. |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 18 – 25 | Poly-Ser | 8 | |
Compositional biasi | 26 – 29 | Poly-Ala | 4 |
Sequence similaritiesi
Belongs to the serine esterase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1552. Eukaryota. COG1073. LUCA. |
GeneTreei | ENSGT00390000006625. |
HOGENOMi | HOG000230822. |
InParanoidi | Q6AYT7. |
KOi | K13704. |
OMAi | WGPVEFH. |
OrthoDBi | EOG091G0QYO. |
PhylomeDBi | Q6AYT7. |
TreeFami | TF315122. |
Family and domain databases
Gene3Di | 3.40.50.1820. 1 hit. |
InterProi | View protein in InterPro IPR029058. AB_hydrolase. IPR026605. ABHD12. IPR022742. Hydrolase_4. |
PANTHERi | PTHR12277:SF61. PTHR12277:SF61. 1 hit. |
Pfami | View protein in Pfam PF12146. Hydrolase_4. 1 hit. |
SUPFAMi | SSF53474. SSF53474. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q6AYT7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRKRTEPVTL EHERCAASGS SSSGSAAAAL DADCSLKQNL RLAGKGTAEP
60 70 80 90 100
HSASDAGMKR ALGRRKSLWF RLRKILLCVL GFYIAIPFLV KLCPGIQAKL
110 120 130 140 150
IFLNFVRVPY FIDLKKPQDQ GLNHTCNYYL QPEDDVTIGV WHTIPSVWWK
160 170 180 190 200
NAQGKDQMWY EDALASNHPI ILYLHGNAGT RGGDHRVELY KVLSSLGYHV
210 220 230 240 250
VTFDYRGWGD SVGTPSERGM TYDALHVFDW IKARSGDNPV YIWGHSLGTG
260 270 280 290 300
VATNLVRRLC ERETPPDALI LESPFTNIRE EAKSHPFSVI YRYFPGFDWF
310 320 330 340 350
FLDPITSSGI KFANDENMKH ISCPLLILHA EDDPVVPFHL GRKLYNIAAP
360 370 380 390
SRSFRDFKVQ FIPFHSDLGY RHKYIYKSPE LPRILREFLG KSEPERQH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH474050 Genomic DNA. Translation: EDL86136.1. BC078918 mRNA. Translation: AAH78918.1. |
RefSeqi | NP_001019485.1. NM_001024314.1. |
UniGenei | Rn.128955. |
Genome annotation databases
Ensembli | ENSRNOT00000010641; ENSRNOP00000010640; ENSRNOG00000036934. |
GeneIDi | 499913. |
KEGGi | rno:499913. |
UCSCi | RGD:1562570. rat. |
Similar proteinsi
Entry informationi
Entry namei | ABD12_RAT | |
Accessioni | Q6AYT7Primary (citable) accession number: Q6AYT7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 26, 2009 |
Last sequence update: | September 13, 2004 | |
Last modified: | March 28, 2018 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |