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Protein

Protein-glutamate O-methyltransferase

Gene

Armt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Methylates PCNA, suggesting it is involved in the DNA damage response.By similarity

Catalytic activityi

S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei256S-adenosyl-L-methionineBy similarity1
Binding sitei289S-adenosyl-L-methionineBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

DNA damage

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamate O-methyltransferaseBy similarity (EC:2.1.1.-By similarity)
Alternative name(s):
Acidic residue methyltransferase 1By similarity
Gene namesi
Name:Armt1By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1305235. Armt1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002307972 – 439Protein-glutamate O-methyltransferaseAdd BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei4PhosphoserineCombined sources1
Modified residuei40N6-acetyllysineBy similarity1

Post-translational modificationi

Automethylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6AYT5.
PRIDEiQ6AYT5.

PTM databases

iPTMnetiQ6AYT5.
PhosphoSitePlusiQ6AYT5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019489.
GenevisibleiQ6AYT5. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026367.

Structurei

3D structure databases

ProteinModelPortaliQ6AYT5.
SMRiQ6AYT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARMT1 family.Curated

Phylogenomic databases

eggNOGiKOG3870. Eukaryota.
ENOG410XPAF. LUCA.
GeneTreeiENSGT00530000064023.
HOGENOMiHOG000172710.
HOVERGENiHBG054833.
InParanoidiQ6AYT5.
OMAiRIQEAIW.
OrthoDBiEOG091G0557.
PhylomeDBiQ6AYT5.
TreeFamiTF314853.

Family and domain databases

InterProiIPR002791. DUF89.
[Graphical view]
PfamiPF01937. DUF89. 1 hit.
[Graphical view]
SUPFAMiSSF111321. SSF111321. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AYT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESPAFLSA QDVGSFAYLT IKDRTPQILT KVIDTLHRHK SEFFEKHGEE
60 70 80 90 100
GVEAEKKAIS LLSKLRNELQ TDKPIIPLVD KCVDTDIWNQ YLEYQRSLLN
110 120 130 140 150
EGDGEPRWFF SPWLFVECYM YRRIHEAIMQ SPPIHDFDVF KESKDENFFE
160 170 180 190 200
SQDSINALCT HLLQLKPITD LGEKQIQDEF FKLLQISLWG NKCDLSLSGG
210 220 230 240 250
ESSSQKADII NSLKDLKPFI LVNETESLWA LLSKLKKTAE PPAVRVDIVL
260 270 280 290 300
DNSGFELVTD LVFADFLLSS ELATEIHFHG KIIPWFVSDV TVRDFEWIVE
310 320 330 340 350
HMKGSHLESM SACGAAWEAY VGMKKWVYHD HAFWTLPHPF CAMPQVAPDL
360 370 380 390 400
YAELQKAGVV LFKGDLNYRK LMGDRKWKFT VPFHQALSGF HPAPLCSIRT
410 420 430
LKCELQVGLQ PGQAEHLTAS DPHWLTTGKY GIFQFDGPL
Length:439
Mass (Da):50,184
Last modified:September 13, 2004 - v1
Checksum:i629FB0A67E2F6E41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078920 mRNA. Translation: AAH78920.1.
RefSeqiNP_001017447.1. NM_001017447.1.
UniGeneiRn.50425.

Genome annotation databases

EnsembliENSRNOT00000026367; ENSRNOP00000026367; ENSRNOG00000019489.
GeneIDi292267.
KEGGirno:292267.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078920 mRNA. Translation: AAH78920.1.
RefSeqiNP_001017447.1. NM_001017447.1.
UniGeneiRn.50425.

3D structure databases

ProteinModelPortaliQ6AYT5.
SMRiQ6AYT5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026367.

PTM databases

iPTMnetiQ6AYT5.
PhosphoSitePlusiQ6AYT5.

Proteomic databases

PaxDbiQ6AYT5.
PRIDEiQ6AYT5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026367; ENSRNOP00000026367; ENSRNOG00000019489.
GeneIDi292267.
KEGGirno:292267.

Organism-specific databases

CTDi79624.
RGDi1305235. Armt1.

Phylogenomic databases

eggNOGiKOG3870. Eukaryota.
ENOG410XPAF. LUCA.
GeneTreeiENSGT00530000064023.
HOGENOMiHOG000172710.
HOVERGENiHBG054833.
InParanoidiQ6AYT5.
OMAiRIQEAIW.
OrthoDBiEOG091G0557.
PhylomeDBiQ6AYT5.
TreeFamiTF314853.

Miscellaneous databases

PROiQ6AYT5.

Gene expression databases

BgeeiENSRNOG00000019489.
GenevisibleiQ6AYT5. RN.

Family and domain databases

InterProiIPR002791. DUF89.
[Graphical view]
PfamiPF01937. DUF89. 1 hit.
[Graphical view]
SUPFAMiSSF111321. SSF111321. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARMT1_RAT
AccessioniPrimary (citable) accession number: Q6AYT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: September 13, 2004
Last modified: November 2, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.