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Q6AYT3

- RTCB_RAT

UniProt

Q6AYT3 - RTCB_RAT

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Protein

tRNA-splicing ligase RtcB homolog

Gene
Rtcb
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs By similarity.UniRule annotation

Catalytic activityi

ATP + (ribonucleotide)(n) + (ribonucleotide)(m) = AMP + diphosphate + (ribonucleotide)(n+m).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi122 – 1221Zinc Reviewed prediction
Metal bindingi227 – 2271Zinc Reviewed prediction
Metal bindingi259 – 2591Zinc Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. RNA ligase (ATP) activity Source: UniProtKB

GO - Biological processi

  1. tRNA splicing, via endonucleolytic cleavage and ligation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-splicing ligase RtcB homolog (EC:6.5.1.3)
Alternative name(s):
p55
Gene namesi
Name:Rtcb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi1303261. Rtcb.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. tRNA-splicing ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505tRNA-splicing ligase RtcB homologUniRule annotationPRO_0000255245Add
BLAST

Proteomic databases

PaxDbiQ6AYT3.
PRIDEiQ6AYT3.

PTM databases

PhosphoSiteiQ6AYT3.

Expressioni

Gene expression databases

GenevestigatoriQ6AYT3.

Interactioni

Subunit structurei

Catalytic component of the tRNA-splicing ligase complex By similarity.

Protein-protein interaction databases

BioGridi263779. 2 interactions.
IntActiQ6AYT3. 1 interaction.
MINTiMINT-4576391.
STRINGi10116.ENSRNOP00000006570.

Structurei

3D structure databases

ProteinModelPortaliQ6AYT3.
SMRiQ6AYT3. Positions 12-505.

Family & Domainsi

Sequence similaritiesi

Belongs to the RtcB family.

Phylogenomic databases

eggNOGiCOG1690.
GeneTreeiENSGT00390000015260.
HOVERGENiHBG081383.
InParanoidiQ6AYT3.
KOiK14415.
OMAiGRMLNAD.
OrthoDBiEOG7DRJ2Q.
PhylomeDBiQ6AYT3.
TreeFamiTF314404.

Family and domain databases

HAMAPiMF_03144. RtcB_euk.
InterProiIPR001233. RtcB.
IPR027513. RtcB_euk.
[Graphical view]
PANTHERiPTHR11118. PTHR11118. 1 hit.
PfamiPF01139. RtcB. 1 hit.
[Graphical view]
SUPFAMiSSF103365. SSF103365. 1 hit.
PROSITEiPS01288. UPF0027. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AYT3-1 [UniParc]FASTAAdd to Basket

« Hide

MSRNYNDELQ FLDKINKNCW RIKKGFVPNM QVEGVFYVND ALEKLMFEEL    50
RNACRGGGVG GFLPAMKQIG NVAALPGIVH RSIGLPDVHS GYGFAIGNMA 100
AFDMNDPEAV VSPGGVGFDI NCGVRLLRTN LDESDVQPVK EQLAQAMFDH 150
IPVGVGSKGV IPMNAKDLEE ALEMGVDWSL REGYAWAEDK EHCEEYGRML 200
QADPNKVSPR AKKRGLPQLG TLGAGNHYAE IQVVDEIFNE YAAKKMGIDH 250
KGQVCVMIHS GSRGLGHQVA TDALVAMEKA MKRDKIIVND RQLACARIAS 300
PEGQDYLKGM AAAGNYAWVN RSSMTFLTRQ AFAKVFNTTP DDLDLHVIYD 350
VSHNIAKVEQ HVVDGKERTL LVHRKGSTRA FPPHHPLIAV DYQLTGQPVL 400
IGGTMGTCSY VLTGTEQGMT ETFGTTCHGA GRALSRAKSR RNLDFQDVLD 450
KLADMGIAIR VASPKLVMEE APESYKNVTD VVNTCHDAGI SKKAIKLRPI 500
AVIKG 505
Length:505
Mass (Da):55,249
Last modified:September 13, 2004 - v1
Checksum:i3488A9BF91460480
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti316 – 3161Y → C in AAS78621. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY572415 mRNA. Translation: AAS78621.1.
BC078924 mRNA. Translation: AAH78924.1.
RefSeqiNP_997497.1. NM_207614.1.
UniGeneiRn.11875.

Genome annotation databases

EnsembliENSRNOT00000006570; ENSRNOP00000006570; ENSRNOG00000004813.
GeneIDi362855.
KEGGirno:362855.
UCSCiRGD:1303261. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY572415 mRNA. Translation: AAS78621.1 .
BC078924 mRNA. Translation: AAH78924.1 .
RefSeqi NP_997497.1. NM_207614.1.
UniGenei Rn.11875.

3D structure databases

ProteinModelPortali Q6AYT3.
SMRi Q6AYT3. Positions 12-505.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 263779. 2 interactions.
IntActi Q6AYT3. 1 interaction.
MINTi MINT-4576391.
STRINGi 10116.ENSRNOP00000006570.

PTM databases

PhosphoSitei Q6AYT3.

Proteomic databases

PaxDbi Q6AYT3.
PRIDEi Q6AYT3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000006570 ; ENSRNOP00000006570 ; ENSRNOG00000004813 .
GeneIDi 362855.
KEGGi rno:362855.
UCSCi RGD:1303261. rat.

Organism-specific databases

CTDi 51493.
RGDi 1303261. Rtcb.

Phylogenomic databases

eggNOGi COG1690.
GeneTreei ENSGT00390000015260.
HOVERGENi HBG081383.
InParanoidi Q6AYT3.
KOi K14415.
OMAi GRMLNAD.
OrthoDBi EOG7DRJ2Q.
PhylomeDBi Q6AYT3.
TreeFami TF314404.

Miscellaneous databases

NextBioi 681535.
PROi Q6AYT3.

Gene expression databases

Genevestigatori Q6AYT3.

Family and domain databases

HAMAPi MF_03144. RtcB_euk.
InterProi IPR001233. RtcB.
IPR027513. RtcB_euk.
[Graphical view ]
PANTHERi PTHR11118. PTHR11118. 1 hit.
Pfami PF01139. RtcB. 1 hit.
[Graphical view ]
SUPFAMi SSF103365. SSF103365. 1 hit.
PROSITEi PS01288. UPF0027. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the rat P55 gene."
    Ding N.-Z., He M., He C.-Q., Chen J.G.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Brown Norway.
    Tissue: Kidney.

Entry informationi

Entry nameiRTCB_RAT
AccessioniPrimary (citable) accession number: Q6AYT3
Secondary accession number(s): Q6PX76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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