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Protein

Quinone oxidoreductase

Gene

Cryz

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity).By similarity

Catalytic activityi

NADPH + 2 quinone = NADP+ + 2 semiquinone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53NADPBy similarity1
Binding sitei181NADP; via amide nitrogenBy similarity1
Binding sitei200NADPBy similarity1
Binding sitei229NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi158 – 161NADPBy similarity4
Nucleotide bindingi246 – 249NADPBy similarity4
Nucleotide bindingi269 – 271NADPBy similarity3

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: RGD
  • NADPH:quinone reductase activity Source: UniProtKB
  • NADPH binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, RNA-binding
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Quinone oxidoreductase (EC:1.6.5.5)
Alternative name(s):
NADPH:quinone reductase
Zeta-crystallin
Gene namesi
Name:Cryz
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1311639 Cryz

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001609102 – 329Quinone oxidoreductaseAdd BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei23N6-acetyllysineBy similarity1
Modified residuei296N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6AYT0
PRIDEiQ6AYT0

PTM databases

iPTMnetiQ6AYT0
PhosphoSitePlusiQ6AYT0

Expressioni

Gene expression databases

BgeeiENSRNOG00000028319
GenevisibleiQ6AYT0 RN

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038188

Structurei

3D structure databases

ProteinModelPortaliQ6AYT0
SMRiQ6AYT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1197 Eukaryota
COG0604 LUCA
GeneTreeiENSGT00550000074483
HOGENOMiHOG000294672
HOVERGENiHBG002466
InParanoidiQ6AYT0
KOiK00344
OMAiKCPVVYD
OrthoDBiEOG091G0DQO
PhylomeDBiQ6AYT0
TreeFamiTF314255

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR002364 Quin_OxRdtase/zeta-crystal_CS
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS01162 QOR_ZETA_CRYSTAL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AYT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATGQKLMRA IRVFEFGGPE VLKLQSDVVV PAPQSHQVLI KVHACGVNPV
60 70 80 90 100
ETYIRSGTYS RKPALPYTPG SDVAGIIESV GDGVSAFKKG DRVFCFSTVS
110 120 130 140 150
GGYAEFALSA DNTTYPLPET LDFRQGAALG IPYFTACRAL FHSARARAGE
160 170 180 190 200
SVLVHGASGG VGLATCQIAR AHGLKVLGTA GSEEGKKLVL QNGAHEVFNH
210 220 230 240 250
KEANYIDKIK TSAGDKGVDV IIEMLANKNL SNDLKLLSCG GRVIVVGCRG
260 270 280 290 300
SIEINPRDTM AKETSIIGVS LFSSTKEEFQ QFAGILQAGI EKGWVKPVIG
310 320
SEYPLEKAAQ AHEDIIHSSG KMGKMILLL
Length:329
Mass (Da):34,975
Last modified:September 13, 2004 - v1
Checksum:i02BD613047BF4B04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078927 mRNA Translation: AAH78927.1
RefSeqiNP_001012183.1, NM_001012183.2
XP_006233582.1, XM_006233520.3
UniGeneiRn.6746

Genome annotation databases

EnsembliENSRNOT00000032808; ENSRNOP00000038188; ENSRNOG00000028319
GeneIDi362061
KEGGirno:362061

Similar proteinsi

Entry informationi

Entry nameiQOR_RAT
AccessioniPrimary (citable) accession number: Q6AYT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: September 13, 2004
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health