Reviewed, UniProtKB/Swiss-Prot Q6AYT0 (QOR_RAT)

Names and origin

Protein names

Recommended name:
    Quinone oxidoreductase
    EC=1.6.5.5
Alternative name(s):
    NADPH:quinone reductase
    Zeta-crystallin

Gene names

Name:

Cryz

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones are the best substrates. May act in the detoxification of xenobiotics By similarity.
Catalytic activity	NADPH + 2 quinone = NADP+ + 2 semiquinone.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell soluble fraction Inferred from direct assay. Source: RGD
Molecular function	NADPH:quinone reductase activity Inferred from electronic annotation. Source: EC mRNA 3'-UTR binding Inferred from direct assay. Source: RGD zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 329	329	Quinone oxidoreductase		PRO_0000160910

Sequences

	Sequence		Length	Mass (Da)
	Q6AYT0-1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 02BD613047BF4B04	FASTA	329	34,975
	10 20 30 40 50 60 MATGQKLMRA IRVFEFGGPE VLKLQSDVVV PAPQSHQVLI KVHACGVNPV ETYIRSGTYS 70 80 90 100 110 120 RKPALPYTPG SDVAGIIESV GDGVSAFKKG DRVFCFSTVS GGYAEFALSA DNTTYPLPET 130 140 150 160 170 180 LDFRQGAALG IPYFTACRAL FHSARARAGE SVLVHGASGG VGLATCQIAR AHGLKVLGTA 190 200 210 220 230 240 GSEEGKKLVL QNGAHEVFNH KEANYIDKIK TSAGDKGVDV IIEMLANKNL SNDLKLLSCG 250 260 270 280 290 300 GRVIVVGCRG SIEINPRDTM AKETSIIGVS LFSSTKEEFQ QFAGILQAGI EKGWVKPVIG 310 320 SEYPLEKAAQ AHEDIIHSSG KMGKMILLL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC078927 mRNA. Translation: AAH78927.1.
IPI	IPI00464794.
RefSeq	NP_001012183.1.
UniGene	Rn.6746
3D structure databases
SMR	Q6AYT0. Positions 6-329.
ModBase	Search...
Genome annotation databases
Ensembl	ENSRNOG00000028319. Rattus norvegicus. [Contig view]
GeneID	362061.
KEGG	rno:362061.
NMPDR	fig|10116.3.peg.17202.
Organism-specific databases
RGD	1311639. Cryz.
Phylogenomic databases
HOVERGEN	Q6AYT0.
OMA	Q6AYT0. DTMAKES.
Enzyme and pathway databases
BRENDA	1.6.5.5. 248.
Gene expression databases
ArrayExpress	Q6AYT0.
GermOnline	ENSRNOG00000028319. Rattus norvegicus.
Family and domain databases
InterPro	IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn. IPR013149. ADH_Zn-bd. IPR016040. NAD(P)-bd_dom. IPR002364. Quin_OxRdtase/zeta-crystal_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
PROSITE	PS01162. QOR_ZETA_CRYSTAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	678539.

Entry information

Entry name

QOR_RAT

Accession

Primary (citable) accession number: Q6AYT0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	September 13, 2004
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)