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Protein

Quinone oxidoreductase

Gene

Cryz

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity).By similarity

Catalytic activityi

NADPH + 2 quinone = NADP+ + 2 semiquinone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531NADPBy similarity
Binding sitei181 – 1811NADP; via amide nitrogenBy similarity
Binding sitei200 – 2001NADPBy similarity
Binding sitei229 – 2291NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi158 – 1614NADPBy similarity
Nucleotide bindingi246 – 2494NADPBy similarity
Nucleotide bindingi269 – 2713NADPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Quinone oxidoreductase (EC:1.6.5.5)
Alternative name(s):
NADPH:quinone reductase
Zeta-crystallin
Gene namesi
Name:Cryz
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1311639. Cryz.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 329328Quinone oxidoreductasePRO_0000160910Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei23 – 231N6-acetyllysineBy similarity
Modified residuei296 – 2961N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6AYT0.
PRIDEiQ6AYT0.

PTM databases

iPTMnetiQ6AYT0.

Expressioni

Gene expression databases

GenevisibleiQ6AYT0. RN.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038188.

Structurei

3D structure databases

ProteinModelPortaliQ6AYT0.
SMRiQ6AYT0. Positions 6-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1197. Eukaryota.
COG0604. LUCA.
GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294672.
HOVERGENiHBG002466.
InParanoidiQ6AYT0.
KOiK00344.
OMAiAITCKAT.
OrthoDBiEOG7BGHM8.
PhylomeDBiQ6AYT0.
TreeFamiTF314255.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AYT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATGQKLMRA IRVFEFGGPE VLKLQSDVVV PAPQSHQVLI KVHACGVNPV
60 70 80 90 100
ETYIRSGTYS RKPALPYTPG SDVAGIIESV GDGVSAFKKG DRVFCFSTVS
110 120 130 140 150
GGYAEFALSA DNTTYPLPET LDFRQGAALG IPYFTACRAL FHSARARAGE
160 170 180 190 200
SVLVHGASGG VGLATCQIAR AHGLKVLGTA GSEEGKKLVL QNGAHEVFNH
210 220 230 240 250
KEANYIDKIK TSAGDKGVDV IIEMLANKNL SNDLKLLSCG GRVIVVGCRG
260 270 280 290 300
SIEINPRDTM AKETSIIGVS LFSSTKEEFQ QFAGILQAGI EKGWVKPVIG
310 320
SEYPLEKAAQ AHEDIIHSSG KMGKMILLL
Length:329
Mass (Da):34,975
Last modified:September 13, 2004 - v1
Checksum:i02BD613047BF4B04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078927 mRNA. Translation: AAH78927.1.
RefSeqiNP_001012183.1. NM_001012183.2.
XP_006233582.1. XM_006233520.2.
UniGeneiRn.6746.

Genome annotation databases

EnsembliENSRNOT00000032808; ENSRNOP00000038188; ENSRNOG00000028319.
GeneIDi362061.
KEGGirno:362061.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078927 mRNA. Translation: AAH78927.1.
RefSeqiNP_001012183.1. NM_001012183.2.
XP_006233582.1. XM_006233520.2.
UniGeneiRn.6746.

3D structure databases

ProteinModelPortaliQ6AYT0.
SMRiQ6AYT0. Positions 6-329.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038188.

PTM databases

iPTMnetiQ6AYT0.

Proteomic databases

PaxDbiQ6AYT0.
PRIDEiQ6AYT0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000032808; ENSRNOP00000038188; ENSRNOG00000028319.
GeneIDi362061.
KEGGirno:362061.

Organism-specific databases

CTDi1429.
RGDi1311639. Cryz.

Phylogenomic databases

eggNOGiKOG1197. Eukaryota.
COG0604. LUCA.
GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294672.
HOVERGENiHBG002466.
InParanoidiQ6AYT0.
KOiK00344.
OMAiAITCKAT.
OrthoDBiEOG7BGHM8.
PhylomeDBiQ6AYT0.
TreeFamiTF314255.

Miscellaneous databases

PROiQ6AYT0.

Gene expression databases

GenevisibleiQ6AYT0. RN.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiQOR_RAT
AccessioniPrimary (citable) accession number: Q6AYT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.