Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Estradiol 17-beta-dehydrogenase 11

Gene

Hsd17b11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione.By similarity

Catalytic activityi

17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei172 – 1721SubstrateBy similarity
Active sitei185 – 1851Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 6425NADPBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiR-RNO-193144. Estrogen biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Estradiol 17-beta-dehydrogenase 11 (EC:1.1.1.62By similarity)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase 11
Short name:
17-beta-HSD 11
Short name:
17bHSD11
Short name:
17betaHSD11
17-beta-hydroxysteroid dehydrogenase XI
Short name:
17-beta-HSD XI
Short name:
17betaHSDXI
Dehydrogenase/reductase SDR family member 8
Gene namesi
Name:Hsd17b11
Synonyms:Dhrs8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1303235. Hsd17b11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 298277Estradiol 17-beta-dehydrogenase 11PRO_0000031973Add
BLAST

Proteomic databases

PaxDbiQ6AYS8.
PRIDEiQ6AYS8.

Expressioni

Gene expression databases

GenevisibleiQ6AYS8. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-4579684.
STRINGi10116.ENSRNOP00000003004.

Structurei

3D structure databases

ProteinModelPortaliQ6AYS8.
SMRiQ6AYS8. Positions 30-273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1201. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00540000069900.
HOVERGENiHBG051352.
InParanoidiQ6AYS8.
OMAiFLLAYXL.
OrthoDBiEOG7Z3F50.
PhylomeDBiQ6AYS8.
TreeFamiTF312837.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AYS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYLLDLILL LPLLIVFCIE SFIKRLIPKK KKSVAGEIVL ITGAGHGIGR
60 70 80 90 100
LTAYEFAKLN TKLVLWDINK NGIEETAAKC RKLGAQVHPF VVDCSQREEI
110 120 130 140 150
YSAVRKVKEE VGDVSILVNN AGVVYTADLF ATQDPQIEKT FEVNVLAHFW
160 170 180 190 200
TTKAFLPAMM KNNHGHVVTV ASAAGHTVVP FLLAYCSSKF AAVGFHRALT
210 220 230 240 250
DELAALGCTG VRTSCLCPNF INTGFIKNPS TNLGPTLEPE EVVEHLMHGI
260 270 280 290
LTNQKMIFVP GSIALLTVLE RVFPERFLDV LKRRINVKFD AVVGYKDK
Length:298
Mass (Da):32,938
Last modified:September 13, 2004 - v1
Checksum:i51D6D1D30068B398
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078929 mRNA. Translation: AAH78929.1.
RefSeqiNP_001004209.1. NM_001004209.1.
XP_006250689.1. XM_006250627.2.
XP_006250691.1. XM_006250629.2.
UniGeneiRn.102059.

Genome annotation databases

EnsembliENSRNOT00000003004; ENSRNOP00000003004; ENSRNOG00000002210.
GeneIDi289456.
KEGGirno:289456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078929 mRNA. Translation: AAH78929.1.
RefSeqiNP_001004209.1. NM_001004209.1.
XP_006250689.1. XM_006250627.2.
XP_006250691.1. XM_006250629.2.
UniGeneiRn.102059.

3D structure databases

ProteinModelPortaliQ6AYS8.
SMRiQ6AYS8. Positions 30-273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4579684.
STRINGi10116.ENSRNOP00000003004.

Proteomic databases

PaxDbiQ6AYS8.
PRIDEiQ6AYS8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003004; ENSRNOP00000003004; ENSRNOG00000002210.
GeneIDi289456.
KEGGirno:289456.

Organism-specific databases

CTDi51170.
RGDi1303235. Hsd17b11.

Phylogenomic databases

eggNOGiKOG1201. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00540000069900.
HOVERGENiHBG051352.
InParanoidiQ6AYS8.
OMAiFLLAYXL.
OrthoDBiEOG7Z3F50.
PhylomeDBiQ6AYS8.
TreeFamiTF312837.

Enzyme and pathway databases

ReactomeiR-RNO-193144. Estrogen biosynthesis.

Miscellaneous databases

NextBioi629845.
PROiQ6AYS8.

Gene expression databases

GenevisibleiQ6AYS8. RN.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiDHB11_RAT
AccessioniPrimary (citable) accession number: Q6AYS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: September 13, 2004
Last modified: May 11, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.