Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sorting nexin-17

Gene

Snx17

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361Phosphatidylinositol 3-phosphateBy similarity
Binding sitei38 – 381Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei62 – 621Phosphatidylinositol 3-phosphateBy similarity
Binding sitei75 – 751Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-17
Gene namesi
Name:Snx17
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306424. Snx17.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Sorting nexin-17PRO_0000236206Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei407 – 4071PhosphoserineBy similarity
Modified residuei409 – 4091PhosphoserineBy similarity
Modified residuei415 – 4151PhosphoserineCombined sources
Modified residuei421 – 4211PhosphoserineCombined sources
Modified residuei437 – 4371PhosphoserineCombined sources
Modified residuei440 – 4401PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AYS6.
PRIDEiQ6AYS6.

PTM databases

iPTMnetiQ6AYS6.
PhosphoSiteiQ6AYS6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000026884.

Interactioni

Subunit structurei

Monomer. Interacts with APP (via cytoplasmic YXNPXY motif). Interacts with KIF1B (By similarity). Interacts with the C-termini of P-selectin, PTC, LDLR, VLDLR, LRP1 and LRP8. Interacts with KRIT1 (via N-terminus). Interacts with HRAS. Interacts with ITGB1 and ITGB5 (via NPxY motif) (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029617.

Structurei

3D structure databases

ProteinModelPortaliQ6AYS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 109109PXPROSITE-ProRule annotationAdd
BLAST
Domaini115 – 20692Ras-associatingPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni115 – 432318FERM-likeBy similarityAdd
BLAST
Regioni270 – 432163PTB-like F3 moduleBy similarityAdd
BLAST

Domaini

The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)). Required for association with endosomes (By similarity).By similarity
The PTB-like F3 module within the FERM-like domain mediates cargo recognition via their NPxY sequences, while the F1 module (Ras-associating) is responsible for interaction with membrane-bound HRAS.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation
Contains 1 Ras-associating domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3784. Eukaryota.
ENOG410XT9I. LUCA.
HOVERGENiHBG061207.
InParanoidiQ6AYS6.
KOiK17929.
PhylomeDBiQ6AYS6.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR000159. RA_dom.
IPR028666. SNX17.
[Graphical view]
PANTHERiPTHR12431:SF16. PTHR12431:SF16. 1 hit.
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS50200. RA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AYS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFSIPETES RSGDSGGSTY VAYNIHVNGV LHCRVRYSQL LGLHEQLRKE
60 70 80 90 100
YGANVLPAFP PKKLFSLTPA EVEQRREQLE KYMQAVRQDP LLGSSETFNS
110 120 130 140 150
FLRRAQQETQ QVPTEEVSLE VLLSDGQKVL VNVLTSDQTE DVLEAVAAKL
160 170 180 190 200
DLPDDLIGYF SLFLVREKED GAFSFVRKLQ EFELPYVSVT SLRSQEYKIV
210 220 230 240 250
LRKSYWDSAY DDDVMENRVG LNLLYAQTVS DIEHGWILVT KEQHRQLKSL
260 270 280 290 300
QEKVSKKEFL RLAQTLRHYG YLRFDACVAD FPEKDCPVVV SAGNSELSLQ
310 320 330 340 350
LRLPGQQLRE GSFRVTRMRC WRVTSSVPLP SGGTSTPSRG RGEVRLELAF
360 370 380 390 400
EYLMSKDRLQ WVTITSPQAI MMSICLQSMV DELMVKKSGG SIRKMLRRRV
410 420 430 440 450
GGNLRRSDSQ QAVKSPPLLE SPDASRESMV KLSSKLSAVS LRGIGSPSTD
460 470
ASASAVHGNF AFEGIGDEDL
Length:470
Mass (Da):52,882
Last modified:September 13, 2004 - v1
Checksum:iCB8CB7D8F89469D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078931 mRNA. Translation: AAH78931.1.
RefSeqiNP_001011981.1. NM_001011981.1.
UniGeneiRn.162846.

Genome annotation databases

GeneIDi298836.
KEGGirno:298836.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078931 mRNA. Translation: AAH78931.1.
RefSeqiNP_001011981.1. NM_001011981.1.
UniGeneiRn.162846.

3D structure databases

ProteinModelPortaliQ6AYS6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029617.

PTM databases

iPTMnetiQ6AYS6.
PhosphoSiteiQ6AYS6.

Proteomic databases

PaxDbiQ6AYS6.
PRIDEiQ6AYS6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi298836.
KEGGirno:298836.

Organism-specific databases

CTDi9784.
RGDi1306424. Snx17.

Phylogenomic databases

eggNOGiKOG3784. Eukaryota.
ENOG410XT9I. LUCA.
HOVERGENiHBG061207.
InParanoidiQ6AYS6.
KOiK17929.
PhylomeDBiQ6AYS6.

Miscellaneous databases

PROiQ6AYS6.

Gene expression databases

BgeeiENSRNOG00000026884.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR000159. RA_dom.
IPR028666. SNX17.
[Graphical view]
PANTHERiPTHR12431:SF16. PTHR12431:SF16. 1 hit.
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS50200. RA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX17_RAT
AccessioniPrimary (citable) accession number: Q6AYS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.