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Q6AYS4 (FUCO2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Plasma alpha-L-fucosidase

EC=3.2.1.51
Alternative name(s):
Alpha-L-fucoside fucohydrolase 2
Short name=Alpha-L-fucosidase 2
Gene names
Name:Fuca2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Catalytic activity

An alpha-L-fucoside + H2O = L-fucose + an alcohol.

Subunit structure

Homotetramer By similarity.

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the glycosyl hydrolase 29 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 459436Plasma alpha-L-fucosidase
PRO_0000010315

Sites

Site2861May be important for catalysis By similarity

Amino acid modifications

Glycosylation1631N-linked (GlcNAc...) Potential
Glycosylation2311N-linked (GlcNAc...) Potential
Glycosylation3691N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6AYS4 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: EB194E6F811D851B

FASTA45953,258
        10         20         30         40         50         60 
MRLGLLMFLP LLLLATRYRA VTALSYDPTW ESLDRRPLPA WFDQAKFGIF IHWGVFSVPS 

        70         80         90        100        110        120 
FGSEWFWWYW QKERRPKFVD FMDNNYPPGF KYEDFGVLFT AKYFNANQWA DLLQASGAKY 

       130        140        150        160        170        180 
VVLTSKHHEG FTLWGSAHSW NWNAVDEGPK RDIVKELEVA VRNRTDLHFG LYYSLFEWFH 

       190        200        210        220        230        240 
PLFLEDQSSA FQKQRFPVAK TLPELYELVT KYQPEVLWSD GDGGAPDHYW NSTDFLAWLY 

       250        260        270        280        290        300 
NESPVRDTVV TNDRWGAGSI CKHGGYYTCS DRYNPGHLLP HKWENCMTID KFSWGYRREA 

       310        320        330        340        350        360 
EIGDYLTIEE LVKQLVETVS CGGNLLMNIG PTLDGIIPVI FEERLRQMGT WLKVNGEAIY 

       370        380        390        400        410        420 
ETHTWRSQND TVTPDVWYTS KPEKKLVYAI FLKWPISGKL FLGQPIGSLG ETEVELLGHG 

       430        440        450 
RPLTWTSSKP SGIVVELPRL SVHQMPCKWG WTLALTNVT 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC078933 mRNA. Translation: AAH78933.1.
RefSeqNP_001004218.1. NM_001004218.1.
UniGeneRn.47769.

3D structure databases

ProteinModelPortalQ6AYS4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000020946.

Protein family/group databases

CAZyGH29. Glycoside Hydrolase Family 29.

Proteomic databases

PaxDbQ6AYS4.
PRIDEQ6AYS4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000020946; ENSRNOP00000020946; ENSRNOG00000015551.
GeneID292485.
KEGGrno:292485.
UCSCRGD:1303053. rat.

Organism-specific databases

CTD2519.
RGD1303053. Fuca2.

Phylogenomic databases

eggNOGCOG3669.
GeneTreeENSGT00440000035378.
HOGENOMHOG000029598.
HOVERGENHBG002155.
InParanoidQ6AYS4.
KOK01206.
OMAFFDGGRT.
OrthoDBEOG7DC249.
PhylomeDBQ6AYS4.
TreeFamTF313034.

Enzyme and pathway databases

BRENDA3.2.1.51. 5301.

Gene expression databases

GenevestigatorQ6AYS4.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR016286. FUC_metazoa-typ.
IPR028756. FUCA2.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR10030. PTHR10030. 1 hit.
PTHR10030:SF4. PTHR10030:SF4. 1 hit.
PfamPF01120. Alpha_L_fucos. 1 hit.
[Graphical view]
PIRSFPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSPR00741. GLHYDRLASE29.
SMARTSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio634198.
PROQ6AYS4.

Entry information

Entry nameFUCO2_RAT
AccessionPrimary (citable) accession number: Q6AYS4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries