Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Plasma alpha-L-fucosidase

Gene

Fuca2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei286May be important for catalysisPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.51. 5301.
ReactomeiR-RNO-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-RNO-6798695. Neutrophil degranulation.
R-RNO-8957275. Post-translational protein phosphorylation.

Protein family/group databases

CAZyiGH29. Glycoside Hydrolase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucoside fucohydrolase 2
Short name:
Alpha-L-fucosidase 2
Gene namesi
Name:Fuca2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1303053. Fuca2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001031524 – 459Plasma alpha-L-fucosidaseAdd BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi231N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei293PhosphoserineBy similarity1
Glycosylationi369N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6AYS4.
PRIDEiQ6AYS4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015551.
GenevisibleiQ6AYS4. RN.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020946.

Structurei

3D structure databases

ProteinModelPortaliQ6AYS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 29 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3340. Eukaryota.
COG3669. LUCA.
GeneTreeiENSGT00440000035378.
HOGENOMiHOG000029598.
HOVERGENiHBG002155.
InParanoidiQ6AYS4.
KOiK01206.
OMAiAHWGPQC.
OrthoDBiEOG091G085V.
PhylomeDBiQ6AYS4.
TreeFamiTF313034.

Family and domain databases

InterProiView protein in InterPro
IPR016286. FUC_metazoa-typ.
IPR031919. Fucosidase_C.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR017853. Glycoside_hydrolase_SF.
PANTHERiPTHR10030. PTHR10030. 1 hit.
PfamiView protein in Pfam
PF01120. Alpha_L_fucos. 1 hit.
PF16757. Fucosidase_C. 1 hit.
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiView protein in SMART
SM00812. Alpha_L_fucos. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiView protein in PROSITE
PS00385. ALPHA_L_FUCOSIDASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AYS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLGLLMFLP LLLLATRYRA VTALSYDPTW ESLDRRPLPA WFDQAKFGIF
60 70 80 90 100
IHWGVFSVPS FGSEWFWWYW QKERRPKFVD FMDNNYPPGF KYEDFGVLFT
110 120 130 140 150
AKYFNANQWA DLLQASGAKY VVLTSKHHEG FTLWGSAHSW NWNAVDEGPK
160 170 180 190 200
RDIVKELEVA VRNRTDLHFG LYYSLFEWFH PLFLEDQSSA FQKQRFPVAK
210 220 230 240 250
TLPELYELVT KYQPEVLWSD GDGGAPDHYW NSTDFLAWLY NESPVRDTVV
260 270 280 290 300
TNDRWGAGSI CKHGGYYTCS DRYNPGHLLP HKWENCMTID KFSWGYRREA
310 320 330 340 350
EIGDYLTIEE LVKQLVETVS CGGNLLMNIG PTLDGIIPVI FEERLRQMGT
360 370 380 390 400
WLKVNGEAIY ETHTWRSQND TVTPDVWYTS KPEKKLVYAI FLKWPISGKL
410 420 430 440 450
FLGQPIGSLG ETEVELLGHG RPLTWTSSKP SGIVVELPRL SVHQMPCKWG

WTLALTNVT
Length:459
Mass (Da):53,258
Last modified:September 13, 2004 - v1
Checksum:iEB194E6F811D851B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078933 mRNA. Translation: AAH78933.1.
RefSeqiNP_001004218.1. NM_001004218.1.
UniGeneiRn.47769.

Genome annotation databases

EnsembliENSRNOT00000020946; ENSRNOP00000020946; ENSRNOG00000015551.
GeneIDi292485.
KEGGirno:292485.
UCSCiRGD:1303053. rat.

Similar proteinsi

Entry informationi

Entry nameiFUCO2_RAT
AccessioniPrimary (citable) accession number: Q6AYS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: September 13, 2004
Last modified: November 22, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families