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Q6AYS4

- FUCO2_RAT

UniProt

Q6AYS4 - FUCO2_RAT

Protein

Plasma alpha-L-fucosidase

Gene

Fuca2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

    Catalytic activityi

    An alpha-L-fucoside + H2O = L-fucose + an alcohol.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei286 – 2861May be important for catalysisPROSITE-ProRule annotation

    GO - Molecular functioni

    1. alpha-L-fucosidase activity Source: RGD
    2. fucose binding Source: RefGenome

    GO - Biological processi

    1. carbohydrate metabolic process Source: RGD
    2. fucose metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BRENDAi3.2.1.51. 5301.

    Protein family/group databases

    CAZyiGH29. Glycoside Hydrolase Family 29.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plasma alpha-L-fucosidase (EC:3.2.1.51)
    Alternative name(s):
    Alpha-L-fucoside fucohydrolase 2
    Short name:
    Alpha-L-fucosidase 2
    Gene namesi
    Name:Fuca2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi1303053. Fuca2.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. lysosome Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 459436Plasma alpha-L-fucosidasePRO_0000010315Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi369 – 3691N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ6AYS4.
    PRIDEiQ6AYS4.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6AYS4.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000020946.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AYS4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 29 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3669.
    GeneTreeiENSGT00440000035378.
    HOGENOMiHOG000029598.
    HOVERGENiHBG002155.
    InParanoidiQ6AYS4.
    KOiK01206.
    OMAiNTSAKNH.
    OrthoDBiEOG7DC249.
    PhylomeDBiQ6AYS4.
    TreeFamiTF313034.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR016286. FUC_metazoa-typ.
    IPR028756. FUCA2.
    IPR000933. Glyco_hydro_29.
    IPR018526. Glyco_hydro_29_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10030. PTHR10030. 1 hit.
    PTHR10030:SF24. PTHR10030:SF24. 1 hit.
    PfamiPF01120. Alpha_L_fucos. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
    PRINTSiPR00741. GLHYDRLASE29.
    SMARTiSM00812. Alpha_L_fucos. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6AYS4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLGLLMFLP LLLLATRYRA VTALSYDPTW ESLDRRPLPA WFDQAKFGIF    50
    IHWGVFSVPS FGSEWFWWYW QKERRPKFVD FMDNNYPPGF KYEDFGVLFT 100
    AKYFNANQWA DLLQASGAKY VVLTSKHHEG FTLWGSAHSW NWNAVDEGPK 150
    RDIVKELEVA VRNRTDLHFG LYYSLFEWFH PLFLEDQSSA FQKQRFPVAK 200
    TLPELYELVT KYQPEVLWSD GDGGAPDHYW NSTDFLAWLY NESPVRDTVV 250
    TNDRWGAGSI CKHGGYYTCS DRYNPGHLLP HKWENCMTID KFSWGYRREA 300
    EIGDYLTIEE LVKQLVETVS CGGNLLMNIG PTLDGIIPVI FEERLRQMGT 350
    WLKVNGEAIY ETHTWRSQND TVTPDVWYTS KPEKKLVYAI FLKWPISGKL 400
    FLGQPIGSLG ETEVELLGHG RPLTWTSSKP SGIVVELPRL SVHQMPCKWG 450
    WTLALTNVT 459
    Length:459
    Mass (Da):53,258
    Last modified:September 13, 2004 - v1
    Checksum:iEB194E6F811D851B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC078933 mRNA. Translation: AAH78933.1.
    RefSeqiNP_001004218.1. NM_001004218.1.
    UniGeneiRn.47769.

    Genome annotation databases

    EnsembliENSRNOT00000020946; ENSRNOP00000020946; ENSRNOG00000015551.
    GeneIDi292485.
    KEGGirno:292485.
    UCSCiRGD:1303053. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC078933 mRNA. Translation: AAH78933.1 .
    RefSeqi NP_001004218.1. NM_001004218.1.
    UniGenei Rn.47769.

    3D structure databases

    ProteinModelPortali Q6AYS4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000020946.

    Protein family/group databases

    CAZyi GH29. Glycoside Hydrolase Family 29.

    Proteomic databases

    PaxDbi Q6AYS4.
    PRIDEi Q6AYS4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000020946 ; ENSRNOP00000020946 ; ENSRNOG00000015551 .
    GeneIDi 292485.
    KEGGi rno:292485.
    UCSCi RGD:1303053. rat.

    Organism-specific databases

    CTDi 2519.
    RGDi 1303053. Fuca2.

    Phylogenomic databases

    eggNOGi COG3669.
    GeneTreei ENSGT00440000035378.
    HOGENOMi HOG000029598.
    HOVERGENi HBG002155.
    InParanoidi Q6AYS4.
    KOi K01206.
    OMAi NTSAKNH.
    OrthoDBi EOG7DC249.
    PhylomeDBi Q6AYS4.
    TreeFami TF313034.

    Enzyme and pathway databases

    BRENDAi 3.2.1.51. 5301.

    Miscellaneous databases

    NextBioi 634198.
    PROi Q6AYS4.

    Gene expression databases

    Genevestigatori Q6AYS4.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR016286. FUC_metazoa-typ.
    IPR028756. FUCA2.
    IPR000933. Glyco_hydro_29.
    IPR018526. Glyco_hydro_29_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10030. PTHR10030. 1 hit.
    PTHR10030:SF24. PTHR10030:SF24. 1 hit.
    Pfami PF01120. Alpha_L_fucos. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001092. Alpha-L-fucosidase. 1 hit.
    PRINTSi PR00741. GLHYDRLASE29.
    SMARTi SM00812. Alpha_L_fucos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00385. ALPHA_L_FUCOSIDASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiFUCO2_RAT
    AccessioniPrimary (citable) accession number: Q6AYS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3