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Q6AYS4

- FUCO2_RAT

UniProt

Q6AYS4 - FUCO2_RAT

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Protein
Plasma alpha-L-fucosidase
Gene
Fuca2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei286 – 2861May be important for catalysis By similarity

GO - Molecular functioni

  1. alpha-L-fucosidase activity Source: RGD
  2. fucose binding Source: RefGenome

GO - Biological processi

  1. carbohydrate metabolic process Source: RGD
  2. fucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.51. 5301.

Protein family/group databases

CAZyiGH29. Glycoside Hydrolase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucoside fucohydrolase 2
Short name:
Alpha-L-fucosidase 2
Gene namesi
Name:Fuca2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi1303053. Fuca2.

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. lysosome Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 459436Plasma alpha-L-fucosidase
PRO_0000010315Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi163 – 1631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi231 – 2311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi369 – 3691N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6AYS4.
PRIDEiQ6AYS4.

Expressioni

Gene expression databases

GenevestigatoriQ6AYS4.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020946.

Structurei

3D structure databases

ProteinModelPortaliQ6AYS4.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3669.
GeneTreeiENSGT00440000035378.
HOGENOMiHOG000029598.
HOVERGENiHBG002155.
InParanoidiQ6AYS4.
KOiK01206.
OMAiNTSAKNH.
OrthoDBiEOG7DC249.
PhylomeDBiQ6AYS4.
TreeFamiTF313034.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR016286. FUC_metazoa-typ.
IPR028756. FUCA2.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10030. PTHR10030. 1 hit.
PTHR10030:SF24. PTHR10030:SF24. 1 hit.
PfamiPF01120. Alpha_L_fucos. 1 hit.
[Graphical view]
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AYS4-1 [UniParc]FASTAAdd to Basket

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MRLGLLMFLP LLLLATRYRA VTALSYDPTW ESLDRRPLPA WFDQAKFGIF    50
IHWGVFSVPS FGSEWFWWYW QKERRPKFVD FMDNNYPPGF KYEDFGVLFT 100
AKYFNANQWA DLLQASGAKY VVLTSKHHEG FTLWGSAHSW NWNAVDEGPK 150
RDIVKELEVA VRNRTDLHFG LYYSLFEWFH PLFLEDQSSA FQKQRFPVAK 200
TLPELYELVT KYQPEVLWSD GDGGAPDHYW NSTDFLAWLY NESPVRDTVV 250
TNDRWGAGSI CKHGGYYTCS DRYNPGHLLP HKWENCMTID KFSWGYRREA 300
EIGDYLTIEE LVKQLVETVS CGGNLLMNIG PTLDGIIPVI FEERLRQMGT 350
WLKVNGEAIY ETHTWRSQND TVTPDVWYTS KPEKKLVYAI FLKWPISGKL 400
FLGQPIGSLG ETEVELLGHG RPLTWTSSKP SGIVVELPRL SVHQMPCKWG 450
WTLALTNVT 459
Length:459
Mass (Da):53,258
Last modified:September 13, 2004 - v1
Checksum:iEB194E6F811D851B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC078933 mRNA. Translation: AAH78933.1.
RefSeqiNP_001004218.1. NM_001004218.1.
UniGeneiRn.47769.

Genome annotation databases

EnsembliENSRNOT00000020946; ENSRNOP00000020946; ENSRNOG00000015551.
GeneIDi292485.
KEGGirno:292485.
UCSCiRGD:1303053. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC078933 mRNA. Translation: AAH78933.1 .
RefSeqi NP_001004218.1. NM_001004218.1.
UniGenei Rn.47769.

3D structure databases

ProteinModelPortali Q6AYS4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000020946.

Protein family/group databases

CAZyi GH29. Glycoside Hydrolase Family 29.

Proteomic databases

PaxDbi Q6AYS4.
PRIDEi Q6AYS4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000020946 ; ENSRNOP00000020946 ; ENSRNOG00000015551 .
GeneIDi 292485.
KEGGi rno:292485.
UCSCi RGD:1303053. rat.

Organism-specific databases

CTDi 2519.
RGDi 1303053. Fuca2.

Phylogenomic databases

eggNOGi COG3669.
GeneTreei ENSGT00440000035378.
HOGENOMi HOG000029598.
HOVERGENi HBG002155.
InParanoidi Q6AYS4.
KOi K01206.
OMAi NTSAKNH.
OrthoDBi EOG7DC249.
PhylomeDBi Q6AYS4.
TreeFami TF313034.

Enzyme and pathway databases

BRENDAi 3.2.1.51. 5301.

Miscellaneous databases

NextBioi 634198.
PROi Q6AYS4.

Gene expression databases

Genevestigatori Q6AYS4.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR016286. FUC_metazoa-typ.
IPR028756. FUCA2.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10030. PTHR10030. 1 hit.
PTHR10030:SF24. PTHR10030:SF24. 1 hit.
Pfami PF01120. Alpha_L_fucos. 1 hit.
[Graphical view ]
PIRSFi PIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSi PR00741. GLHYDRLASE29.
SMARTi SM00812. Alpha_L_fucos. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiFUCO2_RAT
AccessioniPrimary (citable) accession number: Q6AYS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: September 13, 2004
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi