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Protein

Torsin-2A

Gene

Tor2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi93 – 100ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Torsin-2A
Alternative name(s):
Torsin family 2 member A
Gene namesi
Name:Tor2a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1359111 Tor2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000022883128 – 321Torsin-2AAdd BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6AYR4
PRIDEiQ6AYR4

Expressioni

Gene expression databases

BgeeiENSRNOG00000022514
ExpressionAtlasiQ6AYR4 baseline and differential
GenevisibleiQ6AYR4 RN

Interactioni

Subunit structurei

Homohexamer. Interacts with TOR1AIP1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030747

Structurei

3D structure databases

ProteinModelPortaliQ6AYR4
SMRiQ6AYR4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpA/ClpB family. Torsin subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2170 Eukaryota
ENOG410XR06 LUCA
GeneTreeiENSGT00390000001920
HOGENOMiHOG000115770
HOVERGENiHBG054188
InParanoidiQ6AYR4
OMAiFVQDPAP
OrthoDBiEOG091G0B5F
TreeFamiTF314941

Family and domain databases

InterProiView protein in InterPro
IPR001270 ClpA/B
IPR027417 P-loop_NTPase
IPR010448 Torsin
IPR017378 Torsin_1/2
PANTHERiPTHR10760 PTHR10760, 1 hit
PfamiView protein in Pfam
PF06309 Torsin, 1 hit
PIRSFiPIRSF038079 Torsin_2A, 1 hit
PRINTSiPR00300 CLPPROTEASEA
SUPFAMiSSF52540 SSF52540, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6AYR4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVARHGCPP WGSILGLLVL ALAAAAAWDV SFLRCSLGSF CECDFWPDLP
60 70 80 90 100
GLECDLARHL AGQHLAKALV VKSLKAFVQD PAPSKPLVLS LHGWTGTGKS
110 120 130 140 150
YVSSLLAQYL FRGGLRSPHV HHFSPIIHFP HPSHTEQYKN ELKSWVQGNL
160 170 180 190 200
TACGRSLFLF DEMDKLPPGL MEVLKPFLGP SWVVYGTNYR KAIFIFISNT
210 220 230 240 250
GGEQINQVAL EAWRSRRDRE EISLQEVEPA VSQAVLDNPH HGFWRSGIME
260 270 280 290 300
EQLLDAVVPF LPLQRHHVRH CVLNELAQLG LEPREEVVQA VLDSTTYFPE
310 320
EEQLFSSNGC KTVASRITFF L
Length:321
Mass (Da):35,871
Last modified:September 13, 2004 - v1
Checksum:i9598BCEF271CE3EB
GO
Isoform 2 (identifier: P0C7W2-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0C7W2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Salusin-beta peptide is derived from isoform 2.
Length:231
Mass (Da):25,127
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078943 mRNA Translation: AAH78943.1
RefSeqiNP_001007745.1, NM_001007744.1 [Q6AYR4-1]
UniGeneiRn.13187

Genome annotation databases

EnsembliENSRNOT00000030694; ENSRNOP00000030747; ENSRNOG00000022514 [Q6AYR4-1]
GeneIDi362112
KEGGirno:362112

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTOR2A_RAT
AccessioniPrimary (citable) accession number: Q6AYR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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