Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Torsin-2A

Gene

Tor2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi93 – 1008ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Torsin-2A
Alternative name(s):
Torsin family 2 member A
Gene namesi
Name:Tor2a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1359111. Tor2a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 321294Torsin-2APRO_0000228831Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6AYR4.
PRIDEiQ6AYR4.

Expressioni

Gene expression databases

ExpressionAtlasiQ6AYR4. baseline and differential.
GenevisibleiQ6AYR4. RN.

Interactioni

Subunit structurei

Homohexamer. Interacts with TOR1AIP1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030747.

Structurei

3D structure databases

ProteinModelPortaliQ6AYR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpA/ClpB family. Torsin subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2170. Eukaryota.
ENOG410XR06. LUCA.
GeneTreeiENSGT00390000001920.
HOGENOMiHOG000115770.
HOVERGENiHBG054188.
InParanoidiQ6AYR4.
OMAiFSPIVHF.
OrthoDBiEOG7TF791.
TreeFamiTF314941.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001270. ClpA/B.
IPR027417. P-loop_NTPase.
IPR010448. Torsin.
IPR017378. Torsin_1/2.
[Graphical view]
PANTHERiPTHR10760. PTHR10760. 1 hit.
PfamiPF06309. Torsin. 1 hit.
[Graphical view]
PIRSFiPIRSF038079. Torsin_2A. 1 hit.
PRINTSiPR00300. CLPPROTEASEA.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6AYR4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVARHGCPP WGSILGLLVL ALAAAAAWDV SFLRCSLGSF CECDFWPDLP
60 70 80 90 100
GLECDLARHL AGQHLAKALV VKSLKAFVQD PAPSKPLVLS LHGWTGTGKS
110 120 130 140 150
YVSSLLAQYL FRGGLRSPHV HHFSPIIHFP HPSHTEQYKN ELKSWVQGNL
160 170 180 190 200
TACGRSLFLF DEMDKLPPGL MEVLKPFLGP SWVVYGTNYR KAIFIFISNT
210 220 230 240 250
GGEQINQVAL EAWRSRRDRE EISLQEVEPA VSQAVLDNPH HGFWRSGIME
260 270 280 290 300
EQLLDAVVPF LPLQRHHVRH CVLNELAQLG LEPREEVVQA VLDSTTYFPE
310 320
EEQLFSSNGC KTVASRITFF L
Length:321
Mass (Da):35,871
Last modified:September 13, 2004 - v1
Checksum:i9598BCEF271CE3EB
GO
Isoform 2 (identifier: P0C7W2-1) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry P0C7W2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Salusin-beta peptide is derived from isoform 2.
Length:231
Mass (Da):25,127
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078943 mRNA. Translation: AAH78943.1.
RefSeqiNP_001007745.1. NM_001007744.1. [Q6AYR4-1]
UniGeneiRn.13187.

Genome annotation databases

EnsembliENSRNOT00000030694; ENSRNOP00000030747; ENSRNOG00000022514. [Q6AYR4-1]
GeneIDi362112.
KEGGirno:362112.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078943 mRNA. Translation: AAH78943.1.
RefSeqiNP_001007745.1. NM_001007744.1. [Q6AYR4-1]
UniGeneiRn.13187.

3D structure databases

ProteinModelPortaliQ6AYR4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030747.

Proteomic databases

PaxDbiQ6AYR4.
PRIDEiQ6AYR4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000030694; ENSRNOP00000030747; ENSRNOG00000022514. [Q6AYR4-1]
GeneIDi362112.
KEGGirno:362112.

Organism-specific databases

CTDi27433.
RGDi1359111. Tor2a.

Phylogenomic databases

eggNOGiKOG2170. Eukaryota.
ENOG410XR06. LUCA.
GeneTreeiENSGT00390000001920.
HOGENOMiHOG000115770.
HOVERGENiHBG054188.
InParanoidiQ6AYR4.
OMAiFSPIVHF.
OrthoDBiEOG7TF791.
TreeFamiTF314941.

Miscellaneous databases

NextBioi678697.

Gene expression databases

ExpressionAtlasiQ6AYR4. baseline and differential.
GenevisibleiQ6AYR4. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001270. ClpA/B.
IPR027417. P-loop_NTPase.
IPR010448. Torsin.
IPR017378. Torsin_1/2.
[Graphical view]
PANTHERiPTHR10760. PTHR10760. 1 hit.
PfamiPF06309. Torsin. 1 hit.
[Graphical view]
PIRSFiPIRSF038079. Torsin_2A. 1 hit.
PRINTSiPR00300. CLPPROTEASEA.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiTOR2A_RAT
AccessioniPrimary (citable) accession number: Q6AYR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: September 13, 2004
Last modified: May 11, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.