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Protein

Acylpyruvase FAHD1, mitochondrial

Gene

Fahd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro. Also has oxaloacetate decarboxylase activity.By similarity

Catalytic activityi

A 3-acylpyruvate + H2O = a carboxylate + pyruvate.
Oxaloacetate = pyruvate + CO2.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi68 – 681Divalent metal cationBy similarity
Metal bindingi70 – 701Divalent metal cationBy similarity
Metal bindingi99 – 991Divalent metal cationBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Lyase

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-2737-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acylpyruvase FAHD1, mitochondrial (EC:3.7.1.5)
Alternative name(s):
Fumarylacetoacetate hydrolase domain-containing protein 1
Oxaloacetate decarboxylaseBy similarity (EC:4.1.1.3By similarity)
Short name:
OAA decarboxylaseBy similarity
Gene namesi
Name:Fahd1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1304560. Fahd1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424MitochondrionSequence analysisAdd
BLAST
Chaini25 – 221197Acylpyruvase FAHD1, mitochondrialPRO_0000156832Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371PhosphoserineCombined sources
Modified residuei110 – 1101N6-acetyllysineBy similarity
Modified residuei112 – 1121N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6AYQ8.
PRIDEiQ6AYQ8.

PTM databases

iPTMnetiQ6AYQ8.
PhosphoSiteiQ6AYQ8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014727.
GenevisibleiQ6AYQ8. RN.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

MINTiMINT-4573929.
STRINGi10116.ENSRNOP00000019767.

Structurei

3D structure databases

ProteinModelPortaliQ6AYQ8.
SMRiQ6AYQ8. Positions 3-221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAH family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1535. Eukaryota.
COG0179. LUCA.
GeneTreeiENSGT00530000063832.
HOGENOMiHOG000063753.
HOVERGENiHBG057495.
InParanoidiQ6AYQ8.
KOiK01557.
OMAiVVSMRFK.
OrthoDBiEOG091G0I6G.
PhylomeDBiQ6AYQ8.

Family and domain databases

Gene3Di3.90.850.10. 1 hit.
InterProiIPR011234. Fumarylacetoacetase_C-rel.
[Graphical view]
PfamiPF01557. FAA_hydrolase. 1 hit.
[Graphical view]
SUPFAMiSSF56529. SSF56529. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AYQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTKPLSRF WEWGKNIVCV GRNYADHVKE MRSTVLSEPV LFLKPSTAYA
60 70 80 90 100
PEGSPVLMPA YCRNLHHEVE LGVLLGRRGE AVPEAAAMDY VAGYALCLDM
110 120 130 140 150
TARDVQDECK KKGLPWTLAK SFTSSCPVSA FVPKEKIPDP HALRLWLKVN
160 170 180 190 200
GELRQEGKTS SMIFSIPYII SYVSKIITLE EGDLILTGTP KGVGAVKEND
210 220
EIEAGIDGVV SMRFKVERSK Y
Length:221
Mass (Da):24,480
Last modified:September 13, 2004 - v1
Checksum:i1CFBC9984C611D09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078950 mRNA. Translation: AAH78950.1.
RefSeqiNP_001020162.1. NM_001024991.1.
UniGeneiRn.3918.

Genome annotation databases

EnsembliENSRNOT00000019767; ENSRNOP00000019767; ENSRNOG00000014727.
GeneIDi302980.
KEGGirno:302980.
UCSCiRGD:1304560. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078950 mRNA. Translation: AAH78950.1.
RefSeqiNP_001020162.1. NM_001024991.1.
UniGeneiRn.3918.

3D structure databases

ProteinModelPortaliQ6AYQ8.
SMRiQ6AYQ8. Positions 3-221.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4573929.
STRINGi10116.ENSRNOP00000019767.

PTM databases

iPTMnetiQ6AYQ8.
PhosphoSiteiQ6AYQ8.

Proteomic databases

PaxDbiQ6AYQ8.
PRIDEiQ6AYQ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019767; ENSRNOP00000019767; ENSRNOG00000014727.
GeneIDi302980.
KEGGirno:302980.
UCSCiRGD:1304560. rat.

Organism-specific databases

CTDi81889.
RGDi1304560. Fahd1.

Phylogenomic databases

eggNOGiKOG1535. Eukaryota.
COG0179. LUCA.
GeneTreeiENSGT00530000063832.
HOGENOMiHOG000063753.
HOVERGENiHBG057495.
InParanoidiQ6AYQ8.
KOiK01557.
OMAiVVSMRFK.
OrthoDBiEOG091G0I6G.
PhylomeDBiQ6AYQ8.

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-2737-MONOMER.

Miscellaneous databases

PROiQ6AYQ8.

Gene expression databases

BgeeiENSRNOG00000014727.
GenevisibleiQ6AYQ8. RN.

Family and domain databases

Gene3Di3.90.850.10. 1 hit.
InterProiIPR011234. Fumarylacetoacetase_C-rel.
[Graphical view]
PfamiPF01557. FAA_hydrolase. 1 hit.
[Graphical view]
SUPFAMiSSF56529. SSF56529. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFAHD1_RAT
AccessioniPrimary (citable) accession number: Q6AYQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.