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Protein

Acylpyruvase FAHD1, mitochondrial

Gene

Fahd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro. Also has oxaloacetate decarboxylase activity.By similarity

Catalytic activityi

A 3-acylpyruvate + H2O = a carboxylate + pyruvate.
Oxaloacetate = pyruvate + CO2.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi68Divalent metal cationBy similarity1
Metal bindingi70Divalent metal cationBy similarity1
Metal bindingi99Divalent metal cationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Lyase
LigandCalcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-71403 Citric acid cycle (TCA cycle)

Names & Taxonomyi

Protein namesi
Recommended name:
Acylpyruvase FAHD1, mitochondrial (EC:3.7.1.5)
Alternative name(s):
Fumarylacetoacetate hydrolase domain-containing protein 1
Oxaloacetate decarboxylaseBy similarity (EC:4.1.1.3By similarity)
Short name:
OAA decarboxylaseBy similarity
Gene namesi
Name:Fahd1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi1304560 Fahd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24MitochondrionSequence analysisAdd BLAST24
ChainiPRO_000015683225 – 221Acylpyruvase FAHD1, mitochondrialAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphoserineCombined sources1
Modified residuei110N6-acetyllysineBy similarity1
Modified residuei112N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6AYQ8
PRIDEiQ6AYQ8

PTM databases

iPTMnetiQ6AYQ8
PhosphoSitePlusiQ6AYQ8

Expressioni

Gene expression databases

BgeeiENSRNOG00000014727
GenevisibleiQ6AYQ8 RN

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019767

Structurei

3D structure databases

ProteinModelPortaliQ6AYQ8
SMRiQ6AYQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAH family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1535 Eukaryota
COG0179 LUCA
GeneTreeiENSGT00530000063832
HOGENOMiHOG000063753
HOVERGENiHBG057495
InParanoidiQ6AYQ8
KOiK01557
OMAiSRFWEWG
OrthoDBiEOG091G0I6G
PhylomeDBiQ6AYQ8

Family and domain databases

Gene3Di3.90.850.10, 1 hit
InterProiView protein in InterPro
IPR011234 Fumarylacetoacetase-like_C
IPR036663 Fumarylacetoacetase_C_sf
PfamiView protein in Pfam
PF01557 FAA_hydrolase, 1 hit
SUPFAMiSSF56529 SSF56529, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AYQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTKPLSRF WEWGKNIVCV GRNYADHVKE MRSTVLSEPV LFLKPSTAYA
60 70 80 90 100
PEGSPVLMPA YCRNLHHEVE LGVLLGRRGE AVPEAAAMDY VAGYALCLDM
110 120 130 140 150
TARDVQDECK KKGLPWTLAK SFTSSCPVSA FVPKEKIPDP HALRLWLKVN
160 170 180 190 200
GELRQEGKTS SMIFSIPYII SYVSKIITLE EGDLILTGTP KGVGAVKEND
210 220
EIEAGIDGVV SMRFKVERSK Y
Length:221
Mass (Da):24,480
Last modified:September 13, 2004 - v1
Checksum:i1CFBC9984C611D09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078950 mRNA Translation: AAH78950.1
RefSeqiNP_001020162.1, NM_001024991.1
UniGeneiRn.3918

Genome annotation databases

EnsembliENSRNOT00000019767; ENSRNOP00000019767; ENSRNOG00000014727
GeneIDi302980
KEGGirno:302980
UCSCiRGD:1304560 rat

Similar proteinsi

Entry informationi

Entry nameiFAHD1_RAT
AccessioniPrimary (citable) accession number: Q6AYQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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