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Protein

Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial

Gene

Mmadhc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-196741. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial
Gene namesi
Name:Mmadhc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1303272. Mmadhc.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3838MitochondrionSequence analysisAdd
BLAST
Chaini39 – 296258Methylmalonic aciduria and homocystinuria type D homolog, mitochondrialPRO_0000019536Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei203 – 2031N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6AYQ6.
PRIDEiQ6AYQ6.

Expressioni

Gene expression databases

ExpressionAtlasiQ6AYQ6. baseline and differential.
GenevisibleiQ6AYQ6. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058814.

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3994. Eukaryota.
ENOG410XRBP. LUCA.
GeneTreeiENSGT00390000015050.
HOGENOMiHOG000231797.
InParanoidiQ6AYQ6.
OMAiQKKSQVH.
OrthoDBiEOG7RBZ9D.
PhylomeDBiQ6AYQ6.
TreeFamiTF314208.

Family and domain databases

InterProiIPR019362. MMADHC.
[Graphical view]
PANTHERiPTHR13192. PTHR13192. 1 hit.
PfamiPF10229. DUF2246. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AYQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHVLCNRAR LVSYLPGFCS LVKRVINPRA FSTAGSSGSD ESHVATAPPD
60 70 80 90 100
ICSRTVWPDE TMGPFGPQDQ RFQLPGNIGF DCHLNGTASQ KKSQAHKTLP
110 120 130 140 150
DVLAEPLSTE RHEFVMAQYV NEFQDSNAPV EQEISSAETY FESARVECAI
160 170 180 190 200
QTCPELLRRD FESLFPEVAN SKLMILTVTQ KTEHDMTVWS EEVEVEREAL
210 220 230 240 250
LEKFINGAKE ICYALRAEGY WADFIDPSSG LAFFGPYTNN TLFETDERYR
260 270 280 290
HLGFSVDDLG CCKVIRHGLW GTHVVVGSIF TNATADSHIM RKLSGD
Length:296
Mass (Da):33,052
Last modified:September 13, 2004 - v1
Checksum:i18908A12413E842C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078953 mRNA. Translation: AAH78953.1.
RefSeqiNP_001004280.1. NM_001004280.1.
UniGeneiRn.3269.

Genome annotation databases

EnsembliENSRNOT00000066058; ENSRNOP00000058814; ENSRNOG00000004740.
GeneIDi362134.
KEGGirno:362134.
UCSCiRGD:1303272. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078953 mRNA. Translation: AAH78953.1.
RefSeqiNP_001004280.1. NM_001004280.1.
UniGeneiRn.3269.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058814.

Proteomic databases

PaxDbiQ6AYQ6.
PRIDEiQ6AYQ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000066058; ENSRNOP00000058814; ENSRNOG00000004740.
GeneIDi362134.
KEGGirno:362134.
UCSCiRGD:1303272. rat.

Organism-specific databases

CTDi27249.
RGDi1303272. Mmadhc.

Phylogenomic databases

eggNOGiKOG3994. Eukaryota.
ENOG410XRBP. LUCA.
GeneTreeiENSGT00390000015050.
HOGENOMiHOG000231797.
InParanoidiQ6AYQ6.
OMAiQKKSQVH.
OrthoDBiEOG7RBZ9D.
PhylomeDBiQ6AYQ6.
TreeFamiTF314208.

Enzyme and pathway databases

ReactomeiR-RNO-196741. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Miscellaneous databases

NextBioi678774.
PROiQ6AYQ6.

Gene expression databases

ExpressionAtlasiQ6AYQ6. baseline and differential.
GenevisibleiQ6AYQ6. RN.

Family and domain databases

InterProiIPR019362. MMADHC.
[Graphical view]
PANTHERiPTHR13192. PTHR13192. 1 hit.
PfamiPF10229. DUF2246. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiMMAD_RAT
AccessioniPrimary (citable) accession number: Q6AYQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: September 13, 2004
Last modified: February 17, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.