Q6AYP7 (5NT3L_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytosolic 5'-nucleotidase III-like protein
Short name=cN-III-like protein
EC=3.1.3.5

Gene names

Name:

Nt5c3l

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Can act both as nucleotidase and as phosphotransferase By similarity.
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the pyrimidine 5'-nucleotidase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase Transferase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nucleotide metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 292	292	Cytosolic 5'-nucleotidase III-like protein		PRO_0000328950
Regions
	Region	148 – 149	2	Substrate binding By similarity
Sites
	Active site	33	1	Nucleophile By similarity
	Active site	35	1	Proton donor By similarity
	Metal binding	33	1	Magnesium By similarity
	Metal binding	35	1	Magnesium; via carbonyl oxygen By similarity
	Metal binding	222	1	Magnesium By similarity
	Binding site	197	1	Substrate By similarity
Amino acid modifications
	Modified residue	248	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6AYP7 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: DB47241AC0BD002D	FASTA	292	33,689
	10 20 30 40 50 60 MKATVLMRQP GRVQEIVSAL RRGGGDRLQV ISDFDMTLSR FAYNGQRCPS SHNILDNSKI 70 80 90 100 110 120 ISEDCRKELT ELFHHYYPIE IDPHRTIKEK LPHMVQWWSK AHSLLCQQRI QKFQIAQVVG 130 140 150 160 170 180 ESTAMLREGY KMFFDTLYHN NIPLFIFSAG IGDILEEIIR QMKVFHPNIH IVSNYMDFSE 190 200 210 220 230 240 DGFLKGFKGQ LIHTYNKNSS VCENSSYFQQ LRNKTNIILL GDSIGDLTMA DGVPGVQNIL 250 260 270 280 290 KIGFLNDKVE ERRERYMDSY DIVLEKDETL DVVNGLLQHI LRQGDCVELQ GS

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC078963 mRNA. Translation: AAH78963.1.
IPI	IPI00372926.
RefSeq	NP_001007724.2. NM_001007723.2.
UniGene	Rn.24114.
3D structure databases
HSSP	HSSP built from PDB template 2CN1 based on UniProtKB Q9UC45.
ProteinModelPortal	Q6AYP7.
SMR	Q6AYP7. Positions 1-281.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	360629.
KEGG	rno:360629.
NMPDR	fig|10116.3.peg.6126.
UCSC	NM_001007723. rat.
Organism-specific databases
CTD	115024.
RGD	1359229. Nt5c3l.
Phylogenomic databases
eggNOG	roNOG04237.
GeneTree	ENSGT00390000012959.
HOVERGEN	HBG059750.
InParanoid	Q6AYP7.
OrthoDB	EOG4JWVDW.
PhylomeDB	Q6AYP7.
Gene expression databases
ArrayExpress	Q6AYP7.
Genevestigator	Q6AYP7.
Family and domain databases
InterPro	IPR023214. HAD-like_dom. IPR006434. Pyrimidine_nucleotidase_eu. [Graphical view]
Gene3D	G3DSA:3.40.50.1000. HAD-like_dom. 1 hit.
PANTHER	PTHR13045. HAD-SF_hydro_IE. 1 hit.
Pfam	PF05822. UMPH-1. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01544. HAD-SF-IE. 1 hit.
ProtoNet	Search...
Other
NextBio	673518.

Entry information

Entry name

5NT3L_RAT

Accession

Primary (citable) accession number: Q6AYP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	September 13, 2004
Last modified:	September 21, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program