Reviewed, UniProtKB/Swiss-Prot Q6AYP0 (ALLC_RAT)

Names and origin

Protein names

Recommended name:
    Probable allantoicase
    EC=3.5.3.4
Alternative name(s):
    Allantoate amidinohydrolase

Gene names

Name:

Allc

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	413 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.
Catalytic activity	Allantoate + H2O = (S)-ureidoglycolate + urea.
Sequence similarities	Belongs to the allantoicase family.

Ontologies

Keywords
Molecular function	Hydrolase
Gene Ontology (GO)
Molecular function	allantoicase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 413	413	Probable allantoicase		PRO_0000205908
Experimental info
	Sequence conflict	227	1	V → G in AAM74035. Ref.2
	Sequence conflict	258	1	R → S Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q6AYP0-1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 58DF636B0566B747	FASTA	413	46,037
	10 20 30 40 50 60 MADTPKEGKL TRFLDFTQLI DLASECVGGK VLFATDDFFG PAENLIKSNN PSFKENEYTE 70 80 90 100 110 120 FGKWVDGWET RRKRIPGHDW CVIQLGIQGI IRGIDVDISY FSGNYAPRMS IQAANLSEDT 130 140 150 160 170 180 VTNIPPRGVK MGAAATSEEF VAITELKSHS WDYLVPMSEL KPGDPDSSHN YFFVNSQQRW 190 200 210 220 230 240 THIRLNIFPD GGVARLRVYG TGQRDWAALD STEPVDLVAI AFGGVCVGFS NAHFGHPNNM 250 260 270 280 290 300 IGVGDPKSIA DGWETARRLD RPPVLEGNEN GFLQVPGCEW AVFRLAHPGV ITQIEIDTKY 310 320 330 340 350 360 FKGNSPDSCK VDGCILTTLE EEDMIRQKWS LPAHKWKPLL PVTKLTPNQN HLLDSLTLEL 370 380 390 400 410 QDVITHARIT IAPDGGVSRL RLKGFPSSIC LLRPLREKPM LRFSLKAGFR ANL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	"Selective pressure on the allantoicase gene during vertebrate evolution." Vigetti D., Binelli G., Monetti C., Prati M., Bernardini G., Gornati R. J. Mol. Evol. 57:650-658(2003) [PubMed: 14745534] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 66-259.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC078971 mRNA. Translation: AAH78971.1. AF480062 mRNA. Translation: AAM74035.1.
IPI	IPI00464761.
RefSeq	NP_001013055.1.
UniGene	Rn.92436
3D structure databases
SMR	Q6AYP0. Positions 15-385.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6AYP0.
Genome annotation databases
Ensembl	ENSRNOT00000011048; ENSRNOP00000011048; ENSRNOG00000008299; Rattus norvegicus. [Genome view]
GeneID	246758.
KEGG	rno:246758.
NMPDR	fig|10116.3.peg.24954.
Organism-specific databases
CTD	246758.
RGD	621804. Allc.
Phylogenomic databases
eggNOG	roNOG12111.
HOVERGEN	Q6AYP0.
PhylomeDB	Q6AYP0.
Enzyme and pathway databases
BRENDA	3.5.3.4. 248.
Gene expression databases
Genevestigator	Q6AYP0.
Family and domain databases
InterPro	IPR005164. Allantoicase. IPR015908. Allantoicase_dom. IPR008979. Galactose-bd-like. [Graphical view]
PANTHER	PTHR12045. Allantoicase. 1 hit.
Pfam	PF03561. Allantoicase. 2 hits. [Graphical view]
TIGRFAMs	TIGR02961. allantoicase. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	623816.

Entry information

Entry name

ALLC_RAT

Accession

Primary (citable) accession number: Q6AYP0
Secondary accession number(s): Q8K470

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	September 13, 2004
Last modified:	February 9, 2010
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)