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Protein

Membrane-anchored junction protein

Gene

Majin

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-anchored junction proteinBy similarity
Gene namesi
Name:MajinBy similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1563886. Majin.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 227NuclearCuratedAdd BLAST227
Transmembranei228 – 246HelicalSequence analysisAdd BLAST19
Topological domaini247 – 251Perinuclear spaceCurated5

Keywords - Cellular componenti

Chromosome, Membrane, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003258341 – 251Membrane-anchored junction proteinAdd BLAST251

Proteomic databases

PaxDbiQ6AYM7.
PRIDEiQ6AYM7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000054336.

Interactioni

Subunit structurei

Component of the MAJIN-TERB1-TERB2 complex, composed of MAJIN, TERB1 and TERB2.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the MAJIN family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJYJ. Eukaryota.
ENOG410XTYT. LUCA.
GeneTreeiENSGT00390000007971.
HOGENOMiHOG000037935.
HOVERGENiHBG101163.
InParanoidiQ6AYM7.
OMAiPHRAKME.
OrthoDBiEOG091G0ITL.
PhylomeDBiQ6AYM7.
TreeFamiTF336863.

Family and domain databases

InterProiView protein in InterPro
IPR027816. MAJIN.
PfamiView protein in Pfam
PF15077. MAJIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AYM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKPFTYPF PETRFLHAGT NVYKFKIRYG NSIRGEEIED KGVIIQELED
60 70 80 90 100
SIRAVLANMD SLQPFVTEHF IVFPYKSKWE RVSHLKFKHG EIILTPYPFV
110 120 130 140 150
FTLYIEMKCF AESLPSGKPT DDIPLELVLT AKEAEEATMR KRKLMEEPST
160 170 180 190 200
PSRPGPHRAK METWSEASST KKALKEHKRS WGEDSQQDTP ASDSTAVTEQ
210 220 230 240 250
DPMLGHSLPG LVVPPLEHSN PPPLKEPAAR GFLGFLSALF PFRYFFRKST

Q
Length:251
Mass (Da):28,646
Last modified:September 13, 2004 - v1
Checksum:iCAA3B87C573C4C93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078985 mRNA. Translation: AAH78985.1.
RefSeqiNP_001019462.1. NM_001024291.1.
UniGeneiRn.162487.

Genome annotation databases

EnsembliENSRNOT00000077274; ENSRNOP00000072946; ENSRNOG00000054336.
GeneIDi499306.
KEGGirno:499306.
UCSCiRGD:1563886. rat.

Similar proteinsi

Entry informationi

Entry nameiMAJIN_RAT
AccessioniPrimary (citable) accession number: Q6AYM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: September 13, 2004
Last modified: August 30, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families