Q6AYK9 (CDYL_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromodomain Y-like protein
Short name=CDY-like
EC=2.3.1.48

Gene names

Name:

Cdyl

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	589 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has histone acetyltransferase activity. May play a role in histone hyperacetylation during spermatid maturation. Acts as repressor of transcription By similarity.
Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Subunit structure	Interacts with HDAC1 and HDAC2 via its C-terminal acetyl-CoA-binding domain By similarity.
Subcellular location	Nucleus By similarity.
Miscellaneous	Interaction with HDAC1 or HDAC2 prevents Coenzyme A binding By similarity.
Sequence similarities	Contains 1 chromo domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Acyltransferase Repressor Transferase
PTM	Methylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histone acetylation Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 589	589	Chromodomain Y-like protein		PRO_0000292138
Regions
	Domain	55 – 115	61	Chromo
Amino acid modifications
	Modified residue	82	1	Phosphoserine By similarity
	Modified residue	129	1	N6,N6,N6-trimethyllysine; by EHMT2; alternate By similarity
	Modified residue	129	1	N6,N6-dimethyllysine; by EHMT2; alternate By similarity
	Modified residue	129	1	N6-methyllysine; by EHMT2; alternate By similarity
	Modified residue	186	1	Phosphoserine By similarity
	Modified residue	195	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6AYK9 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 6AE0CBAF89E30A21	FASTA	589	65,031
	10 20 30 40 50 60 MGLGSSQPST KEAEPCTLQE KEEHPVDDTR QQNNAVPATV SDPDQVSPAV QDAETQVESI 70 80 90 100 110 120 VDKRKNKKGK TEYLVRWKGY DSEDDTWEPE QHLVNCEEYI HDFNRRHNER QKEGTLARAN 130 140 150 160 170 180 RASPSNARKQ ISRSTHSALS KTNPKALVVG KDHESKTNQL LATSQKFRKN TAPSLANRKN 190 200 210 220 230 240 MDLAKSGIKI LVPKSPIKGR TSIDGFHGES PEKLDQGAED TVTPEVTAEK PTGALLGPGA 250 260 270 280 290 300 ERARMGSRPR IHSLVPQVSG PVTAAMATTL AVNGKGTSPF MDALTANGTV TIQTSVTGVT 310 320 330 340 350 360 AGKRKFIDDR RDQPFDKRLR FSVRQTESAY RYRDIVVRKQ DGFTHILLST KSSENNSLNP 370 380 390 400 410 420 EVMKEVQSAL STAAADDSKL VLLSAVGSVF CCGLDFIYFI RRLTDDRKRE STKMAEAIRN 430 440 450 460 470 480 FVNTFIQFKK PIIVAVNGPA IGLGASILPL CDVVWANEKA WFQTPYTTFG QSPDGCSTVM 490 500 510 520 530 540 FPKIMGGASA NEMLLSGRKL TAQEACGKGL VSQVFWPGTF TQEVMVRIKE LASCNPIVLE 550 560 570 580 ESKALVRCNM KMELEQANER ECDALKKIWG SAQGMDSMLK YLQRKIDEF

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC079003 mRNA. Translation: AAH79003.1.
IPI	IPI00464737.
RefSeq	NP_001014167.1. NM_001014145.1.
UniGene	Rn.146844.
3D structure databases
ProteinModelPortal	Q6AYK9.
SMR	Q6AYK9. Positions 56-113, 332-589.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000048651.
PTM databases
PhosphoSite	Q6AYK9.
Proteomic databases
PaxDb	Q6AYK9.
PRIDE	Q6AYK9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000048757; ENSRNOP00000048651; ENSRNOG00000032215.
GeneID	361237.
KEGG	rno:361237.
UCSC	RGD:1549745. rat.
Organism-specific databases
CTD	9425.
RGD	1549745. Cdyl.
Phylogenomic databases
eggNOG	COG1024.
GeneTree	ENSGT00670000097595.
HOGENOM	HOG000111507.
HOVERGEN	HBG006723.
InParanoid	Q6AYK9.
OrthoDB	EOG4KPT9K.
Gene expression databases
Genevestigator	Q6AYK9.
Family and domain databases
InterPro	IPR023780. Chromo_domain. IPR000953. Chromo_domain/shadow. IPR016197. Chromodomain-like. IPR023779. Chromodomain_CS. IPR001753. Crotonase_core_superfam. [Graphical view]
Pfam	PF00385. Chromo. 1 hit. PF00378. ECH. 1 hit. [Graphical view]
SMART	SM00298. CHROMO. 1 hit. [Graphical view]
SUPFAM	SSF54160. Chromodomain-like. 1 hit.
PROSITE	PS00598. CHROMO_1. 1 hit. PS50013. CHROMO_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	675654.

Entry information

Entry name

CDYL_RAT

Accession

Primary (citable) accession number: Q6AYK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	September 13, 2004
Last modified:	May 29, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program