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Q6AYK9

- CDYL_RAT

UniProt

Q6AYK9 - CDYL_RAT

Protein

Chromodomain Y-like protein

Gene

Cdyl

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Has histone acetyltransferase activity. May play a role in histone hyperacetylation during spermatid maturation By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC
    2. methylated histone binding Source: UniProtKB
    3. transcription corepressor activity Source: UniProtKB

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Repressor, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chromodomain Y-like protein (EC:2.3.1.48)
    Short name:
    CDY-like
    Gene namesi
    Name:Cdyl
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 17

    Organism-specific databases

    RGDi1549745. Cdyl.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 589589Chromodomain Y-like proteinPRO_0000292138Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei129 – 1291N6,N6,N6-trimethyllysine; by EHMT2; alternateBy similarity
    Modified residuei129 – 1291N6,N6-dimethyllysine; by EHMT2; alternateBy similarity
    Modified residuei129 – 1291N6-methyllysine; by EHMT2; alternateBy similarity

    Keywords - PTMi

    Methylation

    Proteomic databases

    PaxDbiQ6AYK9.
    PRIDEiQ6AYK9.

    PTM databases

    PhosphoSiteiQ6AYK9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6AYK9.

    Interactioni

    Subunit structurei

    Forms multimers and multimerization is required for stable binding to chromatin. Interacts with histone H3K9me3, histone H3K27me2 and histone H3K27me3. Interacts with EZH2, EED, SUZ12, REST, EHMT1 and EHMT2. Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2. Interacts with HDAC1 and HDAC2 via its C-terminal acetyl-CoA-binding domain By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000048651.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AYK9.
    SMRiQ6AYK9. Positions 56-113, 332-589.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 11561ChromoPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni55 – 300246Interaction with EZH2By similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 chromo domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1024.
    GeneTreeiENSGT00670000097595.
    HOGENOMiHOG000111507.
    HOVERGENiHBG006723.
    InParanoidiQ6AYK9.
    OMAiIHDFNRR.
    OrthoDBiEOG72RN06.
    PhylomeDBiQ6AYK9.
    TreeFamiTF313375.

    Family and domain databases

    Gene3Di3.90.226.10. 1 hit.
    InterProiIPR023780. Chromo_domain.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR023779. Chromodomain_CS.
    IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    [Graphical view]
    PfamiPF00385. Chromo. 1 hit.
    PF00378. ECH. 1 hit.
    [Graphical view]
    SMARTiSM00298. CHROMO. 1 hit.
    [Graphical view]
    SUPFAMiSSF52096. SSF52096. 1 hit.
    SSF54160. SSF54160. 1 hit.
    PROSITEiPS00598. CHROMO_1. 1 hit.
    PS50013. CHROMO_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6AYK9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLGSSQPST KEAEPCTLQE KEEHPVDDTR QQNNAVPATV SDPDQVSPAV    50
    QDAETQVESI VDKRKNKKGK TEYLVRWKGY DSEDDTWEPE QHLVNCEEYI 100
    HDFNRRHNER QKEGTLARAN RASPSNARKQ ISRSTHSALS KTNPKALVVG 150
    KDHESKTNQL LATSQKFRKN TAPSLANRKN MDLAKSGIKI LVPKSPIKGR 200
    TSIDGFHGES PEKLDQGAED TVTPEVTAEK PTGALLGPGA ERARMGSRPR 250
    IHSLVPQVSG PVTAAMATTL AVNGKGTSPF MDALTANGTV TIQTSVTGVT 300
    AGKRKFIDDR RDQPFDKRLR FSVRQTESAY RYRDIVVRKQ DGFTHILLST 350
    KSSENNSLNP EVMKEVQSAL STAAADDSKL VLLSAVGSVF CCGLDFIYFI 400
    RRLTDDRKRE STKMAEAIRN FVNTFIQFKK PIIVAVNGPA IGLGASILPL 450
    CDVVWANEKA WFQTPYTTFG QSPDGCSTVM FPKIMGGASA NEMLLSGRKL 500
    TAQEACGKGL VSQVFWPGTF TQEVMVRIKE LASCNPIVLE ESKALVRCNM 550
    KMELEQANER ECDALKKIWG SAQGMDSMLK YLQRKIDEF 589
    Length:589
    Mass (Da):65,031
    Last modified:September 13, 2004 - v1
    Checksum:i6AE0CBAF89E30A21
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079003 mRNA. Translation: AAH79003.1.
    RefSeqiNP_001014167.1. NM_001014145.1.
    UniGeneiRn.146844.

    Genome annotation databases

    EnsembliENSRNOT00000048757; ENSRNOP00000048651; ENSRNOG00000032215.
    GeneIDi361237.
    KEGGirno:361237.
    UCSCiRGD:1549745. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079003 mRNA. Translation: AAH79003.1 .
    RefSeqi NP_001014167.1. NM_001014145.1.
    UniGenei Rn.146844.

    3D structure databases

    ProteinModelPortali Q6AYK9.
    SMRi Q6AYK9. Positions 56-113, 332-589.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000048651.

    PTM databases

    PhosphoSitei Q6AYK9.

    Proteomic databases

    PaxDbi Q6AYK9.
    PRIDEi Q6AYK9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000048757 ; ENSRNOP00000048651 ; ENSRNOG00000032215 .
    GeneIDi 361237.
    KEGGi rno:361237.
    UCSCi RGD:1549745. rat.

    Organism-specific databases

    CTDi 9425.
    RGDi 1549745. Cdyl.

    Phylogenomic databases

    eggNOGi COG1024.
    GeneTreei ENSGT00670000097595.
    HOGENOMi HOG000111507.
    HOVERGENi HBG006723.
    InParanoidi Q6AYK9.
    OMAi IHDFNRR.
    OrthoDBi EOG72RN06.
    PhylomeDBi Q6AYK9.
    TreeFami TF313375.

    Miscellaneous databases

    NextBioi 675654.

    Gene expression databases

    Genevestigatori Q6AYK9.

    Family and domain databases

    Gene3Di 3.90.226.10. 1 hit.
    InterProi IPR023780. Chromo_domain.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR023779. Chromodomain_CS.
    IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    [Graphical view ]
    Pfami PF00385. Chromo. 1 hit.
    PF00378. ECH. 1 hit.
    [Graphical view ]
    SMARTi SM00298. CHROMO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52096. SSF52096. 1 hit.
    SSF54160. SSF54160. 1 hit.
    PROSITEi PS00598. CHROMO_1. 1 hit.
    PS50013. CHROMO_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiCDYL_RAT
    AccessioniPrimary (citable) accession number: Q6AYK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Interaction with HDAC1 or HDAC2 prevents Coenzyme A binding.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3