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Q6AYK9 (CDYL_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chromodomain Y-like protein

Short name=CDY-like
EC=2.3.1.48
Gene names
Name:Cdyl
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length589 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Has histone acetyltransferase activity. May play a role in histone hyperacetylation during spermatid maturation By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subunit structure

Forms multimers and multimerization is required for stable binding to chromatin. Interacts with histone H3K9me3, histone H3K27me2 and histone H3K27me3. Interacts with EZH2, EED, SUZ12, REST, EHMT1 and EHMT2. Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2. Interacts with HDAC1 and HDAC2 via its C-terminal acetyl-CoA-binding domain By similarity.

Subcellular location

Nucleus By similarity.

Miscellaneous

Interaction with HDAC1 or HDAC2 prevents Coenzyme A binding By similarity.

Sequence similarities

Contains 1 chromo domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 589589Chromodomain Y-like protein
PRO_0000292138

Regions

Domain55 – 11561Chromo
Region55 – 300246Interaction with EZH2 By similarity

Amino acid modifications

Modified residue1291N6,N6,N6-trimethyllysine; by EHMT2; alternate By similarity
Modified residue1291N6,N6-dimethyllysine; by EHMT2; alternate By similarity
Modified residue1291N6-methyllysine; by EHMT2; alternate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AYK9 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 6AE0CBAF89E30A21

FASTA58965,031
        10         20         30         40         50         60 
MGLGSSQPST KEAEPCTLQE KEEHPVDDTR QQNNAVPATV SDPDQVSPAV QDAETQVESI 

        70         80         90        100        110        120 
VDKRKNKKGK TEYLVRWKGY DSEDDTWEPE QHLVNCEEYI HDFNRRHNER QKEGTLARAN 

       130        140        150        160        170        180 
RASPSNARKQ ISRSTHSALS KTNPKALVVG KDHESKTNQL LATSQKFRKN TAPSLANRKN 

       190        200        210        220        230        240 
MDLAKSGIKI LVPKSPIKGR TSIDGFHGES PEKLDQGAED TVTPEVTAEK PTGALLGPGA 

       250        260        270        280        290        300 
ERARMGSRPR IHSLVPQVSG PVTAAMATTL AVNGKGTSPF MDALTANGTV TIQTSVTGVT 

       310        320        330        340        350        360 
AGKRKFIDDR RDQPFDKRLR FSVRQTESAY RYRDIVVRKQ DGFTHILLST KSSENNSLNP 

       370        380        390        400        410        420 
EVMKEVQSAL STAAADDSKL VLLSAVGSVF CCGLDFIYFI RRLTDDRKRE STKMAEAIRN 

       430        440        450        460        470        480 
FVNTFIQFKK PIIVAVNGPA IGLGASILPL CDVVWANEKA WFQTPYTTFG QSPDGCSTVM 

       490        500        510        520        530        540 
FPKIMGGASA NEMLLSGRKL TAQEACGKGL VSQVFWPGTF TQEVMVRIKE LASCNPIVLE 

       550        560        570        580 
ESKALVRCNM KMELEQANER ECDALKKIWG SAQGMDSMLK YLQRKIDEF 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC079003 mRNA. Translation: AAH79003.1.
RefSeqNP_001014167.1. NM_001014145.1.
UniGeneRn.146844.

3D structure databases

ProteinModelPortalQ6AYK9.
SMRQ6AYK9. Positions 56-113, 332-589.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000048651.

PTM databases

PhosphoSiteQ6AYK9.

Proteomic databases

PaxDbQ6AYK9.
PRIDEQ6AYK9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000048757; ENSRNOP00000048651; ENSRNOG00000032215.
GeneID361237.
KEGGrno:361237.
UCSCRGD:1549745. rat.

Organism-specific databases

CTD9425.
RGD1549745. Cdyl.

Phylogenomic databases

eggNOGCOG1024.
GeneTreeENSGT00670000097595.
HOGENOMHOG000111507.
HOVERGENHBG006723.
InParanoidQ6AYK9.
OMAIHDFNRR.
OrthoDBEOG72RN06.
PhylomeDBQ6AYK9.
TreeFamTF313375.

Gene expression databases

GenevestigatorQ6AYK9.

Family and domain databases

Gene3D3.90.226.10. 1 hit.
InterProIPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
[Graphical view]
PfamPF00385. Chromo. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
SMARTSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMSSF52096. SSF52096. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio675654.

Entry information

Entry nameCDYL_RAT
AccessionPrimary (citable) accession number: Q6AYK9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: September 13, 2004
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families