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Q6AYK9

- CDYL_RAT

UniProt

Q6AYK9 - CDYL_RAT

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Protein

Chromodomain Y-like protein

Gene

Cdyl

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Has histone acetyltransferase activity. May play a role in histone hyperacetylation during spermatid maturation (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC
  2. methylated histone binding Source: UniProtKB
  3. transcription corepressor activity Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Chromodomain Y-like protein (EC:2.3.1.48)
Short name:
CDY-like
Gene namesi
Name:Cdyl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 17

Organism-specific databases

RGDi1549745. Cdyl.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589Chromodomain Y-like proteinPRO_0000292138Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei129 – 1291N6,N6,N6-trimethyllysine; by EHMT2; alternateBy similarity
Modified residuei129 – 1291N6,N6-dimethyllysine; by EHMT2; alternateBy similarity
Modified residuei129 – 1291N6-methyllysine; by EHMT2; alternateBy similarity

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ6AYK9.
PRIDEiQ6AYK9.

PTM databases

PhosphoSiteiQ6AYK9.

Expressioni

Gene expression databases

GenevestigatoriQ6AYK9.

Interactioni

Subunit structurei

Forms multimers and multimerization is required for stable binding to chromatin. Interacts with histone H3K9me3, histone H3K27me2 and histone H3K27me3. Interacts with EZH2, EED, SUZ12, REST, EHMT1 and EHMT2. Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2. Interacts with HDAC1 and HDAC2 via its C-terminal acetyl-CoA-binding domain (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048651.

Structurei

3D structure databases

ProteinModelPortaliQ6AYK9.
SMRiQ6AYK9. Positions 56-113, 332-589.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 11561ChromoPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni55 – 300246Interaction with EZH2By similarityAdd
BLAST

Sequence similaritiesi

Contains 1 chromo domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1024.
GeneTreeiENSGT00760000119100.
HOGENOMiHOG000111507.
HOVERGENiHBG006723.
InParanoidiQ6AYK9.
OMAiIHDFNRR.
OrthoDBiEOG72RN06.
PhylomeDBiQ6AYK9.
TreeFamiTF313375.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AYK9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLGSSQPST KEAEPCTLQE KEEHPVDDTR QQNNAVPATV SDPDQVSPAV
60 70 80 90 100
QDAETQVESI VDKRKNKKGK TEYLVRWKGY DSEDDTWEPE QHLVNCEEYI
110 120 130 140 150
HDFNRRHNER QKEGTLARAN RASPSNARKQ ISRSTHSALS KTNPKALVVG
160 170 180 190 200
KDHESKTNQL LATSQKFRKN TAPSLANRKN MDLAKSGIKI LVPKSPIKGR
210 220 230 240 250
TSIDGFHGES PEKLDQGAED TVTPEVTAEK PTGALLGPGA ERARMGSRPR
260 270 280 290 300
IHSLVPQVSG PVTAAMATTL AVNGKGTSPF MDALTANGTV TIQTSVTGVT
310 320 330 340 350
AGKRKFIDDR RDQPFDKRLR FSVRQTESAY RYRDIVVRKQ DGFTHILLST
360 370 380 390 400
KSSENNSLNP EVMKEVQSAL STAAADDSKL VLLSAVGSVF CCGLDFIYFI
410 420 430 440 450
RRLTDDRKRE STKMAEAIRN FVNTFIQFKK PIIVAVNGPA IGLGASILPL
460 470 480 490 500
CDVVWANEKA WFQTPYTTFG QSPDGCSTVM FPKIMGGASA NEMLLSGRKL
510 520 530 540 550
TAQEACGKGL VSQVFWPGTF TQEVMVRIKE LASCNPIVLE ESKALVRCNM
560 570 580
KMELEQANER ECDALKKIWG SAQGMDSMLK YLQRKIDEF
Length:589
Mass (Da):65,031
Last modified:September 13, 2004 - v1
Checksum:i6AE0CBAF89E30A21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079003 mRNA. Translation: AAH79003.1.
RefSeqiNP_001014167.1. NM_001014145.1.
UniGeneiRn.146844.

Genome annotation databases

EnsembliENSRNOT00000048757; ENSRNOP00000048651; ENSRNOG00000032215.
GeneIDi361237.
KEGGirno:361237.
UCSCiRGD:1549745. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079003 mRNA. Translation: AAH79003.1 .
RefSeqi NP_001014167.1. NM_001014145.1.
UniGenei Rn.146844.

3D structure databases

ProteinModelPortali Q6AYK9.
SMRi Q6AYK9. Positions 56-113, 332-589.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000048651.

PTM databases

PhosphoSitei Q6AYK9.

Proteomic databases

PaxDbi Q6AYK9.
PRIDEi Q6AYK9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000048757 ; ENSRNOP00000048651 ; ENSRNOG00000032215 .
GeneIDi 361237.
KEGGi rno:361237.
UCSCi RGD:1549745. rat.

Organism-specific databases

CTDi 9425.
RGDi 1549745. Cdyl.

Phylogenomic databases

eggNOGi COG1024.
GeneTreei ENSGT00760000119100.
HOGENOMi HOG000111507.
HOVERGENi HBG006723.
InParanoidi Q6AYK9.
OMAi IHDFNRR.
OrthoDBi EOG72RN06.
PhylomeDBi Q6AYK9.
TreeFami TF313375.

Miscellaneous databases

NextBioi 675654.

Gene expression databases

Genevestigatori Q6AYK9.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
InterProi IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
[Graphical view ]
Pfami PF00385. Chromo. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view ]
SMARTi SM00298. CHROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF52096. SSF52096. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEi PS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiCDYL_RAT
AccessioniPrimary (citable) accession number: Q6AYK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: September 13, 2004
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Interaction with HDAC1 or HDAC2 prevents Coenzyme A binding.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3