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Protein

Calcyclin-binding protein

Gene

Cacybp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • cardiac muscle cell differentiation Source: RGD
  • cellular response to calcium ion Source: RGD
  • cellular response to leukemia inhibitory factor Source: Ensembl
  • heart development Source: RGD
  • negative regulation of cell death Source: RGD
  • positive regulation of DNA replication Source: RGD
  • response to growth hormone Source: RGD

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Calcyclin-binding protein
Short name:
CacyBP
Gene namesi
Name:Cacybp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1303146. Cacybp.

Subcellular locationi

GO - Cellular componenti

  • beta-catenin destruction complex Source: Ensembl
  • cell body Source: RGD
  • cytoplasm Source: RGD
  • cytosol Source: Ensembl
  • extracellular exosome Source: Ensembl
  • neuron projection Source: RGD
  • nuclear envelope lumen Source: Ensembl
  • nucleoplasm Source: Ensembl
  • nucleus Source: RGD
  • SCF ubiquitin ligase complex Source: Ensembl

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002713912 – 229Calcyclin-binding proteinAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei3PhosphoserineBy similarity1
Modified residuei10N6-acetyllysineBy similarity1
Modified residuei21N6-acetyllysineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei86N6-acetyllysineBy similarity1
Modified residuei119N6-acetyllysineBy similarity1

Post-translational modificationi

Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6AYK6.
PRIDEiQ6AYK6.

PTM databases

iPTMnetiQ6AYK6.
PhosphoSitePlusiQ6AYK6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002572.
ExpressionAtlasiQ6AYK6. baseline and differential.
GenevisibleiQ6AYK6. RN.

Interactioni

Subunit structurei

Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1 (By similarity). Interacts with protein of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003586.

Structurei

3D structure databases

ProteinModelPortaliQ6AYK6.
SMRiQ6AYK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 168CSPROSITE-ProRule annotationAdd BLAST95
Domaini169 – 229SGSPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 81Interaction with SIAH1By similarityAdd BLAST80
Regioni74 – 229Interaction with SKP1By similarityAdd BLAST156
Regioni155 – 229Interaction with S100A6By similarityAdd BLAST75

Phylogenomic databases

eggNOGiKOG3260. Eukaryota.
ENOG410XSB6. LUCA.
GeneTreeiENSGT00390000016470.
HOGENOMiHOG000238284.
HOVERGENiHBG003242.
InParanoidiQ6AYK6.
KOiK04507.
OMAiWDVLTSI.
OrthoDBiEOG091G0LQC.
PhylomeDBiQ6AYK6.
TreeFamiTF323891.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiView protein in InterPro
IPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR007699. SGS_dom.
IPR015120. Siah-Interact_N.
PfamiView protein in Pfam
PF04969. CS. 1 hit.
PF05002. SGS. 1 hit.
PF09032. Siah-Interact_N. 1 hit.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiView protein in PROSITE
PS51203. CS. 1 hit.
PS51048. SGS. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AYK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASALEELQK DLEEVKVLLE KSTRKRLRDT LTNEKSKIET ELRNKMQQKS
60 70 80 90 100
QKKPEFDNEK PAAVVAPLTT GYTVKISNYG WDQSDKFVKI YITLTGVHQV
110 120 130 140 150
PAENVQVHFT ERSFDLLVKN LNGKNYSMIV NNLLKPISVE SSSKKVKTDT
160 170 180 190 200
VIILCRKKAE NTRWDYLTQV EKECKEKEKP SYDTEADPSE GLMNVLKKIY
210 220
EDGDDDMKRT INKAWVESRE KQAREDTEF
Length:229
Mass (Da):26,541
Last modified:September 13, 2004 - v1
Checksum:iE5158FA10314CC1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079007 mRNA. Translation: AAH79007.1.
RefSeqiNP_001004208.1. NM_001004208.1.
UniGeneiRn.11540.

Genome annotation databases

EnsembliENSRNOT00000003586; ENSRNOP00000003586; ENSRNOG00000002572.
GeneIDi289144.
KEGGirno:289144.
UCSCiRGD:1303146. rat.

Similar proteinsi

Entry informationi

Entry nameiCYBP_RAT
AccessioniPrimary (citable) accession number: Q6AYK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: September 13, 2004
Last modified: August 30, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome