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Protein

Cell growth-regulating nucleolar protein

Gene

Lyar

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs. Also acts at the level of transcription regulation. Along with PRMT5, binds embryonic globin promoter (By similarity). Represses the expression of embryonic globin Hbb-y gene (By similarity). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and that encoding the small nucleolar RNA SNORD41. Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (By similarity). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells. Prevents NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6Zinc 1By similarity1
Metal bindingi9Zinc 1By similarity1
Metal bindingi21Zinc 1By similarity1
Metal bindingi25Zinc 1By similarity1
Metal bindingi33Zinc 2By similarity1
Metal bindingi36Zinc 2By similarity1
Metal bindingi48Zinc 2By similarity1
Metal bindingi51Zinc 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 26C2HC LYAR-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri28 – 52C2HC LYAR-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cell growth-regulating nucleolar protein
Gene namesi
Name:Lyar
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1305352 Lyar

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000845301 – 386Cell growth-regulating nucleolar proteinAdd BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki202Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ6AYK5
PRIDEiQ6AYK5

Expressioni

Tissue specificityi

Expressed in testis (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000005374
ExpressionAtlasiQ6AYK5 baseline and differential
GenevisibleiQ6AYK5 RN

Interactioni

Subunit structurei

Interacts with PRMT5; this interaction is direct. Interacts with GNL2 and RPL23A (By similarity). Interacts with nucleolin/NCL; this interaction is direct (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007154

Structurei

3D structure databases

ProteinModelPortaliQ6AYK5
SMRiQ6AYK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili172 – 214Sequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi180 – 342Lys-richAdd BLAST163

Domaini

The N-terminal zinc-finger domains are required for the appropriate production of 28S rRNA and the formation of pre-60S particles.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 26C2HC LYAR-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri28 – 52C2HC LYAR-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2186 Eukaryota
ENOG411081U LUCA
GeneTreeiENSGT00390000003477
HOGENOMiHOG000006633
HOVERGENiHBG006298
InParanoidiQ6AYK5
KOiK15263
PhylomeDBiQ6AYK5
TreeFamiTF314925

Family and domain databases

InterProiView protein in InterPro
IPR014898 Znf_C2H2_LYAR
IPR036236 Znf_C2H2_sf
PfamiView protein in Pfam
PF08790 zf-LYAR, 1 hit
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
PS51804 ZF_C2HC_LYAR, 2 hits

Sequencei

Sequence statusi: Complete.

Q6AYK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFFTCNACG ESVKKIQVEK HVSICRNCEC LSCIDCGKDF WGDDYKNHVK
60 70 80 90 100
CISEDQKYGG KGYEAKTHKG DVKQQAWIQK INELIKKPNV SPKVRELLQQ
110 120 130 140 150
ISAFDNVPRK KAKFQNWMRN SLKVHSDSVL EQVWNIFSEA ASSEQDQQPP
160 170 180 190 200
SHMAKPNTEV PTKVPSTKTN GTTEEQTEAK KNKRERKEER QKSRKKEKKE
210 220 230 240 250
LKLENHQENL KGQKPKKRKK GQEAGHEAGG EDAAEANGAP EKKRARDAQA
260 270 280 290 300
SEEGADRNGG PAEDADEGPT KTAAGKRKRQ KHSEVESDNK KKKMKLPGQP
310 320 330 340 350
EEGEPEDHEA PSKGKFNWKG TIKAVLKQAP DNEISVKKLK KKVIAQYHAV
360 370 380
MSDHHTSEEE LLAIFNKKIS RNPTFKVLKD KVKLLK
Length:386
Mass (Da):43,680
Last modified:September 13, 2004 - v1
Checksum:i4CCA06474390EA04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079008 mRNA Translation: AAH79008.1
RefSeqiNP_001011911.1, NM_001011911.1
XP_006251149.1, XM_006251087.1
UniGeneiRn.137862

Genome annotation databases

EnsembliENSRNOT00000007154; ENSRNOP00000007154; ENSRNOG00000005374
GeneIDi289707
KEGGirno:289707

Similar proteinsi

Entry informationi

Entry nameiLYAR_RAT
AccessioniPrimary (citable) accession number: Q6AYK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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