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Protein

Cell growth-regulating nucleolar protein

Gene

Lyar

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61Zinc 1By similarity
Metal bindingi9 – 91Zinc 1By similarity
Metal bindingi21 – 211Zinc 1By similarity
Metal bindingi25 – 251Zinc 1By similarity
Metal bindingi33 – 331Zinc 2By similarity
Metal bindingi36 – 361Zinc 2By similarity
Metal bindingi48 – 481Zinc 2By similarity
Metal bindingi51 – 511Zinc 2By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri6 – 2520C2HC-type 1Add
BLAST
Zinc fingeri33 – 5119C2HC-type 2Add
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cell growth-regulating nucleolar protein
Gene namesi
Name:Lyar
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1305352. Lyar.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 386386Cell growth-regulating nucleolar proteinPRO_0000084530Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki202 – 202Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ6AYK5.
PRIDEiQ6AYK5.

Expressioni

Gene expression databases

ExpressionAtlasiQ6AYK5. baseline and differential.
GenevisibleiQ6AYK5. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007154.

Structurei

3D structure databases

ProteinModelPortaliQ6AYK5.
SMRiQ6AYK5. Positions 1-67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili172 – 21443Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi180 – 342163Lys-richAdd
BLAST

Sequence similaritiesi

Contains 2 C2HC-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri6 – 2520C2HC-type 1Add
BLAST
Zinc fingeri33 – 5119C2HC-type 2Add
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2186. Eukaryota.
ENOG411081U. LUCA.
GeneTreeiENSGT00390000003477.
HOGENOMiHOG000006633.
HOVERGENiHBG006298.
InParanoidiQ6AYK5.
KOiK15263.
OMAiAPDNEIT.
OrthoDBiEOG7PP58C.
PhylomeDBiQ6AYK5.
TreeFamiTF314925.

Family and domain databases

InterProiIPR014898. Znf_C2H2_LYAR.
[Graphical view]
PfamiPF08790. zf-LYAR. 1 hit.
[Graphical view]
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AYK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFFTCNACG ESVKKIQVEK HVSICRNCEC LSCIDCGKDF WGDDYKNHVK
60 70 80 90 100
CISEDQKYGG KGYEAKTHKG DVKQQAWIQK INELIKKPNV SPKVRELLQQ
110 120 130 140 150
ISAFDNVPRK KAKFQNWMRN SLKVHSDSVL EQVWNIFSEA ASSEQDQQPP
160 170 180 190 200
SHMAKPNTEV PTKVPSTKTN GTTEEQTEAK KNKRERKEER QKSRKKEKKE
210 220 230 240 250
LKLENHQENL KGQKPKKRKK GQEAGHEAGG EDAAEANGAP EKKRARDAQA
260 270 280 290 300
SEEGADRNGG PAEDADEGPT KTAAGKRKRQ KHSEVESDNK KKKMKLPGQP
310 320 330 340 350
EEGEPEDHEA PSKGKFNWKG TIKAVLKQAP DNEISVKKLK KKVIAQYHAV
360 370 380
MSDHHTSEEE LLAIFNKKIS RNPTFKVLKD KVKLLK
Length:386
Mass (Da):43,680
Last modified:September 13, 2004 - v1
Checksum:i4CCA06474390EA04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079008 mRNA. Translation: AAH79008.1.
RefSeqiNP_001011911.1. NM_001011911.1.
XP_006251149.1. XM_006251087.1.
UniGeneiRn.137862.

Genome annotation databases

EnsembliENSRNOT00000007154; ENSRNOP00000007154; ENSRNOG00000005374.
GeneIDi289707.
KEGGirno:289707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079008 mRNA. Translation: AAH79008.1.
RefSeqiNP_001011911.1. NM_001011911.1.
XP_006251149.1. XM_006251087.1.
UniGeneiRn.137862.

3D structure databases

ProteinModelPortaliQ6AYK5.
SMRiQ6AYK5. Positions 1-67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007154.

Proteomic databases

PaxDbiQ6AYK5.
PRIDEiQ6AYK5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007154; ENSRNOP00000007154; ENSRNOG00000005374.
GeneIDi289707.
KEGGirno:289707.

Organism-specific databases

CTDi55646.
RGDi1305352. Lyar.

Phylogenomic databases

eggNOGiKOG2186. Eukaryota.
ENOG411081U. LUCA.
GeneTreeiENSGT00390000003477.
HOGENOMiHOG000006633.
HOVERGENiHBG006298.
InParanoidiQ6AYK5.
KOiK15263.
OMAiAPDNEIT.
OrthoDBiEOG7PP58C.
PhylomeDBiQ6AYK5.
TreeFamiTF314925.

Miscellaneous databases

PROiQ6AYK5.

Gene expression databases

ExpressionAtlasiQ6AYK5. baseline and differential.
GenevisibleiQ6AYK5. RN.

Family and domain databases

InterProiIPR014898. Znf_C2H2_LYAR.
[Graphical view]
PfamiPF08790. zf-LYAR. 1 hit.
[Graphical view]
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiLYAR_RAT
AccessioniPrimary (citable) accession number: Q6AYK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.