Reviewed, UniProtKB/Swiss-Prot Q6AYK4 (B2L14_RAT)

Names and origin

Protein names

Recommended name:
    Apoptosis facilitator Bcl-2-like protein 14
      Short name=Bcl2-L-14

Gene names

Name:

Bcl2l14

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May play a role in apoptosis.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the Bcl-2 family.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW regulation of apoptosis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Apoptosis facilitator Bcl-2-like protein 14		PRO_0000143077
Regions
	Motif	211 – 225	15	BH3
	Motif	307 – 314	8	BH2

Sequences

	Sequence		Length	Mass (Da)
	Q6AYK4-1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: EE4235D7A1EC27B8	FASTA	326	36,891
	10 20 30 40 50 60 MCSTSVYDLE DIPLEDDDPN SIEFKILAFY ARHHVFKSTP AVFSPKLSRT RSLSQKALGT 70 80 90 100 110 120 WSTDSWTQIS LPCRDSLSSE KHISLGKKKS SWRTLFRVTE KEEEPPSSPK EIHAQGPFPV 130 140 150 160 170 180 ERQGRNQHWS RSLSSVEQCL ESEAVDSKVA CIANRVAEIV YSWPPPDDSQ SQGGGKFKES 190 200 210 220 230 240 VPKILHFELQ GPQLRPCDSK KDGEDQIINR IVELLKYSGD QLGREIKRDK ALVSIFQEGL 250 260 270 280 290 300 SYSVFRTITD LFLRDVDTRG ESEIKAQGFK AALAIDAIAK LTAIDNHPMN RMLGFGTKYL 310 320 REYFSPWVQQ NGGWEKILGL SHEEVD

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC079010 mRNA. Translation: AAH79010.1.
IPI	IPI00390142.
RefSeq	NP_001019509.1.
UniGene	Rn.162775
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q6AYK4.
Genome annotation databases
Ensembl	ENSRNOG00000028632. Rattus norvegicus. [Contig view]
GeneID	500348.
KEGG	rno:500348.
NMPDR	fig|10116.3.peg.22412.
Organism-specific databases
RGD	1562777. Bcl2l14.
Phylogenomic databases
HOVERGEN	Q6AYK4.
OMA	Q6AYK4. KKDKALM.
Gene expression databases
ArrayExpress	Q6AYK4.
GermOnline	ENSRNOG00000028632. Rattus norvegicus.
Family and domain databases
InterPro	IPR002475. BCL2_apoptsis. IPR000712. Bcl2_BH. [Graphical view]
PROSITE	PS50062. BCL2_FAMILY. 1 hit. PS01258. BH2. False negative. PS01259. BH3. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	705915.

Entry information

Entry name

B2L14_RAT

Accession

Primary (citable) accession number: Q6AYK4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	September 13, 2004
Last modified:	June 16, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)