Q6AYK4 (B2L14_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Apoptosis facilitator Bcl-2-like protein 14
Short name=Bcl2-L-14

Gene names

Name:

Bcl2l14

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a role in apoptosis.
Subcellular location	Cytoplasm By similarity.
Post-translational modification	Phosphorylated by MELK, leading to inhibit its pro-apoptotic function By similarity.
Sequence similarities	Belongs to the Bcl-2 family.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of apoptotic process Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Apoptosis facilitator Bcl-2-like protein 14		PRO_0000143077
Regions
	Motif	211 – 225	15	BH3
	Motif	307 – 314	8	BH2

Sequences

	Sequence		Length	Mass (Da)
	Q6AYK4 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: EE4235D7A1EC27B8	FASTA	326	36,891
	10 20 30 40 50 60 MCSTSVYDLE DIPLEDDDPN SIEFKILAFY ARHHVFKSTP AVFSPKLSRT RSLSQKALGT 70 80 90 100 110 120 WSTDSWTQIS LPCRDSLSSE KHISLGKKKS SWRTLFRVTE KEEEPPSSPK EIHAQGPFPV 130 140 150 160 170 180 ERQGRNQHWS RSLSSVEQCL ESEAVDSKVA CIANRVAEIV YSWPPPDDSQ SQGGGKFKES 190 200 210 220 230 240 VPKILHFELQ GPQLRPCDSK KDGEDQIINR IVELLKYSGD QLGREIKRDK ALVSIFQEGL 250 260 270 280 290 300 SYSVFRTITD LFLRDVDTRG ESEIKAQGFK AALAIDAIAK LTAIDNHPMN RMLGFGTKYL 310 320 REYFSPWVQQ NGGWEKILGL SHEEVD

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC079010 mRNA. Translation: AAH79010.1.
IPI	IPI00390142.
RefSeq	NP_001019509.1. NM_001024338.1.
UniGene	Rn.162775.
3D structure databases
ProteinModelPortal	Q6AYK4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6AYK4.
PTM databases
PhosphoSite	Q6AYK4.
Proteomic databases
PRIDE	Q6AYK4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000032229; ENSRNOP00000029468; ENSRNOG00000028632.
GeneID	500348.
KEGG	rno:500348.
NMPDR	fig|10116.3.peg.22412.
UCSC	NM_001024338. rat.
Organism-specific databases
CTD	79370.
RGD	1562777. Bcl2l14.
Phylogenomic databases
eggNOG	roNOG13007.
GeneTree	ENSGT00390000007293.
HOVERGEN	HBG050649.
InParanoid	Q6AYK4.
OMA	KKDKALM.
OrthoDB	EOG4Q58Q6.
PhylomeDB	Q6AYK4.
Gene expression databases
ArrayExpress	Q6AYK4.
Genevestigator	Q6AYK4.
GermOnline	ENSRNOG00000028632. Rattus norvegicus.
Family and domain databases
InterPro	IPR002475. Bcl2-like_apoptosis. [Graphical view]
PROSITE	PS50062. BCL2_FAMILY. 1 hit. PS01258. BH2. False negative. PS01259. BH3. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	705915.

Entry information

Entry name

B2L14_RAT

Accession

Primary (citable) accession number: Q6AYK4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	September 13, 2004
Last modified:	October 19, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program