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Protein

Apoptosis facilitator Bcl-2-like protein 14

Gene

Bcl2l14

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in apoptosis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis facilitator Bcl-2-like protein 14
Short name:
Bcl2-L-14
Gene namesi
Name:Bcl2l14
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1562777. Bcl2l14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001430771 – 326Apoptosis facilitator Bcl-2-like protein 14Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by MELK, leading to inhibit its pro-apoptotic function.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AYK4.
PRIDEiQ6AYK4.

PTM databases

iPTMnetiQ6AYK4.
PhosphoSitePlusiQ6AYK4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000028632.
GenevisibleiQ6AYK4. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029468.

Structurei

3D structure databases

ProteinModelPortaliQ6AYK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi211 – 225BH3Add BLAST15
Motifi307 – 314BH28

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
GeneTreeiENSGT00390000007293.
HOGENOMiHOG000013215.
HOVERGENiHBG050649.
InParanoidiQ6AYK4.
OMAiIDNHPMN.
OrthoDBiEOG091G0BS5.
PhylomeDBiQ6AYK4.
TreeFamiTF336214.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR033229. BCL2L14.
[Graphical view]
PANTHERiPTHR14965:SF1. PTHR14965:SF1. 1 hit.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AYK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCSTSVYDLE DIPLEDDDPN SIEFKILAFY ARHHVFKSTP AVFSPKLSRT
60 70 80 90 100
RSLSQKALGT WSTDSWTQIS LPCRDSLSSE KHISLGKKKS SWRTLFRVTE
110 120 130 140 150
KEEEPPSSPK EIHAQGPFPV ERQGRNQHWS RSLSSVEQCL ESEAVDSKVA
160 170 180 190 200
CIANRVAEIV YSWPPPDDSQ SQGGGKFKES VPKILHFELQ GPQLRPCDSK
210 220 230 240 250
KDGEDQIINR IVELLKYSGD QLGREIKRDK ALVSIFQEGL SYSVFRTITD
260 270 280 290 300
LFLRDVDTRG ESEIKAQGFK AALAIDAIAK LTAIDNHPMN RMLGFGTKYL
310 320
REYFSPWVQQ NGGWEKILGL SHEEVD
Length:326
Mass (Da):36,891
Last modified:September 13, 2004 - v1
Checksum:iEE4235D7A1EC27B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079010 mRNA. Translation: AAH79010.1.
RefSeqiNP_001019509.1. NM_001024338.1.
XP_006237595.1. XM_006237533.2.
XP_006237596.1. XM_006237534.3.
XP_008761638.1. XM_008763416.2.
XP_017448325.1. XM_017592836.1.
UniGeneiRn.162775.

Genome annotation databases

EnsembliENSRNOT00000032229; ENSRNOP00000029468; ENSRNOG00000028632.
GeneIDi500348.
KEGGirno:500348.
UCSCiRGD:1562777. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079010 mRNA. Translation: AAH79010.1.
RefSeqiNP_001019509.1. NM_001024338.1.
XP_006237595.1. XM_006237533.2.
XP_006237596.1. XM_006237534.3.
XP_008761638.1. XM_008763416.2.
XP_017448325.1. XM_017592836.1.
UniGeneiRn.162775.

3D structure databases

ProteinModelPortaliQ6AYK4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029468.

PTM databases

iPTMnetiQ6AYK4.
PhosphoSitePlusiQ6AYK4.

Proteomic databases

PaxDbiQ6AYK4.
PRIDEiQ6AYK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000032229; ENSRNOP00000029468; ENSRNOG00000028632.
GeneIDi500348.
KEGGirno:500348.
UCSCiRGD:1562777. rat.

Organism-specific databases

CTDi79370.
RGDi1562777. Bcl2l14.

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
GeneTreeiENSGT00390000007293.
HOGENOMiHOG000013215.
HOVERGENiHBG050649.
InParanoidiQ6AYK4.
OMAiIDNHPMN.
OrthoDBiEOG091G0BS5.
PhylomeDBiQ6AYK4.
TreeFamiTF336214.

Miscellaneous databases

PROiQ6AYK4.

Gene expression databases

BgeeiENSRNOG00000028632.
GenevisibleiQ6AYK4. RN.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR033229. BCL2L14.
[Graphical view]
PANTHERiPTHR14965:SF1. PTHR14965:SF1. 1 hit.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB2L14_RAT
AccessioniPrimary (citable) accession number: Q6AYK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: September 13, 2004
Last modified: November 30, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.