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Protein

Inositol-3-phosphate synthase 1

Gene

Isyna1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate.

Cofactori

NAD+By similarity

Pathwayi: myo-inositol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Inositol-3-phosphate synthase 1 (Isyna1)
  2. Inositol-1-monophosphatase (Impa1), Inositol monophosphatase 3 (Impad1), Inositol monophosphatase 1 (Impa1), Inositol-1-monophosphatase (Impa2), Inositol monophosphatase 2 (Impa2)
This subpathway is part of the pathway myo-inositol biosynthesis, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate, the pathway myo-inositol biosynthesis and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processInositol biosynthesis, Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandNAD

Enzyme and pathway databases

BRENDAi5.5.1.4 5301
ReactomeiR-RNO-1855183 Synthesis of IP2, IP, and Ins in the cytosol
SABIO-RKQ6AYK3
UniPathwayiUPA00823; UER00787

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-3-phosphate synthase 1 (EC:5.5.1.4)
Short name:
IPS 1
Alternative name(s):
Myo-inositol 1-phosphate synthase
Short name:
MI-1-P synthase
Short name:
MIP synthase
Gene namesi
Name:Isyna1
Synonyms:Ino1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1359423 Isyna1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003246311 – 557Inositol-3-phosphate synthase 1Add BLAST557

Proteomic databases

PaxDbiQ6AYK3
PRIDEiQ6AYK3

PTM databases

iPTMnetiQ6AYK3
PhosphoSitePlusiQ6AYK3
SwissPalmiQ6AYK3

Expressioni

Gene expression databases

BgeeiENSRNOG00000019741
GenevisibleiQ6AYK3 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026821

Structurei

3D structure databases

ProteinModelPortaliQ6AYK3
SMRiQ6AYK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0693 Eukaryota
COG1260 LUCA
GeneTreeiENSGT00390000018395
HOGENOMiHOG000013469
HOVERGENiHBG061200
InParanoidiQ6AYK3
KOiK01858
OMAiEGWDNID
OrthoDBiEOG091G05DF
PhylomeDBiQ6AYK3
TreeFamiTF300382

Family and domain databases

InterProiView protein in InterPro
IPR002587 Myo-inos-1-P_Synthase
IPR013021 Myo-inos-1-P_Synthase_GAPDH
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR11510 PTHR11510, 1 hit
PfamiView protein in Pfam
PF01658 Inos-1-P_synth, 1 hit
PF07994 NAD_binding_5, 1 hit
PIRSFiPIRSF015578 Myoinos-ppht_syn, 1 hit
SUPFAMiSSF51735 SSF51735, 2 hits

Sequencei

Sequence statusi: Complete.

Q6AYK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPAAEILVD SPDVIFGPEA IEARYEYRTT RVSREGGVLR VRPTATRFTF
60 70 80 90 100
RTARQVPRLG VMLVGWGGNN GSTLTAAVLA NRLRLTWPTR TGRKEANYYG
110 120 130 140 150
SLTQAGTVNL GLDGDGREVF VPFSALLPMV APNDLVFDGW DISSLNLAEA
160 170 180 190 200
MRRAQVLDCG LQEQLWPHME SLRPRPSVYI PEFIAANQTA RADNLIPGTR
210 220 230 240 250
AQQLEQIRKD IRDFRSSAGL DKVIVLWTAN TERFCEVVPG RNDTAENLLR
260 270 280 290 300
TIQLGLEVSP STLFAVASIL EGCAFLNGSP QNTLVPGALE LASQRHVFVG
310 320 330 340 350
GDDFKSGQTK VKSVLVDFLI GSGLKTMSIV SYNHLGNNDG QNLSAPLQFR
360 370 380 390 400
SKEVTKSSVV DDMVQSNRVL YAPGEEPDHC VVIKYVPYVG DSKRALDEYT
410 420 430 440 450
SELMLGGTNT LVLHNTCEDS LLAAPIMLDL VLLTELCQRV SFCTDSDPEP
460 470 480 490 500
QGFHPVLSVL SFLFKAPLVP PGSPVVNALF RQRSCIENIF RACVGLPPQN
510 520 530 540 550
HMLLEHKMER PFPGIKPEEV KATSPLPCKK ESTPATNGCT GDANGHTQAP

TPELSTA
Length:557
Mass (Da):60,884
Last modified:March 18, 2008 - v2
Checksum:iF351B16D74E94281
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03100304 Genomic DNA No translation available.
RefSeqiNP_001013902.2, NM_001013880.2
UniGeneiRn.98850

Genome annotation databases

EnsembliENSRNOT00000026821; ENSRNOP00000026821; ENSRNOG00000019741
GeneIDi290651
KEGGirno:290651
UCSCiRGD:1359423 rat

Similar proteinsi

Entry informationi

Entry nameiINO1_RAT
AccessioniPrimary (citable) accession number: Q6AYK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: May 23, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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