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Protein

Inositol-3-phosphate synthase 1

Gene

Isyna1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate.

Cofactori

NAD+By similarity

Pathwayi: myo-inositol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Inositol-3-phosphate synthase 1 (Isyna1)
  2. Inositol monophosphatase 3 (Impad1), Inositol monophosphatase 1 (Impa1), Inositol monophosphatase 2 (Impa2)
This subpathway is part of the pathway myo-inositol biosynthesis, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate, the pathway myo-inositol biosynthesis and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Inositol biosynthesis, Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi5.5.1.4. 5301.
ReactomeiR-RNO-1855183. Synthesis of IP2, IP, and Ins in the cytosol.
SABIO-RKQ6AYK3.
UniPathwayiUPA00823; UER00787.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-3-phosphate synthase 1 (EC:5.5.1.4)
Short name:
IPS 1
Alternative name(s):
Myo-inositol 1-phosphate synthase
Short name:
MI-1-P synthase
Short name:
MIP synthase
Gene namesi
Name:Isyna1
Synonyms:Ino1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1359423. Isyna1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Inositol-3-phosphate synthase 1PRO_0000324631Add
BLAST

Proteomic databases

PaxDbiQ6AYK3.
PRIDEiQ6AYK3.

PTM databases

iPTMnetiQ6AYK3.

Expressioni

Gene expression databases

GenevisibleiQ6AYK3. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026821.

Structurei

3D structure databases

ProteinModelPortaliQ6AYK3.
SMRiQ6AYK3. Positions 6-512.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0693. Eukaryota.
COG1260. LUCA.
GeneTreeiENSGT00390000018395.
HOGENOMiHOG000013469.
HOVERGENiHBG061200.
InParanoidiQ6AYK3.
KOiK01858.
OMAiFMEHMVP.
OrthoDBiEOG74J97N.
PhylomeDBiQ6AYK3.
TreeFamiTF300382.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR002587. Myo-inos-1-P_Synthase.
IPR013021. Myo-inos-1-P_Synthase_GAPDH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11510. PTHR11510. 1 hit.
PfamiPF01658. Inos-1-P_synth. 1 hit.
PF07994. NAD_binding_5. 1 hit.
[Graphical view]
PIRSFiPIRSF015578. Myoinos-ppht_syn. 1 hit.
SUPFAMiSSF51735. SSF51735. 2 hits.

Sequencei

Sequence statusi: Complete.

Q6AYK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPAAEILVD SPDVIFGPEA IEARYEYRTT RVSREGGVLR VRPTATRFTF
60 70 80 90 100
RTARQVPRLG VMLVGWGGNN GSTLTAAVLA NRLRLTWPTR TGRKEANYYG
110 120 130 140 150
SLTQAGTVNL GLDGDGREVF VPFSALLPMV APNDLVFDGW DISSLNLAEA
160 170 180 190 200
MRRAQVLDCG LQEQLWPHME SLRPRPSVYI PEFIAANQTA RADNLIPGTR
210 220 230 240 250
AQQLEQIRKD IRDFRSSAGL DKVIVLWTAN TERFCEVVPG RNDTAENLLR
260 270 280 290 300
TIQLGLEVSP STLFAVASIL EGCAFLNGSP QNTLVPGALE LASQRHVFVG
310 320 330 340 350
GDDFKSGQTK VKSVLVDFLI GSGLKTMSIV SYNHLGNNDG QNLSAPLQFR
360 370 380 390 400
SKEVTKSSVV DDMVQSNRVL YAPGEEPDHC VVIKYVPYVG DSKRALDEYT
410 420 430 440 450
SELMLGGTNT LVLHNTCEDS LLAAPIMLDL VLLTELCQRV SFCTDSDPEP
460 470 480 490 500
QGFHPVLSVL SFLFKAPLVP PGSPVVNALF RQRSCIENIF RACVGLPPQN
510 520 530 540 550
HMLLEHKMER PFPGIKPEEV KATSPLPCKK ESTPATNGCT GDANGHTQAP

TPELSTA
Length:557
Mass (Da):60,884
Last modified:March 18, 2008 - v2
Checksum:iF351B16D74E94281
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03100304 Genomic DNA. No translation available.
RefSeqiNP_001013902.2. NM_001013880.2.
UniGeneiRn.98850.

Genome annotation databases

EnsembliENSRNOT00000026821; ENSRNOP00000026821; ENSRNOG00000019741.
GeneIDi290651.
KEGGirno:290651.
UCSCiRGD:1359423. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03100304 Genomic DNA. No translation available.
RefSeqiNP_001013902.2. NM_001013880.2.
UniGeneiRn.98850.

3D structure databases

ProteinModelPortaliQ6AYK3.
SMRiQ6AYK3. Positions 6-512.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026821.

PTM databases

iPTMnetiQ6AYK3.

Proteomic databases

PaxDbiQ6AYK3.
PRIDEiQ6AYK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026821; ENSRNOP00000026821; ENSRNOG00000019741.
GeneIDi290651.
KEGGirno:290651.
UCSCiRGD:1359423. rat.

Organism-specific databases

CTDi51477.
RGDi1359423. Isyna1.

Phylogenomic databases

eggNOGiKOG0693. Eukaryota.
COG1260. LUCA.
GeneTreeiENSGT00390000018395.
HOGENOMiHOG000013469.
HOVERGENiHBG061200.
InParanoidiQ6AYK3.
KOiK01858.
OMAiFMEHMVP.
OrthoDBiEOG74J97N.
PhylomeDBiQ6AYK3.
TreeFamiTF300382.

Enzyme and pathway databases

UniPathwayiUPA00823; UER00787.
BRENDAi5.5.1.4. 5301.
ReactomeiR-RNO-1855183. Synthesis of IP2, IP, and Ins in the cytosol.
SABIO-RKQ6AYK3.

Miscellaneous databases

PROiQ6AYK3.

Gene expression databases

GenevisibleiQ6AYK3. RN.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR002587. Myo-inos-1-P_Synthase.
IPR013021. Myo-inos-1-P_Synthase_GAPDH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11510. PTHR11510. 1 hit.
PfamiPF01658. Inos-1-P_synth. 1 hit.
PF07994. NAD_binding_5. 1 hit.
[Graphical view]
PIRSFiPIRSF015578. Myoinos-ppht_syn. 1 hit.
SUPFAMiSSF51735. SSF51735. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.

Entry informationi

Entry nameiINO1_RAT
AccessioniPrimary (citable) accession number: Q6AYK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: June 8, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.