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Protein

Clusterin-associated protein 1

Gene

Cluap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-RNO-5620924. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Clusterin-associated protein 1
Gene namesi
Name:Cluap1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1359189. Cluap1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002394541 – 402Clusterin-associated protein 1Add BLAST402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei303PhosphoserineCombined sources1
Modified residuei313PhosphoserineBy similarity1
Modified residuei315PhosphoserineBy similarity1
Modified residuei398PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AYJ5.
PRIDEiQ6AYJ5.

PTM databases

iPTMnetiQ6AYJ5.
PhosphoSitePlusiQ6AYJ5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007117.
ExpressionAtlasiQ6AYJ5. baseline and differential.
GenevisibleiQ6AYJ5. RN.

Interactioni

Subunit structurei

Interacts with CLU/clusterin.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062395.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili187 – 297Sequence analysisAdd BLAST111

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi369 – 372Poly-Asp4

Sequence similaritiesi

Belongs to the CLUAP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3647. Eukaryota.
ENOG410XRVS. LUCA.
GeneTreeiENSGT00390000008957.
HOGENOMiHOG000257815.
HOVERGENiHBG081253.
InParanoidiQ6AYJ5.
KOiK19684.
PhylomeDBiQ6AYJ5.

Family and domain databases

InterProiIPR019366. Clusterin-associated_protein-1.
[Graphical view]
PANTHERiPTHR21547. PTHR21547. 1 hit.
PfamiPF10234. Cluap1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AYJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRALGYPRH ISMENFRTPN FGLVSEVLLW LVKRYEPQTD IPSDTETEQD
60 70 80 90 100
RVFFIKAIAQ FMATKAHIKL NTKKLYQADG YAVKELLKIT SVLYNAMKTK
110 120 130 140 150
GMEGSNVGEE DISKFKFDLG SKIADLKAAR QLASEITAKG ASLYDLLGKE
160 170 180 190 200
VELRELRTEA IARPLEINET EKVMRIAIKD ILAQVQKTKD LLNNVASDEA
210 220 230 240 250
NLEAKIEKRK LELERNRKRL QTLQSVRPAF MDEYEKVEEE LQKQYDVYLE
260 270 280 290 300
KFRNLAYLEQ QLEDHHRMEQ ERFEEAENTL RLMQNKLKEE EKRLLKSGSN
310 320 330 340 350
DDSDIDIQED DESDSELEDR RLSKPRTAME VLMQGRPSKR IVGTMQGGDS
360 370 380 390 400
DEDEDSEDSE MNMEDDEEDD DDLEDESIAL SPAKPSRRVR KPEPLDESDN

DF
Length:402
Mass (Da):46,572
Last modified:September 13, 2004 - v1
Checksum:iAF48B41E7BD7C4FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079022 mRNA. Translation: AAH79022.1.
RefSeqiNP_001014247.1. NM_001014225.1.
UniGeneiRn.19522.

Genome annotation databases

EnsembliENSRNOT00000064964; ENSRNOP00000062395; ENSRNOG00000007117.
GeneIDi363544.
KEGGirno:363544.
UCSCiRGD:1359189. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079022 mRNA. Translation: AAH79022.1.
RefSeqiNP_001014247.1. NM_001014225.1.
UniGeneiRn.19522.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062395.

PTM databases

iPTMnetiQ6AYJ5.
PhosphoSitePlusiQ6AYJ5.

Proteomic databases

PaxDbiQ6AYJ5.
PRIDEiQ6AYJ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000064964; ENSRNOP00000062395; ENSRNOG00000007117.
GeneIDi363544.
KEGGirno:363544.
UCSCiRGD:1359189. rat.

Organism-specific databases

CTDi23059.
RGDi1359189. Cluap1.

Phylogenomic databases

eggNOGiKOG3647. Eukaryota.
ENOG410XRVS. LUCA.
GeneTreeiENSGT00390000008957.
HOGENOMiHOG000257815.
HOVERGENiHBG081253.
InParanoidiQ6AYJ5.
KOiK19684.
PhylomeDBiQ6AYJ5.

Enzyme and pathway databases

ReactomeiR-RNO-5620924. Intraflagellar transport.

Miscellaneous databases

PROiQ6AYJ5.

Gene expression databases

BgeeiENSRNOG00000007117.
ExpressionAtlasiQ6AYJ5. baseline and differential.
GenevisibleiQ6AYJ5. RN.

Family and domain databases

InterProiIPR019366. Clusterin-associated_protein-1.
[Graphical view]
PANTHERiPTHR21547. PTHR21547. 1 hit.
PfamiPF10234. Cluap1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLUA1_RAT
AccessioniPrimary (citable) accession number: Q6AYJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: September 13, 2004
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.