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Protein

Meiotic recombination protein REC8 homolog

Gene

Rec8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Chromosome partition, Meiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Meiotic recombination protein REC8 homolog
Alternative name(s):
Cohesin Rec8p
Gene namesi
Name:Rec8By similarity
Synonyms:Rec8L1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1309376. Rec8.

Subcellular locationi

  • Nucleus 1 Publication
  • Chromosome 1 Publication
  • Chromosomecentromere 1 Publication

  • Note: In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II.1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Meiotic recombination protein REC8 homologPRO_0000308168Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei149 – 1491PhosphoserineBy similarity
Modified residuei164 – 1641PhosphothreonineCombined sources
Modified residuei192 – 1921PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AYJ4.
PRIDEiQ6AYJ4.

PTM databases

iPTMnetiQ6AYJ4.
PhosphoSiteiQ6AYJ4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019503.

Interactioni

Subunit structurei

Interacts (phosphorylated and unphosphorylated form) with SMC3. Interacts with SYCP3. Interacts (phosphorylated and unphosphorylated form) with SMC1B. Does not interact with SMC1A (By similarity). Interacts with RAD51.By similarity1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026430.

Structurei

3D structure databases

ProteinModelPortaliQ6AYJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi275 – 33763Pro-richSequence analysisAdd
BLAST
Compositional biasi338 – 3447Poly-ArgSequence analysis

Sequence similaritiesi

Belongs to the rad21 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG1213. Eukaryota.
ENOG410XRB4. LUCA.
GeneTreeiENSGT00390000011379.
HOGENOMiHOG000154087.
HOVERGENiHBG056766.
InParanoidiQ6AYJ4.
KOiK13054.
OMAiETQISRK.
PhylomeDBiQ6AYJ4.
TreeFamiTF338144.

Family and domain databases

Gene3Di1.10.10.580. 1 hit.
InterProiIPR023093. Rad21/Rec8_C.
IPR006909. Rad21/Rec8_C_eu.
IPR006910. Rad21_Rec8_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF04824. Rad21_Rec8. 1 hit.
PF04825. Rad21_Rec8_N. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AYJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFYYPNVLQR HTGCFATIWL AATRGSRLVK REYLKVNVVK TCEEILNYVL
60 70 80 90 100
VRVQPPMPGL PRPRFSLYLS AQLQIGVIRV YFQQCQYLVE DIQHILEHLH
110 120 130 140 150
RAQLRIRIDM EEADLPSLLL PNCLAMMETL EDAPEPFFGT MSVDPTLPSP
160 170 180 190 200
FDIPQIRHLL EAATPEKIRE ETLPEATPEP RKPDRTLAMV QSPEVITLQE
210 220 230 240 250
AEPIRMLRIE GEQDLPEISR GDLDLLIAEE DDAILLEERQ RGRLLRQRRA
260 270 280 290 300
SPPLDESKEE PRALEGDGLV SSLSPPAPAQ VEGIREPLPD QAFPPEVQKM
310 320 330 340 350
PGWEPGVLLT EVTPPQELRL PAPPSIEKRP PSPQRPPRRR RRGRQLLFWD
360 370 380 390 400
KETQISREKF EEQLQTGAHC CEYPVVQPPK RKLMSPAELF RTPTLSGWLS
410 420 430 440 450
PELLALWTHC AQVPPRMLRQ RPQLETEETV EEERVADKEE RRKTEALSEI
460 470 480 490 500
EVLREAQEPS GPLMLSSELS LEVAEEEKSR TSFIPPEERW AWIEERQPEP
510 520 530 540 550
PALPMLPELP EVPMEMPPGP ELLSSEAVLR AVALELQANR EPDFSSLVPP
560 570 580 590
LSSRKLASRV FYLLLVLSAQ KILLVDQQKP YGRLLIRLGP KFP
Length:593
Mass (Da):67,874
Last modified:September 13, 2004 - v1
Checksum:iF16504E35995E92D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti435 – 4417Missing in AAS20426 (Ref. 1) Curated
Sequence conflicti490 – 4901W → WW in AAS20426 (Ref. 1) Curated
Sequence conflicti523 – 5231Missing in AAS20426 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY529701 mRNA. Translation: AAS20426.1.
BC079023 mRNA. Translation: AAH79023.1.
RefSeqiNP_001011916.1. NM_001011916.1.
UniGeneiRn.108612.

Genome annotation databases

EnsembliENSRNOT00000026430; ENSRNOP00000026430; ENSRNOG00000019503.
ENSRNOT00000081165; ENSRNOP00000072690; ENSRNOG00000019503.
GeneIDi290227.
KEGGirno:290227.
UCSCiRGD:1309376. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY529701 mRNA. Translation: AAS20426.1.
BC079023 mRNA. Translation: AAH79023.1.
RefSeqiNP_001011916.1. NM_001011916.1.
UniGeneiRn.108612.

3D structure databases

ProteinModelPortaliQ6AYJ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026430.

PTM databases

iPTMnetiQ6AYJ4.
PhosphoSiteiQ6AYJ4.

Proteomic databases

PaxDbiQ6AYJ4.
PRIDEiQ6AYJ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026430; ENSRNOP00000026430; ENSRNOG00000019503.
ENSRNOT00000081165; ENSRNOP00000072690; ENSRNOG00000019503.
GeneIDi290227.
KEGGirno:290227.
UCSCiRGD:1309376. rat.

Organism-specific databases

CTDi9985.
RGDi1309376. Rec8.

Phylogenomic databases

eggNOGiKOG1213. Eukaryota.
ENOG410XRB4. LUCA.
GeneTreeiENSGT00390000011379.
HOGENOMiHOG000154087.
HOVERGENiHBG056766.
InParanoidiQ6AYJ4.
KOiK13054.
OMAiETQISRK.
PhylomeDBiQ6AYJ4.
TreeFamiTF338144.

Miscellaneous databases

PROiQ6AYJ4.

Gene expression databases

BgeeiENSRNOG00000019503.

Family and domain databases

Gene3Di1.10.10.580. 1 hit.
InterProiIPR023093. Rad21/Rec8_C.
IPR006909. Rad21/Rec8_C_eu.
IPR006910. Rad21_Rec8_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF04824. Rad21_Rec8. 1 hit.
PF04825. Rad21_Rec8_N. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiREC8_RAT
AccessioniPrimary (citable) accession number: Q6AYJ4
Secondary accession number(s): Q6QQR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.