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Protein

ATP-dependent DNA helicase Q1

Gene

Recql

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi113 – 1208ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent DNA helicase Q1 (EC:3.6.4.12)
Alternative name(s):
DNA-dependent ATPase Q1
RecQ protein-like 1
Gene namesi
Name:Recql
Synonyms:Recql1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1311071. Recql.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 621621ATP-dependent DNA helicase Q1PRO_0000205052Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei514 – 5141N6-acetyllysineBy similarity
Modified residuei522 – 5221N6-acetyllysineBy similarity
Modified residuei602 – 6021PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6AYJ1.
PRIDEiQ6AYJ1.

PTM databases

iPTMnetiQ6AYJ1.

Expressioni

Gene expression databases

ExpressionAtlasiQ6AYJ1. baseline and differential.
GenevisibleiQ6AYJ1. RN.

Interactioni

Subunit structurei

Interacts with EXO1 and MLH1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060671.

Structurei

3D structure databases

ProteinModelPortaliQ6AYJ1.
SMRiQ6AYJ1. Positions 63-592.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini100 – 275176Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini296 – 451156Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi219 – 2224DEVH box

Sequence similaritiesi

Belongs to the helicase family. RecQ subfamily.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0351. Eukaryota.
COG0514. LUCA.
GeneTreeiENSGT00550000074520.
HOGENOMiHOG000044388.
HOVERGENiHBG057654.
InParanoidiQ6AYJ1.
KOiK10899.
OMAiQKFRPLQ.
OrthoDBiEOG7K0ZC0.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR004589. DNA_helicase_ATP-dep_RecQ.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR032284. RecQ_Zn-bd.
IPR018982. RQC_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF16124. RecQ_Zn_bind. 1 hit.
PF09382. RQC. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00614. recQ_fam. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AYJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASIPALTDE LESVSSELHA VDIQIQELTE RQHELLQRKS VLTKRIKQCL
60 70 80 90 100
EDSAAEASGD CDTSPAAWSK EDFPWSGKVK HVLRDVFKLQ KFRPLQLETV
110 120 130 140 150
NATMARKDIF LVMPTGGGKS LCYQLPALCS DGFTLVICPL ISLMEDQLMV
160 170 180 190 200
LQQLGISATM LNSSSSKEHV KCVHTEMMNK NSHLKLIYVT PEKIAKSKMF
210 220 230 240 250
MSRLEKAYEA GRLTGVAVDE VHCCSQWGHD FRPDYKALGI LKRQFPNISL
260 270 280 290 300
IGLTATATNH VLKDAQKILC VEKCLTFTAS FNRPNLYYEV RQKPSSAEDF
310 320 330 340 350
IENIANLING RYKGKSGIIY CFSQKDSEQV TISLQKLGVR AGTYHANMEP
360 370 380 390 400
EDRTKVHTQW SANELQVVVA TVAFGMGIDK PDVRFVIHHS MSKSMENYYQ
410 420 430 440 450
ESGRAGRDDW RADCILYYGF GDIFRISSMV VMENVGQQKL YEMVSYCQNI
460 470 480 490 500
SKCRRALIAQ HFDEVWNADA CNKMCDNCCK DDSFEKKNIT EHCQALIKIL
510 520 530 540 550
KQAEGLNEKL TPLKLIDAWM GKGAAKFRVA GVAVPALPRE DLEKIIVHAL
560 570 580 590 600
LQQYLKEDYS FTAYATISYL KVGPRASLLS NEGHAVTMQV KRSTQSSVRA
610 620
ASPEACEVDS KGKEKSSAVL C
Length:621
Mass (Da):69,642
Last modified:September 13, 2004 - v1
Checksum:iFA8F6B04ADA341C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079026 mRNA. Translation: AAH79026.1.
RefSeqiNP_001012098.1. NM_001012098.1.
XP_006237683.1. XM_006237621.2.
UniGeneiRn.203166.

Genome annotation databases

EnsembliENSRNOT00000065576; ENSRNOP00000060671; ENSRNOG00000012602.
GeneIDi312824.
KEGGirno:312824.
UCSCiRGD:1311071. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079026 mRNA. Translation: AAH79026.1.
RefSeqiNP_001012098.1. NM_001012098.1.
XP_006237683.1. XM_006237621.2.
UniGeneiRn.203166.

3D structure databases

ProteinModelPortaliQ6AYJ1.
SMRiQ6AYJ1. Positions 63-592.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060671.

PTM databases

iPTMnetiQ6AYJ1.

Proteomic databases

PaxDbiQ6AYJ1.
PRIDEiQ6AYJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000065576; ENSRNOP00000060671; ENSRNOG00000012602.
GeneIDi312824.
KEGGirno:312824.
UCSCiRGD:1311071. rat.

Organism-specific databases

CTDi5965.
RGDi1311071. Recql.

Phylogenomic databases

eggNOGiKOG0351. Eukaryota.
COG0514. LUCA.
GeneTreeiENSGT00550000074520.
HOGENOMiHOG000044388.
HOVERGENiHBG057654.
InParanoidiQ6AYJ1.
KOiK10899.
OMAiQKFRPLQ.
OrthoDBiEOG7K0ZC0.

Miscellaneous databases

NextBioi665291.
PROiQ6AYJ1.

Gene expression databases

ExpressionAtlasiQ6AYJ1. baseline and differential.
GenevisibleiQ6AYJ1. RN.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR004589. DNA_helicase_ATP-dep_RecQ.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR032284. RecQ_Zn-bd.
IPR018982. RQC_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF16124. RecQ_Zn_bind. 1 hit.
PF09382. RQC. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00614. recQ_fam. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-602, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRECQ1_RAT
AccessioniPrimary (citable) accession number: Q6AYJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: September 13, 2004
Last modified: May 11, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.