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Protein

ATP-dependent DNA helicase Q1

Gene

Recql

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi113 – 120ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent DNA helicase Q1 (EC:3.6.4.12)
Alternative name(s):
DNA-dependent ATPase Q1
RecQ protein-like 1
Gene namesi
Name:Recql
Synonyms:Recql1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1311071 Recql

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002050521 – 621ATP-dependent DNA helicase Q1Add BLAST621

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei514N6-acetyllysineBy similarity1
Modified residuei522N6-acetyllysineBy similarity1
Modified residuei597PhosphoserineBy similarity1
Modified residuei602PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6AYJ1
PRIDEiQ6AYJ1

PTM databases

iPTMnetiQ6AYJ1
PhosphoSitePlusiQ6AYJ1

Expressioni

Gene expression databases

BgeeiENSRNOG00000012602
ExpressionAtlasiQ6AYJ1 baseline and differential
GenevisibleiQ6AYJ1 RN

Interactioni

Subunit structurei

Interacts with EXO1 and MLH1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060671

Structurei

3D structure databases

ProteinModelPortaliQ6AYJ1
SMRiQ6AYJ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 275Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST176
Domaini296 – 451Helicase C-terminalPROSITE-ProRule annotationAdd BLAST156

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi219 – 222DEVH box4

Sequence similaritiesi

Belongs to the helicase family. RecQ subfamily.Curated

Phylogenomic databases

eggNOGiKOG0351 Eukaryota
COG0514 LUCA
GeneTreeiENSGT00550000074520
HOGENOMiHOG000044388
HOVERGENiHBG057654
InParanoidiQ6AYJ1
KOiK10899
OMAiESSQTCH
OrthoDBiEOG091G05Q8

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR004589 DNA_helicase_ATP-dep_RecQ
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR032284 RecQ_Zn-bd
IPR018982 RQC_domain
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF16124 RecQ_Zn_bind, 1 hit
PF09382 RQC, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00614 recQ_fam, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AYJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASIPALTDE LESVSSELHA VDIQIQELTE RQHELLQRKS VLTKRIKQCL
60 70 80 90 100
EDSAAEASGD CDTSPAAWSK EDFPWSGKVK HVLRDVFKLQ KFRPLQLETV
110 120 130 140 150
NATMARKDIF LVMPTGGGKS LCYQLPALCS DGFTLVICPL ISLMEDQLMV
160 170 180 190 200
LQQLGISATM LNSSSSKEHV KCVHTEMMNK NSHLKLIYVT PEKIAKSKMF
210 220 230 240 250
MSRLEKAYEA GRLTGVAVDE VHCCSQWGHD FRPDYKALGI LKRQFPNISL
260 270 280 290 300
IGLTATATNH VLKDAQKILC VEKCLTFTAS FNRPNLYYEV RQKPSSAEDF
310 320 330 340 350
IENIANLING RYKGKSGIIY CFSQKDSEQV TISLQKLGVR AGTYHANMEP
360 370 380 390 400
EDRTKVHTQW SANELQVVVA TVAFGMGIDK PDVRFVIHHS MSKSMENYYQ
410 420 430 440 450
ESGRAGRDDW RADCILYYGF GDIFRISSMV VMENVGQQKL YEMVSYCQNI
460 470 480 490 500
SKCRRALIAQ HFDEVWNADA CNKMCDNCCK DDSFEKKNIT EHCQALIKIL
510 520 530 540 550
KQAEGLNEKL TPLKLIDAWM GKGAAKFRVA GVAVPALPRE DLEKIIVHAL
560 570 580 590 600
LQQYLKEDYS FTAYATISYL KVGPRASLLS NEGHAVTMQV KRSTQSSVRA
610 620
ASPEACEVDS KGKEKSSAVL C
Length:621
Mass (Da):69,642
Last modified:September 13, 2004 - v1
Checksum:iFA8F6B04ADA341C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079026 mRNA Translation: AAH79026.1
RefSeqiNP_001012098.1, NM_001012098.1
XP_006237683.1, XM_006237621.2
XP_017448156.1, XM_017592667.1
UniGeneiRn.203166

Genome annotation databases

EnsembliENSRNOT00000065576; ENSRNOP00000060671; ENSRNOG00000012602
GeneIDi312824
KEGGirno:312824
UCSCiRGD:1311071 rat

Similar proteinsi

Entry informationi

Entry nameiRECQ1_RAT
AccessioniPrimary (citable) accession number: Q6AYJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health