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Protein

Leucine-rich repeat protein SHOC-2

Gene

Shoc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat protein SHOC-2
Alternative name(s):
Protein soc-2 homolog
Protein sur-8 homolog
Gene namesi
Name:Shoc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1308146. Shoc2.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Translocates from cytoplasm to nucleus upon growth factor stimulation.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003174221 – 582Leucine-rich repeat protein SHOC-2Add BLAST582

Proteomic databases

PaxDbiQ6AYI5.
PRIDEiQ6AYI5.

PTM databases

PhosphoSitePlusiQ6AYI5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015339.
GenevisibleiQ6AYI5. RN.

Interactioni

Subunit structurei

Interacts with M-Ras/MRAS, and RAF1. Forms a multiprotein complex with Ras (M-Ras/MRAS), Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC). Interacts with ERBIN; disrupts the interaction with RAF1 and Ras, leading to prevent activation of the Ras signaling pathway. Specifically binds K-Ras/KRAS, M-Ras/MRAS and N-Ras/NRAS but not H-Ras/HRAS (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi259419. 1 interactor.
STRINGi10116.ENSRNOP00000020580.

Structurei

3D structure databases

ProteinModelPortaliQ6AYI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati101 – 122LRR 1Add BLAST22
Repeati124 – 145LRR 2Add BLAST22
Repeati147 – 169LRR 3Add BLAST23
Repeati170 – 191LRR 4Add BLAST22
Repeati193 – 215LRR 5Add BLAST23
Repeati216 – 237LRR 6Add BLAST22
Repeati239 – 260LRR 7Add BLAST22
Repeati262 – 283LRR 8Add BLAST22
Repeati285 – 307LRR 9Add BLAST23
Repeati308 – 329LRR 10Add BLAST22
Repeati332 – 353LRR 11Add BLAST22
Repeati356 – 377LRR 12Add BLAST22
Repeati380 – 400LRR 13Add BLAST21
Repeati403 – 424LRR 14Add BLAST22
Repeati426 – 448LRR 15Add BLAST23
Repeati449 – 470LRR 16Add BLAST22
Repeati472 – 494LRR 17Add BLAST23
Repeati495 – 516LRR 18Add BLAST22
Repeati518 – 540LRR 19Add BLAST23
Repeati542 – 563LRR 20Add BLAST22

Sequence similaritiesi

Belongs to the SHOC2 family.Curated
Contains 20 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
HOGENOMiHOG000116557.
HOVERGENiHBG055661.
InParanoidiQ6AYI5.
KOiK19613.
OMAiEAPTLCF.
OrthoDBiEOG091G05NZ.
PhylomeDBiQ6AYI5.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 16 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 17 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AYI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSLGKEKD SKEKDPKVPS AKEREKEAKA SGGFGKESKE KEPKTKGKDA
60 70 80 90 100
KDGKKESSAA QPGVAFSVDN TIKRPNPALG TRKKSSNAEV TKELNKCREE
110 120 130 140 150
NSMRLDLSKR SIHILPPSVK ELTQLTELYL YSNKLQSLPA EVGCLVNLMT
160 170 180 190 200
LALSENSLTS LPDSLDNLKK LRMLDLRHNK LREIPSVVYR LDSLTTLYLR
210 220 230 240 250
FNRITAVEKD VRNLPRLSTL SIRENKIKQL PAEIGELCNL ITLDVAHNQL
260 270 280 290 300
EHLPKEIGNC TQITNLDLQH NELLDLPDTI GNLSSLNRLG LRYNRLSAIP
310 320 330 340 350
RSLAKCSALE ELNLENNNIS TLPESLLSSL VKLNSLTLAR NCFQLYPVGG
360 370 380 390 400
PSQFSTIYSL NMEHNRINKI PFGIFSRAKV LSKLNMKDNQ LTSLPLDFGT
410 420 430 440 450
WTSMVELNLA TNQLTKIPED VSGLVSLEVL ILSNNLLKKL PHGLGNLRKL
460 470 480 490 500
RELDLEENKL ESLPNEIAYL KDLQKLVLTN NQLTTLPRGI GHLTNLTHLG
510 520 530 540 550
LGENLLTHLP EEIGTLENLE ELYLNDNPNL HSLPFELALC SKLSIMSIEN
560 570 580
CPLSHLPPQI VAGGPSFIIQ FLKMQGPYRA MV
Length:582
Mass (Da):64,921
Last modified:September 13, 2004 - v1
Checksum:i27DFF097AD9FA37B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079032 mRNA. Translation: AAH79032.1.
RefSeqiNP_001013173.1. NM_001013155.1.
UniGeneiRn.156055.

Genome annotation databases

EnsembliENSRNOT00000020580; ENSRNOP00000020580; ENSRNOG00000015339.
GeneIDi309548.
KEGGirno:309548.
UCSCiRGD:1308146. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079032 mRNA. Translation: AAH79032.1.
RefSeqiNP_001013173.1. NM_001013155.1.
UniGeneiRn.156055.

3D structure databases

ProteinModelPortaliQ6AYI5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi259419. 1 interactor.
STRINGi10116.ENSRNOP00000020580.

PTM databases

PhosphoSitePlusiQ6AYI5.

Proteomic databases

PaxDbiQ6AYI5.
PRIDEiQ6AYI5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020580; ENSRNOP00000020580; ENSRNOG00000015339.
GeneIDi309548.
KEGGirno:309548.
UCSCiRGD:1308146. rat.

Organism-specific databases

CTDi8036.
RGDi1308146. Shoc2.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
HOGENOMiHOG000116557.
HOVERGENiHBG055661.
InParanoidiQ6AYI5.
KOiK19613.
OMAiEAPTLCF.
OrthoDBiEOG091G05NZ.
PhylomeDBiQ6AYI5.

Miscellaneous databases

PROiQ6AYI5.

Gene expression databases

BgeeiENSRNOG00000015339.
GenevisibleiQ6AYI5. RN.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 16 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 17 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSHOC2_RAT
AccessioniPrimary (citable) accession number: Q6AYI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 13, 2004
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.