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Q6AYI4

- NHEJ1_RAT

UniProt

Q6AYI4 - NHEJ1_RAT

Protein

Non-homologous end-joining factor 1

Gene

Nhej1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. B cell differentiation Source: UniProtKB
    2. DNA recombination Source: InterPro
    3. double-strand break repair via nonhomologous end joining Source: UniProtKB
    4. response to ionizing radiation Source: UniProtKB
    5. T cell differentiation Source: UniProtKB

    Keywords - Biological processi

    DNA damage, DNA repair

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-homologous end-joining factor 1
    Alternative name(s):
    Protein cernunnos
    XRCC4-like factor
    Gene namesi
    Name:Nhej1
    Synonyms:Xlf
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi1359338. Nhej1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nonhomologous end joining complex Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 304304Non-homologous end-joining factor 1PRO_0000228656Add
    BLAST

    Proteomic databases

    PaxDbiQ6AYI4.

    PTM databases

    PhosphoSiteiQ6AYI4.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6AYI4.

    Interactioni

    Subunit structurei

    Exists mainly as a homodimer. Interacts with XRCC4 and the XRCC4-LIG4 complex. Binds DNA in a length-dependent manner By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000024444.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AYI4.
    SMRiQ6AYI4. Positions 1-235.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 140140Globular headBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili133 – 17543By similarityAdd
    BLAST

    Domaini

    The coiled-coil region mediates homodimerization.By similarity

    Sequence similaritiesi

    Belongs to the XLF family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG47408.
    GeneTreeiENSGT00390000009940.
    HOGENOMiHOG000089974.
    HOVERGENiHBG080703.
    InParanoidiQ6AYI4.
    KOiK10980.
    OMAiYWNFHCI.
    OrthoDBiEOG7Z0JXT.
    PhylomeDBiQ6AYI4.
    TreeFamiTF328567.

    Family and domain databases

    Gene3Di2.170.210.10. 1 hit.
    InterProiIPR015381. XLF/Cernunnos.
    IPR009089. XRCC4_N.
    [Graphical view]
    PfamiPF09302. XLF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6AYI4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEELEQGLLM QPWAWLQLAE NSLLAKASIT KHGYALLISD LQQVWHEQVD    50
    TLEVSQRAKE LNKRLTAPPA AFLHHLDEVL RPLFKDSAHQ DAAHPSKATF 100
    SCDRGEEVLI LRVRSELSGL PFNWHFHCLP ASSLLVSQHL ICPLMGVSLA 150
    LHSHVRELAA LLRMKDLEIQ AYQESGAVLS RGRLKTEPFE ENSFLEQFMV 200
    EKLPEACAVG DGRPFAMNLQ SLYVAVTKQQ VQARQKHKGS GEPQTSSSTS 250
    PQGTDSQLQN QPEQQISPTP TLSEPECEPM AASGPVHRAQ LVKAKRKKPR 300
    GLFS 304
    Length:304
    Mass (Da):33,885
    Last modified:September 13, 2004 - v1
    Checksum:iDDB56676EB94B4DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079033 mRNA. Translation: AAH79033.1.
    RefSeqiNP_001014239.1. NM_001014217.1.
    XP_006245299.1. XM_006245237.1.
    XP_006245300.1. XM_006245238.1.
    XP_006245301.1. XM_006245239.1.
    XP_006245302.1. XM_006245240.1.
    XP_006245303.1. XM_006245241.1.
    XP_006245304.1. XM_006245242.1.
    UniGeneiRn.35483.

    Genome annotation databases

    EnsembliENSRNOT00000024444; ENSRNOP00000024444; ENSRNOG00000018162.
    GeneIDi363251.
    KEGGirno:363251.
    UCSCiRGD:1359338. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079033 mRNA. Translation: AAH79033.1 .
    RefSeqi NP_001014239.1. NM_001014217.1.
    XP_006245299.1. XM_006245237.1.
    XP_006245300.1. XM_006245238.1.
    XP_006245301.1. XM_006245239.1.
    XP_006245302.1. XM_006245240.1.
    XP_006245303.1. XM_006245241.1.
    XP_006245304.1. XM_006245242.1.
    UniGenei Rn.35483.

    3D structure databases

    ProteinModelPortali Q6AYI4.
    SMRi Q6AYI4. Positions 1-235.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000024444.

    PTM databases

    PhosphoSitei Q6AYI4.

    Proteomic databases

    PaxDbi Q6AYI4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000024444 ; ENSRNOP00000024444 ; ENSRNOG00000018162 .
    GeneIDi 363251.
    KEGGi rno:363251.
    UCSCi RGD:1359338. rat.

    Organism-specific databases

    CTDi 79840.
    RGDi 1359338. Nhej1.

    Phylogenomic databases

    eggNOGi NOG47408.
    GeneTreei ENSGT00390000009940.
    HOGENOMi HOG000089974.
    HOVERGENi HBG080703.
    InParanoidi Q6AYI4.
    KOi K10980.
    OMAi YWNFHCI.
    OrthoDBi EOG7Z0JXT.
    PhylomeDBi Q6AYI4.
    TreeFami TF328567.

    Miscellaneous databases

    NextBioi 683004.
    PROi Q6AYI4.

    Gene expression databases

    Genevestigatori Q6AYI4.

    Family and domain databases

    Gene3Di 2.170.210.10. 1 hit.
    InterProi IPR015381. XLF/Cernunnos.
    IPR009089. XRCC4_N.
    [Graphical view ]
    Pfami PF09302. XLF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiNHEJ1_RAT
    AccessioniPrimary (citable) accession number: Q6AYI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3