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Q6AYI4

- NHEJ1_RAT

UniProt

Q6AYI4 - NHEJ1_RAT

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Protein
Non-homologous end-joining factor 1
Gene
Nhej1, Xlf
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary By similarity.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. B cell differentiation Source: UniProtKB
  2. DNA recombination Source: InterPro
  3. T cell differentiation Source: UniProtKB
  4. double-strand break repair via nonhomologous end joining Source: UniProtKB
  5. response to ionizing radiation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-homologous end-joining factor 1
Alternative name(s):
Protein cernunnos
XRCC4-like factor
Gene namesi
Name:Nhej1
Synonyms:Xlf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi1359338. Nhej1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nonhomologous end joining complex Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Non-homologous end-joining factor 1
PRO_0000228656Add
BLAST

Proteomic databases

PaxDbiQ6AYI4.

PTM databases

PhosphoSiteiQ6AYI4.

Expressioni

Gene expression databases

GenevestigatoriQ6AYI4.

Interactioni

Subunit structurei

Exists mainly as a homodimer. Interacts with XRCC4 and the XRCC4-LIG4 complex. Binds DNA in a length-dependent manner By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024444.

Structurei

3D structure databases

ProteinModelPortaliQ6AYI4.
SMRiQ6AYI4. Positions 1-235.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 140140Globular head By similarity
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili133 – 17543 By similarity
Add
BLAST

Domaini

The coiled-coil region mediates homodimerization By similarity.

Sequence similaritiesi

Belongs to the XLF family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG47408.
GeneTreeiENSGT00390000009940.
HOGENOMiHOG000089974.
HOVERGENiHBG080703.
InParanoidiQ6AYI4.
KOiK10980.
OMAiYWNFHCI.
OrthoDBiEOG7Z0JXT.
PhylomeDBiQ6AYI4.
TreeFamiTF328567.

Family and domain databases

Gene3Di2.170.210.10. 1 hit.
InterProiIPR015381. XLF/Cernunnos.
IPR009089. XRCC4_N.
[Graphical view]
PfamiPF09302. XLF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AYI4-1 [UniParc]FASTAAdd to Basket

« Hide

MEELEQGLLM QPWAWLQLAE NSLLAKASIT KHGYALLISD LQQVWHEQVD    50
TLEVSQRAKE LNKRLTAPPA AFLHHLDEVL RPLFKDSAHQ DAAHPSKATF 100
SCDRGEEVLI LRVRSELSGL PFNWHFHCLP ASSLLVSQHL ICPLMGVSLA 150
LHSHVRELAA LLRMKDLEIQ AYQESGAVLS RGRLKTEPFE ENSFLEQFMV 200
EKLPEACAVG DGRPFAMNLQ SLYVAVTKQQ VQARQKHKGS GEPQTSSSTS 250
PQGTDSQLQN QPEQQISPTP TLSEPECEPM AASGPVHRAQ LVKAKRKKPR 300
GLFS 304
Length:304
Mass (Da):33,885
Last modified:September 13, 2004 - v1
Checksum:iDDB56676EB94B4DD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079033 mRNA. Translation: AAH79033.1.
RefSeqiNP_001014239.1. NM_001014217.1.
XP_006245299.1. XM_006245237.1.
XP_006245300.1. XM_006245238.1.
XP_006245301.1. XM_006245239.1.
XP_006245302.1. XM_006245240.1.
XP_006245303.1. XM_006245241.1.
XP_006245304.1. XM_006245242.1.
UniGeneiRn.35483.

Genome annotation databases

EnsembliENSRNOT00000024444; ENSRNOP00000024444; ENSRNOG00000018162.
GeneIDi363251.
KEGGirno:363251.
UCSCiRGD:1359338. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079033 mRNA. Translation: AAH79033.1 .
RefSeqi NP_001014239.1. NM_001014217.1.
XP_006245299.1. XM_006245237.1.
XP_006245300.1. XM_006245238.1.
XP_006245301.1. XM_006245239.1.
XP_006245302.1. XM_006245240.1.
XP_006245303.1. XM_006245241.1.
XP_006245304.1. XM_006245242.1.
UniGenei Rn.35483.

3D structure databases

ProteinModelPortali Q6AYI4.
SMRi Q6AYI4. Positions 1-235.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000024444.

PTM databases

PhosphoSitei Q6AYI4.

Proteomic databases

PaxDbi Q6AYI4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000024444 ; ENSRNOP00000024444 ; ENSRNOG00000018162 .
GeneIDi 363251.
KEGGi rno:363251.
UCSCi RGD:1359338. rat.

Organism-specific databases

CTDi 79840.
RGDi 1359338. Nhej1.

Phylogenomic databases

eggNOGi NOG47408.
GeneTreei ENSGT00390000009940.
HOGENOMi HOG000089974.
HOVERGENi HBG080703.
InParanoidi Q6AYI4.
KOi K10980.
OMAi YWNFHCI.
OrthoDBi EOG7Z0JXT.
PhylomeDBi Q6AYI4.
TreeFami TF328567.

Miscellaneous databases

NextBioi 683004.
PROi Q6AYI4.

Gene expression databases

Genevestigatori Q6AYI4.

Family and domain databases

Gene3Di 2.170.210.10. 1 hit.
InterProi IPR015381. XLF/Cernunnos.
IPR009089. XRCC4_N.
[Graphical view ]
Pfami PF09302. XLF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiNHEJ1_RAT
AccessioniPrimary (citable) accession number: Q6AYI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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