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Q6AYI4 (NHEJ1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Non-homologous end-joining factor 1
Alternative name(s):
Protein cernunnos
XRCC4-like factor
Gene names
Name:Nhej1
Synonyms:Xlf
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary By similarity.

Subunit structure

Exists mainly as a homodimer. Interacts with XRCC4 and the XRCC4-LIG4 complex. Binds DNA in a length-dependent manner By similarity.

Subcellular location

Nucleus By similarity.

Domain

The coiled-coil region mediates homodimerization By similarity.

Sequence similarities

Belongs to the XLF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 304304Non-homologous end-joining factor 1
PRO_0000228656

Regions

Region1 – 140140Globular head By similarity
Coiled coil133 – 17543 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AYI4 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: DDB56676EB94B4DD

FASTA30433,885
        10         20         30         40         50         60 
MEELEQGLLM QPWAWLQLAE NSLLAKASIT KHGYALLISD LQQVWHEQVD TLEVSQRAKE 

        70         80         90        100        110        120 
LNKRLTAPPA AFLHHLDEVL RPLFKDSAHQ DAAHPSKATF SCDRGEEVLI LRVRSELSGL 

       130        140        150        160        170        180 
PFNWHFHCLP ASSLLVSQHL ICPLMGVSLA LHSHVRELAA LLRMKDLEIQ AYQESGAVLS 

       190        200        210        220        230        240 
RGRLKTEPFE ENSFLEQFMV EKLPEACAVG DGRPFAMNLQ SLYVAVTKQQ VQARQKHKGS 

       250        260        270        280        290        300 
GEPQTSSSTS PQGTDSQLQN QPEQQISPTP TLSEPECEPM AASGPVHRAQ LVKAKRKKPR 


GLFS 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC079033 mRNA. Translation: AAH79033.1.
RefSeqNP_001014239.1. NM_001014217.1.
XP_006245299.1. XM_006245237.1.
XP_006245300.1. XM_006245238.1.
XP_006245301.1. XM_006245239.1.
XP_006245302.1. XM_006245240.1.
XP_006245303.1. XM_006245241.1.
XP_006245304.1. XM_006245242.1.
UniGeneRn.35483.

3D structure databases

ProteinModelPortalQ6AYI4.
SMRQ6AYI4. Positions 1-235.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000024444.

PTM databases

PhosphoSiteQ6AYI4.

Proteomic databases

PaxDbQ6AYI4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000024444; ENSRNOP00000024444; ENSRNOG00000018162.
GeneID363251.
KEGGrno:363251.
UCSCRGD:1359338. rat.

Organism-specific databases

CTD79840.
RGD1359338. Nhej1.

Phylogenomic databases

eggNOGNOG47408.
GeneTreeENSGT00390000009940.
HOGENOMHOG000089974.
HOVERGENHBG080703.
InParanoidQ6AYI4.
KOK10980.
OMAYWNFHCI.
OrthoDBEOG7Z0JXT.
PhylomeDBQ6AYI4.
TreeFamTF328567.

Gene expression databases

GenevestigatorQ6AYI4.

Family and domain databases

Gene3D2.170.210.10. 1 hit.
InterProIPR015381. XLF/Cernunnos.
IPR009089. XRCC4_N.
[Graphical view]
PfamPF09302. XLF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio683004.
PROQ6AYI4.

Entry information

Entry nameNHEJ1_RAT
AccessionPrimary (citable) accession number: Q6AYI4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families