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Protein

Dynein assembly factor 1, axonemal

Gene

Dnaaf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms (By similarity). Involved in regulation of microtubule-based cilia and actin-based brush border microvilli (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein assembly factor 1, axonemal
Alternative name(s):
Leucine-rich repeat-containing protein 50
Gene namesi
Name:Dnaaf1
Synonyms:Lrrc50
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1310542 Dnaaf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002328911 – 633Dynein assembly factor 1, axonemalAdd BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei349PhosphoserineCombined sources1
Modified residuei462PhosphothreonineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Modified residuei488PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AYH9
PRIDEiQ6AYH9

PTM databases

iPTMnetiQ6AYH9
PhosphoSitePlusiQ6AYH9

Expressioni

Gene expression databases

BgeeiENSRNOG00000015590
ExpressionAtlasiQ6AYH9 baseline and differential
GenevisibleiQ6AYH9 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020917

Structurei

3D structure databases

ProteinModelPortaliQ6AYH9
SMRiQ6AYH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati101 – 123LRR 1Add BLAST23
Repeati124 – 145LRR 2Add BLAST22
Repeati146 – 167LRR 3Add BLAST22
Repeati168 – 189LRR 4Add BLAST22
Repeati190 – 211LRR 5Add BLAST22
Repeati215 – 236LRR 6Add BLAST22
Domaini249 – 288LRRCTAdd BLAST40

Sequence similaritiesi

Belongs to the DNAAF1 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IG8N Eukaryota
ENOG410XQAN LUCA
GeneTreeiENSGT00900000140836
HOVERGENiHBG066969
InParanoidiQ6AYH9
KOiK19750
PhylomeDBiQ6AYH9
TreeFamiTF315818

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR027734 DNAAF1
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PANTHERiPTHR45256 PTHR45256, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits

Sequencei

Sequence statusi: Complete.

Q6AYH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPEASEPPV DSAAEPSLEE SAGDHGDAGP GVRKEEINET KETCVGPCTT
60 70 80 90 100
SCQSQQQPSG DNGSDGLFTH SRDDRDDRGP RMTKQFLQKL CKQHKLYVTP
110 120 130 140 150
ALNDTLYLHF KGFDRIENLE EYTGLRCLWL ECNGIQRIEN LQAQSELRCL
160 170 180 190 200
FLQVNLLHKI ENLEPLQKLD ALNLSNNYIK TIENLSCLPV LNTLQMAHNR
210 220 230 240 250
LETVADIEHL RECLQLCVLD LSHNSLSDPE ILSVLETMPC LRVLNLMGNP
260 270 280 290 300
VTKHIPNYRR TVTVRLKHLT YLDDRPVFPK DRACAEAWAR GGYAAEKEER
310 320 330 340 350
HQWESREHKK ITDSLEALAM IKRRAEERKK ARDRGETPLP ESEKSIPTSP
360 370 380 390 400
EAQEKPPKGE TQQKMESFVK ESFEAKDELF PEKPGEGEEL SVVVGNRAVE
410 420 430 440 450
DADLSGNLAH TQTPVVVTPE EVTSPVEATD GARTEDTEAI ALETKEKLFI
460 470 480 490 500
DDLPDLEDVD GTDVSVEDQT KDTGIRKIQA ISSLSDDSDL ELEELPLSVF
510 520 530 540 550
EGTPISPTGA LSHIFAVSKD PSEAARVPFA DICMPTATTD LETQSQDPST
560 570 580 590 600
ASSHPLIQEL GEDELTEGES NQPLPPQSCA SDPTLAQSSE GGDSQLPAAT
610 620 630
PLGDGAENEA QSSLYPEEPS TRIGLEDIEF GLD
Length:633
Mass (Da):69,956
Last modified:September 13, 2004 - v1
Checksum:iEFC7D371075A1FB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079038 mRNA Translation: AAH79038.1
RefSeqiNP_001014176.1, NM_001014154.1
UniGeneiRn.160929

Genome annotation databases

EnsembliENSRNOT00000020917; ENSRNOP00000020917; ENSRNOG00000015590
GeneIDi361419
KEGGirno:361419
UCSCiRGD:1310542 rat

Similar proteinsi

Entry informationi

Entry nameiDAAF1_RAT
AccessioniPrimary (citable) accession number: Q6AYH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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