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Protein

Dynein assembly factor 1, axonemal

Gene

Dnaaf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms (By similarity). Involved in regulation of microtubule-based cilia and actin-based brush border microvilli (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein assembly factor 1, axonemal
Alternative name(s):
Leucine-rich repeat-containing protein 50
Gene namesi
Name:Dnaaf1
Synonyms:Lrrc50
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1310542. Dnaaf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 633633Dynein assembly factor 1, axonemalPRO_0000232891Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei349 – 3491PhosphoserineCombined sources
Modified residuei462 – 4621PhosphothreonineCombined sources
Modified residuei465 – 4651PhosphoserineCombined sources
Modified residuei488 – 4881PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AYH9.

PTM databases

iPTMnetiQ6AYH9.
PhosphoSiteiQ6AYH9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015590.
ExpressionAtlasiQ6AYH9. baseline and differential.
GenevisibleiQ6AYH9. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020917.

Structurei

3D structure databases

ProteinModelPortaliQ6AYH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati101 – 12323LRR 1Add
BLAST
Repeati124 – 14522LRR 2Add
BLAST
Repeati146 – 16722LRR 3Add
BLAST
Repeati168 – 18922LRR 4Add
BLAST
Repeati190 – 21122LRR 5Add
BLAST
Repeati215 – 23622LRR 6Add
BLAST
Domaini249 – 28840LRRCTAdd
BLAST

Sequence similaritiesi

Belongs to the DNAAF1 family.Curated
Contains 6 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IG8N. Eukaryota.
ENOG410XQAN. LUCA.
GeneTreeiENSGT00730000110223.
HOVERGENiHBG066969.
InParanoidiQ6AYH9.
KOiK19750.
PhylomeDBiQ6AYH9.
TreeFamiTF315818.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR027734. DNAAF1.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PANTHERiPTHR24365:SF315. PTHR24365:SF315. 2 hits.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AYH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPEASEPPV DSAAEPSLEE SAGDHGDAGP GVRKEEINET KETCVGPCTT
60 70 80 90 100
SCQSQQQPSG DNGSDGLFTH SRDDRDDRGP RMTKQFLQKL CKQHKLYVTP
110 120 130 140 150
ALNDTLYLHF KGFDRIENLE EYTGLRCLWL ECNGIQRIEN LQAQSELRCL
160 170 180 190 200
FLQVNLLHKI ENLEPLQKLD ALNLSNNYIK TIENLSCLPV LNTLQMAHNR
210 220 230 240 250
LETVADIEHL RECLQLCVLD LSHNSLSDPE ILSVLETMPC LRVLNLMGNP
260 270 280 290 300
VTKHIPNYRR TVTVRLKHLT YLDDRPVFPK DRACAEAWAR GGYAAEKEER
310 320 330 340 350
HQWESREHKK ITDSLEALAM IKRRAEERKK ARDRGETPLP ESEKSIPTSP
360 370 380 390 400
EAQEKPPKGE TQQKMESFVK ESFEAKDELF PEKPGEGEEL SVVVGNRAVE
410 420 430 440 450
DADLSGNLAH TQTPVVVTPE EVTSPVEATD GARTEDTEAI ALETKEKLFI
460 470 480 490 500
DDLPDLEDVD GTDVSVEDQT KDTGIRKIQA ISSLSDDSDL ELEELPLSVF
510 520 530 540 550
EGTPISPTGA LSHIFAVSKD PSEAARVPFA DICMPTATTD LETQSQDPST
560 570 580 590 600
ASSHPLIQEL GEDELTEGES NQPLPPQSCA SDPTLAQSSE GGDSQLPAAT
610 620 630
PLGDGAENEA QSSLYPEEPS TRIGLEDIEF GLD
Length:633
Mass (Da):69,956
Last modified:September 13, 2004 - v1
Checksum:iEFC7D371075A1FB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079038 mRNA. Translation: AAH79038.1.
RefSeqiNP_001014176.1. NM_001014154.1.
UniGeneiRn.160929.

Genome annotation databases

EnsembliENSRNOT00000020917; ENSRNOP00000020917; ENSRNOG00000015590.
GeneIDi361419.
KEGGirno:361419.
UCSCiRGD:1310542. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079038 mRNA. Translation: AAH79038.1.
RefSeqiNP_001014176.1. NM_001014154.1.
UniGeneiRn.160929.

3D structure databases

ProteinModelPortaliQ6AYH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020917.

PTM databases

iPTMnetiQ6AYH9.
PhosphoSiteiQ6AYH9.

Proteomic databases

PaxDbiQ6AYH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020917; ENSRNOP00000020917; ENSRNOG00000015590.
GeneIDi361419.
KEGGirno:361419.
UCSCiRGD:1310542. rat.

Organism-specific databases

CTDi123872.
RGDi1310542. Dnaaf1.

Phylogenomic databases

eggNOGiENOG410IG8N. Eukaryota.
ENOG410XQAN. LUCA.
GeneTreeiENSGT00730000110223.
HOVERGENiHBG066969.
InParanoidiQ6AYH9.
KOiK19750.
PhylomeDBiQ6AYH9.
TreeFamiTF315818.

Miscellaneous databases

PROiQ6AYH9.

Gene expression databases

BgeeiENSRNOG00000015590.
ExpressionAtlasiQ6AYH9. baseline and differential.
GenevisibleiQ6AYH9. RN.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR027734. DNAAF1.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PANTHERiPTHR24365:SF315. PTHR24365:SF315. 2 hits.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDAAF1_RAT
AccessioniPrimary (citable) accession number: Q6AYH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.