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Protein

Dynactin subunit 2

Gene

Dctn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • mitotic cell cycle Source: RGD
  • mitotic spindle organization Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-2132295. MHC class II antigen presentation.
R-RNO-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-RNO-3371497. HSP90 chaperone cycle for steroid hormone receptors (SHR).
R-RNO-380259. Loss of Nlp from mitotic centrosomes.
R-RNO-380270. Recruitment of mitotic centrosome proteins and complexes.
R-RNO-380320. Recruitment of NuMA to mitotic centrosomes.
R-RNO-5620912. Anchoring of the basal body to the plasma membrane.
R-RNO-6807878. COPI-mediated anterograde transport.
R-RNO-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-RNO-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynactin subunit 2
Gene namesi
Name:Dctn2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1303182. Dctn2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002887662 – 402Dynactin subunit 2Add BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei6PhosphotyrosineBy similarity1
Modified residuei83PhosphoserineBy similarity1
Modified residuei86PhosphotyrosineBy similarity1
Modified residuei134PhosphothreonineBy similarity1
Modified residuei199PhosphothreonineCombined sources1
Modified residuei321PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6AYH5.
PRIDEiQ6AYH5.

PTM databases

iPTMnetiQ6AYH5.
PhosphoSitePlusiQ6AYH5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000025481.
ExpressionAtlasiQ6AYH5. baseline and differential.
GenevisibleiQ6AYH5. RN.

Interactioni

Subunit structurei

Subunit of dynactin, a multiprotein complex associated with dynein. Interacts with BICD2, CEP135, DYNAP, ECM29 and MAPRE1.By similarity

Protein-protein interaction databases

BioGridi256357. 4 interactors.
IntActiQ6AYH5. 1 interactor.
STRINGi10116.ENSRNOP00000008120.

Structurei

3D structure databases

SMRiQ6AYH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili100 – 130Sequence analysisAdd BLAST31
Coiled coili215 – 247Sequence analysisAdd BLAST33

Sequence similaritiesi

Belongs to the dynactin subunit 2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3958. Eukaryota.
ENOG410XSZK. LUCA.
GeneTreeiENSGT00390000003427.
HOGENOMiHOG000007303.
HOVERGENiHBG051323.
InParanoidiQ6AYH5.
KOiK10424.
PhylomeDBiQ6AYH5.
TreeFamiTF105247.

Family and domain databases

InterProiView protein in InterPro
IPR028133. Dynamitin.
PANTHERiPTHR15346:SF1. PTHR15346:SF1. 1 hit.
PfamiView protein in Pfam
PF04912. Dynamitin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AYH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPKYADLP GIARNEPDVY ETSDLPEDDQ AEFDAEELSS TSVEHIIVNP
60 70 80 90 100
NAAYDKFKDK RVGTKGLDFS DRIGKTKRTG YESGDYEMLG EGLGVKETPQ
110 120 130 140 150
QKYQRLLHEV QELTTEVEKI KTTVKESATE EKLTPVVLAK QLAALKQQLV
160 170 180 190 200
ASHLEKLLGP DAAINLADPD GALAKRLLLQ LEATKSSKGS SGGKSTGGTP
210 220 230 240 250
PDSSLVTYEL HSRPEQDKFS QAAKVAELEK RLTELEATVR CDQDAQNPLS
260 270 280 290 300
AGLQGACLME TVELLQAKVN ALDLAVLDQV EARLQSVLGK VNEIAKHKAS
310 320 330 340 350
VEDADTQNKV HQLYETIQRW SPVASTLPEL VQRLVTIKQL HEQAMQFGQL
360 370 380 390 400
LTHLDTTQQM MASSLKDNTA LLTQVQTTMR ENLATVEGNF ASIDARMKKL

GK
Length:402
Mass (Da):44,148
Last modified:September 13, 2004 - v1
Checksum:i550335535A4FB052
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079042 mRNA. Translation: AAH79042.1.
RefSeqiNP_001004239.1. NM_001004239.1.
UniGeneiRn.101923.

Genome annotation databases

EnsembliENSRNOT00000008120; ENSRNOP00000008120; ENSRNOG00000025481.
GeneIDi299850.
KEGGirno:299850.
UCSCiRGD:1303182. rat.

Similar proteinsi

Entry informationi

Entry nameiDCTN2_RAT
AccessioniPrimary (citable) accession number: Q6AYH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2004
Last modified: September 27, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families