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Protein

Dynactin subunit 2

Gene

Dctn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • mitotic nuclear division Source: RGD
  • mitotic spindle organization Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-2132295. MHC class II antigen presentation.
R-RNO-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-RNO-380259. Loss of Nlp from mitotic centrosomes.
R-RNO-380270. Recruitment of mitotic centrosome proteins and complexes.
R-RNO-5620912. Anchoring of the basal body to the plasma membrane.
R-RNO-6807878. COPI-mediated anterograde transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynactin subunit 2
Gene namesi
Name:Dctn2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1303182. Dctn2.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: RGD
  • cytoplasm Source: UniProtKB-KW
  • cytoskeleton Source: RGD
  • dynactin complex Source: RGD
  • dynein complex Source: UniProtKB-KW
  • kinetochore Source: RGD
  • membrane Source: UniProtKB-SubCell
  • microtubule Source: UniProtKB-KW
  • vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 402401Dynactin subunit 2PRO_0000288766Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei6 – 61PhosphotyrosineBy similarity
Modified residuei83 – 831PhosphoserineBy similarity
Modified residuei86 – 861PhosphotyrosineBy similarity
Modified residuei199 – 1991PhosphothreonineCombined sources
Modified residuei321 – 3211PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6AYH5.
PRIDEiQ6AYH5.

PTM databases

iPTMnetiQ6AYH5.
PhosphoSiteiQ6AYH5.

Expressioni

Gene expression databases

ExpressionAtlasiQ6AYH5. baseline and differential.
GenevisibleiQ6AYH5. RN.

Interactioni

Subunit structurei

Subunit of dynactin, a multiprotein complex associated with dynein. Interacts with BICD2, CEP135, DYNAP, ECM29 and MAPRE1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi256357. 4 interactions.
IntActiQ6AYH5. 1 interaction.
STRINGi10116.ENSRNOP00000008120.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili100 – 13031Sequence analysisAdd
BLAST
Coiled coili215 – 24733Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the dynactin subunit 2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3958. Eukaryota.
ENOG410XSZK. LUCA.
GeneTreeiENSGT00390000003427.
HOGENOMiHOG000007303.
HOVERGENiHBG051323.
InParanoidiQ6AYH5.
KOiK10424.
OMAiKYQRLVN.
OrthoDBiEOG7JT6WG.
PhylomeDBiQ6AYH5.
TreeFamiTF105247.

Family and domain databases

InterProiIPR028133. Dynamitin.
[Graphical view]
PANTHERiPTHR15346:SF0. PTHR15346:SF0. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AYH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPKYADLP GIARNEPDVY ETSDLPEDDQ AEFDAEELSS TSVEHIIVNP
60 70 80 90 100
NAAYDKFKDK RVGTKGLDFS DRIGKTKRTG YESGDYEMLG EGLGVKETPQ
110 120 130 140 150
QKYQRLLHEV QELTTEVEKI KTTVKESATE EKLTPVVLAK QLAALKQQLV
160 170 180 190 200
ASHLEKLLGP DAAINLADPD GALAKRLLLQ LEATKSSKGS SGGKSTGGTP
210 220 230 240 250
PDSSLVTYEL HSRPEQDKFS QAAKVAELEK RLTELEATVR CDQDAQNPLS
260 270 280 290 300
AGLQGACLME TVELLQAKVN ALDLAVLDQV EARLQSVLGK VNEIAKHKAS
310 320 330 340 350
VEDADTQNKV HQLYETIQRW SPVASTLPEL VQRLVTIKQL HEQAMQFGQL
360 370 380 390 400
LTHLDTTQQM MASSLKDNTA LLTQVQTTMR ENLATVEGNF ASIDARMKKL

GK
Length:402
Mass (Da):44,148
Last modified:September 13, 2004 - v1
Checksum:i550335535A4FB052
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079042 mRNA. Translation: AAH79042.1.
RefSeqiNP_001004239.1. NM_001004239.1.
UniGeneiRn.101923.

Genome annotation databases

EnsembliENSRNOT00000008120; ENSRNOP00000008120; ENSRNOG00000025481.
GeneIDi299850.
KEGGirno:299850.
UCSCiRGD:1303182. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079042 mRNA. Translation: AAH79042.1.
RefSeqiNP_001004239.1. NM_001004239.1.
UniGeneiRn.101923.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi256357. 4 interactions.
IntActiQ6AYH5. 1 interaction.
STRINGi10116.ENSRNOP00000008120.

PTM databases

iPTMnetiQ6AYH5.
PhosphoSiteiQ6AYH5.

Proteomic databases

PaxDbiQ6AYH5.
PRIDEiQ6AYH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008120; ENSRNOP00000008120; ENSRNOG00000025481.
GeneIDi299850.
KEGGirno:299850.
UCSCiRGD:1303182. rat.

Organism-specific databases

CTDi10540.
RGDi1303182. Dctn2.

Phylogenomic databases

eggNOGiKOG3958. Eukaryota.
ENOG410XSZK. LUCA.
GeneTreeiENSGT00390000003427.
HOGENOMiHOG000007303.
HOVERGENiHBG051323.
InParanoidiQ6AYH5.
KOiK10424.
OMAiKYQRLVN.
OrthoDBiEOG7JT6WG.
PhylomeDBiQ6AYH5.
TreeFamiTF105247.

Enzyme and pathway databases

ReactomeiR-RNO-2132295. MHC class II antigen presentation.
R-RNO-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-RNO-380259. Loss of Nlp from mitotic centrosomes.
R-RNO-380270. Recruitment of mitotic centrosome proteins and complexes.
R-RNO-5620912. Anchoring of the basal body to the plasma membrane.
R-RNO-6807878. COPI-mediated anterograde transport.

Miscellaneous databases

NextBioi645898.
PROiQ6AYH5.

Gene expression databases

ExpressionAtlasiQ6AYH5. baseline and differential.
GenevisibleiQ6AYH5. RN.

Family and domain databases

InterProiIPR028133. Dynamitin.
[Graphical view]
PANTHERiPTHR15346:SF0. PTHR15346:SF0. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Lubec G., Chen W.-Q.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 269-283; 320-333 AND 381-396, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-199, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDCTN2_RAT
AccessioniPrimary (citable) accession number: Q6AYH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2004
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.