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Protein

NFATC2-interacting protein

Gene

Nfatc2ip

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
NFATC2-interacting protein
Alternative name(s):
Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein
Gene namesi
Name:Nfatc2ip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1359096. Nfatc2ip.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414NFATC2-interacting proteinPRO_0000281011Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521PhosphoserineCombined sources
Modified residuei54 – 541PhosphoserineCombined sources
Modified residuei83 – 831PhosphoserineCombined sources
Modified residuei85 – 851PhosphoserineBy similarity
Modified residuei87 – 871PhosphoserineCombined sources
Modified residuei121 – 1211PhosphoserineBy similarity
Modified residuei193 – 1931PhosphoserineBy similarity
Modified residuei199 – 1991PhosphoserineBy similarity
Modified residuei309 – 3091PhosphoserineBy similarity
Modified residuei311 – 3111PhosphothreonineBy similarity
Modified residuei313 – 3131PhosphothreonineBy similarity
Modified residuei364 – 3641PhosphoserineBy similarity
Modified residuei385 – 3851PhosphoserineBy similarity

Post-translational modificationi

Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ6AYG7.

PTM databases

iPTMnetiQ6AYG7.

Interactioni

Subunit structurei

Interacts with NFATC2, TRAF1, TRAF2 and PRMT1. Interacts with UBE2I/UBC9 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041221.

Structurei

3D structure databases

ProteinModelPortaliQ6AYG7.
SMRiQ6AYG7. Positions 337-414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini343 – 41472Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili170 – 22960Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1769. Eukaryota.
COG5227. LUCA.
GeneTreeiENSGT00390000007119.
HOGENOMiHOG000285948.
HOVERGENiHBG082020.
InParanoidiQ6AYG7.
OMAiSHYEEAM.
OrthoDBiEOG73806D.
PhylomeDBiQ6AYG7.
TreeFamiTF328600.

Family and domain databases

InterProiIPR022617. Rad60/SUMO-like_dom.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF11976. Rad60-SLD. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 2 hits.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AYG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEPLRRRGP RSRGGRASRG ARRARAARGR CPRAPRSPTR LIPDTVLVDL
60 70 80 90 100
VSDSDEEVLE VVADPGEVPV ARLPAPAAPE QDSDSDSEGA AEGPAGAPRT
110 120 130 140 150
LVRRRRRLLD PGEAPVVPVY SGKVQSSLNL IPDNSSLLKL CPSEPEDEAD
160 170 180 190 200
LTDSGSPPSE DALPPGSPWK KKLRKKHEKE EKKMEEFPDQ DISPLPQPSS
210 220 230 240 250
RNKSRKHTEA LQKLREVNKR LQDLRSCLSP KQHQSPALQN TDDEVVLVEG
260 270 280 290 300
SVLPQNPRLF TLKIRCRADL VRLPVKTSEP LQNVVDHMAS HLGVSPNRIL
310 320 330 340 350
LLFGETELSP TATPRTLKLG VADIIDCVVL ASSSEDTETS QELRLRVQGK
360 370 380 390 400
EKHQMLEISL SPDSPLKVLM SHYEEAMGLS GHKLSFFFDG TKLSGKELPT
410
DLGLESGDLI EVWG
Length:414
Mass (Da):45,430
Last modified:September 13, 2004 - v1
Checksum:iE11DAA35B3DB8F19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079050 mRNA. Translation: AAH79050.1.
RefSeqiNP_001007693.1. NM_001007692.1.
UniGeneiRn.101030.

Genome annotation databases

EnsembliENSRNOT00000090200; ENSRNOP00000073844; ENSRNOG00000057384.
GeneIDi308983.
KEGGirno:308983.
UCSCiRGD:1359096. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079050 mRNA. Translation: AAH79050.1.
RefSeqiNP_001007693.1. NM_001007692.1.
UniGeneiRn.101030.

3D structure databases

ProteinModelPortaliQ6AYG7.
SMRiQ6AYG7. Positions 337-414.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041221.

PTM databases

iPTMnetiQ6AYG7.

Proteomic databases

PaxDbiQ6AYG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000090200; ENSRNOP00000073844; ENSRNOG00000057384.
GeneIDi308983.
KEGGirno:308983.
UCSCiRGD:1359096. rat.

Organism-specific databases

CTDi84901.
RGDi1359096. Nfatc2ip.

Phylogenomic databases

eggNOGiKOG1769. Eukaryota.
COG5227. LUCA.
GeneTreeiENSGT00390000007119.
HOGENOMiHOG000285948.
HOVERGENiHBG082020.
InParanoidiQ6AYG7.
OMAiSHYEEAM.
OrthoDBiEOG73806D.
PhylomeDBiQ6AYG7.
TreeFamiTF328600.

Miscellaneous databases

PROiQ6AYG7.

Family and domain databases

InterProiIPR022617. Rad60/SUMO-like_dom.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF11976. Rad60-SLD. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 2 hits.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52; SER-54; SER-83 AND SER-87, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNF2IP_RAT
AccessioniPrimary (citable) accession number: Q6AYG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.