Q6AYG5 (ECHD1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ethylmalonyl-CoA decarboxylase
EC=4.1.1.94

Alternative name(s):
Enoyl-CoA hydratase domain-containing protein 1
Methylmalonyl-CoA decarboxylase
Short name=MMCD
EC=4.1.1.41

Gene names

Name:

Echdc1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activityx at lower level By similarity.
Catalytic activity	(S)-ethylmalonyl-CoA = butanoyl-CoA + CO2. (S)-methylmalonyl-CoA = propanoyl-CoA + CO2.
Subcellular location	Cytoplasm › cytosol By similarity.
Sequence similarities	Belongs to the enoyl-CoA hydratase/isomerase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	carboxy-lyase activity Inferred from sequence or structural similarity. Source: UniProtKB methylmalonyl-CoA decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	Ethylmalonyl-CoA decarboxylase		PRO_0000273249

Sequences

	Sequence		Length	Mass (Da)
	Q6AYG5 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: B74CCD89B663C42E	FASTA	299	32,631
	10 20 30 40 50 60 MAKSLLASSL SVRTKILQTG VSLYNTTHGF HEEEVKKILE QFPGGSIDLQ KKQNGIGILT 70 80 90 100 110 120 LNNSNKMNAF SGAMMLQLLE RVIELENWTE GKGLIVHGAK NTFCSGSDLN AVKALSTPEN 130 140 150 160 170 180 GVALSMFMQN TLTRFMRLPL ISVALVQGWA MGGGAELTTA CDFRLMTEES VIRFVHKEMG 190 200 210 220 230 240 IVPSWGGASR LVEIIGSRQA LKVLSGTFKL DSKEALRIGL ADEVLQPSDE ATALEQAQEW 250 260 270 280 290 LEQFVSGPAQ VIRGLKKSVC SGRELYLEEA LQNERDVLET LWGGPANLEA IAKKGKHTK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	Lubec G., Afjehi-Sadat L. Submitted (DEC-2006) to UniProtKB Cited for: PROTEIN SEQUENCE OF 38-51, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Spinal cord.
[3]	"Ethylmalonyl-CoA decarboxylase, a new enzyme involved in metabolite proofreading." Linster C.L., Noel G., Stroobant V., Vertommen D., Vincent M.F., Bommer G.T., Veiga-da-Cunha M., Van Schaftingen E. J. Biol. Chem. 286:42992-43003(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC079052 mRNA. Translation: AAH79052.1.
IPI	IPI00214033.
RefSeq	NP_001007735.1. NM_001007734.1.
UniGene	Rn.4220.
3D structure databases
ProteinModelPortal	Q6AYG5.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000015440.
Proteomic databases
PaxDb	Q6AYG5.
PRIDE	Q6AYG5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000015440; ENSRNOP00000015440; ENSRNOG00000011622.
GeneID	361465.
KEGG	rno:361465.
UCSC	RGD:1359654. rat.
Organism-specific databases
CTD	55862.
RGD	1359654. Echdc1.
Phylogenomic databases
eggNOG	COG1024.
GeneTree	ENSGT00700000104549.
HOGENOM	HOG000007808.
HOVERGEN	HBG054783.
InParanoid	Q6AYG5.
OrthoDB	EOG447FTV.
Gene expression databases
Genevestigator	Q6AYG5.
Family and domain databases
InterPro	IPR001753. Crotonase_core_superfam. IPR018376. Enoyl-CoA_hyd/isom_CS. [Graphical view]
Pfam	PF00378. ECH. 1 hit. [Graphical view]
PROSITE	PS00166. ENOYL_COA_HYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	676398.

Entry information

Entry name

ECHD1_RAT

Accession

Primary (citable) accession number: Q6AYG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	September 13, 2004
Last modified:	April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program