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Q6AYG5

- ECHD1_RAT

UniProt

Q6AYG5 - ECHD1_RAT

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Protein
Ethylmalonyl-CoA decarboxylase
Gene
Echdc1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level By similarity.

Catalytic activityi

(S)-ethylmalonyl-CoA = butanoyl-CoA + CO2.
(S)-methylmalonyl-CoA = propanoyl-CoA + CO2.

GO - Molecular functioni

  1. carboxy-lyase activity Source: UniProtKB
  2. methylmalonyl-CoA decarboxylase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Lyase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ethylmalonyl-CoA decarboxylase (EC:4.1.1.94)
    Alternative name(s):
    Enoyl-CoA hydratase domain-containing protein 1
    Methylmalonyl-CoA decarboxylase (EC:4.1.1.41)
    Short name:
    MMCD
    Gene namesi
    Name:Echdc1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi1359654. Echdc1.

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Ethylmalonyl-CoA decarboxylase
    PRO_0000273249Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei209 – 2091N6-acetyllysine; alternate By similarity
    Modified residuei209 – 2091N6-succinyllysine; alternate By similarity
    Modified residuei293 – 2931N6-succinyllysine By similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ6AYG5.
    PRIDEiQ6AYG5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6AYG5.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000015440.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AYG5.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1024.
    GeneTreeiENSGT00720000108837.
    HOGENOMiHOG000007808.
    HOVERGENiHBG054783.
    InParanoidiQ6AYG5.
    OMAiHKHMGLV.
    OrthoDBiEOG79W95T.
    PhylomeDBiQ6AYG5.
    TreeFamiTF315986.

    Family and domain databases

    Gene3Di3.90.226.10. 1 hit.
    InterProiIPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    IPR018376. Enoyl-CoA_hyd/isom_CS.
    [Graphical view]
    PfamiPF00378. ECH. 1 hit.
    [Graphical view]
    SUPFAMiSSF52096. SSF52096. 1 hit.
    PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6AYG5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKSLLASSL SVRTKILQTG VSLYNTTHGF HEEEVKKILE QFPGGSIDLQ    50
    KKQNGIGILT LNNSNKMNAF SGAMMLQLLE RVIELENWTE GKGLIVHGAK 100
    NTFCSGSDLN AVKALSTPEN GVALSMFMQN TLTRFMRLPL ISVALVQGWA 150
    MGGGAELTTA CDFRLMTEES VIRFVHKEMG IVPSWGGASR LVEIIGSRQA 200
    LKVLSGTFKL DSKEALRIGL ADEVLQPSDE ATALEQAQEW LEQFVSGPAQ 250
    VIRGLKKSVC SGRELYLEEA LQNERDVLET LWGGPANLEA IAKKGKHTK 299
    Length:299
    Mass (Da):32,631
    Last modified:September 13, 2004 - v1
    Checksum:iB74CCD89B663C42E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079052 mRNA. Translation: AAH79052.1.
    RefSeqiNP_001007735.1. NM_001007734.1.
    XP_006227809.1. XM_006227747.1.
    UniGeneiRn.4220.

    Genome annotation databases

    EnsembliENSRNOT00000015440; ENSRNOP00000015440; ENSRNOG00000011622.
    GeneIDi361465.
    KEGGirno:361465.
    UCSCiRGD:1359654. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079052 mRNA. Translation: AAH79052.1 .
    RefSeqi NP_001007735.1. NM_001007734.1.
    XP_006227809.1. XM_006227747.1.
    UniGenei Rn.4220.

    3D structure databases

    ProteinModelPortali Q6AYG5.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000015440.

    Proteomic databases

    PaxDbi Q6AYG5.
    PRIDEi Q6AYG5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000015440 ; ENSRNOP00000015440 ; ENSRNOG00000011622 .
    GeneIDi 361465.
    KEGGi rno:361465.
    UCSCi RGD:1359654. rat.

    Organism-specific databases

    CTDi 55862.
    RGDi 1359654. Echdc1.

    Phylogenomic databases

    eggNOGi COG1024.
    GeneTreei ENSGT00720000108837.
    HOGENOMi HOG000007808.
    HOVERGENi HBG054783.
    InParanoidi Q6AYG5.
    OMAi HKHMGLV.
    OrthoDBi EOG79W95T.
    PhylomeDBi Q6AYG5.
    TreeFami TF315986.

    Miscellaneous databases

    NextBioi 676398.

    Gene expression databases

    Genevestigatori Q6AYG5.

    Family and domain databases

    Gene3Di 3.90.226.10. 1 hit.
    InterProi IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    IPR018376. Enoyl-CoA_hyd/isom_CS.
    [Graphical view ]
    Pfami PF00378. ECH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52096. SSF52096. 1 hit.
    PROSITEi PS00166. ENOYL_COA_HYDRATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. Lubec G., Afjehi-Sadat L.
      Submitted (DEC-2006) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 38-51, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Spinal cord.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiECHD1_RAT
    AccessioniPrimary (citable) accession number: Q6AYG5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: September 13, 2004
    Last modified: June 11, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3
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