Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6AYG5

- ECHD1_RAT

UniProt

Q6AYG5 - ECHD1_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ethylmalonyl-CoA decarboxylase

Gene

Echdc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity).By similarity

Catalytic activityi

(S)-ethylmalonyl-CoA = butanoyl-CoA + CO2.
(S)-methylmalonyl-CoA = propanoyl-CoA + CO2.

GO - Molecular functioni

  1. carboxy-lyase activity Source: UniProtKB
  2. methylmalonyl-CoA decarboxylase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylmalonyl-CoA decarboxylase (EC:4.1.1.94)
Alternative name(s):
Enoyl-CoA hydratase domain-containing protein 1
Methylmalonyl-CoA decarboxylase (EC:4.1.1.41)
Short name:
MMCD
Gene namesi
Name:Echdc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi1359654. Echdc1.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Ethylmalonyl-CoA decarboxylasePRO_0000273249Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei209 – 2091N6-acetyllysine; alternateBy similarity
Modified residuei209 – 2091N6-succinyllysine; alternateBy similarity
Modified residuei293 – 2931N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6AYG5.
PRIDEiQ6AYG5.

Expressioni

Gene expression databases

GenevestigatoriQ6AYG5.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015440.

Structurei

3D structure databases

ProteinModelPortaliQ6AYG5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1024.
GeneTreeiENSGT00720000108837.
HOGENOMiHOG000007808.
HOVERGENiHBG054783.
InParanoidiQ6AYG5.
KOiK18426.
OMAiHKHMGLV.
OrthoDBiEOG79W95T.
PhylomeDBiQ6AYG5.
TreeFamiTF315986.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AYG5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKSLLASSL SVRTKILQTG VSLYNTTHGF HEEEVKKILE QFPGGSIDLQ
60 70 80 90 100
KKQNGIGILT LNNSNKMNAF SGAMMLQLLE RVIELENWTE GKGLIVHGAK
110 120 130 140 150
NTFCSGSDLN AVKALSTPEN GVALSMFMQN TLTRFMRLPL ISVALVQGWA
160 170 180 190 200
MGGGAELTTA CDFRLMTEES VIRFVHKEMG IVPSWGGASR LVEIIGSRQA
210 220 230 240 250
LKVLSGTFKL DSKEALRIGL ADEVLQPSDE ATALEQAQEW LEQFVSGPAQ
260 270 280 290
VIRGLKKSVC SGRELYLEEA LQNERDVLET LWGGPANLEA IAKKGKHTK
Length:299
Mass (Da):32,631
Last modified:September 13, 2004 - v1
Checksum:iB74CCD89B663C42E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079052 mRNA. Translation: AAH79052.1.
RefSeqiNP_001007735.1. NM_001007734.1.
XP_006227809.1. XM_006227747.2.
UniGeneiRn.4220.

Genome annotation databases

EnsembliENSRNOT00000015440; ENSRNOP00000015440; ENSRNOG00000011622.
GeneIDi361465.
KEGGirno:361465.
UCSCiRGD:1359654. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079052 mRNA. Translation: AAH79052.1 .
RefSeqi NP_001007735.1. NM_001007734.1.
XP_006227809.1. XM_006227747.2.
UniGenei Rn.4220.

3D structure databases

ProteinModelPortali Q6AYG5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000015440.

Proteomic databases

PaxDbi Q6AYG5.
PRIDEi Q6AYG5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000015440 ; ENSRNOP00000015440 ; ENSRNOG00000011622 .
GeneIDi 361465.
KEGGi rno:361465.
UCSCi RGD:1359654. rat.

Organism-specific databases

CTDi 55862.
RGDi 1359654. Echdc1.

Phylogenomic databases

eggNOGi COG1024.
GeneTreei ENSGT00720000108837.
HOGENOMi HOG000007808.
HOVERGENi HBG054783.
InParanoidi Q6AYG5.
KOi K18426.
OMAi HKHMGLV.
OrthoDBi EOG79W95T.
PhylomeDBi Q6AYG5.
TreeFami TF315986.

Miscellaneous databases

NextBioi 676398.

Gene expression databases

Genevestigatori Q6AYG5.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
InterProi IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view ]
Pfami PF00378. ECH. 1 hit.
[Graphical view ]
SUPFAMi SSF52096. SSF52096. 1 hit.
PROSITEi PS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Lubec G., Afjehi-Sadat L.
    Submitted (DEC-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 38-51, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Spinal cord.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiECHD1_RAT
AccessioniPrimary (citable) accession number: Q6AYG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: September 13, 2004
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3