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Protein

Ethylmalonyl-CoA decarboxylase

Gene

Echdc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity).By similarity

Catalytic activityi

(S)-ethylmalonyl-CoA = butanoyl-CoA + CO2.
(S)-methylmalonyl-CoA = propanoyl-CoA + CO2.

GO - Molecular functioni

  1. carboxy-lyase activity Source: UniProtKB
  2. methylmalonyl-CoA decarboxylase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylmalonyl-CoA decarboxylase (EC:4.1.1.94)
Alternative name(s):
Enoyl-CoA hydratase domain-containing protein 1
Methylmalonyl-CoA decarboxylase (EC:4.1.1.41)
Short name:
MMCD
Gene namesi
Name:Echdc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi1359654. Echdc1.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Ethylmalonyl-CoA decarboxylasePRO_0000273249Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei209 – 2091N6-acetyllysine; alternateBy similarity
Modified residuei209 – 2091N6-succinyllysine; alternateBy similarity
Modified residuei293 – 2931N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6AYG5.
PRIDEiQ6AYG5.

Expressioni

Gene expression databases

GenevestigatoriQ6AYG5.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015440.

Structurei

3D structure databases

ProteinModelPortaliQ6AYG5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1024.
GeneTreeiENSGT00720000108837.
HOGENOMiHOG000007808.
HOVERGENiHBG054783.
InParanoidiQ6AYG5.
KOiK18426.
OMAiHKHMGLV.
OrthoDBiEOG79W95T.
PhylomeDBiQ6AYG5.
TreeFamiTF315986.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AYG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKSLLASSL SVRTKILQTG VSLYNTTHGF HEEEVKKILE QFPGGSIDLQ
60 70 80 90 100
KKQNGIGILT LNNSNKMNAF SGAMMLQLLE RVIELENWTE GKGLIVHGAK
110 120 130 140 150
NTFCSGSDLN AVKALSTPEN GVALSMFMQN TLTRFMRLPL ISVALVQGWA
160 170 180 190 200
MGGGAELTTA CDFRLMTEES VIRFVHKEMG IVPSWGGASR LVEIIGSRQA
210 220 230 240 250
LKVLSGTFKL DSKEALRIGL ADEVLQPSDE ATALEQAQEW LEQFVSGPAQ
260 270 280 290
VIRGLKKSVC SGRELYLEEA LQNERDVLET LWGGPANLEA IAKKGKHTK
Length:299
Mass (Da):32,631
Last modified:September 13, 2004 - v1
Checksum:iB74CCD89B663C42E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079052 mRNA. Translation: AAH79052.1.
RefSeqiNP_001007735.1. NM_001007734.1.
XP_006227809.1. XM_006227747.2.
UniGeneiRn.4220.

Genome annotation databases

EnsembliENSRNOT00000015440; ENSRNOP00000015440; ENSRNOG00000011622.
GeneIDi361465.
KEGGirno:361465.
UCSCiRGD:1359654. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079052 mRNA. Translation: AAH79052.1.
RefSeqiNP_001007735.1. NM_001007734.1.
XP_006227809.1. XM_006227747.2.
UniGeneiRn.4220.

3D structure databases

ProteinModelPortaliQ6AYG5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015440.

Proteomic databases

PaxDbiQ6AYG5.
PRIDEiQ6AYG5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015440; ENSRNOP00000015440; ENSRNOG00000011622.
GeneIDi361465.
KEGGirno:361465.
UCSCiRGD:1359654. rat.

Organism-specific databases

CTDi55862.
RGDi1359654. Echdc1.

Phylogenomic databases

eggNOGiCOG1024.
GeneTreeiENSGT00720000108837.
HOGENOMiHOG000007808.
HOVERGENiHBG054783.
InParanoidiQ6AYG5.
KOiK18426.
OMAiHKHMGLV.
OrthoDBiEOG79W95T.
PhylomeDBiQ6AYG5.
TreeFamiTF315986.

Miscellaneous databases

NextBioi676398.

Gene expression databases

GenevestigatoriQ6AYG5.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Lubec G., Afjehi-Sadat L.
    Submitted (DEC-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 38-51, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Spinal cord.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiECHD1_RAT
AccessioniPrimary (citable) accession number: Q6AYG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: September 13, 2004
Last modified: March 4, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.