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Protein

Ethylmalonyl-CoA decarboxylase

Gene

Echdc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity).By similarity

Catalytic activityi

(S)-ethylmalonyl-CoA = butanoyl-CoA + CO2.
(S)-methylmalonyl-CoA = propanoyl-CoA + CO2.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylmalonyl-CoA decarboxylase (EC:4.1.1.94)
Alternative name(s):
Enoyl-CoA hydratase domain-containing protein 1
Methylmalonyl-CoA decarboxylase (EC:4.1.1.41)
Short name:
MMCD
Gene namesi
Name:Echdc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1359654 Echdc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002732491 – 299Ethylmalonyl-CoA decarboxylaseAdd BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei209N6-acetyllysine; alternateBy similarity1
Modified residuei209N6-succinyllysine; alternateBy similarity1
Modified residuei293N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6AYG5
PRIDEiQ6AYG5

PTM databases

iPTMnetiQ6AYG5
PhosphoSitePlusiQ6AYG5

Expressioni

Gene expression databases

BgeeiENSRNOG00000011622
GenevisibleiQ6AYG5 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015440

Structurei

3D structure databases

ProteinModelPortaliQ6AYG5
SMRiQ6AYG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1680 Eukaryota
COG1024 LUCA
GeneTreeiENSGT00880000138038
HOGENOMiHOG000007808
HOVERGENiHBG054783
InParanoidiQ6AYG5
KOiK18426
OMAiHMGLVPG
OrthoDBiEOG091G0DFV
PhylomeDBiQ6AYG5
TreeFamiTF315986

Family and domain databases

InterProiView protein in InterPro
IPR029045 ClpP/crotonase-like_dom_sf
IPR018376 Enoyl-CoA_hyd/isom_CS
IPR001753 Enoyl-CoA_hydra/iso
PfamiView protein in Pfam
PF00378 ECH_1, 1 hit
SUPFAMiSSF52096 SSF52096, 1 hit
PROSITEiView protein in PROSITE
PS00166 ENOYL_COA_HYDRATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AYG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKSLLASSL SVRTKILQTG VSLYNTTHGF HEEEVKKILE QFPGGSIDLQ
60 70 80 90 100
KKQNGIGILT LNNSNKMNAF SGAMMLQLLE RVIELENWTE GKGLIVHGAK
110 120 130 140 150
NTFCSGSDLN AVKALSTPEN GVALSMFMQN TLTRFMRLPL ISVALVQGWA
160 170 180 190 200
MGGGAELTTA CDFRLMTEES VIRFVHKEMG IVPSWGGASR LVEIIGSRQA
210 220 230 240 250
LKVLSGTFKL DSKEALRIGL ADEVLQPSDE ATALEQAQEW LEQFVSGPAQ
260 270 280 290
VIRGLKKSVC SGRELYLEEA LQNERDVLET LWGGPANLEA IAKKGKHTK
Length:299
Mass (Da):32,631
Last modified:September 13, 2004 - v1
Checksum:iB74CCD89B663C42E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079052 mRNA Translation: AAH79052.1
RefSeqiNP_001007735.1, NM_001007734.1
XP_006227809.1, XM_006227747.3
XP_017444821.1, XM_017589332.1
UniGeneiRn.4220

Genome annotation databases

EnsembliENSRNOT00000015440; ENSRNOP00000015440; ENSRNOG00000011622
GeneIDi361465
KEGGirno:361465
UCSCiRGD:1359654 rat

Similar proteinsi

Entry informationi

Entry nameiECHD1_RAT
AccessioniPrimary (citable) accession number: Q6AYG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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