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Protein

Integrin beta-6

Gene

Itgb6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-RNO-1566948. Elastic fibre formation.
R-RNO-2129379. Molecules associated with elastic fibres.
R-RNO-216083. Integrin cell surface interactions.
R-RNO-3000178. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-6
Gene namesi
Name:Itgb6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1303119. Itgb6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 708687ExtracellularSequence analysisAdd
BLAST
Transmembranei709 – 72921HelicalSequence analysisAdd
BLAST
Topological domaini730 – 78758CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 787766Integrin beta-6PRO_0000273712Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 454By similarity
Disulfide bondi31 ↔ 41By similarity
Disulfide bondi34 ↔ 70By similarity
Disulfide bondi44 ↔ 59By similarity
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence analysis
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence analysis
Disulfide bondi197 ↔ 204By similarity
Disulfide bondi252 ↔ 293By similarity
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence analysis
Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence analysis
Disulfide bondi394 ↔ 406By similarity
Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence analysis
Disulfide bondi426 ↔ 669By similarity
Disulfide bondi452 ↔ 456By similarity
Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence analysis
Disulfide bondi467 ↔ 479By similarity
Glycosylationi471 – 4711N-linked (GlcNAc...)Sequence analysis
Disulfide bondi476 ↔ 511By similarity
Disulfide bondi481 ↔ 490By similarity
Disulfide bondi492 ↔ 502By similarity
Disulfide bondi517 ↔ 522By similarity
Disulfide bondi519 ↔ 552By similarity
Disulfide bondi524 ↔ 537By similarity
Disulfide bondi539 ↔ 544By similarity
Glycosylationi541 – 5411N-linked (GlcNAc...)Sequence analysis
Disulfide bondi558 ↔ 563By similarity
Disulfide bondi560 ↔ 591By similarity
Disulfide bondi565 ↔ 574By similarity
Glycosylationi575 – 5751N-linked (GlcNAc...)Sequence analysis
Disulfide bondi576 ↔ 583By similarity
Disulfide bondi597 ↔ 602By similarity
Disulfide bondi599 ↔ 645By similarity
Disulfide bondi604 ↔ 614By similarity
Disulfide bondi617 ↔ 620By similarity
Disulfide bondi624 ↔ 633By similarity
Disulfide bondi630 ↔ 701By similarity
Disulfide bondi649 ↔ 677By similarity
Glycosylationi695 – 6951N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6AYF4.
PRIDEiQ6AYF4.

Expressioni

Gene expression databases

GenevisibleiQ6AYF4. RN.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-6 associates with alpha-V. Interacts with FLNB. Interacts with HAX1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011030.

Structurei

3D structure databases

ProteinModelPortaliQ6AYF4.
SMRiQ6AYF4. Positions 699-774.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini131 – 371241VWFAAdd
BLAST
Repeati456 – 50146IAdd
BLAST
Repeati502 – 54342IIAdd
BLAST
Repeati544 – 58239IIIAdd
BLAST
Repeati583 – 61937IVAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni456 – 619164Cysteine-rich tandem repeatsAdd
BLAST
Regioni730 – 75728Interaction with HAX1By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the integrin beta chain family.Curated
Contains 1 VWFA domain.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
InParanoidiQ6AYF4.
KOiK06589.
OMAiGRGDCYC.
OrthoDBiEOG7T7GSB.
PhylomeDBiQ6AYF4.
TreeFamiTF105392.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR013111. EGF_extracell.
IPR015812. Integrin_bsu.
IPR015436. Integrin_bsu-6.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR032695. Integrin_dom.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF11. PTHR10082:SF11. 1 hit.
PfamiPF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
SM00423. PSI. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 2 hits.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AYF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIELVCLFL LLLGRNDHVQ GGCAWSGAET CSDCLLTGPH CAWCSQENFT
60 70 80 90 100
HLSGAGERCD TPENLLAKGC QLPFIENPVS QVEILQNKPL SVGRQKNSSD
110 120 130 140 150
IVQIAPQSLV LKLRPGGEQT LQVQVRQTED YPVDLYYLMD LSASMDDDLN
160 170 180 190 200
TIKELGSRLA KEMSKLTSNF RLGFGSFVEK PVSPFMKTTP EEITNPCSSI
210 220 230 240 250
PYFCLPTFGF KHILPLTDDA ERFNEIVRKQ KISANIDTPE GGFDAIMQAA
260 270 280 290 300
VCKEKIGWRN DSLHLLVFVS DADSHFGMDS KLAGIVIPND GLCHLDNRNE
310 320 330 340 350
YSMSTVLEYP TIGQLIDKLV QNNVLLIFAV TQEQVHLYEN YAKLIPGATV
360 370 380 390 400
GLLQKDSGNI LQLIISAYEE LRSEVELEVL GDTEGLNLSF TALCSNGILF
410 420 430 440 450
PHQKKCSHMK VGDTASFNVS VSITNCEKRS RKLIIKPVGL GDTLEILVSA
460 470 480 490 500
ECDCDCQREV EANSSKCHHG NGSFQCGVCA CNPGHMGPRC ECGEDMVSTD
510 520 530 540 550
SCKESPGHPS CSGRGDCYCG QCVCHLSPYG SIYGPYCQCD NFSCLRHKGL
560 570 580 590 600
LCGDNGDCDC GECVCRDGWT GEYCNCTTSR DACASEDGVL CSGRGDCVCG
610 620 630 640 650
KCVCRNPGAS GPTCERCPTC GDPCNSRRSC IECYLSADGQ AQEECEDKCK
660 670 680 690 700
ATGATISEEE FSKDTSVPCS LQGENECLIT FLITADNEGK TIIHNISEKD
710 720 730 740 750
CPKPPNIPMI MLGVSLAILL IGVVLLCIWK LLVSFHDRKE VAKFEAERSK
760 770 780
AKWQTGTNPL YRGSTSTFKN VTYKHREKHK VGLSSDG
Length:787
Mass (Da):85,959
Last modified:September 13, 2004 - v1
Checksum:i549EBAE3C9DB77BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079069 mRNA. Translation: AAH79069.1.
RefSeqiNP_001004263.1. NM_001004263.1.
XP_006234294.1. XM_006234232.1.
XP_006234295.1. XM_006234233.2.
UniGeneiRn.19828.

Genome annotation databases

EnsembliENSRNOT00000011030; ENSRNOP00000011030; ENSRNOG00000008346.
ENSRNOT00000086576; ENSRNOP00000074271; ENSRNOG00000008346.
GeneIDi311061.
KEGGirno:311061.
UCSCiRGD:1303119. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079069 mRNA. Translation: AAH79069.1.
RefSeqiNP_001004263.1. NM_001004263.1.
XP_006234294.1. XM_006234232.1.
XP_006234295.1. XM_006234233.2.
UniGeneiRn.19828.

3D structure databases

ProteinModelPortaliQ6AYF4.
SMRiQ6AYF4. Positions 699-774.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011030.

Proteomic databases

PaxDbiQ6AYF4.
PRIDEiQ6AYF4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011030; ENSRNOP00000011030; ENSRNOG00000008346.
ENSRNOT00000086576; ENSRNOP00000074271; ENSRNOG00000008346.
GeneIDi311061.
KEGGirno:311061.
UCSCiRGD:1303119. rat.

Organism-specific databases

CTDi3694.
RGDi1303119. Itgb6.

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
InParanoidiQ6AYF4.
KOiK06589.
OMAiGRGDCYC.
OrthoDBiEOG7T7GSB.
PhylomeDBiQ6AYF4.
TreeFamiTF105392.

Enzyme and pathway databases

ReactomeiR-RNO-1566948. Elastic fibre formation.
R-RNO-2129379. Molecules associated with elastic fibres.
R-RNO-216083. Integrin cell surface interactions.
R-RNO-3000178. ECM proteoglycans.

Miscellaneous databases

NextBioi662945.
PROiQ6AYF4.

Gene expression databases

GenevisibleiQ6AYF4. RN.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR013111. EGF_extracell.
IPR015812. Integrin_bsu.
IPR015436. Integrin_bsu-6.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR032695. Integrin_dom.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF11. PTHR10082:SF11. 1 hit.
PfamiPF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
SM00423. PSI. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 2 hits.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiITB6_RAT
AccessioniPrimary (citable) accession number: Q6AYF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: September 13, 2004
Last modified: May 11, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.