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Protein

Artemin

Gene

Artn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-RNO-5673001. RAF/MAP kinase cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Artemin
Gene namesi
Name:Artn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621427. Artn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939Sequence analysisAdd
BLAST
Propeptidei40 – 11172Sequence analysisPRO_0000240290Add
BLAST
Chaini112 – 224113ArteminPRO_0000240291Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi127 ↔ 192By similarity
Disulfide bondi154 ↔ 220By similarity
Disulfide bondi158 ↔ 222By similarity
Disulfide bondi191 – 191InterchainBy similarity
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6AYE8.
PRIDEiQ6AYE8.

Expressioni

Tissue specificityi

Cochlea. Expressed at higher level in sesorineural epithelium than in the modiolus region or substantia nigra.2 Publications

Developmental stagei

Expressed during embryogenesis. At embryonic day 14 (E14) not detected in the brain or spinal cord. A striking expression seen in the nerve roots but not in the developing neurons of the dorsal root ganglia. A significant expression also seen around the superior mesentric artery.1 Publication

Gene expression databases

BgeeiENSRNOG00000019842.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Binds to RET (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026852.

Structurei

3D structure databases

ProteinModelPortaliQ6AYE8.
SMRiQ6AYE8. Positions 124-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi43 – 10159Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the TGF-beta family. GDNF subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0YD. Eukaryota.
ENOG4111W7C. LUCA.
GeneTreeiENSGT00520000055559.
HOGENOMiHOG000220877.
HOVERGENiHBG080137.
InParanoidiQ6AYE8.
OMAiISQPCCR.
OrthoDBiEOG091G0L16.
PhylomeDBiQ6AYE8.
TreeFamiTF332366.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
[Graphical view]
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AYE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELGLGEPTA LSHCLRPRWQ PALWPTLAAL ALLSSVTEAS LDPMSRSPAS
60 70 80 90 100
RDVPSPVLAP PTDYLPGGHT AHLCSERALR PPPQSPQPAP PPPGPALQSP
110 120 130 140 150
PAALRGARAA RAGTRSSRAR ATDARGCRLR SQLVPVSALG LGHSSDELIR
160 170 180 190 200
FRFCSGSCRR ARSPHDLSLA SLLDAGALRS PPGSRPISQP CCRPTRYEAV
210 220
SFMDVNSTWR TVDHLSATAC GCLG
Length:224
Mass (Da):23,656
Last modified:September 13, 2004 - v1
Checksum:i08907D743F651495
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti174 – 1741D → G in AAF01241 (PubMed:10719212).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079078 mRNA. Translation: AAH79078.1.
AY230412 mRNA. Translation: AAO73543.1.
AY230413 mRNA. Translation: AAO73544.1.
AF184919 mRNA. Translation: AAF01241.1.
RefSeqiNP_445849.1. NM_053397.1.
XP_006238746.1. XM_006238684.2.
XP_006238747.1. XM_006238685.2.
XP_006238749.1. XM_006238687.2.
UniGeneiRn.154711.

Genome annotation databases

EnsembliENSRNOT00000026852; ENSRNOP00000026852; ENSRNOG00000019842.
GeneIDi362572.
KEGGirno:362572.
UCSCiRGD:621427. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079078 mRNA. Translation: AAH79078.1.
AY230412 mRNA. Translation: AAO73543.1.
AY230413 mRNA. Translation: AAO73544.1.
AF184919 mRNA. Translation: AAF01241.1.
RefSeqiNP_445849.1. NM_053397.1.
XP_006238746.1. XM_006238684.2.
XP_006238747.1. XM_006238685.2.
XP_006238749.1. XM_006238687.2.
UniGeneiRn.154711.

3D structure databases

ProteinModelPortaliQ6AYE8.
SMRiQ6AYE8. Positions 124-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026852.

Proteomic databases

PaxDbiQ6AYE8.
PRIDEiQ6AYE8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026852; ENSRNOP00000026852; ENSRNOG00000019842.
GeneIDi362572.
KEGGirno:362572.
UCSCiRGD:621427. rat.

Organism-specific databases

CTDi9048.
RGDi621427. Artn.

Phylogenomic databases

eggNOGiENOG410J0YD. Eukaryota.
ENOG4111W7C. LUCA.
GeneTreeiENSGT00520000055559.
HOGENOMiHOG000220877.
HOVERGENiHBG080137.
InParanoidiQ6AYE8.
OMAiISQPCCR.
OrthoDBiEOG091G0L16.
PhylomeDBiQ6AYE8.
TreeFamiTF332366.

Enzyme and pathway databases

ReactomeiR-RNO-5673001. RAF/MAP kinase cascade.

Miscellaneous databases

PROiQ6AYE8.

Gene expression databases

BgeeiENSRNOG00000019842.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
[Graphical view]
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARTN_RAT
AccessioniPrimary (citable) accession number: Q6AYE8
Secondary accession number(s): Q810F6, Q810F7, Q9QZG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.