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Protein

V-type proton ATPase subunit C 2

Gene

Atp6v1c2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit C 2
Short name:
V-ATPase subunit C 2
Alternative name(s):
Vacuolar proton pump subunit C 2
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359430 Atp6v1c2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002856711 – 425V-type proton ATPase subunit C 2Add BLAST425

Proteomic databases

PRIDEiQ6AYE4

Expressioni

Tissue specificityi

Lung, kidney and testis. Expressed in both bronchiolar and alveolar lung epithelial cells. Isoform 1 is predominantly expressed in the lung while isoform 2 is strongly expressed in the kidney and testis.1 Publication

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ6AYE4
SMRiQ6AYE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase C subunit family.Curated

Phylogenomic databases

HOVERGENiHBG002470
InParanoidiQ6AYE4
KOiK02148
PhylomeDBiQ6AYE4

Family and domain databases

CDDicd14785 V-ATPase_C, 1 hit
InterProiView protein in InterPro
IPR004907 ATPase_V1-cplx_csu
IPR036132 Vac_ATP_synth_c_sf
PANTHERiPTHR10137 PTHR10137, 1 hit
PfamiView protein in Pfam
PF03223 V-ATPase_C, 1 hit
SUPFAMiSSF118203 SSF118203, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6AYE4-1) [UniParc]FASTAAdd to basket
Also known as: C2-a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEFWLISAP GDKENLQALE RMNSVTSKSN LSHNTKFAIP DFKVGTLDSL
60 70 80 90 100
VGLSDELGKL DTFAESLIKR MAQSVVEVME DSKGKVHENL LANGVDLTSF
110 120 130 140 150
VTHFEWDMAK YPAKQPLVSV VDTLAKQLAQ IETDLKSRTA AYSVLKANLE
160 170 180 190 200
NLEKKSTGNL FTRTLSDIVS KEDFVLDSEY LITLLVIVPK SSYVQWQKTY
210 220 230 240 250
ESLSDMVVPR STKLIAEDNE GGLFTVTLFR KVIEDFKVKA KENKFIVREF
260 270 280 290 300
YYDEKEIKRE REEMTRLLSD KKQQYQTSCV ALKKGSATYR DHKVKVTPLG
310 320 330 340 350
NPTRPTAGQN DRESEGEGEG PLLRWLKVNF SEAFIAWIHI KALRVFVESV
360 370 380 390 400
LRYGLPVNFQ AVLLQPHKKS ATKRLREVLN SVFRHLDEVA AASILDASVE
410 420
IPGLQLSNQD YFPYVYFHID LSLLD
Length:425
Mass (Da):48,243
Last modified:September 13, 2004 - v1
Checksum:i698606392087372D
GO
Isoform 2 (identifier: Q6AYE4-2) [UniParc]FASTAAdd to basket
Also known as: C2-b

The sequence of this isoform differs from the canonical sequence as follows:
     276-319: Missing.

Show »
Length:381
Mass (Da):43,547
Checksum:iAE6D1B386731F8C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49S → P in AAT44904 (PubMed:16283434).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024886276 – 319Missing in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY594319 mRNA Translation: AAT44904.1
BC079083 mRNA Translation: AAH79083.1
RefSeqiNP_001014221.1, NM_001014199.1 [Q6AYE4-1]
UniGeneiRn.145217

Genome annotation databases

GeneIDi362802
KEGGirno:362802

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVATC2_RAT
AccessioniPrimary (citable) accession number: Q6AYE4
Secondary accession number(s): Q53B80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: September 13, 2004
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health