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Protein

V-type proton ATPase subunit C 2

Gene

Atp6v1c2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit C 2
Short name:
V-ATPase subunit C 2
Alternative name(s):
Vacuolar proton pump subunit C 2
Gene namesi
Name:Atp6v1c2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359430. Atp6v1c2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425V-type proton ATPase subunit C 2PRO_0000285671Add
BLAST

Expressioni

Tissue specificityi

Lung, kidney and testis. Expressed in both bronchiolar and alveolar lung epithelial cells. Isoform 1 is predominantly expressed in the lung while isoform 2 is strongly expressed in the kidney and testis.1 Publication

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Structurei

3D structure databases

ProteinModelPortaliQ6AYE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase C subunit family.Curated

Phylogenomic databases

HOVERGENiHBG002470.
InParanoidiQ6AYE4.
KOiK02148.
PhylomeDBiQ6AYE4.

Family and domain databases

InterProiIPR004907. ATPase_V1-cplx_csu.
[Graphical view]
PANTHERiPTHR10137. PTHR10137. 2 hits.
PfamiPF03223. V-ATPase_C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6AYE4-1) [UniParc]FASTAAdd to basket

Also known as: C2-a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEFWLISAP GDKENLQALE RMNSVTSKSN LSHNTKFAIP DFKVGTLDSL
60 70 80 90 100
VGLSDELGKL DTFAESLIKR MAQSVVEVME DSKGKVHENL LANGVDLTSF
110 120 130 140 150
VTHFEWDMAK YPAKQPLVSV VDTLAKQLAQ IETDLKSRTA AYSVLKANLE
160 170 180 190 200
NLEKKSTGNL FTRTLSDIVS KEDFVLDSEY LITLLVIVPK SSYVQWQKTY
210 220 230 240 250
ESLSDMVVPR STKLIAEDNE GGLFTVTLFR KVIEDFKVKA KENKFIVREF
260 270 280 290 300
YYDEKEIKRE REEMTRLLSD KKQQYQTSCV ALKKGSATYR DHKVKVTPLG
310 320 330 340 350
NPTRPTAGQN DRESEGEGEG PLLRWLKVNF SEAFIAWIHI KALRVFVESV
360 370 380 390 400
LRYGLPVNFQ AVLLQPHKKS ATKRLREVLN SVFRHLDEVA AASILDASVE
410 420
IPGLQLSNQD YFPYVYFHID LSLLD
Length:425
Mass (Da):48,243
Last modified:September 13, 2004 - v1
Checksum:i698606392087372D
GO
Isoform 2 (identifier: Q6AYE4-2) [UniParc]FASTAAdd to basket

Also known as: C2-b

The sequence of this isoform differs from the canonical sequence as follows:
     276-319: Missing.

Show »
Length:381
Mass (Da):43,547
Checksum:iAE6D1B386731F8C7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491S → P in AAT44904 (PubMed:16283434).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei276 – 31944Missing in isoform 2. 1 PublicationVSP_024886Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY594319 mRNA. Translation: AAT44904.1.
BC079083 mRNA. Translation: AAH79083.1.
RefSeqiNP_001014221.1. NM_001014199.1. [Q6AYE4-1]
UniGeneiRn.145217.

Genome annotation databases

GeneIDi362802.
KEGGirno:362802.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY594319 mRNA. Translation: AAT44904.1.
BC079083 mRNA. Translation: AAH79083.1.
RefSeqiNP_001014221.1. NM_001014199.1. [Q6AYE4-1]
UniGeneiRn.145217.

3D structure databases

ProteinModelPortaliQ6AYE4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi362802.
KEGGirno:362802.

Organism-specific databases

CTDi245973.
RGDi1359430. Atp6v1c2.

Phylogenomic databases

HOVERGENiHBG002470.
InParanoidiQ6AYE4.
KOiK02148.
PhylomeDBiQ6AYE4.

Miscellaneous databases

PROiQ6AYE4.

Family and domain databases

InterProiIPR004907. ATPase_V1-cplx_csu.
[Graphical view]
PANTHERiPTHR10137. PTHR10137. 2 hits.
PfamiPF03223. V-ATPase_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expression of a V-type ATPase C subunit gene, Atp6v1c2, during culture of rat lung type II pneumocytes."
    Feng N.-H., Lin H.-I., Wang J.-S., Chou S.-T., Ma H.-K., Rooney S.A., Lu J.-F.
    J. Biomed. Sci. 12:899-911(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.

Entry informationi

Entry nameiVATC2_RAT
AccessioniPrimary (citable) accession number: Q6AYE4
Secondary accession number(s): Q53B80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.