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Protein

Transcriptional adapter 2-alpha

Gene

Tada2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi426 – 43510By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional adapter 2-alpha
Alternative name(s):
Transcriptional adapter 2-like
Short name:
ADA2-like protein
Gene namesi
Name:Tada2a
Synonyms:Tada2l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1309959. Tada2a.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation
  • Chromosome By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Transcriptional adapter 2-alphaPRO_0000240670Add
BLAST

Proteomic databases

PaxDbiQ6AYE3.
PRIDEiQ6AYE3.

PTM databases

iPTMnetiQ6AYE3.

Expressioni

Gene expression databases

ExpressionAtlasiQ6AYE3. baseline.
GenevisibleiQ6AYE3. RN.

Interactioni

Subunit structurei

Interacts with GCN5 and NR3C1. Associated with the P/CAF protein in the PCAF complex. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003699.

Structurei

3D structure databases

ProteinModelPortaliQ6AYE3.
SMRiQ6AYE3. Positions 72-118, 349-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini70 – 12253SANTPROSITE-ProRule annotationAdd
BLAST
Domaini356 – 44388SWIRMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 4529Cys-richAdd
BLAST

Sequence similaritiesi

Contains 1 SANT domain.PROSITE-ProRule annotation
Contains 1 SWIRM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0457. Eukaryota.
COG5114. LUCA.
GeneTreeiENSGT00530000063657.
HOGENOMiHOG000068147.
HOVERGENiHBG057413.
InParanoidiQ6AYE3.
KOiK11314.
OMAiQMCTKSK.
OrthoDBiEOG7RFTK1.
PhylomeDBiQ6AYE3.
TreeFamiTF313975.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR016827. Ada2/TADA2.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR007526. SWIRM.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 1 hit.
PF04433. SWIRM. 1 hit.
[Graphical view]
PIRSFiPIRSF025024. Transcriptional_adaptor_2. 1 hit.
SMARTiSM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51293. SANT. 1 hit.
PS50934. SWIRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AYE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRLGSFSND PSDKPPCRGC SSYLMEPYIK CAECGPPPFF LCLQCFTRGF
60 70 80 90 100
EYKKHQSDHT YEIMTSDFPV LDPSWTAQEE MALLEAVMDC GFGNWQDVAN
110 120 130 140 150
QMCTKTKEEC EKHYMKHFIN NPLFASTLLN LKQAEAAKTA DTAIPFHSAD
160 170 180 190 200
DPPRPAFDSL LSRDMAGYMP ARADFIEEFD NYAEWDLRDI DFVEDDSDIL
210 220 230 240 250
HALKMAVVDI YHSRLKERQR RKKIIRDHGL VNLRKFRLME RRYPKEVQDL
260 270 280 290 300
YETMRRFARI VGPVEHDKFI ESHALEFELR REIKRLQEYR TAGITNFCSA
310 320 330 340 350
RTYDHLKKTR EEERLKRTML SEVLQYIQDS SACQQWLRRQ ADIDSGLSPS
360 370 380 390 400
VLMASNSGRR SAPPLNLTGL PGTEKLNEKE KELCQVVRLV PGAYLEYKSA
410 420 430 440
LLNECHKQGG LRLAQARALI KIDVNKTRKI YDFLIREGYI TKA
Length:443
Mass (Da):51,399
Last modified:September 13, 2004 - v1
Checksum:iE89255BB908880DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF121983 mRNA. Translation: ABL63422.1.
EF121984 mRNA. Translation: ABL63423.1.
BC079084 mRNA. Translation: AAH79084.1.
RefSeqiNP_001012141.1. NM_001012141.1.
UniGeneiRn.8027.

Genome annotation databases

EnsembliENSRNOT00000003699; ENSRNOP00000003699; ENSRNOG00000002757.
GeneIDi360581.
KEGGirno:360581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF121983 mRNA. Translation: ABL63422.1.
EF121984 mRNA. Translation: ABL63423.1.
BC079084 mRNA. Translation: AAH79084.1.
RefSeqiNP_001012141.1. NM_001012141.1.
UniGeneiRn.8027.

3D structure databases

ProteinModelPortaliQ6AYE3.
SMRiQ6AYE3. Positions 72-118, 349-443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003699.

PTM databases

iPTMnetiQ6AYE3.

Proteomic databases

PaxDbiQ6AYE3.
PRIDEiQ6AYE3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003699; ENSRNOP00000003699; ENSRNOG00000002757.
GeneIDi360581.
KEGGirno:360581.

Organism-specific databases

CTDi6871.
RGDi1309959. Tada2a.

Phylogenomic databases

eggNOGiKOG0457. Eukaryota.
COG5114. LUCA.
GeneTreeiENSGT00530000063657.
HOGENOMiHOG000068147.
HOVERGENiHBG057413.
InParanoidiQ6AYE3.
KOiK11314.
OMAiQMCTKSK.
OrthoDBiEOG7RFTK1.
PhylomeDBiQ6AYE3.
TreeFamiTF313975.

Miscellaneous databases

PROiQ6AYE3.

Gene expression databases

ExpressionAtlasiQ6AYE3. baseline.
GenevisibleiQ6AYE3. RN.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR016827. Ada2/TADA2.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR007526. SWIRM.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 1 hit.
PF04433. SWIRM. 1 hit.
[Graphical view]
PIRSFiPIRSF025024. Transcriptional_adaptor_2. 1 hit.
SMARTiSM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51293. SANT. 1 hit.
PS50934. SWIRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10."
    Saad Y., Garrett M.R., Manickavasagam E., Yerga-Woolwine S., Farms P., Radecki T., Joe B.
    Genomics 89:343-353(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Dahl salt-sensitive and Lewis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiTAD2A_RAT
AccessioniPrimary (citable) accession number: Q6AYE3
Secondary accession number(s): A1EC76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.