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Protein

PDZ and LIM domain protein 2

Gene

Pdlim2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity (By similarity).By similarity1 Publication

GO - Molecular functioni

  • alpha-actinin binding Source: RGD
  • filamin binding Source: RGD
  • metal ion binding Source: UniProtKB-KW
  • muscle alpha-actinin binding Source: RGD
  • myosin heavy chain binding Source: RGD

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ and LIM domain protein 2
Gene namesi
Name:Pdlim2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1359203. Pdlim2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758651 – 349PDZ and LIM domain protein 2Add BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphoserineBy similarity1
Modified residuei127PhosphoserineBy similarity1
Modified residuei129PhosphoserineBy similarity1
Modified residuei134PhosphoserineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei138PhosphothreonineBy similarity1
Modified residuei142PhosphothreonineBy similarity1
Modified residuei143PhosphoserineBy similarity1
Modified residuei163PhosphoserineBy similarity1
Modified residuei199PhosphoserineCombined sources1
Modified residuei204PhosphoserineBy similarity1
Modified residuei205PhosphoserineBy similarity1
Modified residuei209PhosphoserineBy similarity1
Modified residuei210PhosphoserineCombined sources1
Modified residuei263PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AYD6.
PRIDEiQ6AYD6.

PTM databases

iPTMnetiQ6AYD6.
PhosphoSitePlusiQ6AYD6.

Expressioni

Tissue specificityi

Highly expressed in cornea and lung. Expressed at intermediate level in sclera and combined tissues of the eye irido-corneal angle. Specifically expressed in the corneal epithelial cells but not in other corneal layers.1 Publication

Gene expression databases

BgeeiENSRNOG00000008543.
GenevisibleiQ6AYD6. RN.

Interactioni

Subunit structurei

Interacts with alpha-actinins ACTN1 and ACTN4, FLNA and MYH9.1 Publication

GO - Molecular functioni

  • alpha-actinin binding Source: RGD
  • filamin binding Source: RGD
  • muscle alpha-actinin binding Source: RGD
  • myosin heavy chain binding Source: RGD

Protein-protein interaction databases

BioGridi253175. 5 interactors.
STRINGi10116.ENSRNOP00000011663.

Structurei

3D structure databases

ProteinModelPortaliQ6AYD6.
SMRiQ6AYD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 84PDZPROSITE-ProRule annotationAdd BLAST84
Domaini281 – 341LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiKOG1703. Eukaryota.
ENOG410XRD4. LUCA.
GeneTreeiENSGT00590000082980.
HOGENOMiHOG000290704.
HOVERGENiHBG061371.
InParanoidiQ6AYD6.
OMAiFQSLAHS.
OrthoDBiEOG091G0A6C.
PhylomeDBiQ6AYD6.
TreeFamiTF106408.

Family and domain databases

InterProiView protein in InterPro
IPR031847. DUF4749.
IPR001478. PDZ.
IPR036034. PDZ_sf.
IPR001781. Znf_LIM.
PfamiView protein in Pfam
PF15936. DUF4749. 1 hit.
PF00412. LIM. 1 hit.
PF00595. PDZ. 1 hit.
SMARTiView protein in SMART
SM00132. LIM. 1 hit.
SM00228. PDZ. 1 hit.
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiView protein in PROSITE
PS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS50106. PDZ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AYD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTVNVVGP APWGFRISGG RDFHTPIIVT KVTERGKAEA ADLRPGDIIV
60 70 80 90 100
AINGESAESM LHAEAQSKIR QSASPLRLQL DRSQTASPGQ INGEGSLDML
110 120 130 140 150
ATRFQGSLRT HHNSQSSQRS ACFSPASLSP RPDSPFSTPP PTSPIALSGE
160 170 180 190 200
NVIGCSFQSL THSPGLAATH HLTYPGQPTS QQAGHSSPSD STVRVLLHSP
210 220 230 240 250
GRPSSPRLSS LDLEEDSEVF KMLQENRQGR AAPRQSSSFR LLQEALEAEE
260 270 280 290 300
RGGTPAFVPS SLSPKASLPT SRALATPPKL HTCEKCSVNI SNQAVRIQEG
310 320 330 340
RYRHPGCYTC ADCGLNLKMR GHFWVGNELY CEKHARQRYS MPGTLSSQA
Length:349
Mass (Da):37,580
Last modified:September 13, 2004 - v1
Checksum:i39AE7B31979668D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY531526 mRNA. Translation: AAS99334.1.
BC079091 mRNA. Translation: AAH79091.1.
RefSeqiNP_001007623.1. NM_001007622.1.
XP_006252318.1. XM_006252256.3.
XP_006252319.1. XM_006252257.3.
XP_006252320.1. XM_006252258.2.
XP_006252321.1. XM_006252259.3.
XP_008769045.1. XM_008770823.2.
UniGeneiRn.105730.

Genome annotation databases

EnsembliENSRNOT00000011663; ENSRNOP00000011663; ENSRNOG00000008543.
GeneIDi290354.
KEGGirno:290354.
UCSCiRGD:1359203. rat.

Similar proteinsi

Entry informationi

Entry nameiPDLI2_RAT
AccessioniPrimary (citable) accession number: Q6AYD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: September 13, 2004
Last modified: November 22, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome