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Protein

Endothelial cell-selective adhesion molecule

Gene

Esam

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Can mediate aggregation most likely through a homophilic molecular interaction.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-RNO-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial cell-selective adhesion molecule
Gene namesi
Name:Esam
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1303286. Esam.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 251ExtracellularSequence analysisAdd BLAST222
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Topological domaini273 – 394CytoplasmicSequence analysisAdd BLAST122

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29By similarityAdd BLAST29
ChainiPRO_000001475530 – 394Endothelial cell-selective adhesion moleculeAdd BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi111N-linked (GlcNAc...)Sequence analysis1
Glycosylationi172N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi177 ↔ 227PROSITE-ProRule annotation
Glycosylationi216N-linked (GlcNAc...)Sequence analysis1
Glycosylationi239N-linked (GlcNAc...)Sequence analysis1
Modified residuei304PhosphoserineCombined sources1
Modified residuei336PhosphothreonineBy similarity1
Modified residuei338PhosphothreonineBy similarity1
Modified residuei340PhosphoserineBy similarity1
Modified residuei343PhosphoserineBy similarity1
Modified residuei348PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6AYD4.
PRIDEiQ6AYD4.

PTM databases

iPTMnetiQ6AYD4.
PhosphoSitePlusiQ6AYD4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000033217.
ExpressionAtlasiQ6AYD4. baseline and differential.
GenevisibleiQ6AYD4. RN.

Interactioni

Subunit structurei

Interacts with BAIAP1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051485.

Structurei

3D structure databases

ProteinModelPortaliQ6AYD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 146Ig-like V-typeAdd BLAST110
Domaini156 – 243Ig-like C2-typeAdd BLAST88

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHVB. Eukaryota.
ENOG4111DT8. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000111222.
HOVERGENiHBG000420.
InParanoidiQ6AYD4.
KOiK06787.
OMAiYSMPSRN.
OrthoDBiEOG091G05PI.
PhylomeDBiQ6AYD4.
TreeFamiTF330875.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AYD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILPARTPET SLLRVLFLGL STLAAFSLAQ MELHVPPGLN KLEAVEGEEV
60 70 80 90 100
VLPAWYTMAR EESSSHPWEA PFLIWFLEQE GKEPKQVLSY FKGSLSNKPG
110 120 130 140 150
VTLVHSISTR NVSLRLDALQ EGDSGTYRCS VNAYDSDGKN IGHSIKTIEL
160 170 180 190 200
KVLVPPAPPS CSFQGVPYVG TNVTLNCKSP RSKPTAQYQW ERLAPSSQVF
210 220 230 240 250
FGPALDTVRG SLKLTNISTA MSGVYVCKAQ NRVGFAQCNV TLDVMTGSKA
260 270 280 290 300
AVVAGAVVGT FVGLVLIAGL VLLYQRRSKT LEELANDIKE DAIAPRTLPW
310 320 330 340 350
TKGSDTISKN GTLSSVTSAR ALRPPKAAPP RPGTFTPTPS VSSQALSSPR
360 370 380 390
LPRTDGPPPQ AVSLTPGGVS SSTLNRMGAV PVMVPAQSQA GSLV
Length:394
Mass (Da):41,936
Last modified:September 13, 2004 - v1
Checksum:i9CA7402EA46F1195
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079093 mRNA. Translation: AAH79093.1.
RefSeqiNP_001004245.1. NM_001004245.1.
UniGeneiRn.17089.

Genome annotation databases

EnsembliENSRNOT00000050609; ENSRNOP00000051485; ENSRNOG00000033217.
GeneIDi300519.
KEGGirno:300519.
UCSCiRGD:1303286. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079093 mRNA. Translation: AAH79093.1.
RefSeqiNP_001004245.1. NM_001004245.1.
UniGeneiRn.17089.

3D structure databases

ProteinModelPortaliQ6AYD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051485.

PTM databases

iPTMnetiQ6AYD4.
PhosphoSitePlusiQ6AYD4.

Proteomic databases

PaxDbiQ6AYD4.
PRIDEiQ6AYD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000050609; ENSRNOP00000051485; ENSRNOG00000033217.
GeneIDi300519.
KEGGirno:300519.
UCSCiRGD:1303286. rat.

Organism-specific databases

CTDi90952.
RGDi1303286. Esam.

Phylogenomic databases

eggNOGiENOG410IHVB. Eukaryota.
ENOG4111DT8. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000111222.
HOVERGENiHBG000420.
InParanoidiQ6AYD4.
KOiK06787.
OMAiYSMPSRN.
OrthoDBiEOG091G05PI.
PhylomeDBiQ6AYD4.
TreeFamiTF330875.

Enzyme and pathway databases

ReactomeiR-RNO-202733. Cell surface interactions at the vascular wall.

Miscellaneous databases

PROiQ6AYD4.

Gene expression databases

BgeeiENSRNOG00000033217.
ExpressionAtlasiQ6AYD4. baseline and differential.
GenevisibleiQ6AYD4. RN.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiESAM_RAT
AccessioniPrimary (citable) accession number: Q6AYD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: September 13, 2004
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.