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Protein

Endothelial cell-selective adhesion molecule

Gene

Esam

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Can mediate aggregation most likely through a homophilic molecular interaction.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-RNO-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial cell-selective adhesion molecule
Gene namesi
Name:Esam
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1303286. Esam.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 251222ExtracellularSequence analysisAdd
BLAST
Transmembranei252 – 27221HelicalSequence analysisAdd
BLAST
Topological domaini273 – 394122CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929By similarityAdd
BLAST
Chaini30 – 394365Endothelial cell-selective adhesion moleculePRO_0000014755Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence analysis
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence analysis
Disulfide bondi177 ↔ 227PROSITE-ProRule annotation
Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence analysis
Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence analysis
Modified residuei304 – 3041PhosphoserineCombined sources
Modified residuei336 – 3361PhosphothreonineBy similarity
Modified residuei338 – 3381PhosphothreonineBy similarity
Modified residuei340 – 3401PhosphoserineBy similarity
Modified residuei343 – 3431PhosphoserineBy similarity
Modified residuei348 – 3481PhosphoserineCombined sources

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6AYD4.
PRIDEiQ6AYD4.

Expressioni

Gene expression databases

ExpressionAtlasiQ6AYD4. baseline and differential.
GenevisibleiQ6AYD4. RN.

Interactioni

Subunit structurei

Interacts with BAIAP1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051485.

Structurei

3D structure databases

ProteinModelPortaliQ6AYD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 146110Ig-like V-typeAdd
BLAST
Domaini156 – 24388Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHVB. Eukaryota.
ENOG4111DT8. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000111222.
HOVERGENiHBG000420.
InParanoidiQ6AYD4.
KOiK06787.
OMAiYSMPSRN.
OrthoDBiEOG7MH0Z1.
PhylomeDBiQ6AYD4.
TreeFamiTF330875.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AYD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILPARTPET SLLRVLFLGL STLAAFSLAQ MELHVPPGLN KLEAVEGEEV
60 70 80 90 100
VLPAWYTMAR EESSSHPWEA PFLIWFLEQE GKEPKQVLSY FKGSLSNKPG
110 120 130 140 150
VTLVHSISTR NVSLRLDALQ EGDSGTYRCS VNAYDSDGKN IGHSIKTIEL
160 170 180 190 200
KVLVPPAPPS CSFQGVPYVG TNVTLNCKSP RSKPTAQYQW ERLAPSSQVF
210 220 230 240 250
FGPALDTVRG SLKLTNISTA MSGVYVCKAQ NRVGFAQCNV TLDVMTGSKA
260 270 280 290 300
AVVAGAVVGT FVGLVLIAGL VLLYQRRSKT LEELANDIKE DAIAPRTLPW
310 320 330 340 350
TKGSDTISKN GTLSSVTSAR ALRPPKAAPP RPGTFTPTPS VSSQALSSPR
360 370 380 390
LPRTDGPPPQ AVSLTPGGVS SSTLNRMGAV PVMVPAQSQA GSLV
Length:394
Mass (Da):41,936
Last modified:September 13, 2004 - v1
Checksum:i9CA7402EA46F1195
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079093 mRNA. Translation: AAH79093.1.
RefSeqiNP_001004245.1. NM_001004245.1.
UniGeneiRn.17089.

Genome annotation databases

EnsembliENSRNOT00000050609; ENSRNOP00000051485; ENSRNOG00000033217.
GeneIDi300519.
KEGGirno:300519.
UCSCiRGD:1303286. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079093 mRNA. Translation: AAH79093.1.
RefSeqiNP_001004245.1. NM_001004245.1.
UniGeneiRn.17089.

3D structure databases

ProteinModelPortaliQ6AYD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051485.

Proteomic databases

PaxDbiQ6AYD4.
PRIDEiQ6AYD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000050609; ENSRNOP00000051485; ENSRNOG00000033217.
GeneIDi300519.
KEGGirno:300519.
UCSCiRGD:1303286. rat.

Organism-specific databases

CTDi90952.
RGDi1303286. Esam.

Phylogenomic databases

eggNOGiENOG410IHVB. Eukaryota.
ENOG4111DT8. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000111222.
HOVERGENiHBG000420.
InParanoidiQ6AYD4.
KOiK06787.
OMAiYSMPSRN.
OrthoDBiEOG7MH0Z1.
PhylomeDBiQ6AYD4.
TreeFamiTF330875.

Enzyme and pathway databases

ReactomeiR-RNO-202733. Cell surface interactions at the vascular wall.

Miscellaneous databases

NextBioi646992.
PROiQ6AYD4.

Gene expression databases

ExpressionAtlasiQ6AYD4. baseline and differential.
GenevisibleiQ6AYD4. RN.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-304 AND SER-348, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiESAM_RAT
AccessioniPrimary (citable) accession number: Q6AYD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: September 13, 2004
Last modified: May 11, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.