ID   SH24A_RAT               Reviewed;         422 AA.
AC   Q6AYC8;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   24-JAN-2024, entry version 111.
DE   RecName: Full=SH2 domain-containing protein 4A;
GN   Name=Sh2d4a;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Inhibits estrogen-induced cell proliferation by competing
CC       with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG
CC       and repressing estrogen-induced proliferation. May play a role in T-
CC       cell development and function (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ESR1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Located at podocyte
CC       foot processes. {ECO:0000250}.
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DR   EMBL; BC079100; AAH79100.1; -; mRNA.
DR   RefSeq; NP_001012048.1; NM_001012048.1.
DR   RefSeq; XP_006253094.1; XM_006253032.3.
DR   AlphaFoldDB; Q6AYC8; -.
DR   SMR; Q6AYC8; -.
DR   BioGRID; 258441; 1.
DR   STRING; 10116.ENSRNOP00000018543; -.
DR   iPTMnet; Q6AYC8; -.
DR   PhosphoSitePlus; Q6AYC8; -.
DR   PaxDb; 10116-ENSRNOP00000018543; -.
DR   Ensembl; ENSRNOT00000018543.6; ENSRNOP00000018543.3; ENSRNOG00000013541.6.
DR   Ensembl; ENSRNOT00060026442; ENSRNOP00060021141; ENSRNOG00060015405.
DR   Ensembl; ENSRNOT00065007141; ENSRNOP00065004951; ENSRNOG00065004903.
DR   GeneID; 306376; -.
DR   KEGG; rno:306376; -.
DR   UCSC; RGD:1307991; rat.
DR   AGR; RGD:1307991; -.
DR   CTD; 63898; -.
DR   RGD; 1307991; Sh2d4a.
DR   eggNOG; ENOG502QVV5; Eukaryota.
DR   GeneTree; ENSGT00940000157357; -.
DR   HOGENOM; CLU_029296_1_0_1; -.
DR   InParanoid; Q6AYC8; -.
DR   OMA; YPCGQQG; -.
DR   OrthoDB; 5361172at2759; -.
DR   PhylomeDB; Q6AYC8; -.
DR   TreeFam; TF336893; -.
DR   PRO; PR:Q6AYC8; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000013541; Expressed in stomach and 18 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0019902; F:phosphatase binding; ISS:UniProtKB.
DR   CDD; cd10350; SH2_SH2D4A; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   PANTHER; PTHR14388:SF5; SH2 DOMAIN-CONTAINING PROTEIN 4A; 1.
DR   PANTHER; PTHR14388; T CELL-SPECIFIC ADAPTER PROTEIN TSAD; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   Genevisible; Q6AYC8; RN.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Phosphoprotein; Reference proteome; SH2 domain.
FT   CHAIN           1..422
FT                   /note="SH2 domain-containing protein 4A"
FT                   /id="PRO_0000233135"
FT   DOMAIN          316..408
FT                   /note="SH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT   REGION          141..190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          202..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        158..190
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..235
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        249..266
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         117
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D7V1"
FT   MOD_RES         123
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H788"
FT   MOD_RES         233
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H788"
SQ   SEQUENCE   422 AA;  48522 MW;  56CC672C2297F803 CRC64;
     MLRQILSEMF IDPDLLAELS EEQKQILFYK MREEQIRRWK EREAAMERKE SLPVKSRPKK
     ENGKSVHWKL GADKQVWVWV MGEHHLDKPY DVLCDEILAE REHLRAAKDA ELRKAQSLQF
     TNSLKVKSLN CDLQAVKKTE PQNVTRKAAA EEATDQGPRA IPTKKDDKAQ TKDLTKKKDS
     EELKQTEDEK TKQIYKNWKE DSEWQASLRK SKAADEKRRS LAKQAREDYK RLSQRGRSGD
     GLQNPLTGPQ KPKRPPLPPK PQFLQPLGSP PKSLGNQGVI RTKTSSTQED IIRWFKEEQL
     PFRAGYQKNS DTIAPWFHGI LTLKKANELL STGMPGSFLI RVSEKIKGYA LSYLSEEGCK
     HFLIDASANS YSFLGVDQLQ HATLADLVEY HKEEPITSLG KELLLFPCGQ QDKPPDYLEL
     FQ
//